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Fusion gene ID: 24221 |
FusionGeneSummary for NFIB_FREM1 |
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Fusion gene information | Fusion gene name: NFIB_FREM1 | Fusion gene ID: 24221 | Hgene | Tgene | Gene symbol | NFIB | FREM1 | Gene ID | 4781 | 158326 |
Gene name | nuclear factor I B | FRAS1 related extracellular matrix 1 | |
Synonyms | CTF|HMGIC/NFIB|NF-I/B|NF1-B|NFI-B|NFI-RED|NFIB2|NFIB3 | BNAR|C9orf143|C9orf145|C9orf154|MOTA|TILRR|TRIGNO2 | |
Cytomap | 9p23-p22.3 | 9p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/B | FRAS1-related extracellular matrix protein 1extracellular matrix protein QBRICK | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O00712 | Q5H8C1 | |
Ensembl transtripts involved in fusion gene | ENST00000380934, ENST00000380959, ENST00000380953, ENST00000397575, ENST00000397581, ENST00000397579, ENST00000543693, ENST00000380924, ENST00000380921, | ENST00000422223, ENST00000380881, ENST00000380880, ENST00000380894, ENST00000486223, | |
Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 4 X 5 X 4=80 |
# samples | 8 | 4 | |
** MAII score | log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NFIB [Title/Abstract] AND FREM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NFIB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9099724|19540848 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-43-6143-01A | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
TCGA | LD | LUSC | TCGA-43-6143-01A | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000380934 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380934 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380934 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380934 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
5CDS-5UTR | ENST00000380934 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380959 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380959 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380959 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380959 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
5CDS-5UTR | ENST00000380959 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380953 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380953 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380953 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380953 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
5CDS-5UTR | ENST00000380953 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397575 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397575 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397575 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397575 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
5CDS-5UTR | ENST00000397575 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397581 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397581 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397581 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397581 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
5CDS-5UTR | ENST00000397581 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397579 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397579 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397579 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000397579 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
5CDS-5UTR | ENST00000397579 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000543693 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000543693 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000543693 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000543693 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
5CDS-5UTR | ENST00000543693 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380924 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380924 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380924 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380924 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
5CDS-5UTR | ENST00000380924 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
intron-3CDS | ENST00000380921 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
intron-3CDS | ENST00000380921 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
intron-3CDS | ENST00000380921 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
intron-3CDS | ENST00000380921 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
intron-5UTR | ENST00000380921 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14759899 | - |
Frame-shift | ENST00000380934 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380934 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380934 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380934 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
5CDS-5UTR | ENST00000380934 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380959 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380959 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380959 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380959 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
5CDS-5UTR | ENST00000380959 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380953 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380953 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380953 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380953 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
5CDS-5UTR | ENST00000380953 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397575 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397575 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397575 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397575 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
5CDS-5UTR | ENST00000397575 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397581 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397581 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397581 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397581 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
5CDS-5UTR | ENST00000397581 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397579 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397579 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397579 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000397579 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
5CDS-5UTR | ENST00000397579 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000543693 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000543693 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000543693 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000543693 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
5CDS-5UTR | ENST00000543693 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380924 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380924 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380924 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
Frame-shift | ENST00000380924 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
5CDS-5UTR | ENST00000380924 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
intron-3CDS | ENST00000380921 | ENST00000422223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
intron-3CDS | ENST00000380921 | ENST00000380881 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
intron-3CDS | ENST00000380921 | ENST00000380880 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
intron-3CDS | ENST00000380921 | ENST00000380894 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
intron-5UTR | ENST00000380921 | ENST00000486223 | NFIB | chr9 | 14146688 | - | FREM1 | chr9 | 14756444 | - |
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FusionProtFeatures for NFIB_FREM1 |
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Hgene | Tgene |
NFIB | FREM1 |
Extracellular matrix protein that plays a role inepidermal differentiation and is required for epidermal adhesionduring embryonic development. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NFIB_FREM1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NFIB_FREM1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NFIB | RFX1, NFIC, NFIX, SOX2, ELAVL1, GRK5, EED, UNK, XRCC5, SASS6, NFIA | FREM1 | STK3, KRAS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFIB_FREM1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NFIB_FREM1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NFIB | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Tgene | FREM1 | C1855425 | Marles Greenberg Persaud syndrome | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | FREM1 | C2750433 | Bifid Nose With Or Without Anorectal And Renal Anomalies | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | FREM1 | C0015393 | Eye Abnormalities | 1 | CTD_human |
Tgene | FREM1 | C0221363 | Bifid nose | 1 | CTD_human |
Tgene | FREM1 | C0235833 | Congenital diaphragmatic hernia | 1 | CTD_human |
Tgene | FREM1 | C1609433 | Congenital absence of kidneys syndrome | 1 | CTD_human |
Tgene | FREM1 | C3280974 | TRIGONOCEPHALY 2 | 1 | UNIPROT |