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Fusion gene ID: 24201 |
FusionGeneSummary for NFE2L3_NPY |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NFE2L3_NPY | Fusion gene ID: 24201 | Hgene | Tgene | Gene symbol | NFE2L3 | NPY | Gene ID | 9603 | 4852 |
| Gene name | nuclear factor, erythroid 2 like 3 | neuropeptide Y | |
| Synonyms | NRF3 | PYY4 | |
| Cytomap | 7p15.2 | 7p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear factor erythroid 2-related factor 3NF-E2-related factor 3NFE2-related factor 3nuclear factor, erythroid derived 2, like 3nuclear factor-erythroid 2 p45-related factor 3 | pro-neuropeptide Yprepro-neuropeptide Y | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9Y4A8 | P01303 | |
| Ensembl transtripts involved in fusion gene | ENST00000056233, | ENST00000242152, ENST00000407573, ENST00000405982, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 5 X 4=100 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NFE2L3 [Title/Abstract] AND NPY [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-V5-A7RB-01A | NFE2L3 | chr7 | 26192688 | + | NPY | chr7 | 24324860 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000056233 | ENST00000242152 | NFE2L3 | chr7 | 26192688 | + | NPY | chr7 | 24324860 | + |
| In-frame | ENST00000056233 | ENST00000407573 | NFE2L3 | chr7 | 26192688 | + | NPY | chr7 | 24324860 | + |
| Frame-shift | ENST00000056233 | ENST00000405982 | NFE2L3 | chr7 | 26192688 | + | NPY | chr7 | 24324860 | + |
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FusionProtFeatures for NFE2L3_NPY |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NFE2L3 | NPY |
| Activates erythroid-specific, globin gene expression. | NPY is implicated in the control of feeding and insecretion of gonadotrophin-release hormone. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NFE2L3 | chr7:26192688 | chr7:24324860 | ENST00000056233 | + | 1 | 4 | 14_49 | 190 | 695 | Compositional bias | Note=Leu-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NFE2L3 | chr7:26192688 | chr7:24324860 | ENST00000056233 | + | 1 | 4 | 578_641 | 190 | 695 | Domain | bZIP |
| Hgene | >NFE2L3 | chr7:26192688 | chr7:24324860 | ENST00000056233 | + | 1 | 4 | 580_599 | 190 | 695 | Region | Basic motif |
| Hgene | >NFE2L3 | chr7:26192688 | chr7:24324860 | ENST00000056233 | + | 1 | 4 | 606_620 | 190 | 695 | Region | Leucine-zipper |
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FusionGeneSequence for NFE2L3_NPY |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NFE2L3_ENST00000056233_chr7_26192688_+_NPY_ENST00000242152_chr7_24324860_+_288aa MKHLKRWWSAGGGLLHLTLLLSLAGLRVDLDLYLLLPPPTLLQDELLFLGGPASSAYALSPFSASGGWGRAGHLHPKGRELDPAAPPEGQ LLREVRALGVPFVPRTSVDAWLVHSVAAGSADEAHGLLGAAAASSTGGAGASVDGGSQAVQGGGGDPRAARSGPLDAGEEEKAPAEPTAQ VPDAGGCASEMLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMR >In-frame_NFE2L3_ENST00000056233_chr7_26192688_+_NPY_ENST00000407573_chr7_24324860_+_288aa MKHLKRWWSAGGGLLHLTLLLSLAGLRVDLDLYLLLPPPTLLQDELLFLGGPASSAYALSPFSASGGWGRAGHLHPKGRELDPAAPPEGQ LLREVRALGVPFVPRTSVDAWLVHSVAAGSADEAHGLLGAAAASSTGGAGASVDGGSQAVQGGGGDPRAARSGPLDAGEEEKAPAEPTAQ VPDAGGCASEMLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NFE2L3_ENST00000056233_chr7_26192688_+_NPY_ENST00000242152_chr7_24324860_+_864nt ATGAAGCACCTGAAGCGGTGGTGGTCGGCCGGCGGCGGCCTCCTGCACCTCACCCTCCTGCTGAGCTTGGCGGGGCTCCGCGTAGACCTA GATCTTTACCTGCTGCTGCCGCCGCCCACCCTGCTGCAGGACGAGCTGCTGTTCCTGGGCGGCCCGGCCAGCTCCGCCTACGCGCTCAGC CCCTTCTCGGCCTCGGGAGGGTGGGGGCGCGCGGGCCACTTGCACCCCAAGGGCCGGGAGCTGGACCCTGCCGCGCCGCCCGAGGGCCAG CTGCTCCGGGAGGTGCGCGCGCTCGGGGTCCCCTTCGTCCCTCGCACCAGCGTGGATGCATGGCTGGTGCACAGCGTGGCTGCCGGGAGC GCGGACGAGGCCCACGGGCTGCTCGGCGCCGCCGCCGCCTCGTCCACCGGAGGAGCCGGCGCCAGCGTGGACGGCGGCAGCCAGGCTGTG CAGGGGGGCGGCGGGGACCCCCGAGCGGCTCGGAGTGGCCCCTTGGACGCCGGGGAAGAGGAGAAGGCACCCGCGGAACCGACGGCTCAG GTGCCGGACGCTGGCGGATGTGCGAGCGAGATGCTAGGTAACAAGCGACTGGGGCTGTCCGGACTGACCCTCGCCCTGTCCCTGCTCGTG TGCCTGGGTGCGCTGGCCGAGGCGTACCCCTCCAAGCCGGACAACCCGGGCGAGGACGCACCAGCGGAGGACATGGCCAGATACTACTCG GCGCTGCGACACTACATCAACCTCATCACCAGGCAGAGATATGGAAAACGATCCAGCCCAGAGACACTGATTTCAGACCTCTTGATGAGA >In-frame_NFE2L3_ENST00000056233_chr7_26192688_+_NPY_ENST00000407573_chr7_24324860_+_864nt ATGAAGCACCTGAAGCGGTGGTGGTCGGCCGGCGGCGGCCTCCTGCACCTCACCCTCCTGCTGAGCTTGGCGGGGCTCCGCGTAGACCTA GATCTTTACCTGCTGCTGCCGCCGCCCACCCTGCTGCAGGACGAGCTGCTGTTCCTGGGCGGCCCGGCCAGCTCCGCCTACGCGCTCAGC CCCTTCTCGGCCTCGGGAGGGTGGGGGCGCGCGGGCCACTTGCACCCCAAGGGCCGGGAGCTGGACCCTGCCGCGCCGCCCGAGGGCCAG CTGCTCCGGGAGGTGCGCGCGCTCGGGGTCCCCTTCGTCCCTCGCACCAGCGTGGATGCATGGCTGGTGCACAGCGTGGCTGCCGGGAGC GCGGACGAGGCCCACGGGCTGCTCGGCGCCGCCGCCGCCTCGTCCACCGGAGGAGCCGGCGCCAGCGTGGACGGCGGCAGCCAGGCTGTG CAGGGGGGCGGCGGGGACCCCCGAGCGGCTCGGAGTGGCCCCTTGGACGCCGGGGAAGAGGAGAAGGCACCCGCGGAACCGACGGCTCAG GTGCCGGACGCTGGCGGATGTGCGAGCGAGATGCTAGGTAACAAGCGACTGGGGCTGTCCGGACTGACCCTCGCCCTGTCCCTGCTCGTG TGCCTGGGTGCGCTGGCCGAGGCGTACCCCTCCAAGCCGGACAACCCGGGCGAGGACGCACCAGCGGAGGACATGGCCAGATACTACTCG GCGCTGCGACACTACATCAACCTCATCACCAGGCAGAGATATGGAAAACGATCCAGCCCAGAGACACTGATTTCAGACCTCTTGATGAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NFE2L3_ENST00000056233_chr7_26192688_+_NPY_ENST00000242152_chr7_24324860_+_1301nt GGGCTCGGCGCTCAGGTGGCTCCTTCTTCGCTTCTCCCGATCCCCGGCGGTGCCAGGCACGGTGCCGGCTGCCGAGGGAACGCCTTTGTG CCCGGTGCTGGGAACCCGCGACGGCCGCCACGCGCCCCGGTCCATTGTTTCGCTTATCTGGGTTCCAGGCAGGTGCGGGCGGCGCGCGGG GTCCGCACGTGTCACCCCGGCGGCTGGGGCGCCGGGACCCGCGGGCGCCGGCAGGGGCGTTCCCGGGCGCGCGGCGGCGATGAAGCACCT GAAGCGGTGGTGGTCGGCCGGCGGCGGCCTCCTGCACCTCACCCTCCTGCTGAGCTTGGCGGGGCTCCGCGTAGACCTAGATCTTTACCT GCTGCTGCCGCCGCCCACCCTGCTGCAGGACGAGCTGCTGTTCCTGGGCGGCCCGGCCAGCTCCGCCTACGCGCTCAGCCCCTTCTCGGC CTCGGGAGGGTGGGGGCGCGCGGGCCACTTGCACCCCAAGGGCCGGGAGCTGGACCCTGCCGCGCCGCCCGAGGGCCAGCTGCTCCGGGA GGTGCGCGCGCTCGGGGTCCCCTTCGTCCCTCGCACCAGCGTGGATGCATGGCTGGTGCACAGCGTGGCTGCCGGGAGCGCGGACGAGGC CCACGGGCTGCTCGGCGCCGCCGCCGCCTCGTCCACCGGAGGAGCCGGCGCCAGCGTGGACGGCGGCAGCCAGGCTGTGCAGGGGGGCGG CGGGGACCCCCGAGCGGCTCGGAGTGGCCCCTTGGACGCCGGGGAAGAGGAGAAGGCACCCGCGGAACCGACGGCTCAGGTGCCGGACGC TGGCGGATGTGCGAGCGAGATGCTAGGTAACAAGCGACTGGGGCTGTCCGGACTGACCCTCGCCCTGTCCCTGCTCGTGTGCCTGGGTGC GCTGGCCGAGGCGTACCCCTCCAAGCCGGACAACCCGGGCGAGGACGCACCAGCGGAGGACATGGCCAGATACTACTCGGCGCTGCGACA CTACATCAACCTCATCACCAGGCAGAGATATGGAAAACGATCCAGCCCAGAGACACTGATTTCAGACCTCTTGATGAGAGAAAGCACAGA AAATGTTCCCAGAACTCGGCTTGAAGACCCTGCAATGTGGTGATGGGAAATGAGACTTGCTCTCTGGCCTTTTCCTATTTTCAGCCCATA TTTCATCGTGTAAAACGAGAATCCACCCATCCTACCAATGCATGCAGCCACTGTGCTGAATTCTGCAATGTTTTCCTTTGTCATCATTGT >In-frame_NFE2L3_ENST00000056233_chr7_26192688_+_NPY_ENST00000407573_chr7_24324860_+_1244nt GGGCTCGGCGCTCAGGTGGCTCCTTCTTCGCTTCTCCCGATCCCCGGCGGTGCCAGGCACGGTGCCGGCTGCCGAGGGAACGCCTTTGTG CCCGGTGCTGGGAACCCGCGACGGCCGCCACGCGCCCCGGTCCATTGTTTCGCTTATCTGGGTTCCAGGCAGGTGCGGGCGGCGCGCGGG GTCCGCACGTGTCACCCCGGCGGCTGGGGCGCCGGGACCCGCGGGCGCCGGCAGGGGCGTTCCCGGGCGCGCGGCGGCGATGAAGCACCT GAAGCGGTGGTGGTCGGCCGGCGGCGGCCTCCTGCACCTCACCCTCCTGCTGAGCTTGGCGGGGCTCCGCGTAGACCTAGATCTTTACCT GCTGCTGCCGCCGCCCACCCTGCTGCAGGACGAGCTGCTGTTCCTGGGCGGCCCGGCCAGCTCCGCCTACGCGCTCAGCCCCTTCTCGGC CTCGGGAGGGTGGGGGCGCGCGGGCCACTTGCACCCCAAGGGCCGGGAGCTGGACCCTGCCGCGCCGCCCGAGGGCCAGCTGCTCCGGGA GGTGCGCGCGCTCGGGGTCCCCTTCGTCCCTCGCACCAGCGTGGATGCATGGCTGGTGCACAGCGTGGCTGCCGGGAGCGCGGACGAGGC CCACGGGCTGCTCGGCGCCGCCGCCGCCTCGTCCACCGGAGGAGCCGGCGCCAGCGTGGACGGCGGCAGCCAGGCTGTGCAGGGGGGCGG CGGGGACCCCCGAGCGGCTCGGAGTGGCCCCTTGGACGCCGGGGAAGAGGAGAAGGCACCCGCGGAACCGACGGCTCAGGTGCCGGACGC TGGCGGATGTGCGAGCGAGATGCTAGGTAACAAGCGACTGGGGCTGTCCGGACTGACCCTCGCCCTGTCCCTGCTCGTGTGCCTGGGTGC GCTGGCCGAGGCGTACCCCTCCAAGCCGGACAACCCGGGCGAGGACGCACCAGCGGAGGACATGGCCAGATACTACTCGGCGCTGCGACA CTACATCAACCTCATCACCAGGCAGAGATATGGAAAACGATCCAGCCCAGAGACACTGATTTCAGACCTCTTGATGAGAGAAAGCACAGA AAATGTTCCCAGAACTCGGCTTGAAGACCCTGCAATGTGGTGATGGGAAATGAGACTTGCTCTCTGGCCTTTTCCTATTTTCAGCCCATA |
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FusionGenePPI for NFE2L3_NPY |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NFE2L3 | MAFK, BACH2, NFE2L3, NFE2L2, NFE2L1, NFE2, MAFG, MAFF, CREB3, PPARG, FBXW7, GSK3B, HCFC2, HCFC1 | NPY | PMCH, NPY1R, MEP1A, NR1H2, BAG6, ATP12A, UBQLN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFE2L3_NPY |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NFE2L3_NPY |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NPY | C0011581 | Depressive disorder | 7 | CTD_human;PSYGENET |
| Tgene | NPY | C0001973 | Alcoholic Intoxication, Chronic | 6 | CTD_human;PSYGENET |
| Tgene | NPY | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | NPY | C0041696 | Unipolar Depression | 5 | PSYGENET |
| Tgene | NPY | C0525045 | Mood Disorders | 5 | PSYGENET |
| Tgene | NPY | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| Tgene | NPY | C0003123 | Anorexia | 3 | CTD_human |
| Tgene | NPY | C0036572 | Seizures | 3 | CTD_human |
| Tgene | NPY | C0014544 | Epilepsy | 2 | CTD_human |
| Tgene | NPY | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | NPY | C0085762 | Alcohol abuse | 2 | PSYGENET |
| Tgene | NPY | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Tgene | NPY | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Tgene | NPY | C0004096 | Asthma | 1 | CTD_human |
| Tgene | NPY | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
| Tgene | NPY | C0007785 | Cerebral Infarction | 1 | CTD_human |
| Tgene | NPY | C0008677 | Bronchitis, Chronic | 1 | CTD_human |
| Tgene | NPY | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
| Tgene | NPY | C0020564 | Hypertrophy | 1 | CTD_human |
| Tgene | NPY | C0025261 | Memory Disorders | 1 | CTD_human |
| Tgene | NPY | C0026837 | Muscle Rigidity | 1 | CTD_human |
| Tgene | NPY | C0027429 | Nasal obstruction present finding | 1 | CTD_human |
| Tgene | NPY | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| Tgene | NPY | C0035455 | Rhinitis | 1 | CTD_human |
| Tgene | NPY | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |
| Tgene | NPY | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
| Tgene | NPY | C0085159 | Seasonal Affective Disorder | 1 | PSYGENET |
| Tgene | NPY | C0236664 | Alcohol-Related Disorders | 1 | PSYGENET |
| Tgene | NPY | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | NPY | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | NPY | C0424295 | Hyperactive behavior | 1 | CTD_human |
| Tgene | NPY | C0600427 | Cocaine Dependence | 1 | PSYGENET |
| Tgene | NPY | C1262477 | Weight decreased | 1 | CTD_human |
| Tgene | NPY | C2362914 | clinical depression | 1 | PSYGENET |
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