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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24203

FusionGeneSummary for NFE2L3_TPST1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFE2L3_TPST1
Fusion gene ID: 24203
HgeneTgene
Gene symbol

NFE2L3

TPST1

Gene ID

9603

8460

Gene namenuclear factor, erythroid 2 like 3tyrosylprotein sulfotransferase 1
SynonymsNRF3TANGO13A
Cytomap

7p15.2

7q11.21

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor erythroid 2-related factor 3NF-E2-related factor 3NFE2-related factor 3nuclear factor, erythroid derived 2, like 3nuclear factor-erythroid 2 p45-related factor 3protein-tyrosine sulfotransferase 1TPST-1transport and golgi organization 13 homolog A
Modification date2018052320180523
UniProtAcc

Q9Y4A8

O60507

Ensembl transtripts involved in fusion geneENST00000056233, ENST00000304842, 
ENST00000480281, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 3 X 3=36
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFE2L3 [Title/Abstract] AND TPST1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTPST1

GO:0006478

peptidyl-tyrosine sulfation

9501187


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-MZ-A5BI-01ANFE2L3chr7

26223404

+TPST1chr7

65817492

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000056233ENST00000304842NFE2L3chr7

26223404

+TPST1chr7

65817492

+
5CDS-3UTRENST00000056233ENST00000480281NFE2L3chr7

26223404

+TPST1chr7

65817492

+

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FusionProtFeatures for NFE2L3_TPST1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFE2L3

Q9Y4A8

TPST1

O60507

Activates erythroid-specific, globin gene expression. Catalyzes the O-sulfation of tyrosine residues withinacidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate(PAPS) as cosubstrate. {ECO:0000269|PubMed:28821720,ECO:0000269|PubMed:9501187, ECO:0000269|PubMed:9733778}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFE2L3chr7:26223404chr7:65817492ENST00000056233+3414_49278695Compositional biasNote=Leu-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFE2L3chr7:26223404chr7:65817492ENST00000056233+34578_641278695DomainbZIP
HgeneNFE2L3chr7:26223404chr7:65817492ENST00000056233+34580_599278695RegionBasic motif
HgeneNFE2L3chr7:26223404chr7:65817492ENST00000056233+34606_620278695RegionLeucine-zipper
TgeneTPST1chr7:26223404chr7:65817492ENST00000304842+26286_295348446RegionPAPS binding
TgeneTPST1chr7:26223404chr7:65817492ENST00000304842+2679_83348446RegionPAPS binding
TgeneTPST1chr7:26223404chr7:65817492ENST00000304842+261_8348446Topological domainCytoplasmic
TgeneTPST1chr7:26223404chr7:65817492ENST00000304842+2626_370348446Topological domainLumenal
TgeneTPST1chr7:26223404chr7:65817492ENST00000304842+269_25348446TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for NFE2L3_TPST1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NFE2L3_ENST00000056233_chr7_26223404_+_TPST1_ENST00000304842_chr7_65817492_+_301aa
MKHLKRWWSAGGGLLHLTLLLSLAGLRVDLDLYLLLPPPTLLQDELLFLGGPASSAYALSPFSASGGWGRAGHLHPKGRELDPAAPPEGQ
LLREVRALGVPFVPRTSVDAWLVHSVAAGSADEAHGLLGAAAASSTGGAGASVDGGSQAVQGGGGDPRAARSGPLDAGEEEKAPAEPTAQ
VPDAGGCASEENGVLREKHEAVDHSSQHEENEERVSAQKENSLQQNDDDENKIAEKPDWEAEKTTESRNERHLNGTDTSFSLEDLFQLLS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NFE2L3_ENST00000056233_chr7_26223404_+_TPST1_ENST00000304842_chr7_65817492_+_903nt
ATGAAGCACCTGAAGCGGTGGTGGTCGGCCGGCGGCGGCCTCCTGCACCTCACCCTCCTGCTGAGCTTGGCGGGGCTCCGCGTAGACCTA
GATCTTTACCTGCTGCTGCCGCCGCCCACCCTGCTGCAGGACGAGCTGCTGTTCCTGGGCGGCCCGGCCAGCTCCGCCTACGCGCTCAGC
CCCTTCTCGGCCTCGGGAGGGTGGGGGCGCGCGGGCCACTTGCACCCCAAGGGCCGGGAGCTGGACCCTGCCGCGCCGCCCGAGGGCCAG
CTGCTCCGGGAGGTGCGCGCGCTCGGGGTCCCCTTCGTCCCTCGCACCAGCGTGGATGCATGGCTGGTGCACAGCGTGGCTGCCGGGAGC
GCGGACGAGGCCCACGGGCTGCTCGGCGCCGCCGCCGCCTCGTCCACCGGAGGAGCCGGCGCCAGCGTGGACGGCGGCAGCCAGGCTGTG
CAGGGGGGCGGCGGGGACCCCCGAGCGGCTCGGAGTGGCCCCTTGGACGCCGGGGAAGAGGAGAAGGCACCCGCGGAACCGACGGCTCAG
GTGCCGGACGCTGGCGGATGTGCGAGCGAGGAGAATGGGGTACTAAGAGAAAAGCACGAAGCTGTGGATCATAGTTCCCAGCATGAGGAA
AATGAAGAAAGGGTGTCAGCCCAGAAGGAGAACTCACTTCAGCAGAATGATGATGATGAAAACAAAATAGCAGAGAAACCTGACTGGGAG
GCAGAAAAGACCACTGAATCTAGAAATGAGAGACATCTGAATGGGACAGATACTTCTTTCTCTCTGGAAGACTTATTCCAGTTGCTTTCA
TCACAGCCTGAAAATTCACTGGAGGTCTATAAGGGAGAATTCCAACTACCTGACTTTCTTAAAGAAAAACCACAGACTGAGCAAGTGGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NFE2L3_ENST00000056233_chr7_26223404_+_TPST1_ENST00000304842_chr7_65817492_+_1740nt
GGGCTCGGCGCTCAGGTGGCTCCTTCTTCGCTTCTCCCGATCCCCGGCGGTGCCAGGCACGGTGCCGGCTGCCGAGGGAACGCCTTTGTG
CCCGGTGCTGGGAACCCGCGACGGCCGCCACGCGCCCCGGTCCATTGTTTCGCTTATCTGGGTTCCAGGCAGGTGCGGGCGGCGCGCGGG
GTCCGCACGTGTCACCCCGGCGGCTGGGGCGCCGGGACCCGCGGGCGCCGGCAGGGGCGTTCCCGGGCGCGCGGCGGCGATGAAGCACCT
GAAGCGGTGGTGGTCGGCCGGCGGCGGCCTCCTGCACCTCACCCTCCTGCTGAGCTTGGCGGGGCTCCGCGTAGACCTAGATCTTTACCT
GCTGCTGCCGCCGCCCACCCTGCTGCAGGACGAGCTGCTGTTCCTGGGCGGCCCGGCCAGCTCCGCCTACGCGCTCAGCCCCTTCTCGGC
CTCGGGAGGGTGGGGGCGCGCGGGCCACTTGCACCCCAAGGGCCGGGAGCTGGACCCTGCCGCGCCGCCCGAGGGCCAGCTGCTCCGGGA
GGTGCGCGCGCTCGGGGTCCCCTTCGTCCCTCGCACCAGCGTGGATGCATGGCTGGTGCACAGCGTGGCTGCCGGGAGCGCGGACGAGGC
CCACGGGCTGCTCGGCGCCGCCGCCGCCTCGTCCACCGGAGGAGCCGGCGCCAGCGTGGACGGCGGCAGCCAGGCTGTGCAGGGGGGCGG
CGGGGACCCCCGAGCGGCTCGGAGTGGCCCCTTGGACGCCGGGGAAGAGGAGAAGGCACCCGCGGAACCGACGGCTCAGGTGCCGGACGC
TGGCGGATGTGCGAGCGAGGAGAATGGGGTACTAAGAGAAAAGCACGAAGCTGTGGATCATAGTTCCCAGCATGAGGAAAATGAAGAAAG
GGTGTCAGCCCAGAAGGAGAACTCACTTCAGCAGAATGATGATGATGAAAACAAAATAGCAGAGAAACCTGACTGGGAGGCAGAAAAGAC
CACTGAATCTAGAAATGAGAGACATCTGAATGGGACAGATACTTCTTTCTCTCTGGAAGACTTATTCCAGTTGCTTTCATCACAGCCTGA
AAATTCACTGGAGGTCTATAAGGGAGAATTCCAACTACCTGACTTTCTTAAAGAAAAACCACAGACTGAGCAAGTGGAGTAGCAGAACCA
GGAGCCTCTTCCATACATGAGGAAAGATTGCTGCCTTTTCAGCAGAAGGGAAATTCCTAGGATTGGCTGTCCCCTGCCAAGCTTGGTGGA
GCGTCTGCACCTTGGCTGCGCCGCCTGTGCATTTGCCAGTTTCCTCCCACTGAGAGGATGGAGGTGTCCGCACAGCTTTGGGCCTCGTGA
GGGATCTGCCTCCTGAGCAAAGAGCTCTTGATCCCGATTTCATGCACAGCCCTGCAGTAAGGAGCCCAGAAGGAACATGTGTTTCCTGTT
AAAACTCCTCTTGTTCTCTTTTCTTACATTATGACGTTTGTTTTCAAGGAGAGGGTTTAAAAATGGGATCCTGTAAGCAGACTTGGGCAG
TCTCCTTTTGAAATAGGTTGTCTGTACATGTTCTAATGTTTTGTAGAACACGTGTGCCTGTTTAAGTGTATTGATGTGAATAATATTAAA
TATCCTAATTATTTAATTCATTGTATTGTTTCTGAGAAGTTGGGAAATTACCATTATACATTTACAACCTAATGACTTTTGTATTTTATT


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FusionGenePPI for NFE2L3_TPST1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NFE2L3MAFK, BACH2, NFE2L3, NFE2L2, NFE2L1, NFE2, MAFG, MAFF, CREB3, PPARG, FBXW7, GSK3B, HCFC2, HCFC1TPST1ACTB, GINM1, CD97, SCGB2A2, B2M


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTPST1chr7:26223404chr7:65817492ENST00000304842+26102_106348446peptide substrate


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFE2L3_TPST1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NFE2L3_TPST1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource