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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2412

FusionGeneSummary for ARHGAP24_BANK1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP24_BANK1
Fusion gene ID: 2412
HgeneTgene
Gene symbol

ARHGAP24

BANK1

Gene ID

83478

55024

Gene nameRho GTPase activating protein 24B cell scaffold protein with ankyrin repeats 1
SynonymsFILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAPBANK
Cytomap

4q21.23-q21.3

4q24

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 24RAC1- and CDC42-specific GTPase-activating protein of 72 kDafilamin-A-associated RhoGAPrhoGAP of 73 kDasarcoma antigen NY-SAR-88B-cell scaffold protein with ankyrin repeats
Modification date2018051920180519
UniProtAcc

Q8N264

Q8NDB2

Ensembl transtripts involved in fusion geneENST00000395184, ENST00000503995, 
ENST00000506421, ENST00000395183, 
ENST00000264343, 		ENST00000504592, 
ENST00000322953, ENST00000428908, 
ENST00000508653, ENST00000444316, 
ENST00000510950, 
Fusion gene scores* DoF score5 X 6 X 4=1204 X 4 X 3=48
# samples 64
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP24 [Title/Abstract] AND BANK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBANK1

GO:0042113

B cell activation

11782428


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA819158ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000395184ENST00000504592ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
In-frameENST00000395184ENST00000322953ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
In-frameENST00000395184ENST00000428908ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
In-frameENST00000395184ENST00000508653ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
In-frameENST00000395184ENST00000444316ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
5CDS-3UTRENST00000395184ENST00000510950ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
In-frameENST00000503995ENST00000504592ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
In-frameENST00000503995ENST00000322953ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
In-frameENST00000503995ENST00000428908ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
In-frameENST00000503995ENST00000508653ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
In-frameENST00000503995ENST00000444316ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
5CDS-3UTRENST00000503995ENST00000510950ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
3UTR-3CDSENST00000506421ENST00000504592ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
3UTR-3CDSENST00000506421ENST00000322953ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
3UTR-3CDSENST00000506421ENST00000428908ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
3UTR-3CDSENST00000506421ENST00000508653ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
3UTR-3CDSENST00000506421ENST00000444316ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
3UTR-3UTRENST00000506421ENST00000510950ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000395183ENST00000504592ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000395183ENST00000322953ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000395183ENST00000428908ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000395183ENST00000508653ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000395183ENST00000444316ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3UTRENST00000395183ENST00000510950ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000264343ENST00000504592ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000264343ENST00000322953ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000264343ENST00000428908ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000264343ENST00000508653ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3CDSENST00000264343ENST00000444316ARHGAP24chr4

86491874

+BANK1chr4

102942670

+
intron-3UTRENST00000264343ENST00000510950ARHGAP24chr4

86491874

+BANK1chr4

102942670

+

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FusionProtFeatures for ARHGAP24_BANK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP24

Q8N264

BANK1

Q8NDB2

Rho GTPase-activating protein involved in cell polarity,cell morphology and cytoskeletal organization. Acts as a GTPaseactivator for the Rac-type GTPase by converting it to an inactiveGDP-bound state. Controls actin remodeling by inactivating Racdownstream of Rho leading to suppress leading edge protrusion andpromotes cell retraction to achieve cellular polarity. Able tosuppress RAC1 and CDC42 activity in vitro. Overexpression inducescell rounding with partial or complete disruption of actin stressfibers and formation of membrane ruffles, lamellipodia, andfilopodia. Isoform 2 is a vascular cell-specific GAP involved inmodulation of angiogenesis. {ECO:0000269|PubMed:15302923,ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. Involved in B-cell receptor (BCR)-induced Ca(2+)mobilization from intracellular stores. Promotes Lyn-mediatedphosphorylation of IP3 receptors 1 and 2.{ECO:0000269|PubMed:11782428}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBANK1chr4:86491874chr4:102942670ENST00000428908+516342_371269807RepeatNote=ANK 1
TgeneBANK1chr4:86491874chr4:102942670ENST00000428908+516378_408269807RepeatNote=ANK 2
TgeneBANK1chr4:86491874chr4:102942670ENST00000444316+617378_408372963RepeatNote=ANK 2
TgeneBANK1chr4:86491874chr4:102942670ENST00000508653+515342_371269653RepeatNote=ANK 1
TgeneBANK1chr4:86491874chr4:102942670ENST00000508653+515378_408269653RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000264343+17649_729-220656Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000395183+18649_729-93654Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000395184+210649_72960749Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000503995+26649_72960247Coiled coilOntology_term=ECO:0000255
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000264343+17135_329-220656DomainRho-GAP
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000264343+1719_125-220656DomainPH
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000395183+18135_329-93654DomainRho-GAP
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000395183+1819_125-93654DomainPH
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000395184+210135_32960749DomainRho-GAP
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000395184+21019_12560749DomainPH
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000503995+26135_32960247DomainRho-GAP
HgeneARHGAP24chr4:86491874chr4:102942670ENST00000503995+2619_12560247DomainPH
TgeneBANK1chr4:86491874chr4:102942670ENST00000322953+617200_327402916DomainDBB
TgeneBANK1chr4:86491874chr4:102942670ENST00000428908+516200_327269807DomainDBB
TgeneBANK1chr4:86491874chr4:102942670ENST00000444316+617200_327372963DomainDBB
TgeneBANK1chr4:86491874chr4:102942670ENST00000504592+1021200_327387994DomainDBB
TgeneBANK1chr4:86491874chr4:102942670ENST00000508653+515200_327269653DomainDBB
TgeneBANK1chr4:86491874chr4:102942670ENST00000322953+617342_371402916RepeatNote=ANK 1
TgeneBANK1chr4:86491874chr4:102942670ENST00000322953+617378_408402916RepeatNote=ANK 2
TgeneBANK1chr4:86491874chr4:102942670ENST00000444316+617342_371372963RepeatNote=ANK 1
TgeneBANK1chr4:86491874chr4:102942670ENST00000504592+1021342_371387994RepeatNote=ANK 1
TgeneBANK1chr4:86491874chr4:102942670ENST00000504592+1021378_408387994RepeatNote=ANK 2


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FusionGeneSequence for ARHGAP24_BANK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGAP24_BANK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGAP24APPBANK1LYN, ITPR1, YWHAQ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneBANK1chr4:86491874chr4:102942670ENST00000322953+6171_154402916ITPR2
TgeneBANK1chr4:86491874chr4:102942670ENST00000428908+5161_154269807ITPR2
TgeneBANK1chr4:86491874chr4:102942670ENST00000444316+6171_154372963ITPR2
TgeneBANK1chr4:86491874chr4:102942670ENST00000504592+10211_154387994ITPR2
TgeneBANK1chr4:86491874chr4:102942670ENST00000508653+5151_154269653ITPR2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP24_BANK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP24_BANK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBANK1C0024141Lupus Erythematosus, Systemic1CTD_human