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Fusion gene ID: 24203 |
FusionGeneSummary for NFE2L3_TPST1 |
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Fusion gene information | Fusion gene name: NFE2L3_TPST1 | Fusion gene ID: 24203 | Hgene | Tgene | Gene symbol | NFE2L3 | TPST1 | Gene ID | 9603 | 8460 |
Gene name | nuclear factor, erythroid 2 like 3 | tyrosylprotein sulfotransferase 1 | |
Synonyms | NRF3 | TANGO13A | |
Cytomap | 7p15.2 | 7q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear factor erythroid 2-related factor 3NF-E2-related factor 3NFE2-related factor 3nuclear factor, erythroid derived 2, like 3nuclear factor-erythroid 2 p45-related factor 3 | protein-tyrosine sulfotransferase 1TPST-1transport and golgi organization 13 homolog A | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9Y4A8 | O60507 | |
Ensembl transtripts involved in fusion gene | ENST00000056233, | ENST00000304842, ENST00000480281, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 3 X 3=36 |
# samples | 3 | 4 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NFE2L3 [Title/Abstract] AND TPST1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TPST1 | GO:0006478 | peptidyl-tyrosine sulfation | 9501187 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-MZ-A5BI-01A | NFE2L3 | chr7 | 26223404 | + | TPST1 | chr7 | 65817492 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000056233 | ENST00000304842 | NFE2L3 | chr7 | 26223404 | + | TPST1 | chr7 | 65817492 | + |
5CDS-3UTR | ENST00000056233 | ENST00000480281 | NFE2L3 | chr7 | 26223404 | + | TPST1 | chr7 | 65817492 | + |
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FusionProtFeatures for NFE2L3_TPST1 |
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Hgene | Tgene |
NFE2L3 | TPST1 |
Activates erythroid-specific, globin gene expression. | Catalyzes the O-sulfation of tyrosine residues withinacidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate(PAPS) as cosubstrate. {ECO:0000269|PubMed:28821720,ECO:0000269|PubMed:9501187, ECO:0000269|PubMed:9733778}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | NFE2L3 | chr7:26223404 | chr7:65817492 | ENST00000056233 | + | 3 | 4 | 14_49 | 278 | 695 | Compositional bias | Note=Leu-rich |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >NFE2L3 | chr7:26223404 | chr7:65817492 | ENST00000056233 | + | 3 | 4 | 578_641 | 278 | 695 | Domain | bZIP |
Hgene | >NFE2L3 | chr7:26223404 | chr7:65817492 | ENST00000056233 | + | 3 | 4 | 580_599 | 278 | 695 | Region | Basic motif |
Hgene | >NFE2L3 | chr7:26223404 | chr7:65817492 | ENST00000056233 | + | 3 | 4 | 606_620 | 278 | 695 | Region | Leucine-zipper |
Tgene | TPST1 | chr7:26223404 | chr7:65817492 | ENST00000304842 | + | 2 | 6 | 286_295 | 348 | 446 | Region | PAPS binding |
Tgene | TPST1 | chr7:26223404 | chr7:65817492 | ENST00000304842 | + | 2 | 6 | 79_83 | 348 | 446 | Region | PAPS binding |
Tgene | TPST1 | chr7:26223404 | chr7:65817492 | ENST00000304842 | + | 2 | 6 | 1_8 | 348 | 446 | Topological domain | Cytoplasmic |
Tgene | TPST1 | chr7:26223404 | chr7:65817492 | ENST00000304842 | + | 2 | 6 | 26_370 | 348 | 446 | Topological domain | Lumenal |
Tgene | TPST1 | chr7:26223404 | chr7:65817492 | ENST00000304842 | + | 2 | 6 | 9_25 | 348 | 446 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for NFE2L3_TPST1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_NFE2L3_ENST00000056233_chr7_26223404_+_TPST1_ENST00000304842_chr7_65817492_+_301aa MKHLKRWWSAGGGLLHLTLLLSLAGLRVDLDLYLLLPPPTLLQDELLFLGGPASSAYALSPFSASGGWGRAGHLHPKGRELDPAAPPEGQ LLREVRALGVPFVPRTSVDAWLVHSVAAGSADEAHGLLGAAAASSTGGAGASVDGGSQAVQGGGGDPRAARSGPLDAGEEEKAPAEPTAQ VPDAGGCASEENGVLREKHEAVDHSSQHEENEERVSAQKENSLQQNDDDENKIAEKPDWEAEKTTESRNERHLNGTDTSFSLEDLFQLLS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_NFE2L3_ENST00000056233_chr7_26223404_+_TPST1_ENST00000304842_chr7_65817492_+_903nt ATGAAGCACCTGAAGCGGTGGTGGTCGGCCGGCGGCGGCCTCCTGCACCTCACCCTCCTGCTGAGCTTGGCGGGGCTCCGCGTAGACCTA GATCTTTACCTGCTGCTGCCGCCGCCCACCCTGCTGCAGGACGAGCTGCTGTTCCTGGGCGGCCCGGCCAGCTCCGCCTACGCGCTCAGC CCCTTCTCGGCCTCGGGAGGGTGGGGGCGCGCGGGCCACTTGCACCCCAAGGGCCGGGAGCTGGACCCTGCCGCGCCGCCCGAGGGCCAG CTGCTCCGGGAGGTGCGCGCGCTCGGGGTCCCCTTCGTCCCTCGCACCAGCGTGGATGCATGGCTGGTGCACAGCGTGGCTGCCGGGAGC GCGGACGAGGCCCACGGGCTGCTCGGCGCCGCCGCCGCCTCGTCCACCGGAGGAGCCGGCGCCAGCGTGGACGGCGGCAGCCAGGCTGTG CAGGGGGGCGGCGGGGACCCCCGAGCGGCTCGGAGTGGCCCCTTGGACGCCGGGGAAGAGGAGAAGGCACCCGCGGAACCGACGGCTCAG GTGCCGGACGCTGGCGGATGTGCGAGCGAGGAGAATGGGGTACTAAGAGAAAAGCACGAAGCTGTGGATCATAGTTCCCAGCATGAGGAA AATGAAGAAAGGGTGTCAGCCCAGAAGGAGAACTCACTTCAGCAGAATGATGATGATGAAAACAAAATAGCAGAGAAACCTGACTGGGAG GCAGAAAAGACCACTGAATCTAGAAATGAGAGACATCTGAATGGGACAGATACTTCTTTCTCTCTGGAAGACTTATTCCAGTTGCTTTCA TCACAGCCTGAAAATTCACTGGAGGTCTATAAGGGAGAATTCCAACTACCTGACTTTCTTAAAGAAAAACCACAGACTGAGCAAGTGGAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_NFE2L3_ENST00000056233_chr7_26223404_+_TPST1_ENST00000304842_chr7_65817492_+_1740nt GGGCTCGGCGCTCAGGTGGCTCCTTCTTCGCTTCTCCCGATCCCCGGCGGTGCCAGGCACGGTGCCGGCTGCCGAGGGAACGCCTTTGTG CCCGGTGCTGGGAACCCGCGACGGCCGCCACGCGCCCCGGTCCATTGTTTCGCTTATCTGGGTTCCAGGCAGGTGCGGGCGGCGCGCGGG GTCCGCACGTGTCACCCCGGCGGCTGGGGCGCCGGGACCCGCGGGCGCCGGCAGGGGCGTTCCCGGGCGCGCGGCGGCGATGAAGCACCT GAAGCGGTGGTGGTCGGCCGGCGGCGGCCTCCTGCACCTCACCCTCCTGCTGAGCTTGGCGGGGCTCCGCGTAGACCTAGATCTTTACCT GCTGCTGCCGCCGCCCACCCTGCTGCAGGACGAGCTGCTGTTCCTGGGCGGCCCGGCCAGCTCCGCCTACGCGCTCAGCCCCTTCTCGGC CTCGGGAGGGTGGGGGCGCGCGGGCCACTTGCACCCCAAGGGCCGGGAGCTGGACCCTGCCGCGCCGCCCGAGGGCCAGCTGCTCCGGGA GGTGCGCGCGCTCGGGGTCCCCTTCGTCCCTCGCACCAGCGTGGATGCATGGCTGGTGCACAGCGTGGCTGCCGGGAGCGCGGACGAGGC CCACGGGCTGCTCGGCGCCGCCGCCGCCTCGTCCACCGGAGGAGCCGGCGCCAGCGTGGACGGCGGCAGCCAGGCTGTGCAGGGGGGCGG CGGGGACCCCCGAGCGGCTCGGAGTGGCCCCTTGGACGCCGGGGAAGAGGAGAAGGCACCCGCGGAACCGACGGCTCAGGTGCCGGACGC TGGCGGATGTGCGAGCGAGGAGAATGGGGTACTAAGAGAAAAGCACGAAGCTGTGGATCATAGTTCCCAGCATGAGGAAAATGAAGAAAG GGTGTCAGCCCAGAAGGAGAACTCACTTCAGCAGAATGATGATGATGAAAACAAAATAGCAGAGAAACCTGACTGGGAGGCAGAAAAGAC CACTGAATCTAGAAATGAGAGACATCTGAATGGGACAGATACTTCTTTCTCTCTGGAAGACTTATTCCAGTTGCTTTCATCACAGCCTGA AAATTCACTGGAGGTCTATAAGGGAGAATTCCAACTACCTGACTTTCTTAAAGAAAAACCACAGACTGAGCAAGTGGAGTAGCAGAACCA GGAGCCTCTTCCATACATGAGGAAAGATTGCTGCCTTTTCAGCAGAAGGGAAATTCCTAGGATTGGCTGTCCCCTGCCAAGCTTGGTGGA GCGTCTGCACCTTGGCTGCGCCGCCTGTGCATTTGCCAGTTTCCTCCCACTGAGAGGATGGAGGTGTCCGCACAGCTTTGGGCCTCGTGA GGGATCTGCCTCCTGAGCAAAGAGCTCTTGATCCCGATTTCATGCACAGCCCTGCAGTAAGGAGCCCAGAAGGAACATGTGTTTCCTGTT AAAACTCCTCTTGTTCTCTTTTCTTACATTATGACGTTTGTTTTCAAGGAGAGGGTTTAAAAATGGGATCCTGTAAGCAGACTTGGGCAG TCTCCTTTTGAAATAGGTTGTCTGTACATGTTCTAATGTTTTGTAGAACACGTGTGCCTGTTTAAGTGTATTGATGTGAATAATATTAAA TATCCTAATTATTTAATTCATTGTATTGTTTCTGAGAAGTTGGGAAATTACCATTATACATTTACAACCTAATGACTTTTGTATTTTATT |
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FusionGenePPI for NFE2L3_TPST1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NFE2L3 | MAFK, BACH2, NFE2L3, NFE2L2, NFE2L1, NFE2, MAFG, MAFF, CREB3, PPARG, FBXW7, GSK3B, HCFC2, HCFC1 | TPST1 | ACTB, GINM1, CD97, SCGB2A2, B2M |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | TPST1 | chr7:26223404 | chr7:65817492 | ENST00000304842 | + | 2 | 6 | 102_106 | 348 | 446 | peptide substrate |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFE2L3_TPST1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NFE2L3_TPST1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |