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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 24119

FusionGeneSummary for NF2_EIF3D

check button Fusion gene summary
Fusion gene informationFusion gene name: NF2_EIF3D
Fusion gene ID: 24119
HgeneTgene
Gene symbol

NF2

EIF3D

Gene ID

4771

8664

Gene nameneurofibromin 2eukaryotic translation initiation factor 3 subunit D
SynonymsACN|BANF|SCHEIF3S7|eIF3-p66|eIF3-zeta
Cytomap

22q12.2

22q12.3

Type of geneprotein-codingprotein-coding
Descriptionmerlinmoesin-ezrin-radixin likemoesin-ezrin-radixin-like proteinmoesin-ezrin-radizin-like proteinneurofibromin 2 (bilateral acoustic neuroma)schwannomerlinschwannomineukaryotic translation initiation factor 3 subunit DeIF3 p66eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDatranslation initiation factor eIF3 p66 subunit
Modification date2018051920180523
UniProtAcc

P35240

O15371

Ensembl transtripts involved in fusion geneENST00000347330, ENST00000413209, 
ENST00000338641, ENST00000403435, 
ENST00000361452, ENST00000403999, 
ENST00000334961, ENST00000353887, 
ENST00000361166, ENST00000397789, 
ENST00000361676, 
ENST00000216190, 
ENST00000478547, ENST00000541106, 
ENST00000405442, 
Fusion gene scores* DoF score12 X 7 X 7=5887 X 8 X 5=280
# samples 139
** MAII scorelog2(13/588*10)=-2.17730453180791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NF2 [Title/Abstract] AND EIF3D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNF2

GO:0008285

negative regulation of cell proliferation

12444102|20178741

HgeneNF2

GO:0022408

negative regulation of cell-cell adhesion

17210637

HgeneNF2

GO:0042532

negative regulation of tyrosine phosphorylation of STAT protein

12444102

HgeneNF2

GO:0046426

negative regulation of JAK-STAT cascade

12444102

TgeneEIF3D

GO:0002191

cap-dependent translational initiation

27462815

TgeneEIF3D

GO:0006413

translational initiation

17581632

TgeneEIF3D

GO:0075522

IRES-dependent viral translational initiation

9573242

TgeneEIF3D

GO:0075525

viral translational termination-reinitiation

21347434


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-V7-A7HQ-01ANF2chr22

30000101

+EIF3Dchr22

36908649

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000347330ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000347330ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000347330ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000347330ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000413209ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000413209ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000413209ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000413209ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000338641ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000338641ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000338641ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000338641ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000403435ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000403435ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000403435ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000403435ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000361452ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000361452ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000361452ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000361452ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000403999ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000403999ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000403999ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000403999ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000334961ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000334961ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000334961ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000334961ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000353887ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000353887ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000353887ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000353887ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000361166ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000361166ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000361166ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000361166ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000397789ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000397789ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000397789ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000397789ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-
In-frameENST00000361676ENST00000216190NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000361676ENST00000478547NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000361676ENST00000541106NF2chr22

30000101

+EIF3Dchr22

36908649

-
5CDS-intronENST00000361676ENST00000405442NF2chr22

30000101

+EIF3Dchr22

36908649

-

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FusionProtFeatures for NF2_EIF3D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NF2

P35240

EIF3D

O15371

mRNA cap-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, a complex required forseveral steps in the initiation of protein synthesis of aspecialized repertoire of mRNAs (PubMed:27462815). The eIF-3complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5to form the 43S pre-initiation complex (43S PIC). The eIF-3complex stimulates mRNA recruitment to the 43S PIC and scanning ofthe mRNA for AUG recognition. The eIF-3 complex is also requiredfor disassembly and recycling of post-termination ribosomalcomplexes and subsequently prevents premature joining of the 40Sand 60S ribosomal subunits prior to initiation (PubMed:18599441,PubMed:25849773). The eIF-3 complex specifically targets andinitiates translation of a subset of mRNAs involved in cellproliferation, including cell cycling, differentiation andapoptosis, and uses different modes of RNA stem-loop binding toexert either translational activation or repression(PubMed:25849773). In the eIF-3 complex, EIF3D specificallyrecognizes and binds the 7-methylguanosine cap of a subset ofmRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441,ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEIF3Dchr22:30000101chr22:36908649ENST00000216190-1115530_547402549Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneEIF3Dchr22:30000101chr22:36908649ENST00000405442-1115530_547402549Compositional biasNote=Asp/Glu-rich (highly acidic)

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNF2chr22:30000101chr22:36908649ENST00000334961+115327_46538451Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000338641+116327_46538596Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000347330+110327_465381312Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000353887+115327_46538406Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000361166+117327_46538571Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000361452+116327_465381665Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000361676+116327_46538531Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000397789+117327_46538573Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000403435+117327_46538541Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000403999+116327_46538591Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000413209+15327_46538166Compositional biasNote=Glu-rich
HgeneNF2chr22:30000101chr22:36908649ENST00000334961+11522_31138451DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000338641+11622_31138596DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000347330+11022_311381312DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000353887+11522_31138406DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000361166+11722_31138571DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000361452+11622_311381665DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000361676+11622_31138531DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000397789+11722_31138573DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000403435+11722_31138541DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000403999+11622_31138591DomainFERM
HgeneNF2chr22:30000101chr22:36908649ENST00000413209+1522_31138166DomainFERM
TgeneEIF3Dchr22:30000101chr22:36908649ENST00000216190-1115285_299402549RegionRNA gate
TgeneEIF3Dchr22:30000101chr22:36908649ENST00000405442-1115285_299402549RegionRNA gate


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FusionGeneSequence for NF2_EIF3D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NF2_ENST00000347330_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000413209_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000338641_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000403435_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000361452_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000403999_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000334961_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000353887_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000361166_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000397789_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE

>In-frame_NF2_ENST00000361676_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_185aa
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGTVSR
YHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NF2_ENST00000347330_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000413209_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000338641_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000403435_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000361452_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000403999_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000334961_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000353887_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000361166_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000397789_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA

>In-frame_NF2_ENST00000361676_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_555nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_NF2_ENST00000347330_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1135nt
TGCGCTTCCCGCGGGCGCGCGGAGTGAGGACGGTGACAGCCACGCGCGCGCGTACGCGCCCGATGCAGCGCGGCCCCGTGACCCTAGTCG
GCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCCCGAATCCCGGAGT
GCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGC
AGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAG
GCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCG
GGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGA
TGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGA
ACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACG
TGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATG
CCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCA
TCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAG
AAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTG

>In-frame_NF2_ENST00000413209_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1135nt
TGCGCTTCCCGCGGGCGCGCGGAGTGAGGACGGTGACAGCCACGCGCGCGCGTACGCGCCCGATGCAGCGCGGCCCCGTGACCCTAGTCG
GCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCCCGAATCCCGGAGT
GCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGC
AGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAG
GCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCG
GGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGA
TGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGA
ACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACG
TGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATG
CCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCA
TCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAG
AAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTG

>In-frame_NF2_ENST00000338641_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1133nt
CGCTTCCCGCGGGCGCGCGGAGTGAGGACGGTGACAGCCACGCGCGCGCGTACGCGCCCGATGCAGCGCGGCCCCGTGACCCTAGTCGGC
CGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCCCGAATCCCGGAGTGC
CGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGCAG
GGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAGGC
CTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCGGG
GCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGATG
GAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAAC
AACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTG
AAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCC
TGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATC
CGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAA
ACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCT

>In-frame_NF2_ENST00000403435_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1103nt
GTGACAGCCACGCGCGCGCGTACGCGCCCGATGCAGCGCGGCCCCGTGACCCTAGTCGGCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCT
GCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCCCGAATCCCGGAGTGCCGGGTCGCGCCTGCACCGAAGGTCCCGGCT
CCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGCAGGGTCCTCGCGGCCCATGCTGGCCGCTGGGG
ACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAGGCCTGTGCAGCAACTCCAGGGGGGCTAAAGGG
CTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCT
CTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTT
GACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGC
TGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGC
ACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATC
TGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTC
AGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTT
GTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCTCTCTGACATTTAGCAGATGAAATAAAATAT

>In-frame_NF2_ENST00000361452_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1074nt
GATGCAGCGCGGCCCCGTGACCCTAGTCGGCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTC
CCCGGCATCTCCGGCCCGAATCCCGGAGTGCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCC
CGTCCCCCAACTCCCCTTTCCGCTCAGGCAGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCC
GGGCAGCCGGCCACCATGGTGGCCCTGAGGCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGG
TCCCGGGCCTGAGCCCCGCGCCATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCAC
CGTGAGGATCGTCACCATGGACGCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCG
AGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCT
CAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGC
CAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCT
CATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGA
GGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTT

>In-frame_NF2_ENST00000403999_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_1058nt
GTGACCCTAGTCGGCCGCTGAGAGGCGCGCGGAGTCTGGGCCGCTGCCGTCTAGGGGTCCCGTCCCGAGGCGTCCCCGGCATCTCCGGCC
CGAATCCCGGAGTGCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCC
TTTCCGCTCAGGCAGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCA
TGGTGGCCCTGAGGCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCC
CGCGCCATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACC
ATGGACGCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCC
ACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTG
TCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTG
AGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCC
AACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAA
GAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATG

>In-frame_NF2_ENST00000334961_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_964nt
TCCCGGAGTGCCGGGTCGCGCCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTC
CGCTCAGGCAGGGTCCTCGCGGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGT
GGCCCTGAGGCCTGTGCAGCAACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCG
CCATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGG
ACGCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGG
AGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTC
GGTACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCG
TGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACA
AGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAG
AAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTG

>In-frame_NF2_ENST00000353887_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_944nt
CCTGCACCGAAGGTCCCGGCTCCTGTGCCCTCCCTGCAGCCGTCAGGGCCCGTCCCCCAACTCCCCTTTCCGCTCAGGCAGGGTCCTCGC
GGCCCATGCTGGCCGCTGGGGACCCGCGCAGCCCAGACCGTTCCCGGGCCGGGCAGCCGGCCACCATGGTGGCCCTGAGGCCTGTGCAGC
AACTCCAGGGGGGCTAAAGGGCTCAGAGTGCAGGCCGTGGGGCGCGAGGGTCCCGGGCCTGAGCCCCGCGCCATGGCCGGGGCCATCGCT
TCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGACGCCGAGATGGAGTTCAAT
TGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTAC
AAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCC
TCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATT
TTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTAC
AGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACC
AGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCTCTCTGACAT

>In-frame_NF2_ENST00000361166_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_692nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA
GAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTC

>In-frame_NF2_ENST00000397789_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_692nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA
GAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTC

>In-frame_NF2_ENST00000361676_chr22_30000101_+_EIF3D_ENST00000216190_chr22_36908649_-_692nt
ATGGCCGGGGCCATCGCTTCCCGCATGAGCTTCAGCTCTCTCAAGAGGAAGCAACCCAAGACGTTCACCGTGAGGATCGTCACCATGGAC
GCCGAGATGGAGTTCAATTGCGAGCACTGTAATGGCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAG
CTGAAGAACAACAGCTACAAGTTGGCCCGGTGGACCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGG
TACCACGTGAAAGACTCCTCACGCCACGTCATCCTAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTG
GAGAATGCCTGGGGCATTTTACGCTGCGTCATTGACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAG
CAGGTCATCCGTGTCTACAGCCTCCCTGATGGCACCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAA
GAGGAAGAAACTTAAACCAGTGATGTGGAGCTGGAGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTC


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FusionGenePPI for NF2_EIF3D


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NF2SGSM3, MED28, HGS, EZR, NF2, SOS1, PXN, SLC9A3R1, SPTBN1, SDCBP, SCHIP1, VPRBP, DDB1, CUL4A, RIT1, AKT1, AGAP2, CD44, AMOT, PYGO2, WWC1, GPS1, CCNB1IP1, PPP1R8, AMOTL2, YAP1, KDM1A, MOV10, NXF1, RNF166, CCNL2, LATS1, LATS2, AMOTL1, DNAJA1, DNAJA2, DYNLL1, HSPH1, HSPA4, TUBA1C, DBN1, SLC33A1, KSR1, SRRM2, LIG3, TFCP2, TMPO, CLCC1, UBA3, EMD, LEMD2, CHMP4B, LIN7C, TRIM21, IST1, RPA1, ZBTB10, EPDR1, PDCD6IP, PRPF38B, XRCC1, PNKP, RPA2, PGAM5, MVP, SP1, TBP, PRKAG2, DBT, CPNE3, PARP1, PANX1, SLC25A6, WBP2, CHMP1A, OR4X1, GPD2, LPCAT1, PYCR2, CD2AP, ATP6V1H, LUC7L3, TUBB4A, GRPEL1, XRCC4, CBR4, HSPA9, TSG101, SRPR, RBBP4, NIT1, TBL2, EIF3M, DLAT, XRCC5, PEF1, CDK1, TSN, IRS4, TAF15, RPL18A, ERLIN2, XRCC6, RFC1, DNPEP, KPNA2, RPS5, SLC25A1, SLC25A5, MPP2, AFG3L2, MPP6, S100A8, TGM3, GRN, MTTP, GTPBP1, PABPC4, MTPAP, RPL15, SERBP1, RPL13, CALML5, RPL14, PDHX, RPL13A, TOP1, PRPF19, MC1R, DHX30, SLC25A12, SMAD3, RPL18, SLC25A11, AKAP8L, SSRP1, VTA1, RPS3, PREB, SERPINB3, PIP4K2C, FARSA, EIF2S3, RPS7, CPSF6, ATAD3A, ATAD3B, LSM12, GRSF1, SLC25A13, HDAC1, RPS2, SLC25A22, CDK5, RPL8, PDCD6, SH3GL1, RFC3, CBS, GMDS, SARS2, DSC1, SEC23B, SMC3, HSD17B4, G3BP2, DECR1, RPL10, DHX15, SUPT16H, SMC1A, EIF3J, C1orf35, RARS, TPR, SF3B4, RCC2, RPS3A, PHB, IGF2BP1, DARS, RPL3, PRDX1, SFXN2, SLC25A3, RPL4, CAPRIN1, RPS4X, CKAP5, S100A9, LANCL2, IKBIP, PRKCA, GLTSCR2, CDH1, EGFR, CTDSPL, PTPRA, PTPRG, PPFIA1, TSPYL4, PDCL, CYLD, UBE2AEIF3DEIF1B, EIF4A2, EIF3A, EIF3L, PHLDA1, EIF3G, EIF3H, EIF3F, USP3, HAX1, CD4, EIF3E, PSMD12, DNAJB11, RAD21, SIRT7, CAND1, EIF3C, EIF3K, EIF3B, EIF3I, EIF3M, NCL, DDX3X, FN1, VCAM1, EIF3J, HNRNPU, RPL23A, RPL35, RPS11, RPS12, RPS18, RPS20, RPS27, RPS28, RPS4X, RPS9, STAU1, REL, TRIM27, SAT1, HOMER3, BEND5, LZTS2, CCDC8, RNF2, ABCE1, FBXW11, EIF3CL, SRSF7, SRSF5, SUPT4H1, NTRK1, HERC2, XPO1, MATR3, GAN, MCM2, BCOR, NANOG, POU5F1, ZNF746, EIF4A1, RAF1, CYLD, DLD, DNM1L, HSD17B10, SOD1, TRIM25, G3BP1, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NF2_EIF3D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NF2_EIF3D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNF2C0027832Neurofibromatosis 29CTD_human;ORPHANET;UNIPROT
HgeneNF2C0025500Mesothelioma6CTD_human
HgeneNF2C0345967Malignant mesothelioma4CTD_human
HgeneNF2C0007134Renal Cell Carcinoma1CTD_human
HgeneNF2C0025286Meningioma1CTD_human;HPO
HgeneNF2C0032229Pleural Neoplasms1CTD_human