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Fusion gene ID: 24161 |
FusionGeneSummary for NFATC2IP_HS3ST4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NFATC2IP_HS3ST4 | Fusion gene ID: 24161 | Hgene | Tgene | Gene symbol | NFATC2IP | HS3ST4 | Gene ID | 84901 | 9951 |
| Gene name | nuclear factor of activated T cells 2 interacting protein | heparan sulfate-glucosamine 3-sulfotransferase 4 | |
| Synonyms | ESC2|NIP45|RAD60 | 3-OST-4|30ST4|3OST4|h3-OST-4 | |
| Cytomap | 16p11.2 | 16p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NFATC2-interacting protein45 kDa NF-AT-interacting protein45 kDa NFAT-interacting proteinnuclear factor of activated T-cells, cytoplasmic 2-interacting proteinnuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protei | heparan sulfate glucosamine 3-O-sulfotransferase 4heparan sulfate (glucosamine) 3-O-sulfotransferase 4heparan sulfate 3-O-sulfotransferase 4heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q8NCF5 | Q9Y661 | |
| Ensembl transtripts involved in fusion gene | ENST00000564978, ENST00000320805, ENST00000562977, ENST00000568148, | ENST00000331351, ENST00000475436, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 6 X 2 X 5=60 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/60*10)=0 | |
| Context | PubMed: NFATC2IP [Title/Abstract] AND HS3ST4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A27M-01A | NFATC2IP | chr16 | 28970421 | + | HS3ST4 | chr16 | 26146933 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000564978 | ENST00000331351 | NFATC2IP | chr16 | 28970421 | + | HS3ST4 | chr16 | 26146933 | + |
| 5CDS-3UTR | ENST00000564978 | ENST00000475436 | NFATC2IP | chr16 | 28970421 | + | HS3ST4 | chr16 | 26146933 | + |
| In-frame | ENST00000320805 | ENST00000331351 | NFATC2IP | chr16 | 28970421 | + | HS3ST4 | chr16 | 26146933 | + |
| 5CDS-3UTR | ENST00000320805 | ENST00000475436 | NFATC2IP | chr16 | 28970421 | + | HS3ST4 | chr16 | 26146933 | + |
| intron-3CDS | ENST00000562977 | ENST00000331351 | NFATC2IP | chr16 | 28970421 | + | HS3ST4 | chr16 | 26146933 | + |
| intron-3UTR | ENST00000562977 | ENST00000475436 | NFATC2IP | chr16 | 28970421 | + | HS3ST4 | chr16 | 26146933 | + |
| In-frame | ENST00000568148 | ENST00000331351 | NFATC2IP | chr16 | 28970421 | + | HS3ST4 | chr16 | 26146933 | + |
| 5CDS-3UTR | ENST00000568148 | ENST00000475436 | NFATC2IP | chr16 | 28970421 | + | HS3ST4 | chr16 | 26146933 | + |
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FusionProtFeatures for NFATC2IP_HS3ST4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NFATC2IP | HS3ST4 |
| In T-helper 2 (Th2) cells, regulates the magnitude ofNFAT-driven transcription of a specific subset of cytokine genes,including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 tothe IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at theIL4 locus, thus promotes robust cytokine expression (Bysimilarity). Down-regulates formation of poly-SUMO chains byUBE2I/UBC9 (By similarity). {ECO:0000250}. | Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid uniton heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NFATC2IP | chr16:28970421 | chr16:26146933 | ENST00000320805 | + | 7 | 8 | 209_231 | 367 | 420 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | NFATC2IP | chr16:28970421 | chr16:26146933 | ENST00000320805 | + | 7 | 8 | 108_112 | 367 | 420 | Compositional bias | Note=Poly-Arg |
| Tgene | >HS3ST4 | chr16:28970421 | chr16:26146933 | ENST00000331351 | + | 0 | 2 | 413_417 | 244 | 457 | Nucleotide binding | PAPS |
| Tgene | >HS3ST4 | chr16:28970421 | chr16:26146933 | ENST00000331351 | + | 0 | 2 | 260_263 | 244 | 457 | Region | Substrate binding |
| Tgene | >HS3ST4 | chr16:28970421 | chr16:26146933 | ENST00000331351 | + | 0 | 2 | 328_329 | 244 | 457 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NFATC2IP | chr16:28970421 | chr16:26146933 | ENST00000568148 | + | 2 | 3 | 209_231 | 75 | 128 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NFATC2IP | chr16:28970421 | chr16:26146933 | ENST00000568148 | + | 2 | 3 | 108_112 | 75 | 128 | Compositional bias | Note=Poly-Arg |
| Hgene | >NFATC2IP | chr16:28970421 | chr16:26146933 | ENST00000320805 | + | 7 | 8 | 348_419 | 367 | 420 | Domain | Ubiquitin-like |
| Hgene | >NFATC2IP | chr16:28970421 | chr16:26146933 | ENST00000568148 | + | 2 | 3 | 348_419 | 75 | 128 | Domain | Ubiquitin-like |
| Tgene | HS3ST4 | chr16:28970421 | chr16:26146933 | ENST00000331351 | + | 0 | 2 | 207_211 | 244 | 457 | Nucleotide binding | PAPS |
| Tgene | HS3ST4 | chr16:28970421 | chr16:26146933 | ENST00000331351 | + | 0 | 2 | 229_235 | 244 | 457 | Region | Substrate binding |
| Tgene | HS3ST4 | chr16:28970421 | chr16:26146933 | ENST00000331351 | + | 0 | 2 | 1_34 | 244 | 457 | Topological domain | Cytoplasmic |
| Tgene | HS3ST4 | chr16:28970421 | chr16:26146933 | ENST00000331351 | + | 0 | 2 | 60_456 | 244 | 457 | Topological domain | Lumenal |
| Tgene | HS3ST4 | chr16:28970421 | chr16:26146933 | ENST00000331351 | + | 0 | 2 | 35_59 | 244 | 457 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for NFATC2IP_HS3ST4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NFATC2IP_ENST00000564978_chr16_28970421_+_HS3ST4_ENST00000331351_chr16_26146933_+_300aa MRKSEPLQSVVDHMATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCVVLTSSPEATETSQQLQLRVQGKEKHQTLEVSLSRKC DAQDFGWANNHGEDSKLLCDKXGSQAHSLHGQGHQTDCGGEKPRDQGHLXLHADTVKETRDPHLXGAGLQKPDPRADRCFLECHSNRDLC AASGKLAPVFPPLPDPLCQWXATHCGPRRGNGQSTGFSRPQTCCDXEAFLFQQNQGVPLPKEARRQQCPEVLRQEQRSDSSSHXPRCHPQ >In-frame_NFATC2IP_ENST00000320805_chr16_28970421_+_HS3ST4_ENST00000331351_chr16_26146933_+_579aa MAEPVGKRGRWSGGSGAGRGGRGGWGGRGRRPRAQRSPSRGTLDVVSVDLVTDSDEEILEVATARGAADEVEVEPPEPPGPVASRDNSNS DSEGEDRRPAGPPREPVRRRRRLVLDPGEAPLVPVYSGKVKSSLRLIPDDLSLLKLYPPGDEEEAELADSSGLYHEGSPSPGSPWKTKLR TKDKEEKKKTEFLDLDNSPLSPPSPRTKSRTHTRALKKLSEVNKRLQDLRSCLSPKPPQGQEQQGQEDEVVLVEGPTLPETPRLFPLKIR CRADLVRLPLRMSEPLQSVVDHMATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCVVLTSSPEATETSQQLQLRVQGKEKHQT LEVSLSRKCDAQDFGWANNHGEDSKLLCDKXGSQAHSLHGQGHQTDCGGEKPRDQGHLXLHADTVKETRDPHLXGAGLQKPDPRADRCFL ECHSNRDLCAASGKLAPVFPPLPDPLCQWXATHCGPRRGNGQSTGFSRPQTCCDXEAFLFQQNQGVPLPKEARRQQCPEVLRQEQRSDSS >In-frame_NFATC2IP_ENST00000568148_chr16_28970421_+_HS3ST4_ENST00000331351_chr16_26146933_+_287aa MATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCVVLTSSPEATETSQQLQLRVQGKEKHQTLEVSLSRKCDAQDFGWANNHGE DSKLLCDKXGSQAHSLHGQGHQTDCGGEKPRDQGHLXLHADTVKETRDPHLXGAGLQKPDPRADRCFLECHSNRDLCAASGKLAPVFPPL PDPLCQWXATHCGPRRGNGQSTGFSRPQTCCDXEAFLFQQNQGVPLPKEARRQQCPEVLRQEQRSDSSSHXPRCHPQTEEILQTLQLDVL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NFATC2IP_ENST00000564978_chr16_28970421_+_HS3ST4_ENST00000331351_chr16_26146933_+_901nt ATGAGGAAGTCGGAGCCCCTGCAGAGTGTGGTGGACCACATGGCCACCCACCTTGGGGTGTCCCCAAGCAGGATCCTTTTGCTTTTTGGA GAGACAGAGCTATCACCTACTGCCACTCCCAGGACCCTAAAGCTCGGAGTGGCTGACATCATTGACTGTGTGGTACTAACAAGTTCTCCA GAGGCCACAGAGACGTCCCAACAGCTCCAGCTCCGGGTGCAGGGAAAGGAGAAACACCAGACACTGGAAGTCTCACTGTCTCGAAAATGT GATGCCCAAGACTTTGGATGGGCAAATAACCATGGAGAAGACTCCAAGTTACTTTGTGACAAATGAGGCTCCCAAGCGCATTCACTCCAT GGCCAAGGACATCAAACTGATTGTGGTGGTGAGAAACCCCGTGACCAGGGCCATCTCTGACTACACGCAGACACTGTCAAAGAAACCCGA GATCCCCACCTTTGAGGTGCTGGCCTTCAAAAACCGGACCCTCGGGCTGATCGATGCTTCCTGGAGTGCCATTCGAATAGGGATCTATGC GCTGCATCTGGAAAACTGGCTCCAGTATTTCCCCCTCTCCCAGATCCTCTTTGTCAGTGGTGAGCGACTCATTGTGGACCCCGCCGGGGA AATGGCCAAAGTACAGGATTTTCTAGGCCTCAAACGTGTTGTGACTGAGAAGCATTTCTATTTCAACAAAACCAAGGGGTTCCCTTGCCT AAAGAAGCCAGAAGACAGCAGTGCCCCGAGGTGCTTAGGCAAGAGCAAAGGTCGGACTCATCCTCGCATTGACCCAGATGTCATCCACAG ACTGAGGAAATTCTACAAACCCTTCAACTTGATGTTTTACCAAATGACTGGTCAAGATTTTCAGTGGGAACAGGAAGAGGGTGATAAATG >In-frame_NFATC2IP_ENST00000320805_chr16_28970421_+_HS3ST4_ENST00000331351_chr16_26146933_+_1738nt ATGGCGGAGCCTGTGGGGAAGCGGGGCCGCTGGTCCGGAGGTAGCGGTGCCGGCCGAGGGGGTCGGGGCGGCTGGGGCGGTCGGGGCCGG CGTCCTCGGGCCCAGCGGTCTCCATCCCGGGGCACGCTGGACGTAGTGTCTGTGGACTTGGTCACCGACAGCGATGAGGAAATTCTGGAG GTCGCCACCGCTCGCGGTGCCGCGGACGAGGTTGAGGTGGAGCCCCCGGAGCCCCCGGGGCCGGTCGCGTCCCGGGATAACAGCAACAGT GACAGCGAAGGGGAGGACAGGCGGCCCGCAGGACCCCCGCGGGAGCCGGTCAGGCGGCGGCGGCGGCTGGTGCTGGATCCGGGGGAGGCG CCGCTGGTTCCGGTGTACTCGGGGAAGGTTAAAAGCAGCCTTCGCCTTATCCCAGATGATCTATCCCTCCTGAAACTCTACCCTCCAGGG GATGAGGAAGAGGCAGAGCTGGCAGATTCGAGTGGTCTCTACCATGAGGGCTCCCCATCACCAGGCTCTCCCTGGAAGACAAAGCTGAGG ACTAAGGATAAAGAAGAGAAGAAAAAGACAGAGTTTCTGGATCTGGACAACTCTCCTCTGTCCCCACCTTCACCAAGGACCAAAAGCAGA ACGCATACTCGGGCACTCAAGAAGTTAAGTGAGGTGAACAAGCGCCTCCAGGATCTCCGTTCCTGTCTGAGCCCCAAGCCACCTCAGGGT CAAGAGCAACAGGGCCAAGAGGATGAAGTGGTCTTGGTGGAAGGGCCCACCCTCCCAGAGACCCCCCGACTCTTCCCACTCAAAATCCGT TGCCGGGCTGACCTGGTCAGATTGCCCCTCAGGATGTCGGAGCCCCTGCAGAGTGTGGTGGACCACATGGCCACCCACCTTGGGGTGTCC CCAAGCAGGATCCTTTTGCTTTTTGGAGAGACAGAGCTATCACCTACTGCCACTCCCAGGACCCTAAAGCTCGGAGTGGCTGACATCATT GACTGTGTGGTACTAACAAGTTCTCCAGAGGCCACAGAGACGTCCCAACAGCTCCAGCTCCGGGTGCAGGGAAAGGAGAAACACCAGACA CTGGAAGTCTCACTGTCTCGAAAATGTGATGCCCAAGACTTTGGATGGGCAAATAACCATGGAGAAGACTCCAAGTTACTTTGTGACAAA TGAGGCTCCCAAGCGCATTCACTCCATGGCCAAGGACATCAAACTGATTGTGGTGGTGAGAAACCCCGTGACCAGGGCCATCTCTGACTA CACGCAGACACTGTCAAAGAAACCCGAGATCCCCACCTTTGAGGTGCTGGCCTTCAAAAACCGGACCCTCGGGCTGATCGATGCTTCCTG GAGTGCCATTCGAATAGGGATCTATGCGCTGCATCTGGAAAACTGGCTCCAGTATTTCCCCCTCTCCCAGATCCTCTTTGTCAGTGGTGA GCGACTCATTGTGGACCCCGCCGGGGAAATGGCCAAAGTACAGGATTTTCTAGGCCTCAAACGTGTTGTGACTGAGAAGCATTTCTATTT CAACAAAACCAAGGGGTTCCCTTGCCTAAAGAAGCCAGAAGACAGCAGTGCCCCGAGGTGCTTAGGCAAGAGCAAAGGTCGGACTCATCC TCGCATTGACCCAGATGTCATCCACAGACTGAGGAAATTCTACAAACCCTTCAACTTGATGTTTTACCAAATGACTGGTCAAGATTTTCA >In-frame_NFATC2IP_ENST00000568148_chr16_28970421_+_HS3ST4_ENST00000331351_chr16_26146933_+_862nt ATGGCCACCCACCTTGGGGTGTCCCCAAGCAGGATCCTTTTGCTTTTTGGAGAGACAGAGCTATCACCTACTGCCACTCCCAGGACCCTA AAGCTCGGAGTGGCTGACATCATTGACTGTGTGGTACTAACAAGTTCTCCAGAGGCCACAGAGACGTCCCAACAGCTCCAGCTCCGGGTG CAGGGAAAGGAGAAACACCAGACACTGGAAGTCTCACTGTCTCGAAAATGTGATGCCCAAGACTTTGGATGGGCAAATAACCATGGAGAA GACTCCAAGTTACTTTGTGACAAATGAGGCTCCCAAGCGCATTCACTCCATGGCCAAGGACATCAAACTGATTGTGGTGGTGAGAAACCC CGTGACCAGGGCCATCTCTGACTACACGCAGACACTGTCAAAGAAACCCGAGATCCCCACCTTTGAGGTGCTGGCCTTCAAAAACCGGAC CCTCGGGCTGATCGATGCTTCCTGGAGTGCCATTCGAATAGGGATCTATGCGCTGCATCTGGAAAACTGGCTCCAGTATTTCCCCCTCTC CCAGATCCTCTTTGTCAGTGGTGAGCGACTCATTGTGGACCCCGCCGGGGAAATGGCCAAAGTACAGGATTTTCTAGGCCTCAAACGTGT TGTGACTGAGAAGCATTTCTATTTCAACAAAACCAAGGGGTTCCCTTGCCTAAAGAAGCCAGAAGACAGCAGTGCCCCGAGGTGCTTAGG CAAGAGCAAAGGTCGGACTCATCCTCGCATTGACCCAGATGTCATCCACAGACTGAGGAAATTCTACAAACCCTTCAACTTGATGTTTTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NFATC2IP_ENST00000564978_chr16_28970421_+_HS3ST4_ENST00000331351_chr16_26146933_+_2433nt TGGAATCTTTGGCGCCTTGGTTTCAGAGGTTAAAAGCAGCCTTCGCCTTATCCCAGATGATCTATCCCTCCTGAAACTCTACCCTCCAGG GGATGAGGAAGTCGGAGCCCCTGCAGAGTGTGGTGGACCACATGGCCACCCACCTTGGGGTGTCCCCAAGCAGGATCCTTTTGCTTTTTG GAGAGACAGAGCTATCACCTACTGCCACTCCCAGGACCCTAAAGCTCGGAGTGGCTGACATCATTGACTGTGTGGTACTAACAAGTTCTC CAGAGGCCACAGAGACGTCCCAACAGCTCCAGCTCCGGGTGCAGGGAAAGGAGAAACACCAGACACTGGAAGTCTCACTGTCTCGAAAAT GTGATGCCCAAGACTTTGGATGGGCAAATAACCATGGAGAAGACTCCAAGTTACTTTGTGACAAATGAGGCTCCCAAGCGCATTCACTCC ATGGCCAAGGACATCAAACTGATTGTGGTGGTGAGAAACCCCGTGACCAGGGCCATCTCTGACTACACGCAGACACTGTCAAAGAAACCC GAGATCCCCACCTTTGAGGTGCTGGCCTTCAAAAACCGGACCCTCGGGCTGATCGATGCTTCCTGGAGTGCCATTCGAATAGGGATCTAT GCGCTGCATCTGGAAAACTGGCTCCAGTATTTCCCCCTCTCCCAGATCCTCTTTGTCAGTGGTGAGCGACTCATTGTGGACCCCGCCGGG GAAATGGCCAAAGTACAGGATTTTCTAGGCCTCAAACGTGTTGTGACTGAGAAGCATTTCTATTTCAACAAAACCAAGGGGTTCCCTTGC CTAAAGAAGCCAGAAGACAGCAGTGCCCCGAGGTGCTTAGGCAAGAGCAAAGGTCGGACTCATCCTCGCATTGACCCAGATGTCATCCAC AGACTGAGGAAATTCTACAAACCCTTCAACTTGATGTTTTACCAAATGACTGGTCAAGATTTTCAGTGGGAACAGGAAGAGGGTGATAAA TGAGGCTAGAGAGGCAGAGGAAGGCTAGTCAATAAGCTAAGGAGGCTCCTTGCCTGAGTCCTTGAATACCCCAGCTTCTGCAGCTTCACT TGCTGGAGTGCCAAGTAGATCTCCTCCTCCTTCATGCAGCCAGGATTGCCTCCAGTGCTGTTAGCTTAGGCAAACAGGTGGATCCCATGG CATCCCCATGGAGGAACCAGGCCCATCTGGGCAGCAGCATCTGGTTGACCAGATGGCCACCAGAACCCACTGTTCATTCTTATCTTCTGC TAGTTAATATAGCCTGAAGACAGAGGATAAATAGTTGTCAATGTCAGAGACAGTGCTATTAATGTATATGTGAGCGACAAAAAAGGTCTG CTTTATAGGGGTTCTCACTCTAGCTTGGGGAGCCAGGGTTCTAGCCCTGTATCTGTCATGGGCACCTGCTGTCTAAACCTCTGCTTGGGC TTCTCCCCAGAATGCACTTTGTGGCTGAGTGCTCCAGGACTCCTAGGGAGCAAGGTCCTCCCTCTAAGGTGTTTCTAGTCTTCTCTTTAA AGGTCTCATCCCACAACCCCTGACTTCCTCCCTCCCCACATCATGAAGGCAGAGGCATGCACATTCCTCACTGAAAAAGAAAACACACAC CCACCCACACACACACACACAGAAGAAAATGAAAGCTGACACACCTCGAAGCCTTCTTTCCAAGAGCCCTCTAAATGGGGTTGGGTCTCA CTCTTCATGAGTATCCTGGGTTGTGCAGAAGCTTAGCATATGCCCTTGTGTTCGGATCAGGCCCACAGGGCTGCTCAAAGAGTAGAGTAA TTGTAACCGAGGTCAGAGCTCTGGGGTTGGCAGAGATGAGTGGCCATATCTGGGGGTAAAAGAAGAAATCCTGTCCTCTTGGTGGGAGGT TACCTTACCTGAAGACCATCTCTCCCAAGCACTGTAGTTCTGAGCATGTTTTTGGGGTGGACTCTGTCCCCTAGGGTCCCTAGAAGGGCA AAGACCAGAGAGTTGACAAGTCTGTTATTAGGAATAATCCTTAGCCATGTAATGGAGAAAGGAGCAGTCAGCATTCTTCCAATTTGCCCC ACCACCACCTCCTCGGGCTTCATTTTCTCTATTTAGAGATGGCAGAGAGTGAGGTAGTGGCGAGAAAGCTGACTCCATTCATCAGATCCA GTTTATGAGGGTTGGGGGTGAGCAAGGGCTGTCTGCAGAAACCCCCATCAAGAGCTGCTGAATGAAGTGTCCCTTCCCATCAGTTTGATT CAATTAAAATGCATCATTTGACATAAAGCACTTGTTCACAGATCTCCAAAACCAGGAATTGTTCTAGTAAAACTGGAAATTTGTATGAGT GGGGGGAGTTAAATCTGTTCAGCTGTTATTAAACTGTCATTTCTCCCGCTAAATGAAAACCGTGTTGTTATAAAGCTTAATGCAACCTGA >In-frame_NFATC2IP_ENST00000320805_chr16_28970421_+_HS3ST4_ENST00000331351_chr16_26146933_+_3253nt TGCAAGGCGAAAGTCGCTGAAGGGGGCGGGGCGAGGCGAGAGGAGGCGGGCGTGTGTTGTGGAGGAAAGTGTGCCATGGCGGAGCCTGTG GGGAAGCGGGGCCGCTGGTCCGGAGGTAGCGGTGCCGGCCGAGGGGGTCGGGGCGGCTGGGGCGGTCGGGGCCGGCGTCCTCGGGCCCAG CGGTCTCCATCCCGGGGCACGCTGGACGTAGTGTCTGTGGACTTGGTCACCGACAGCGATGAGGAAATTCTGGAGGTCGCCACCGCTCGC GGTGCCGCGGACGAGGTTGAGGTGGAGCCCCCGGAGCCCCCGGGGCCGGTCGCGTCCCGGGATAACAGCAACAGTGACAGCGAAGGGGAG GACAGGCGGCCCGCAGGACCCCCGCGGGAGCCGGTCAGGCGGCGGCGGCGGCTGGTGCTGGATCCGGGGGAGGCGCCGCTGGTTCCGGTG TACTCGGGGAAGGTTAAAAGCAGCCTTCGCCTTATCCCAGATGATCTATCCCTCCTGAAACTCTACCCTCCAGGGGATGAGGAAGAGGCA GAGCTGGCAGATTCGAGTGGTCTCTACCATGAGGGCTCCCCATCACCAGGCTCTCCCTGGAAGACAAAGCTGAGGACTAAGGATAAAGAA GAGAAGAAAAAGACAGAGTTTCTGGATCTGGACAACTCTCCTCTGTCCCCACCTTCACCAAGGACCAAAAGCAGAACGCATACTCGGGCA CTCAAGAAGTTAAGTGAGGTGAACAAGCGCCTCCAGGATCTCCGTTCCTGTCTGAGCCCCAAGCCACCTCAGGGTCAAGAGCAACAGGGC CAAGAGGATGAAGTGGTCTTGGTGGAAGGGCCCACCCTCCCAGAGACCCCCCGACTCTTCCCACTCAAAATCCGTTGCCGGGCTGACCTG GTCAGATTGCCCCTCAGGATGTCGGAGCCCCTGCAGAGTGTGGTGGACCACATGGCCACCCACCTTGGGGTGTCCCCAAGCAGGATCCTT TTGCTTTTTGGAGAGACAGAGCTATCACCTACTGCCACTCCCAGGACCCTAAAGCTCGGAGTGGCTGACATCATTGACTGTGTGGTACTA ACAAGTTCTCCAGAGGCCACAGAGACGTCCCAACAGCTCCAGCTCCGGGTGCAGGGAAAGGAGAAACACCAGACACTGGAAGTCTCACTG TCTCGAAAATGTGATGCCCAAGACTTTGGATGGGCAAATAACCATGGAGAAGACTCCAAGTTACTTTGTGACAAATGAGGCTCCCAAGCG CATTCACTCCATGGCCAAGGACATCAAACTGATTGTGGTGGTGAGAAACCCCGTGACCAGGGCCATCTCTGACTACACGCAGACACTGTC AAAGAAACCCGAGATCCCCACCTTTGAGGTGCTGGCCTTCAAAAACCGGACCCTCGGGCTGATCGATGCTTCCTGGAGTGCCATTCGAAT AGGGATCTATGCGCTGCATCTGGAAAACTGGCTCCAGTATTTCCCCCTCTCCCAGATCCTCTTTGTCAGTGGTGAGCGACTCATTGTGGA CCCCGCCGGGGAAATGGCCAAAGTACAGGATTTTCTAGGCCTCAAACGTGTTGTGACTGAGAAGCATTTCTATTTCAACAAAACCAAGGG GTTCCCTTGCCTAAAGAAGCCAGAAGACAGCAGTGCCCCGAGGTGCTTAGGCAAGAGCAAAGGTCGGACTCATCCTCGCATTGACCCAGA TGTCATCCACAGACTGAGGAAATTCTACAAACCCTTCAACTTGATGTTTTACCAAATGACTGGTCAAGATTTTCAGTGGGAACAGGAAGA GGGTGATAAATGAGGCTAGAGAGGCAGAGGAAGGCTAGTCAATAAGCTAAGGAGGCTCCTTGCCTGAGTCCTTGAATACCCCAGCTTCTG CAGCTTCACTTGCTGGAGTGCCAAGTAGATCTCCTCCTCCTTCATGCAGCCAGGATTGCCTCCAGTGCTGTTAGCTTAGGCAAACAGGTG GATCCCATGGCATCCCCATGGAGGAACCAGGCCCATCTGGGCAGCAGCATCTGGTTGACCAGATGGCCACCAGAACCCACTGTTCATTCT TATCTTCTGCTAGTTAATATAGCCTGAAGACAGAGGATAAATAGTTGTCAATGTCAGAGACAGTGCTATTAATGTATATGTGAGCGACAA AAAAGGTCTGCTTTATAGGGGTTCTCACTCTAGCTTGGGGAGCCAGGGTTCTAGCCCTGTATCTGTCATGGGCACCTGCTGTCTAAACCT CTGCTTGGGCTTCTCCCCAGAATGCACTTTGTGGCTGAGTGCTCCAGGACTCCTAGGGAGCAAGGTCCTCCCTCTAAGGTGTTTCTAGTC TTCTCTTTAAAGGTCTCATCCCACAACCCCTGACTTCCTCCCTCCCCACATCATGAAGGCAGAGGCATGCACATTCCTCACTGAAAAAGA AAACACACACCCACCCACACACACACACACAGAAGAAAATGAAAGCTGACACACCTCGAAGCCTTCTTTCCAAGAGCCCTCTAAATGGGG TTGGGTCTCACTCTTCATGAGTATCCTGGGTTGTGCAGAAGCTTAGCATATGCCCTTGTGTTCGGATCAGGCCCACAGGGCTGCTCAAAG AGTAGAGTAATTGTAACCGAGGTCAGAGCTCTGGGGTTGGCAGAGATGAGTGGCCATATCTGGGGGTAAAAGAAGAAATCCTGTCCTCTT GGTGGGAGGTTACCTTACCTGAAGACCATCTCTCCCAAGCACTGTAGTTCTGAGCATGTTTTTGGGGTGGACTCTGTCCCCTAGGGTCCC TAGAAGGGCAAAGACCAGAGAGTTGACAAGTCTGTTATTAGGAATAATCCTTAGCCATGTAATGGAGAAAGGAGCAGTCAGCATTCTTCC AATTTGCCCCACCACCACCTCCTCGGGCTTCATTTTCTCTATTTAGAGATGGCAGAGAGTGAGGTAGTGGCGAGAAAGCTGACTCCATTC ATCAGATCCAGTTTATGAGGGTTGGGGGTGAGCAAGGGCTGTCTGCAGAAACCCCCATCAAGAGCTGCTGAATGAAGTGTCCCTTCCCAT CAGTTTGATTCAATTAAAATGCATCATTTGACATAAAGCACTTGTTCACAGATCTCCAAAACCAGGAATTGTTCTAGTAAAACTGGAAAT TTGTATGAGTGGGGGGAGTTAAATCTGTTCAGCTGTTATTAAACTGTCATTTCTCCCGCTAAATGAAAACCGTGTTGTTATAAAGCTTAA >In-frame_NFATC2IP_ENST00000568148_chr16_28970421_+_HS3ST4_ENST00000331351_chr16_26146933_+_2659nt CATACTGGCCCACGTTCCCACACAGTGCCAATCAGCTGGAGCTGCGTAACAGCCAGCCTGTCTAGGTGGCATGTGAATTCCAGTTTGCTG CAATCCCCACCACCCCTTTCTTTGTTCTAACCCATGGCTGCTATATTTCTTTGTGTTACTCGCCTGTACCCCTTGCTGACACGATTTTAT TCTATACCTTGCCAGGTAAATATGATGAAACTCACAGCTGAGGAGCTTAGCAAGTAGCTAAGGCCAGAGCTTGTGTTTGGGTGGTGTGGC TGGGGGCATGGATTTCAAGGCAGGAAGACCTCTTTTGCTTGTTGTCCCCATCCCTAGTCGGAGCCCCTGCAGAGTGTGGTGGACCACATG GCCACCCACCTTGGGGTGTCCCCAAGCAGGATCCTTTTGCTTTTTGGAGAGACAGAGCTATCACCTACTGCCACTCCCAGGACCCTAAAG CTCGGAGTGGCTGACATCATTGACTGTGTGGTACTAACAAGTTCTCCAGAGGCCACAGAGACGTCCCAACAGCTCCAGCTCCGGGTGCAG GGAAAGGAGAAACACCAGACACTGGAAGTCTCACTGTCTCGAAAATGTGATGCCCAAGACTTTGGATGGGCAAATAACCATGGAGAAGAC TCCAAGTTACTTTGTGACAAATGAGGCTCCCAAGCGCATTCACTCCATGGCCAAGGACATCAAACTGATTGTGGTGGTGAGAAACCCCGT GACCAGGGCCATCTCTGACTACACGCAGACACTGTCAAAGAAACCCGAGATCCCCACCTTTGAGGTGCTGGCCTTCAAAAACCGGACCCT CGGGCTGATCGATGCTTCCTGGAGTGCCATTCGAATAGGGATCTATGCGCTGCATCTGGAAAACTGGCTCCAGTATTTCCCCCTCTCCCA GATCCTCTTTGTCAGTGGTGAGCGACTCATTGTGGACCCCGCCGGGGAAATGGCCAAAGTACAGGATTTTCTAGGCCTCAAACGTGTTGT GACTGAGAAGCATTTCTATTTCAACAAAACCAAGGGGTTCCCTTGCCTAAAGAAGCCAGAAGACAGCAGTGCCCCGAGGTGCTTAGGCAA GAGCAAAGGTCGGACTCATCCTCGCATTGACCCAGATGTCATCCACAGACTGAGGAAATTCTACAAACCCTTCAACTTGATGTTTTACCA AATGACTGGTCAAGATTTTCAGTGGGAACAGGAAGAGGGTGATAAATGAGGCTAGAGAGGCAGAGGAAGGCTAGTCAATAAGCTAAGGAG GCTCCTTGCCTGAGTCCTTGAATACCCCAGCTTCTGCAGCTTCACTTGCTGGAGTGCCAAGTAGATCTCCTCCTCCTTCATGCAGCCAGG ATTGCCTCCAGTGCTGTTAGCTTAGGCAAACAGGTGGATCCCATGGCATCCCCATGGAGGAACCAGGCCCATCTGGGCAGCAGCATCTGG TTGACCAGATGGCCACCAGAACCCACTGTTCATTCTTATCTTCTGCTAGTTAATATAGCCTGAAGACAGAGGATAAATAGTTGTCAATGT CAGAGACAGTGCTATTAATGTATATGTGAGCGACAAAAAAGGTCTGCTTTATAGGGGTTCTCACTCTAGCTTGGGGAGCCAGGGTTCTAG CCCTGTATCTGTCATGGGCACCTGCTGTCTAAACCTCTGCTTGGGCTTCTCCCCAGAATGCACTTTGTGGCTGAGTGCTCCAGGACTCCT AGGGAGCAAGGTCCTCCCTCTAAGGTGTTTCTAGTCTTCTCTTTAAAGGTCTCATCCCACAACCCCTGACTTCCTCCCTCCCCACATCAT GAAGGCAGAGGCATGCACATTCCTCACTGAAAAAGAAAACACACACCCACCCACACACACACACACAGAAGAAAATGAAAGCTGACACAC CTCGAAGCCTTCTTTCCAAGAGCCCTCTAAATGGGGTTGGGTCTCACTCTTCATGAGTATCCTGGGTTGTGCAGAAGCTTAGCATATGCC CTTGTGTTCGGATCAGGCCCACAGGGCTGCTCAAAGAGTAGAGTAATTGTAACCGAGGTCAGAGCTCTGGGGTTGGCAGAGATGAGTGGC CATATCTGGGGGTAAAAGAAGAAATCCTGTCCTCTTGGTGGGAGGTTACCTTACCTGAAGACCATCTCTCCCAAGCACTGTAGTTCTGAG CATGTTTTTGGGGTGGACTCTGTCCCCTAGGGTCCCTAGAAGGGCAAAGACCAGAGAGTTGACAAGTCTGTTATTAGGAATAATCCTTAG CCATGTAATGGAGAAAGGAGCAGTCAGCATTCTTCCAATTTGCCCCACCACCACCTCCTCGGGCTTCATTTTCTCTATTTAGAGATGGCA GAGAGTGAGGTAGTGGCGAGAAAGCTGACTCCATTCATCAGATCCAGTTTATGAGGGTTGGGGGTGAGCAAGGGCTGTCTGCAGAAACCC CCATCAAGAGCTGCTGAATGAAGTGTCCCTTCCCATCAGTTTGATTCAATTAAAATGCATCATTTGACATAAAGCACTTGTTCACAGATC TCCAAAACCAGGAATTGTTCTAGTAAAACTGGAAATTTGTATGAGTGGGGGGAGTTAAATCTGTTCAGCTGTTATTAAACTGTCATTTCT |
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FusionGenePPI for NFATC2IP_HS3ST4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NFATC2IP | BATF3, TRAF1, TRAF2, TRAF3, TRAF5, TRAF6, MOV10, NXF1, ZDHHC17, GTF2I, RNMT, SMNDC1, TCEA1, TMA7, ZMAT2, HIST1H2BG, FOS, WDYHV1, P4HA3, CHD8, ACTR6, ELF2, ZNHIT1, PDLIM5, SRCAP, VPS72, RHEB, DMAP1, PDLIM7, EIF4G3, EIF4G1, SMARCA1 | HS3ST4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFATC2IP_HS3ST4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NFATC2IP_HS3ST4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | HS3ST4 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
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