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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 24114

FusionGeneSummary for NF1_TRMT61B

check button Fusion gene summary
Fusion gene informationFusion gene name: NF1_TRMT61B
Fusion gene ID: 24114
HgeneTgene
Gene symbol

NF1

TRMT61B

Gene ID

4763

55006

Gene nameneurofibromin 1tRNA methyltransferase 61B
SynonymsNFNS|VRNF|WSS-
Cytomap

17q11.2

2p23.2

Type of geneprotein-codingprotein-coding
Descriptionneurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1tRNA (adenine(58)-N(1))-methyltransferase, mitochondrialmRNA methyladenosine-N(1)-methyltransferasepotential tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61Bpotential tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61Bt
Modification date2018052720180523
UniProtAcc

P21359

Q9BVS5

Ensembl transtripts involved in fusion geneENST00000356175, ENST00000358273, 
ENST00000431387, ENST00000581113, 
ENST00000417592, ENST00000444181, 
ENST00000306108, ENST00000484060, 
Fusion gene scores* DoF score35 X 18 X 19=119701 X 1 X 1=1
# samples 461
** MAII scorelog2(46/11970*10)=-4.70164548088649
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: NF1 [Title/Abstract] AND TRMT61B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNF1

GO:0043547

positive regulation of GTPase activity

2121371

TgeneTRMT61B

GO:0051260

protein homooligomerization

23097428

TgeneTRMT61B

GO:0070901

mitochondrial tRNA methylation

23097428

TgeneTRMT61B

GO:0080009

mRNA methylation

29107537


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-FG-7643-01ANF1chr17

29497015

+TRMT61Bchr2

29084174

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356175ENST00000306108NF1chr17

29497015

+TRMT61Bchr2

29084174

-
5CDS-5UTRENST00000356175ENST00000484060NF1chr17

29497015

+TRMT61Bchr2

29084174

-
In-frameENST00000358273ENST00000306108NF1chr17

29497015

+TRMT61Bchr2

29084174

-
5CDS-5UTRENST00000358273ENST00000484060NF1chr17

29497015

+TRMT61Bchr2

29084174

-
In-frameENST00000431387ENST00000306108NF1chr17

29497015

+TRMT61Bchr2

29084174

-
5CDS-5UTRENST00000431387ENST00000484060NF1chr17

29497015

+TRMT61Bchr2

29084174

-
intron-3CDSENST00000581113ENST00000306108NF1chr17

29497015

+TRMT61Bchr2

29084174

-
intron-5UTRENST00000581113ENST00000484060NF1chr17

29497015

+TRMT61Bchr2

29084174

-
intron-3CDSENST00000417592ENST00000306108NF1chr17

29497015

+TRMT61Bchr2

29084174

-
intron-5UTRENST00000417592ENST00000484060NF1chr17

29497015

+TRMT61Bchr2

29084174

-
intron-3CDSENST00000444181ENST00000306108NF1chr17

29497015

+TRMT61Bchr2

29084174

-
intron-5UTRENST00000444181ENST00000484060NF1chr17

29497015

+TRMT61Bchr2

29084174

-

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FusionProtFeatures for NF1_TRMT61B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NF1

P21359

TRMT61B

Q9BVS5

Stimulates the GTPase activity of Ras. NF1 shows greateraffinity for Ras GAP, but lower specific activity. May be aregulator of Ras activity. {ECO:0000269|PubMed:2121371,ECO:0000269|PubMed:8417346}. Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs inmitochondrion, including tRNA(Leu) (deciphering codons UUA orUUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG orUCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNAand this modification is most likely important for mitoribosomalstructure and function (PubMed:27631568). In addition to tRNAN(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residuesat the N(1) position of MT-ND5 mRNA, leading to interfere withmitochondrial translation (PubMed:29107537).{ECO:0000269|PubMed:23097428, ECO:0000269|PubMed:27631568,ECO:0000269|PubMed:29107537}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRMT61Bchr17:29497015chr2:29084174ENST00000306108-17278_279267478RegionS-adenosyl-L-methionine binding
TgeneTRMT61Bchr17:29497015chr2:29084174ENST00000306108-17334_337267478RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST00000306108-17358_365267478RegionSubstrate

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNF1chr17:29497015chr2:29084174ENST00000356175+5571352_13551952819Compositional biasNote=Poly-Ser
HgeneNF1chr17:29497015chr2:29084174ENST00000358273+5581352_13551952840Compositional biasNote=Poly-Ser
HgeneNF1chr17:29497015chr2:29084174ENST00000431387+5151352_1355195594Compositional biasNote=Poly-Ser
HgeneNF1chr17:29497015chr2:29084174ENST00000356175+5571235_14511952819DomainRas-GAP
HgeneNF1chr17:29497015chr2:29084174ENST00000356175+5571580_17381952819DomainCRAL-TRIO
HgeneNF1chr17:29497015chr2:29084174ENST00000358273+5581235_14511952840DomainRas-GAP
HgeneNF1chr17:29497015chr2:29084174ENST00000358273+5581580_17381952840DomainCRAL-TRIO
HgeneNF1chr17:29497015chr2:29084174ENST00000431387+5151235_1451195594DomainRas-GAP
HgeneNF1chr17:29497015chr2:29084174ENST00000431387+5151580_1738195594DomainCRAL-TRIO
HgeneNF1chr17:29497015chr2:29084174ENST00000356175+5572555_25711952819MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29497015chr2:29084174ENST00000358273+5582555_25711952840MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29497015chr2:29084174ENST00000431387+5152555_2571195594MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29497015chr2:29084174ENST00000356175+5571580_18371952819RegionNote=Lipid binding
HgeneNF1chr17:29497015chr2:29084174ENST00000358273+5581580_18371952840RegionNote=Lipid binding
HgeneNF1chr17:29497015chr2:29084174ENST00000431387+5151580_1837195594RegionNote=Lipid binding
TgeneTRMT61Bchr17:29497015chr2:29084174ENST00000306108-17133_179267478RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST00000306108-17206_207267478RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST00000306108-17228_232267478RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST00000306108-17253_260267478RegionSubstrate
TgeneTRMT61Bchr17:29497015chr2:29084174ENST00000306108-1777_79267478RegionSubstrate


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FusionGeneSequence for NF1_TRMT61B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NF1_ENST00000356175_chr17_29497015_+_TRMT61B_ENST00000306108_chr2_29084174_-_406aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTL
EKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVT
LPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELF

>In-frame_NF1_ENST00000358273_chr17_29497015_+_TRMT61B_ENST00000306108_chr2_29084174_-_406aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTL
EKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVT
LPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELF

>In-frame_NF1_ENST00000431387_chr17_29497015_+_TRMT61B_ENST00000306108_chr2_29084174_-_406aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTL
EKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVT
LPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NF1_ENST00000356175_chr17_29497015_+_TRMT61B_ENST00000306108_chr2_29084174_-_1218nt
ATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACA
CATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACT
ATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTG
GAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTT
CTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTC
AATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTA
CAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGTTGGATCACAAGGACGAGTCATAAGTTTTGAGGTACGAAAAGAC
CACCATGATCTGGCTAAGAAGAATTACAAACACTGGCGTGATTCATGGAAATTAAGTCATGTAGAAGAGTGGCCAGACAATGTGGATTTT
ATTCATAAGGACATTTCAGGAGCAACCGAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGGATATGTTAAATCCTCATGTTACT
TTGCCTGTTTTTTACCCACATCTTAAGCATGGTGGTGTATGTGCTGTATATGTAGTAAACATCACACAGGTTATTGAACTTTTAGATGGA
ATTCGCACCTGTGAACTTGCTCTTTCATGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGGTTTGCCTTGCAAAACAGAAAAAT
GGAATTTTAGCTCAAAAAGTAGAATCTAAAATCAACACAGATGTACAACTAGATTCTCAAGAGAAAATTGGAGTTAAAGGTGAGCTGTTT
CAAGAGGATGACCATGAAGAATCGCATTCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGACCAGTACACTGGCAACCTGGTCAT

>In-frame_NF1_ENST00000358273_chr17_29497015_+_TRMT61B_ENST00000306108_chr2_29084174_-_1218nt
ATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACA
CATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACT
ATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTG
GAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTT
CTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTC
AATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTA
CAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGTTGGATCACAAGGACGAGTCATAAGTTTTGAGGTACGAAAAGAC
CACCATGATCTGGCTAAGAAGAATTACAAACACTGGCGTGATTCATGGAAATTAAGTCATGTAGAAGAGTGGCCAGACAATGTGGATTTT
ATTCATAAGGACATTTCAGGAGCAACCGAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGGATATGTTAAATCCTCATGTTACT
TTGCCTGTTTTTTACCCACATCTTAAGCATGGTGGTGTATGTGCTGTATATGTAGTAAACATCACACAGGTTATTGAACTTTTAGATGGA
ATTCGCACCTGTGAACTTGCTCTTTCATGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGGTTTGCCTTGCAAAACAGAAAAAT
GGAATTTTAGCTCAAAAAGTAGAATCTAAAATCAACACAGATGTACAACTAGATTCTCAAGAGAAAATTGGAGTTAAAGGTGAGCTGTTT
CAAGAGGATGACCATGAAGAATCGCATTCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGACCAGTACACTGGCAACCTGGTCAT

>In-frame_NF1_ENST00000431387_chr17_29497015_+_TRMT61B_ENST00000306108_chr2_29084174_-_1218nt
ATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACA
CATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACT
ATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTG
GAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTT
CTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTC
AATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTA
CAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGTTGGATCACAAGGACGAGTCATAAGTTTTGAGGTACGAAAAGAC
CACCATGATCTGGCTAAGAAGAATTACAAACACTGGCGTGATTCATGGAAATTAAGTCATGTAGAAGAGTGGCCAGACAATGTGGATTTT
ATTCATAAGGACATTTCAGGAGCAACCGAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGGATATGTTAAATCCTCATGTTACT
TTGCCTGTTTTTTACCCACATCTTAAGCATGGTGGTGTATGTGCTGTATATGTAGTAAACATCACACAGGTTATTGAACTTTTAGATGGA
ATTCGCACCTGTGAACTTGCTCTTTCATGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGGTTTGCCTTGCAAAACAGAAAAAT
GGAATTTTAGCTCAAAAAGTAGAATCTAAAATCAACACAGATGTACAACTAGATTCTCAAGAGAAAATTGGAGTTAAAGGTGAGCTGTTT
CAAGAGGATGACCATGAAGAATCGCATTCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGACCAGTACACTGGCAACCTGGTCAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_NF1_ENST00000356175_chr17_29497015_+_TRMT61B_ENST00000306108_chr2_29084174_-_1979nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGTTGGATCACAAGGACGAGTCA
TAAGTTTTGAGGTACGAAAAGACCACCATGATCTGGCTAAGAAGAATTACAAACACTGGCGTGATTCATGGAAATTAAGTCATGTAGAAG
AGTGGCCAGACAATGTGGATTTTATTCATAAGGACATTTCAGGAGCAACCGAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGG
ATATGTTAAATCCTCATGTTACTTTGCCTGTTTTTTACCCACATCTTAAGCATGGTGGTGTATGTGCTGTATATGTAGTAAACATCACAC
AGGTTATTGAACTTTTAGATGGAATTCGCACCTGTGAACTTGCTCTTTCATGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGG
TTTGCCTTGCAAAACAGAAAAATGGAATTTTAGCTCAAAAAGTAGAATCTAAAATCAACACAGATGTACAACTAGATTCTCAAGAGAAAA
TTGGAGTTAAAGGTGAGCTGTTTCAAGAGGATGACCATGAAGAATCGCATTCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGAC
CAGTACACTGGCAACCTGGTCATACAGCTTTTCTTGTCAAGTTGAGGAAGGTCAAACCACAACTTAACTGAGTACTCCAGATGACAGTAA
CTGACTTGAAGATGGAAAAATATCAAAATAGAACTTTATATTGAAAATCACTGCTTCCATAGATTGGCATTTTTAGCTATTACTATGACT
TATATAACTTATACATATAATTTTGAAAATAACAACTAAAAGATGTATAACATAGCAAAACTGCTTAAACATCCCATTTTGACACTTGTC
TTGCAGTTAGTTTGACATTTTGTAGTTAATGATTCCAAATTGGTTTAGTTGGGCCATCTCATTCTTCACTTCCTGTAAACCACTCCATAG

>In-frame_NF1_ENST00000358273_chr17_29497015_+_TRMT61B_ENST00000306108_chr2_29084174_-_1979nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGTTGGATCACAAGGACGAGTCA
TAAGTTTTGAGGTACGAAAAGACCACCATGATCTGGCTAAGAAGAATTACAAACACTGGCGTGATTCATGGAAATTAAGTCATGTAGAAG
AGTGGCCAGACAATGTGGATTTTATTCATAAGGACATTTCAGGAGCAACCGAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGG
ATATGTTAAATCCTCATGTTACTTTGCCTGTTTTTTACCCACATCTTAAGCATGGTGGTGTATGTGCTGTATATGTAGTAAACATCACAC
AGGTTATTGAACTTTTAGATGGAATTCGCACCTGTGAACTTGCTCTTTCATGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGG
TTTGCCTTGCAAAACAGAAAAATGGAATTTTAGCTCAAAAAGTAGAATCTAAAATCAACACAGATGTACAACTAGATTCTCAAGAGAAAA
TTGGAGTTAAAGGTGAGCTGTTTCAAGAGGATGACCATGAAGAATCGCATTCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGAC
CAGTACACTGGCAACCTGGTCATACAGCTTTTCTTGTCAAGTTGAGGAAGGTCAAACCACAACTTAACTGAGTACTCCAGATGACAGTAA
CTGACTTGAAGATGGAAAAATATCAAAATAGAACTTTATATTGAAAATCACTGCTTCCATAGATTGGCATTTTTAGCTATTACTATGACT
TATATAACTTATACATATAATTTTGAAAATAACAACTAAAAGATGTATAACATAGCAAAACTGCTTAAACATCCCATTTTGACACTTGTC
TTGCAGTTAGTTTGACATTTTGTAGTTAATGATTCCAAATTGGTTTAGTTGGGCCATCTCATTCTTCACTTCCTGTAAACCACTCCATAG

>In-frame_NF1_ENST00000431387_chr17_29497015_+_TRMT61B_ENST00000306108_chr2_29084174_-_1929nt
ACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGATGGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCC
CCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCCTCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCC
CCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTCCACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCC
CTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGCCGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGG
GTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAAC
AAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGA
ATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAG
GACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAG
CATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACC
AGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAA
TTAAAACGACTCCTGAAGGTTGGATCACAAGGACGAGTCATAAGTTTTGAGGTACGAAAAGACCACCATGATCTGGCTAAGAAGAATTAC
AAACACTGGCGTGATTCATGGAAATTAAGTCATGTAGAAGAGTGGCCAGACAATGTGGATTTTATTCATAAGGACATTTCAGGAGCAACC
GAAGACATAAAATCTTTAACATTTGACGCAGTAGCTTTGGATATGTTAAATCCTCATGTTACTTTGCCTGTTTTTTACCCACATCTTAAG
CATGGTGGTGTATGTGCTGTATATGTAGTAAACATCACACAGGTTATTGAACTTTTAGATGGAATTCGCACCTGTGAACTTGCTCTTTCA
TGTGAAAAGATAAGCGAGGTCATTGTCAGAGATTGGTTGGTTTGCCTTGCAAAACAGAAAAATGGAATTTTAGCTCAAAAAGTAGAATCT
AAAATCAACACAGATGTACAACTAGATTCTCAAGAGAAAATTGGAGTTAAAGGTGAGCTGTTTCAAGAGGATGACCATGAAGAATCGCAT
TCTGATTTTCCATATGGATCATTTCCCTATGTTGCTAGACCAGTACACTGGCAACCTGGTCATACAGCTTTTCTTGTCAAGTTGAGGAAG
GTCAAACCACAACTTAACTGAGTACTCCAGATGACAGTAACTGACTTGAAGATGGAAAAATATCAAAATAGAACTTTATATTGAAAATCA
CTGCTTCCATAGATTGGCATTTTTAGCTATTACTATGACTTATATAACTTATACATATAATTTTGAAAATAACAACTAAAAGATGTATAA
CATAGCAAAACTGCTTAAACATCCCATTTTGACACTTGTCTTGCAGTTAGTTTGACATTTTGTAGTTAATGATTCCAAATTGGTTTAGTT
GGGCCATCTCATTCTTCACTTCCTGTAAACCACTCCATAGATTTGTCTTTCTTCAAGAAATTAGTTTTCTTTCCTTTATTTGATTGATGG


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FusionGenePPI for NF1_TRMT61B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NF1HRAS, SMARCA4, POLR2A, TIRAP, SIRT7, VCP, NSFL1C, CAV1, YWHAB, FAF2, NXF1, CCDC8, HLA-DPA1, EFNB2, CD274, TNFSF13B, CA14, SLAMF1, VSIG4, TGOLN2, HTR6, NOSIP, KRAS, CLK1, CDC5L, APP, YWHAH, PML, TRAF6, PTEN, SDC2, EGFR, CD79B, P4HA3, SCN3B, VSIG1, SIGLECL1, EPHA1, FAM174A, KCTD3, KIF13B, ZBTB21, KSR1, CGN, GIGYF1, LRFN1, RTKN, MAST3, DENND1A, SH3PXD2A, SRGAP2, DENND4C, PPM1H, EIF4E2, SIPA1L1, LIMA1, RALGPS2, MAGI1, CBY1, TESK2, CDC25C, DCLK1, GIGYF2, HDAC4, LPIN3, ZNF638, CAMSAP2, NADK, MAPKAP1, SRSF12, RASAL2, SYDE1, KIAA1804, TIAM1, AGAP1, CDC25B, CDK16, SH3RF3, PHLDB2, PLEKHA7, KIF1C, OSBPL6, FAM110B, USP21, NAV1, TANC2, PTPN13, FAM53C, ANKRD34A, STARD13, PTPN14, GAB2, DENND4A, INPP5E, TOP1, TOP2A, TOP3A, NRASTRMT61BSQSTM1, IRF7, PPP2CB, FAM9B, RHOD, PPIE, UBXN11, TRPV5, ACAA2, TRIM10, ECSIT, CTBP1, OXLD1, PPTC7, NFATC1, CARS2, POLR1C, ATPAF2, ALAS1, NDUFAF5, ACAD9, HNRNPK, MMAB, PDK1, GLS, C11orf73, ACSF3, LYRM7, TRAPPC2, MTIF2, DBT, PTPN2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NF1_TRMT61B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NF1_TRMT61B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNF1C0027831Neurofibromatosis 134CTD_human;ORPHANET;UNIPROT
HgeneNF1C2931482Neurofibromatosis-Noonan syndrome5CTD_human;ORPHANET;UNIPROT
HgeneNF1C0349639Juvenile Myelomonocytic Leukemia3CTD_human;HPO;ORPHANET
HgeneNF1C0004114Astrocytoma2CTD_human;HPO
HgeneNF1C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneNF1C0025202melanoma2CTD_human
HgeneNF1C0206727Nerve Sheath Tumors2CTD_human
HgeneNF1C0001430Adenoma1CTD_human
HgeneNF1C0004352Autistic Disorder1CTD_human
HgeneNF1C0016057Fibrosarcoma1CTD_human
HgeneNF1C0017636Glioblastoma1CTD_human
HgeneNF1C0017638Glioma1CTD_human
HgeneNF1C0023186Learning Disorders1CTD_human
HgeneNF1C0023827liposarcoma1CTD_human
HgeneNF1C0027809Neurilemmoma1CTD_human
HgeneNF1C0027830neurofibroma1CTD_human
HgeneNF1C0027962Melanocytic nevus1CTD_human
HgeneNF1C0031511Pheochromocytoma1CTD_human
HgeneNF1C0162678Neurofibromatoses1CTD_human;HPO
HgeneNF1C1261473Sarcoma1CTD_human
HgeneNF1C1834235NEUROFIBROMATOSIS, FAMILIAL SPINAL1CTD_human;UNIPROT
HgeneNF1C3714756Intellectual Disability1CTD_human;HPO