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Fusion gene ID: 24191 |
FusionGeneSummary for NFE2L2_HNRNPD |
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Fusion gene information | Fusion gene name: NFE2L2_HNRNPD | Fusion gene ID: 24191 | Hgene | Tgene | Gene symbol | NFE2L2 | HNRNPD | Gene ID | 4780 | 3184 |
Gene name | nuclear factor, erythroid 2 like 2 | heterogeneous nuclear ribonucleoprotein D | |
Synonyms | HEBP1|IMDDHH|NRF2 | AUF1|AUF1A|HNRPD|P37|hnRNPD0 | |
Cytomap | 2q31.2 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear factor erythroid 2-related factor 2nuclear factor erythroid-derived 2-like 2 | heterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q16236 | Q14103 | |
Ensembl transtripts involved in fusion gene | ENST00000397063, ENST00000397062, ENST00000446151, ENST00000464747, ENST00000423513, | ENST00000313899, ENST00000353341, ENST00000543098, ENST00000352301, ENST00000508119, ENST00000541060, | |
Fusion gene scores | * DoF score | 15 X 14 X 7=1470 | 10 X 10 X 3=300 |
# samples | 21 | 12 | |
** MAII score | log2(21/1470*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/300*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NFE2L2 [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NFE2L2 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process | 19424503 |
Hgene | NFE2L2 | GO:0016567 | protein ubiquitination | 15983046 |
Hgene | NFE2L2 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 15983046 |
Hgene | NFE2L2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17015834 |
Hgene | NFE2L2 | GO:0071498 | cellular response to fluid shear stress | 25190803 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF096106 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000397063 | ENST00000313899 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000397063 | ENST00000353341 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000397063 | ENST00000543098 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000397063 | ENST00000352301 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000397063 | ENST00000508119 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000397063 | ENST00000541060 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000397062 | ENST00000313899 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000397062 | ENST00000353341 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000397062 | ENST00000543098 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000397062 | ENST00000352301 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000397062 | ENST00000508119 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000397062 | ENST00000541060 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000446151 | ENST00000313899 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000446151 | ENST00000353341 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000446151 | ENST00000543098 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000446151 | ENST00000352301 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000446151 | ENST00000508119 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000446151 | ENST00000541060 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000464747 | ENST00000313899 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000464747 | ENST00000353341 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000464747 | ENST00000543098 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000464747 | ENST00000352301 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000464747 | ENST00000508119 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000464747 | ENST00000541060 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000423513 | ENST00000313899 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000423513 | ENST00000353341 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000423513 | ENST00000543098 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-3UTR | ENST00000423513 | ENST00000352301 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000423513 | ENST00000508119 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
intron-intron | ENST00000423513 | ENST00000541060 | NFE2L2 | chr2 | 178096309 | - | HNRNPD | chr4 | 83275272 | + |
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FusionProtFeatures for NFE2L2_HNRNPD |
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Hgene | Tgene |
NFE2L2 | HNRNPD |
Transcription activator that binds to antioxidantresponse (ARE) elements in the promoter regions of target genes.Important for the coordinated up-regulation of genes in responseto oxidative stress and the regulation of cellular redoxconditions. May be involved in the transcriptional activation ofgenes of the beta-globin cluster by mediating enhancer activity ofhypersensitive site 2 of the beta-globin locus control region.{ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:29018201}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NFE2L2_HNRNPD |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NFE2L2_HNRNPD |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFE2L2_HNRNPD |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | HNRNPD | Q14103 | DB11638 | Artenimol | Heterogeneous nuclear ribonucleoprotein D0 | small molecule | approved|investigational |
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RelatedDiseases for NFE2L2_HNRNPD |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NFE2L2 | C4277682 | Chemical and Drug Induced Liver Injury | 4 | CTD_human |
Hgene | NFE2L2 | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
Hgene | NFE2L2 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Hgene | NFE2L2 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | NFE2L2 | C0008370 | Cholestasis | 1 | CTD_human |
Hgene | NFE2L2 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
Hgene | NFE2L2 | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |
Hgene | NFE2L2 | C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | CTD_human |
Hgene | NFE2L2 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | NFE2L2 | C0017178 | Gastrointestinal Diseases | 1 | CTD_human |
Hgene | NFE2L2 | C0020456 | Hyperglycemia | 1 | CTD_human |
Hgene | NFE2L2 | C0020507 | Hyperplasia | 1 | CTD_human |
Hgene | NFE2L2 | C0022593 | Keratosis | 1 | CTD_human |
Hgene | NFE2L2 | C0022658 | Kidney Diseases | 1 | CTD_human |
Hgene | NFE2L2 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | NFE2L2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | NFE2L2 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | NFE2L2 | C0027540 | Necrosis | 1 | CTD_human |
Hgene | NFE2L2 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Hgene | NFE2L2 | C0037286 | Skin Neoplasms | 1 | CTD_human |
Hgene | NFE2L2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | NFE2L2 | C0085215 | Ovarian Failure, Premature | 1 | CTD_human |
Hgene | NFE2L2 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Hgene | NFE2L2 | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
Hgene | NFE2L2 | C0242488 | Acute Lung Injury | 1 | CTD_human |
Hgene | NFE2L2 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | NFE2L2 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
Hgene | NFE2L2 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
Hgene | NFE2L2 | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | NFE2L2 | C2609414 | Acute kidney injury | 1 | CTD_human |