FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 24221

FusionGeneSummary for NFIB_FREM1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIB_FREM1
Fusion gene ID: 24221
HgeneTgene
Gene symbol

NFIB

FREM1

Gene ID

4781

158326

Gene namenuclear factor I BFRAS1 related extracellular matrix 1
SynonymsCTF|HMGIC/NFIB|NF-I/B|NF1-B|NFI-B|NFI-RED|NFIB2|NFIB3BNAR|C9orf143|C9orf145|C9orf154|MOTA|TILRR|TRIGNO2
Cytomap

9p23-p22.3

9p22.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/BFRAS1-related extracellular matrix protein 1extracellular matrix protein QBRICK
Modification date2018052320180519
UniProtAcc

O00712

Q5H8C1

Ensembl transtripts involved in fusion geneENST00000380934, ENST00000380959, 
ENST00000380953, ENST00000397575, 
ENST00000397581, ENST00000397579, 
ENST00000543693, ENST00000380924, 
ENST00000380921, 
ENST00000422223, 
ENST00000380881, ENST00000380880, 
ENST00000380894, ENST00000486223, 
Fusion gene scores* DoF score8 X 8 X 4=2564 X 5 X 4=80
# samples 84
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFIB [Title/Abstract] AND FREM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIB

GO:0045944

positive regulation of transcription by RNA polymerase II

9099724|19540848


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-43-6143-01ANFIBchr9

14146688

-FREM1chr9

14759899

-
TCGALDLUSCTCGA-43-6143-01ANFIBchr9

14146688

-FREM1chr9

14756444

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380934ENST00000422223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380934ENST00000380881NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380934ENST00000380880NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380934ENST00000380894NFIBchr9

14146688

-FREM1chr9

14759899

-
5CDS-5UTRENST00000380934ENST00000486223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380959ENST00000422223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380959ENST00000380881NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380959ENST00000380880NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380959ENST00000380894NFIBchr9

14146688

-FREM1chr9

14759899

-
5CDS-5UTRENST00000380959ENST00000486223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380953ENST00000422223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380953ENST00000380881NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380953ENST00000380880NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380953ENST00000380894NFIBchr9

14146688

-FREM1chr9

14759899

-
5CDS-5UTRENST00000380953ENST00000486223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397575ENST00000422223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397575ENST00000380881NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397575ENST00000380880NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397575ENST00000380894NFIBchr9

14146688

-FREM1chr9

14759899

-
5CDS-5UTRENST00000397575ENST00000486223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397581ENST00000422223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397581ENST00000380881NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397581ENST00000380880NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397581ENST00000380894NFIBchr9

14146688

-FREM1chr9

14759899

-
5CDS-5UTRENST00000397581ENST00000486223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397579ENST00000422223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397579ENST00000380881NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397579ENST00000380880NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000397579ENST00000380894NFIBchr9

14146688

-FREM1chr9

14759899

-
5CDS-5UTRENST00000397579ENST00000486223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000543693ENST00000422223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000543693ENST00000380881NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000543693ENST00000380880NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000543693ENST00000380894NFIBchr9

14146688

-FREM1chr9

14759899

-
5CDS-5UTRENST00000543693ENST00000486223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380924ENST00000422223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380924ENST00000380881NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380924ENST00000380880NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380924ENST00000380894NFIBchr9

14146688

-FREM1chr9

14759899

-
5CDS-5UTRENST00000380924ENST00000486223NFIBchr9

14146688

-FREM1chr9

14759899

-
intron-3CDSENST00000380921ENST00000422223NFIBchr9

14146688

-FREM1chr9

14759899

-
intron-3CDSENST00000380921ENST00000380881NFIBchr9

14146688

-FREM1chr9

14759899

-
intron-3CDSENST00000380921ENST00000380880NFIBchr9

14146688

-FREM1chr9

14759899

-
intron-3CDSENST00000380921ENST00000380894NFIBchr9

14146688

-FREM1chr9

14759899

-
intron-5UTRENST00000380921ENST00000486223NFIBchr9

14146688

-FREM1chr9

14759899

-
Frame-shiftENST00000380934ENST00000422223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380934ENST00000380881NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380934ENST00000380880NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380934ENST00000380894NFIBchr9

14146688

-FREM1chr9

14756444

-
5CDS-5UTRENST00000380934ENST00000486223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380959ENST00000422223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380959ENST00000380881NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380959ENST00000380880NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380959ENST00000380894NFIBchr9

14146688

-FREM1chr9

14756444

-
5CDS-5UTRENST00000380959ENST00000486223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380953ENST00000422223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380953ENST00000380881NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380953ENST00000380880NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380953ENST00000380894NFIBchr9

14146688

-FREM1chr9

14756444

-
5CDS-5UTRENST00000380953ENST00000486223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397575ENST00000422223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397575ENST00000380881NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397575ENST00000380880NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397575ENST00000380894NFIBchr9

14146688

-FREM1chr9

14756444

-
5CDS-5UTRENST00000397575ENST00000486223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397581ENST00000422223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397581ENST00000380881NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397581ENST00000380880NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397581ENST00000380894NFIBchr9

14146688

-FREM1chr9

14756444

-
5CDS-5UTRENST00000397581ENST00000486223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397579ENST00000422223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397579ENST00000380881NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397579ENST00000380880NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000397579ENST00000380894NFIBchr9

14146688

-FREM1chr9

14756444

-
5CDS-5UTRENST00000397579ENST00000486223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000543693ENST00000422223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000543693ENST00000380881NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000543693ENST00000380880NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000543693ENST00000380894NFIBchr9

14146688

-FREM1chr9

14756444

-
5CDS-5UTRENST00000543693ENST00000486223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380924ENST00000422223NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380924ENST00000380881NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380924ENST00000380880NFIBchr9

14146688

-FREM1chr9

14756444

-
Frame-shiftENST00000380924ENST00000380894NFIBchr9

14146688

-FREM1chr9

14756444

-
5CDS-5UTRENST00000380924ENST00000486223NFIBchr9

14146688

-FREM1chr9

14756444

-
intron-3CDSENST00000380921ENST00000422223NFIBchr9

14146688

-FREM1chr9

14756444

-
intron-3CDSENST00000380921ENST00000380881NFIBchr9

14146688

-FREM1chr9

14756444

-
intron-3CDSENST00000380921ENST00000380880NFIBchr9

14146688

-FREM1chr9

14756444

-
intron-3CDSENST00000380921ENST00000380894NFIBchr9

14146688

-FREM1chr9

14756444

-
intron-5UTRENST00000380921ENST00000486223NFIBchr9

14146688

-FREM1chr9

14756444

-

Top

FusionProtFeatures for NFIB_FREM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIB

O00712

FREM1

Q5H8C1

Extracellular matrix protein that plays a role inepidermal differentiation and is required for epidermal adhesionduring embryonic development. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NFIB_FREM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NFIB_FREM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NFIBRFX1, NFIC, NFIX, SOX2, ELAVL1, GRK5, EED, UNK, XRCC5, SASS6, NFIAFREM1STK3, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NFIB_FREM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NFIB_FREM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFIBC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneFREM1C1855425Marles Greenberg Persaud syndrome2CTD_human;ORPHANET;UNIPROT
TgeneFREM1C2750433Bifid Nose With Or Without Anorectal And Renal Anomalies2CTD_human;ORPHANET;UNIPROT
TgeneFREM1C0015393Eye Abnormalities1CTD_human
TgeneFREM1C0221363Bifid nose1CTD_human
TgeneFREM1C0235833Congenital diaphragmatic hernia1CTD_human
TgeneFREM1C1609433Congenital absence of kidneys syndrome1CTD_human
TgeneFREM1C3280974TRIGONOCEPHALY 21UNIPROT