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Fusion gene ID: 24202 |
FusionGeneSummary for NFE2L3_POU6F2 |
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Fusion gene information | Fusion gene name: NFE2L3_POU6F2 | Fusion gene ID: 24202 | Hgene | Tgene | Gene symbol | NFE2L3 | POU6F2 | Gene ID | 9603 | 11281 |
Gene name | nuclear factor, erythroid 2 like 3 | POU class 6 homeobox 2 | |
Synonyms | NRF3 | RPF-1|WT5|WTSL | |
Cytomap | 7p15.2 | 7p14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear factor erythroid 2-related factor 3NF-E2-related factor 3NFE2-related factor 3nuclear factor, erythroid derived 2, like 3nuclear factor-erythroid 2 p45-related factor 3 | POU domain, class 6, transcription factor 2Wilms tumor suppressor locusretina-derived POU-domain factor-1 | |
Modification date | 20180523 | 20180403 | |
UniProtAcc | Q9Y4A8 | P78424 | |
Ensembl transtripts involved in fusion gene | ENST00000056233, | ENST00000403058, ENST00000518318, ENST00000517348, ENST00000559001, ENST00000464276, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 5 X 7=175 |
# samples | 3 | 9 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/175*10)=-0.959358015502654 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NFE2L3 [Title/Abstract] AND POU6F2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-RN-AAAQ-01A | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000056233 | ENST00000403058 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
Frame-shift | ENST00000056233 | ENST00000518318 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
5CDS-3UTR | ENST00000056233 | ENST00000517348 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
5CDS-3UTR | ENST00000056233 | ENST00000559001 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
5CDS-intron | ENST00000056233 | ENST00000464276 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
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FusionProtFeatures for NFE2L3_POU6F2 |
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Hgene | Tgene |
NFE2L3 | POU6F2 |
Activates erythroid-specific, globin gene expression. | Probable transcription factor likely to be involved inearly steps in the differentiation of amacrine and ganglion cells.Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1does not bind DNA. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NFE2L3_POU6F2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NFE2L3_POU6F2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NFE2L3 | MAFK, BACH2, NFE2L3, NFE2L2, NFE2L1, NFE2, MAFG, MAFF, CREB3, PPARG, FBXW7, GSK3B, HCFC2, HCFC1 | POU6F2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFE2L3_POU6F2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NFE2L3_POU6F2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | POU6F2 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | POU6F2 | C1832099 | Wilms tumor and radial bilateral aplasia | 1 | CTD_human;UNIPROT |