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Fusion gene ID: 24100 |
FusionGeneSummary for NF1_PDS5B |
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Fusion gene information | Fusion gene name: NF1_PDS5B | Fusion gene ID: 24100 | Hgene | Tgene | Gene symbol | NF1 | PDS5B | Gene ID | 4763 | 23047 |
Gene name | neurofibromin 1 | PDS5 cohesin associated factor B | |
Synonyms | NFNS|VRNF|WSS | APRIN|AS3|CG008 | |
Cytomap | 17q11.2 | 13q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | neurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1 | sister chromatid cohesion protein PDS5 homolog Bandrogen induced inhibitor of proliferationandrogen-induced proliferation inhibitorandrogen-induced prostate proliferative shutoff-associated protein AS3androgen-induced shutoff 3 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P21359 | Q9NTI5 | |
Ensembl transtripts involved in fusion gene | ENST00000356175, ENST00000358273, ENST00000431387, ENST00000581113, ENST00000417592, ENST00000444181, | ENST00000315596, | |
Fusion gene scores | * DoF score | 35 X 18 X 19=11970 | 3 X 3 X 3=27 |
# samples | 46 | 3 | |
** MAII score | log2(46/11970*10)=-4.70164548088649 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NF1 [Title/Abstract] AND PDS5B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NF1 | GO:0043547 | positive regulation of GTPase activity | 2121371 |
Tgene | PDS5B | GO:0008285 | negative regulation of cell proliferation | 10963680 |
Tgene | PDS5B | GO:0042127 | regulation of cell proliferation | 10963680 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-E9-A22D-01A | NF1 | chr17 | 29422387 | + | PDS5B | chr13 | 33281071 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000356175 | ENST00000315596 | NF1 | chr17 | 29422387 | + | PDS5B | chr13 | 33281071 | + |
Frame-shift | ENST00000358273 | ENST00000315596 | NF1 | chr17 | 29422387 | + | PDS5B | chr13 | 33281071 | + |
Frame-shift | ENST00000431387 | ENST00000315596 | NF1 | chr17 | 29422387 | + | PDS5B | chr13 | 33281071 | + |
intron-3CDS | ENST00000581113 | ENST00000315596 | NF1 | chr17 | 29422387 | + | PDS5B | chr13 | 33281071 | + |
intron-3CDS | ENST00000417592 | ENST00000315596 | NF1 | chr17 | 29422387 | + | PDS5B | chr13 | 33281071 | + |
intron-3CDS | ENST00000444181 | ENST00000315596 | NF1 | chr17 | 29422387 | + | PDS5B | chr13 | 33281071 | + |
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FusionProtFeatures for NF1_PDS5B |
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Hgene | Tgene |
NF1 | PDS5B |
Stimulates the GTPase activity of Ras. NF1 shows greateraffinity for Ras GAP, but lower specific activity. May be aregulator of Ras activity. {ECO:0000269|PubMed:2121371,ECO:0000269|PubMed:8417346}. | Regulator of sister chromatid cohesion in mitosis whichmay stabilize cohesin complex association with chromatin. Maycouple sister chromatid cohesion during mitosis to DNAreplication. Cohesion ensures that chromosome partitioning isaccurate in both meiotic and mitotic cells and plays an importantrole in DNA repair. Plays a role in androgen-induced proliferativearrest in prostate cells. {ECO:0000269|PubMed:10963680,ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NF1_PDS5B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NF1_PDS5B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NF1 | HRAS, SMARCA4, POLR2A, TIRAP, SIRT7, VCP, NSFL1C, CAV1, YWHAB, FAF2, NXF1, CCDC8, HLA-DPA1, EFNB2, CD274, TNFSF13B, CA14, SLAMF1, VSIG4, TGOLN2, HTR6, NOSIP, KRAS, CLK1, CDC5L, APP, YWHAH, PML, TRAF6, PTEN, SDC2, EGFR, CD79B, P4HA3, SCN3B, VSIG1, SIGLECL1, EPHA1, FAM174A, KCTD3, KIF13B, ZBTB21, KSR1, CGN, GIGYF1, LRFN1, RTKN, MAST3, DENND1A, SH3PXD2A, SRGAP2, DENND4C, PPM1H, EIF4E2, SIPA1L1, LIMA1, RALGPS2, MAGI1, CBY1, TESK2, CDC25C, DCLK1, GIGYF2, HDAC4, LPIN3, ZNF638, CAMSAP2, NADK, MAPKAP1, SRSF12, RASAL2, SYDE1, KIAA1804, TIAM1, AGAP1, CDC25B, CDK16, SH3RF3, PHLDB2, PLEKHA7, KIF1C, OSBPL6, FAM110B, USP21, NAV1, TANC2, PTPN13, FAM53C, ANKRD34A, STARD13, PTPN14, GAB2, DENND4A, INPP5E, TOP1, TOP2A, TOP3A, NRAS | PDS5B | CDCA5, STAG1, STAG2, SMC3, SMC1A, WFDC5, PDS5A, RAD21, WAPAL, SIRT7, NSMCE2, APP, LAMP2, OBSL1, EED, RNF2, BSG, CD274, SEPT12, LYPD3, SLC30A4, TGOLN2, SCN2B, BRCA2, RAD51, PALB2, CDC45, PCNA, NTRK1, CEP164, GYPB, VIPR2, CHRM4, APLNR, ANK1, SLC15A1, CD70, KIAA1467, SCN3B, HTR2C, MAS1, P2RX5, LPAR4, TRIM25, G3BP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NF1_PDS5B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NF1_PDS5B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NF1 | C0027831 | Neurofibromatosis 1 | 34 | CTD_human;ORPHANET;UNIPROT |
Hgene | NF1 | C2931482 | Neurofibromatosis-Noonan syndrome | 5 | CTD_human;ORPHANET;UNIPROT |
Hgene | NF1 | C0349639 | Juvenile Myelomonocytic Leukemia | 3 | CTD_human;HPO;ORPHANET |
Hgene | NF1 | C0004114 | Astrocytoma | 2 | CTD_human;HPO |
Hgene | NF1 | C0023467 | Leukemia, Myelocytic, Acute | 2 | CTD_human |
Hgene | NF1 | C0025202 | melanoma | 2 | CTD_human |
Hgene | NF1 | C0206727 | Nerve Sheath Tumors | 2 | CTD_human |
Hgene | NF1 | C0001430 | Adenoma | 1 | CTD_human |
Hgene | NF1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | NF1 | C0016057 | Fibrosarcoma | 1 | CTD_human |
Hgene | NF1 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | NF1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | NF1 | C0023186 | Learning Disorders | 1 | CTD_human |
Hgene | NF1 | C0023827 | liposarcoma | 1 | CTD_human |
Hgene | NF1 | C0027809 | Neurilemmoma | 1 | CTD_human |
Hgene | NF1 | C0027830 | neurofibroma | 1 | CTD_human |
Hgene | NF1 | C0027962 | Melanocytic nevus | 1 | CTD_human |
Hgene | NF1 | C0031511 | Pheochromocytoma | 1 | CTD_human |
Hgene | NF1 | C0162678 | Neurofibromatoses | 1 | CTD_human;HPO |
Hgene | NF1 | C1261473 | Sarcoma | 1 | CTD_human |
Hgene | NF1 | C1834235 | NEUROFIBROMATOSIS, FAMILIAL SPINAL | 1 | CTD_human;UNIPROT |
Hgene | NF1 | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |