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Fusion gene ID: 24215 |
FusionGeneSummary for NFIA_PIK3R1 |
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Fusion gene information | Fusion gene name: NFIA_PIK3R1 | Fusion gene ID: 24215 | Hgene | Tgene | Gene symbol | NFIA | PIK3R1 | Gene ID | 4774 | 5295 |
Gene name | nuclear factor I A | phosphoinositide-3-kinase regulatory subunit 1 | |
Synonyms | BRMUTD|CTF|NF-I/A|NF1-A|NFI-A|NFI-L | AGM7|GRB1|IMD36|p85|p85-ALPHA | |
Cytomap | 1p31.3 | 5q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear factor 1 A-typeCCAAT-box-binding transcription factorTGGCA-binding protein | phosphatidylinositol 3-kinase regulatory subunit alphaPI3-kinase subunit p85-alphaPI3K regulatory subunit alphaphosphatidylinositol 3-kinase 85 kDa regulatory subunit alphaphosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)ph | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q12857 | P27986 | |
Ensembl transtripts involved in fusion gene | ENST00000371191, ENST00000407417, ENST00000479364, ENST00000371189, ENST00000403491, ENST00000371187, ENST00000485903, ENST00000371185, ENST00000371184, ENST00000357977, | ENST00000521381, ENST00000521657, ENST00000517643, ENST00000274335, ENST00000396611, ENST00000320694, ENST00000336483, ENST00000523872, | |
Fusion gene scores | * DoF score | 14 X 13 X 7=1274 | 6 X 6 X 3=108 |
# samples | 18 | 6 | |
** MAII score | log2(18/1274*10)=-2.82329646592663 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NFIA [Title/Abstract] AND PIK3R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NFIA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17010934 |
Tgene | PIK3R1 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7782332 |
Tgene | PIK3R1 | GO:0034976 | response to endoplasmic reticulum stress | 20348923 |
Tgene | PIK3R1 | GO:0042307 | positive regulation of protein import into nucleus | 20348923 |
Tgene | PIK3R1 | GO:0048009 | insulin-like growth factor receptor signaling pathway | 7782332 |
Tgene | PIK3R1 | GO:0050821 | protein stabilization | 20348923 |
Tgene | PIK3R1 | GO:0060396 | growth hormone receptor signaling pathway | 7782332 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BX648791 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000371191 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000371191 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371191 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371191 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371191 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371191 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371191 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371191 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000407417 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000407417 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000407417 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000407417 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000407417 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000407417 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000407417 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000407417 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000479364 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000479364 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000479364 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000479364 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000479364 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000479364 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000479364 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000479364 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000371189 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000371189 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371189 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371189 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371189 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371189 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371189 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371189 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000403491 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000403491 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000403491 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000403491 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000403491 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000403491 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000403491 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000403491 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000371187 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000371187 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371187 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371187 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371187 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371187 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371187 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371187 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000485903 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000485903 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000485903 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000485903 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000485903 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000485903 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000485903 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000485903 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000371185 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000371185 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371185 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371185 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371185 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371185 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371185 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371185 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000371184 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000371184 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371184 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371184 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371184 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371184 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371184 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000371184 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000357977 | ENST00000521381 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-3CDS | ENST00000357977 | ENST00000521657 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000357977 | ENST00000517643 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000357977 | ENST00000274335 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000357977 | ENST00000396611 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000357977 | ENST00000320694 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000357977 | ENST00000336483 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
intron-intron | ENST00000357977 | ENST00000523872 | NFIA | chr1 | 61821979 | + | PIK3R1 | chr5 | 67593366 | + |
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FusionProtFeatures for NFIA_PIK3R1 |
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Hgene | Tgene |
NFIA | PIK3R1 |
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and inthe origin of replication of adenovirus type 2. These proteins areindividually capable of activating transcription and replication. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NFIA_PIK3R1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NFIA_PIK3R1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFIA_PIK3R1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PIK3R1 | P27986 | DB01064 | Isoprenaline | Phosphatidylinositol 3-kinase regulatory subunit alpha | small molecule | approved|investigational |
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RelatedDiseases for NFIA_PIK3R1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PIK3R1 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Tgene | PIK3R1 | C0878684 | SHORT syndrome | 2 | ORPHANET;UNIPROT |
Tgene | PIK3R1 | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
Tgene | PIK3R1 | C0021655 | Insulin Resistance | 1 | CTD_human |
Tgene | PIK3R1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | PIK3R1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |