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Fusion gene ID: 24119 |
FusionGeneSummary for NF2_EIF3D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NF2_EIF3D | Fusion gene ID: 24119 | Hgene | Tgene | Gene symbol | NF2 | EIF3D | Gene ID | 4771 | 8664 |
| Gene name | neurofibromin 2 | eukaryotic translation initiation factor 3 subunit D | |
| Synonyms | ACN|BANF|SCH | EIF3S7|eIF3-p66|eIF3-zeta | |
| Cytomap | 22q12.2 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | merlinmoesin-ezrin-radixin likemoesin-ezrin-radixin-like proteinmoesin-ezrin-radizin-like proteinneurofibromin 2 (bilateral acoustic neuroma)schwannomerlinschwannomin | eukaryotic translation initiation factor 3 subunit DeIF3 p66eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDatranslation initiation factor eIF3 p66 subunit | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P35240 | O15371 | |
| Ensembl transtripts involved in fusion gene | ENST00000347330, ENST00000413209, ENST00000338641, ENST00000403435, ENST00000361452, ENST00000403999, ENST00000334961, ENST00000353887, ENST00000361166, ENST00000397789, ENST00000361676, | ENST00000216190, ENST00000478547, ENST00000541106, ENST00000405442, | |
| Fusion gene scores | * DoF score | 12 X 7 X 7=588 | 7 X 8 X 5=280 |
| # samples | 13 | 9 | |
| ** MAII score | log2(13/588*10)=-2.17730453180791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NF2 [Title/Abstract] AND EIF3D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NF2 | GO:0008285 | negative regulation of cell proliferation | 12444102|20178741 |
| Hgene | NF2 | GO:0022408 | negative regulation of cell-cell adhesion | 17210637 |
| Hgene | NF2 | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein | 12444102 |
| Hgene | NF2 | GO:0046426 | negative regulation of JAK-STAT cascade | 12444102 |
| Tgene | EIF3D | GO:0002191 | cap-dependent translational initiation | 27462815 |
| Tgene | EIF3D | GO:0006413 | translational initiation | 17581632 |
| Tgene | EIF3D | GO:0075522 | IRES-dependent viral translational initiation | 9573242 |
| Tgene | EIF3D | GO:0075525 | viral translational termination-reinitiation | 21347434 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-V7-A7HQ-01A | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000347330 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000347330 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000347330 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000347330 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000413209 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000413209 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000413209 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000413209 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000338641 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000338641 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000338641 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000338641 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000403435 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000403435 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000403435 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000403435 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000361452 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000361452 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000361452 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000361452 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000403999 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000403999 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000403999 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000403999 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000334961 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000334961 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000334961 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000334961 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000353887 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000353887 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000353887 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000353887 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000361166 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000361166 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000361166 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000361166 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000397789 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000397789 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000397789 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000397789 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| In-frame | ENST00000361676 | ENST00000216190 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000361676 | ENST00000478547 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000361676 | ENST00000541106 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
| 5CDS-intron | ENST00000361676 | ENST00000405442 | NF2 | chr22 | 30000101 | + | EIF3D | chr22 | 36908649 | - |
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FusionProtFeatures for NF2_EIF3D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NF2 | EIF3D |
| mRNA cap-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, a complex required forseveral steps in the initiation of protein synthesis of aspecialized repertoire of mRNAs (PubMed:27462815). The eIF-3complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5to form the 43S pre-initiation complex (43S PIC). The eIF-3complex stimulates mRNA recruitment to the 43S PIC and scanning ofthe mRNA for AUG recognition. The eIF-3 complex is also requiredfor disassembly and recycling of post-termination ribosomalcomplexes and subsequently prevents premature joining of the 40Sand 60S ribosomal subunits prior to initiation (PubMed:18599441,PubMed:25849773). The eIF-3 complex specifically targets andinitiates translation of a subset of mRNAs involved in cellproliferation, including cell cycling, differentiation andapoptosis, and uses different modes of RNA stem-loop binding toexert either translational activation or repression(PubMed:25849773). In the eIF-3 complex, EIF3D specificallyrecognizes and binds the 7-methylguanosine cap of a subset ofmRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441,ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >EIF3D | chr22:30000101 | chr22:36908649 | ENST00000216190 | - | 11 | 15 | 530_547 | 402 | 549 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Tgene | >EIF3D | chr22:30000101 | chr22:36908649 | ENST00000405442 | - | 11 | 15 | 530_547 | 402 | 549 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000334961 | + | 1 | 15 | 327_465 | 38 | 451 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000338641 | + | 1 | 16 | 327_465 | 38 | 596 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000347330 | + | 1 | 10 | 327_465 | 38 | 1312 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000353887 | + | 1 | 15 | 327_465 | 38 | 406 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000361166 | + | 1 | 17 | 327_465 | 38 | 571 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000361452 | + | 1 | 16 | 327_465 | 38 | 1665 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000361676 | + | 1 | 16 | 327_465 | 38 | 531 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000397789 | + | 1 | 17 | 327_465 | 38 | 573 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000403435 | + | 1 | 17 | 327_465 | 38 | 541 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000403999 | + | 1 | 16 | 327_465 | 38 | 591 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000413209 | + | 1 | 5 | 327_465 | 38 | 166 | Compositional bias | Note=Glu-rich |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000334961 | + | 1 | 15 | 22_311 | 38 | 451 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000338641 | + | 1 | 16 | 22_311 | 38 | 596 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000347330 | + | 1 | 10 | 22_311 | 38 | 1312 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000353887 | + | 1 | 15 | 22_311 | 38 | 406 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000361166 | + | 1 | 17 | 22_311 | 38 | 571 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000361452 | + | 1 | 16 | 22_311 | 38 | 1665 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000361676 | + | 1 | 16 | 22_311 | 38 | 531 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000397789 | + | 1 | 17 | 22_311 | 38 | 573 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000403435 | + | 1 | 17 | 22_311 | 38 | 541 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000403999 | + | 1 | 16 | 22_311 | 38 | 591 | Domain | FERM |
| Hgene | >NF2 | chr22:30000101 | chr22:36908649 | ENST00000413209 | + | 1 | 5 | 22_311 | 38 | 166 | Domain | FERM |
| Tgene | EIF3D | chr22:30000101 | chr22:36908649 | ENST00000216190 | - | 11 | 15 | 285_299 | 402 | 549 | Region | RNA gate |
| Tgene | EIF3D | chr22:30000101 | chr22:36908649 | ENST00000405442 | - | 11 | 15 | 285_299 | 402 | 549 | Region | RNA gate |
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FusionGeneSequence for NF2_EIF3D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NF2_ENST00000347330_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000413209_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000338641_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000403435_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000361452_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000403999_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000334961_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000353887_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000361166_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000397789_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE >In-frame_NF2_ENST00000361676_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NF2_ENST00000347330_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000413209_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000338641_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000403435_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000361452_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000403999_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000334961_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000353887_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000361166_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000397789_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA >In-frame_NF2_ENST00000361676_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NF2_ENST00000347330_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1135nt TGCGCTTCCCGCGGGCGCGCGGAGTGAGGACGGTGACAGCCACGCGCGCGCGTACGCGCCCGATGCAGCGCGGCCCCGTGACCCTAGTCG GCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCCCGAATCCCGGAGT GCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGC AGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAG GCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCG GGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGA TGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGA ACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACG TGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATG CCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCA TCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAG AAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTG >In-frame_NF2_ENST00000413209_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1135nt TGCGCTTCCCGCGGGCGCGCGGAGTGAGGACGGTGACAGCCACGCGCGCGCGTACGCGCCCGATGCAGCGCGGCCCCGTGACCCTAGTCG GCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCCCGAATCCCGGAGT GCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGC AGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAG GCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCG GGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGA TGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGA ACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACG TGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATG CCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCA TCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAG AAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTG >In-frame_NF2_ENST00000338641_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1133nt CGCTTCCCGCGGGCGCGCGGAGTGAGGACGGTGACAGCCACGCGCGCGCGTACGCGCCCGATGCAGCGCGGCCCCGTGACCCTAGTCGGC CGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCCCGAATCCCGGAGTGC CGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGCAG GGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAGGC CTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCGGG GCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGATG GAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAAC AACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTG AAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCC TGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATC CGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAA ACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCT >In-frame_NF2_ENST00000403435_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1103nt GTGACAGCCACGCGCGCGCGTACGCGCCCGATGCAGCGCGGCCCCGTGACCCTAGTCGGCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCT GCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCCCGAATCCCGGAGTGCCGGGTCGCGCCTGCACCGAAGGTCCCGGCT CCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGCAGGGTCCTCGCGGCCCATGCTGGCCGCTGGGG ACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAGGCCTGTGCAGCAACTCCAGGGGGGCTAAAGGG CTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCT CTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTT GACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGC TGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGC ACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATC TGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTC AGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTT GTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCTCTCTGACATTTAGCAGATGAAATAAAATAT >In-frame_NF2_ENST00000361452_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1074nt GATGCAGCGCGGCCCCGTGACCCTAGTCGGCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTC CCCGGCATCTCCGGCCCGAATCCCGGAGTGCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCC CGTCCCCCAACTCCCCTTTCCGCTCAGGCAGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCC GGGCAGCCGGCCACCATGGTGGCCCTGAGGCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGG TCCCGGGCCTGAGCCCCGCGCCATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCAC CGTGAGGATCGTCACCATGGACGCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCG AGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCT CAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGC CAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCT CATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGA GGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTT >In-frame_NF2_ENST00000403999_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1058nt GTGACCCTAGTCGGCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCC CGAATCCCGGAGTGCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCC TTTCCGCTCAGGCAGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCA TGGTGGCCCTGAGGCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCC CGCGCCATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACC ATGGACGCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCC ACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTG TCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTG AGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCC AACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAA GAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATG >In-frame_NF2_ENST00000334961_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_964nt TCCCGGAGTGCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTC CGCTCAGGCAGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGT GGCCCTGAGGCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCG CCATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGG ACGCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGG AGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTC GGTACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCG TGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACA AGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAG AAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTG >In-frame_NF2_ENST00000353887_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_944nt CCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGCAGGGTCCTCGC GGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAGGCCTGTGCAGC AACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCGGGGCCATCGCT TCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGATGGAGTTCAAT TGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTAC AAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCC TCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATT TTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTAC AGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACC AGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCTCTCTGACAT >In-frame_NF2_ENST00000361166_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_692nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA GAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTC >In-frame_NF2_ENST00000397789_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_692nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA GAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTC >In-frame_NF2_ENST00000361676_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_692nt ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA GAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTC |
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FusionGenePPI for NF2_EIF3D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NF2 | SGSM3, MED28, HGS, EZR, NF2, SOS1, PXN, SLC9A3R1, SPTBN1, SDCBP, SCHIP1, VPRBP, DDB1, CUL4A, RIT1, AKT1, AGAP2, CD44, AMOT, PYGO2, WWC1, GPS1, CCNB1IP1, PPP1R8, AMOTL2, YAP1, KDM1A, MOV10, NXF1, RNF166, CCNL2, LATS1, LATS2, AMOTL1, DNAJA1, DNAJA2, DYNLL1, HSPH1, HSPA4, TUBA1C, DBN1, SLC33A1, KSR1, SRRM2, LIG3, TFCP2, TMPO, CLCC1, UBA3, EMD, LEMD2, CHMP4B, LIN7C, TRIM21, IST1, RPA1, ZBTB10, EPDR1, PDCD6IP, PRPF38B, XRCC1, PNKP, RPA2, PGAM5, MVP, SP1, TBP, PRKAG2, DBT, CPNE3, PARP1, PANX1, SLC25A6, WBP2, CHMP1A, OR4X1, GPD2, LPCAT1, PYCR2, CD2AP, ATP6V1H, LUC7L3, TUBB4A, GRPEL1, XRCC4, CBR4, HSPA9, TSG101, SRPR, RBBP4, NIT1, TBL2, EIF3M, DLAT, XRCC5, PEF1, CDK1, TSN, IRS4, TAF15, RPL18A, ERLIN2, XRCC6, RFC1, DNPEP, KPNA2, RPS5, SLC25A1, SLC25A5, MPP2, AFG3L2, MPP6, S100A8, TGM3, GRN, MTTP, GTPBP1, PABPC4, MTPAP, RPL15, SERBP1, RPL13, CALML5, RPL14, PDHX, RPL13A, TOP1, PRPF19, MC1R, DHX30, SLC25A12, SMAD3, RPL18, SLC25A11, AKAP8L, SSRP1, VTA1, RPS3, PREB, SERPINB3, PIP4K2C, FARSA, EIF2S3, RPS7, CPSF6, ATAD3A, ATAD3B, LSM12, GRSF1, SLC25A13, HDAC1, RPS2, SLC25A22, CDK5, RPL8, PDCD6, SH3GL1, RFC3, CBS, GMDS, SARS2, DSC1, SEC23B, SMC3, HSD17B4, G3BP2, DECR1, RPL10, DHX15, SUPT16H, SMC1A, EIF3J, C1orf35, RARS, TPR, SF3B4, RCC2, RPS3A, PHB, IGF2BP1, DARS, RPL3, PRDX1, SFXN2, SLC25A3, RPL4, CAPRIN1, RPS4X, CKAP5, S100A9, LANCL2, IKBIP, PRKCA, GLTSCR2, CDH1, EGFR, CTDSPL, PTPRA, PTPRG, PPFIA1, TSPYL4, PDCL, CYLD, UBE2A | EIF3D | EIF1B, EIF4A2, EIF3A, EIF3L, PHLDA1, EIF3G, EIF3H, EIF3F, USP3, HAX1, CD4, EIF3E, PSMD12, DNAJB11, RAD21, SIRT7, CAND1, EIF3C, EIF3K, EIF3B, EIF3I, EIF3M, NCL, DDX3X, FN1, VCAM1, EIF3J, HNRNPU, RPL23A, RPL35, RPS11, RPS12, RPS18, RPS20, RPS27, RPS28, RPS4X, RPS9, STAU1, REL, TRIM27, SAT1, HOMER3, BEND5, LZTS2, CCDC8, RNF2, ABCE1, FBXW11, EIF3CL, SRSF7, SRSF5, SUPT4H1, NTRK1, HERC2, XPO1, MATR3, GAN, MCM2, BCOR, NANOG, POU5F1, ZNF746, EIF4A1, RAF1, CYLD, DLD, DNM1L, HSD17B10, SOD1, TRIM25, G3BP1, UBE2A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NF2_EIF3D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NF2_EIF3D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NF2 | C0027832 | Neurofibromatosis 2 | 9 | CTD_human;ORPHANET;UNIPROT |
| Hgene | NF2 | C0025500 | Mesothelioma | 6 | CTD_human |
| Hgene | NF2 | C0345967 | Malignant mesothelioma | 4 | CTD_human |
| Hgene | NF2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | NF2 | C0025286 | Meningioma | 1 | CTD_human;HPO |
| Hgene | NF2 | C0032229 | Pleural Neoplasms | 1 | CTD_human |
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