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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 24097

FusionGeneSummary for NF1_MAP2K4

check button Fusion gene summary
Fusion gene informationFusion gene name: NF1_MAP2K4
Fusion gene ID: 24097
HgeneTgene
Gene symbol

NF1

MAP2K4

Gene ID

4763

6416

Gene nameneurofibromin 1mitogen-activated protein kinase kinase 4
SynonymsNFNS|VRNF|WSSJNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1
Cytomap

17q11.2

17p12

Type of geneprotein-codingprotein-coding
Descriptionneurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1
Modification date2018052720180523
UniProtAcc

P21359

P45985

Ensembl transtripts involved in fusion geneENST00000356175, ENST00000358273, 
ENST00000431387, ENST00000581113, 
ENST00000417592, ENST00000444181, 
ENST00000353533, ENST00000415385, 
ENST00000581941, 
Fusion gene scores* DoF score35 X 18 X 19=119706 X 5 X 5=150
# samples 465
** MAII scorelog2(46/11970*10)=-4.70164548088649
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NF1 [Title/Abstract] AND MAP2K4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNF1

GO:0043547

positive regulation of GTPase activity

2121371


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCHOLTCGA-W5-AA31-01ANF1chr17

29509683

+MAP2K4chr17

12028611

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356175ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000356175ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
5CDS-3UTRENST00000356175ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000358273ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000358273ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
5CDS-3UTRENST00000358273ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000431387ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000431387ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
5CDS-3UTRENST00000431387ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000581113ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000581113ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3UTRENST00000581113ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000417592ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000417592ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3UTRENST00000417592ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000444181ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000444181ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3UTRENST00000444181ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+

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FusionProtFeatures for NF1_MAP2K4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NF1

P21359

MAP2K4

P45985

Stimulates the GTPase activity of Ras. NF1 shows greateraffinity for Ras GAP, but lower specific activity. May be aregulator of Ras activity. {ECO:0000269|PubMed:2121371,ECO:0000269|PubMed:8417346}. Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway.Essential component of the stress-activated protein kinase/c-JunN-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,is the one of the only known kinase to directly activate thestress-activated protein kinase/c-Jun N-terminal kinasesMAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 andMAP2K7/MKK7 both activate the JNKs by phosphorylation, but theydiffer in their preference for the phosphorylation site in theThr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation ofthe Tyr residue and MAP2K7/MKK7 for the Thr residue. Thephosphorylation of the Thr residue by MAP2K7/MKK7 seems to be theprerequisite for JNK activation at least in response toproinflammatory cytokines, while other stimuli activate bothMAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylateJNKs. MAP2K4 is required for maintaining peripheral lymphoidhomeostasis. The MKK/JNK signaling pathway is also involved inmitochondrial death signaling pathway, including the releasecytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7exclusively activates JNKs, MAP2K4/MKK4 additionally activates thep38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.{ECO:0000269|PubMed:7716521}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000353533+611364_387271400RegionNote=DVD domain
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000415385+712364_387282411RegionNote=DVD domain

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8571352_13552962819Compositional biasNote=Poly-Ser
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8581352_13552962840Compositional biasNote=Poly-Ser
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8151352_1355296594Compositional biasNote=Poly-Ser
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8571235_14512962819DomainRas-GAP
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8571580_17382962819DomainCRAL-TRIO
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8581235_14512962840DomainRas-GAP
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8581580_17382962840DomainCRAL-TRIO
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8151235_1451296594DomainRas-GAP
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8151580_1738296594DomainCRAL-TRIO
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8572555_25712962819MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8582555_25712962840MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8152555_2571296594MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8571580_18372962819RegionNote=Lipid binding
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8581580_18372962840RegionNote=Lipid binding
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8151580_1837296594RegionNote=Lipid binding
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000353533+6115_19271400Compositional biasNote=Gly/Ser-rich
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000415385+7125_19282411Compositional biasNote=Gly/Ser-rich
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000353533+611102_367271400DomainProtein kinase
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000415385+712102_367282411DomainProtein kinase
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000353533+611108_116271400Nucleotide bindingATP
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000415385+712108_116282411Nucleotide bindingATP
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000353533+61137_52271400RegionNote=D domain
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000415385+71237_52282411RegionNote=D domain


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FusionGeneSequence for NF1_MAP2K4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NF1_ENST00000356175_chr17_29509683_+_MAP2K4_ENST00000353533_chr17_12028611_+_425aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTL
EKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQ
IILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEERE

>In-frame_NF1_ENST00000356175_chr17_29509683_+_MAP2K4_ENST00000415385_chr17_12028611_+_425aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTL
EKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQ
IILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEERE

>In-frame_NF1_ENST00000358273_chr17_29509683_+_MAP2K4_ENST00000353533_chr17_12028611_+_425aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTL
EKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQ
IILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEERE

>In-frame_NF1_ENST00000358273_chr17_29509683_+_MAP2K4_ENST00000415385_chr17_12028611_+_425aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTL
EKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQ
IILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEERE

>In-frame_NF1_ENST00000431387_chr17_29509683_+_MAP2K4_ENST00000353533_chr17_12028611_+_425aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTL
EKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQ
IILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEERE

>In-frame_NF1_ENST00000431387_chr17_29509683_+_MAP2K4_ENST00000415385_chr17_12028611_+_425aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTL
EKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQ
IILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEERE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NF1_ENST00000356175_chr17_29509683_+_MAP2K4_ENST00000353533_chr17_12028611_+_1275nt
ATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACA
CATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACT
ATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTG
GAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTT
CTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTC
AATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTA
CAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTA
GCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACT
GATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAA
ATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATA
GACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTT
CCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAA
TTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCC
TTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCC

>In-frame_NF1_ENST00000356175_chr17_29509683_+_MAP2K4_ENST00000415385_chr17_12028611_+_1275nt
ATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACA
CATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACT
ATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTG
GAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTT
CTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTC
AATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTA
CAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTA
GCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACT
GATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAA
ATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATA
GACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTT
CCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAA
TTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCC
TTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCC

>In-frame_NF1_ENST00000358273_chr17_29509683_+_MAP2K4_ENST00000353533_chr17_12028611_+_1275nt
ATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACA
CATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACT
ATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTG
GAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTT
CTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTC
AATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTA
CAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTA
GCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACT
GATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAA
ATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATA
GACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTT
CCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAA
TTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCC
TTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCC

>In-frame_NF1_ENST00000358273_chr17_29509683_+_MAP2K4_ENST00000415385_chr17_12028611_+_1275nt
ATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACA
CATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACT
ATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTG
GAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTT
CTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTC
AATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTA
CAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTA
GCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACT
GATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAA
ATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATA
GACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTT
CCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAA
TTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCC
TTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCC

>In-frame_NF1_ENST00000431387_chr17_29509683_+_MAP2K4_ENST00000353533_chr17_12028611_+_1275nt
ATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACA
CATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACT
ATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTG
GAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTT
CTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTC
AATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTA
CAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTA
GCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACT
GATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAA
ATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATA
GACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTT
CCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAA
TTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCC
TTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCC

>In-frame_NF1_ENST00000431387_chr17_29509683_+_MAP2K4_ENST00000415385_chr17_12028611_+_1275nt
ATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACA
CATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACT
ATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTG
GAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTT
CTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTC
AATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTA
CAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTA
GCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACT
GATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAA
ATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATA
GACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTT
CCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAA
TTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCC
TTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NF1_ENST00000356175_chr17_29509683_+_MAP2K4_ENST00000353533_chr17_12028611_+_4221nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAG
CCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAA
AACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTA
AAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACA
ACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGT
ATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGC
TGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGT
ATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAA
TGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGT
AAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTA
TACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTT
GTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAA
AACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAG
AAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTC
ACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTG
TTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGG
ACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTA
AGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAG
AAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGAT
ACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAA
AGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCG
CTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTT
TTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTT
TCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTC
TTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTT
CTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCA
CTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATT
GCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGC
AGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGT
TCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTC
TCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTA
ATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCA
AGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAG
CTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAA
AAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATA
TACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAA

>In-frame_NF1_ENST00000356175_chr17_29509683_+_MAP2K4_ENST00000415385_chr17_12028611_+_4228nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAG
CCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAA
AACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTA
AAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACA
ACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGT
ATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGC
TGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGT
ATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAA
TGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGT
AAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTA
TACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTT
GTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAA
AACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAG
AAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTC
ACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTG
TTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGG
ACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTA
AGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAG
AAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGAT
ACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAA
AGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCG
CTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTT
TTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTT
TCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTC
TTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTT
CTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCA
CTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATT
GCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGC
AGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGT
TCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTC
TCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTA
ATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCA
AGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAG
CTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAA
AAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATA
TACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAA

>In-frame_NF1_ENST00000358273_chr17_29509683_+_MAP2K4_ENST00000353533_chr17_12028611_+_4221nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAG
CCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAA
AACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTA
AAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACA
ACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGT
ATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGC
TGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGT
ATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAA
TGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGT
AAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTA
TACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTT
GTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAA
AACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAG
AAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTC
ACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTG
TTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGG
ACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTA
AGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAG
AAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGAT
ACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAA
AGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCG
CTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTT
TTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTT
TCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTC
TTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTT
CTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCA
CTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATT
GCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGC
AGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGT
TCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTC
TCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTA
ATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCA
AGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAG
CTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAA
AAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATA
TACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAA

>In-frame_NF1_ENST00000358273_chr17_29509683_+_MAP2K4_ENST00000415385_chr17_12028611_+_4228nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAG
CCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAA
AACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTA
AAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACA
ACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGT
ATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGC
TGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGT
ATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAA
TGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGT
AAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTA
TACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTT
GTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAA
AACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAG
AAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTC
ACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTG
TTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGG
ACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTA
AGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAG
AAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGAT
ACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAA
AGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCG
CTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTT
TTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTT
TCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTC
TTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTT
CTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCA
CTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATT
GCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGC
AGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGT
TCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTC
TCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTA
ATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCA
AGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAG
CTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAA
AAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATA
TACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAA

>In-frame_NF1_ENST00000431387_chr17_29509683_+_MAP2K4_ENST00000353533_chr17_12028611_+_4171nt
ACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGATGGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCC
CCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCCTCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCC
CCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTCCACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCC
CTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGCCGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGG
GTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAAC
AAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGA
ATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAG
GACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAG
CATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACC
AGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAA
TTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCA
TTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTA
TTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAA
ATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATAT
GATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTT
GATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTC
AACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCC
GTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTAC
ATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGTAAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACC
ATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTATACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACAC
AGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTTGTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGA
CTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCC
TGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAGAAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGC
CTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTCACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACA
GTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTGTTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCAT
GTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGGACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGA
CTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTAAGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACC
TGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAGAAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAAC
TTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGATACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGT
GCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAAAGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCA
GTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCGCTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAA
AACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTTTTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGT
GGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTTTCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGT
TCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTCTTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCC
TCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTTCTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCC
TGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCACTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGAT
GCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATTGCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAG
GGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATC
TTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATC
ATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTCTCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTAT
GCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTAATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTG
TATTAATCATAGATTATTATAAACTATAAACTTAAGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTT
CACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAGCTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAA
AAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAAAAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTAT
CCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATATACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGG
TCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAATTTGATTTTCTGAAATCAGACCCTGAGAGGGGAAAATCTTAAAGTAAATT

>In-frame_NF1_ENST00000431387_chr17_29509683_+_MAP2K4_ENST00000415385_chr17_12028611_+_4178nt
ACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGATGGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCC
CCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCCTCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCC
CCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTCCACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCC
CTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGCCGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGG
GTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAAC
AAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGA
ATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAG
GACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAG
CATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACC
AGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAA
TTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCA
TTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTA
TTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAA
ATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATAT
GATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTT
GATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTC
AACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCC
GTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTAC
ATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGTAAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACC
ATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTATACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACAC
AGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTTGTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGA
CTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCC
TGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAGAAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGC
CTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTCACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACA
GTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTGTTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCAT
GTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGGACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGA
CTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTAAGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACC
TGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAGAAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAAC
TTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGATACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGT
GCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAAAGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCA
GTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCGCTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAA
AACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTTTTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGT
GGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTTTCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGT
TCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTCTTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCC
TCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTTCTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCC
TGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCACTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGAT
GCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATTGCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAG
GGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATC
TTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATC
ATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTCTCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTAT
GCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTAATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTG
TATTAATCATAGATTATTATAAACTATAAACTTAAGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTT
CACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAGCTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAA
AAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAAAAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTAT
CCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATATACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGG
TCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAATTTGATTTTCTGAAATCAGACCCTGAGAGGGGAAAATCTTAAAGTAAATT


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FusionGenePPI for NF1_MAP2K4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NF1HRAS, SMARCA4, POLR2A, TIRAP, SIRT7, VCP, NSFL1C, CAV1, YWHAB, FAF2, NXF1, CCDC8, HLA-DPA1, EFNB2, CD274, TNFSF13B, CA14, SLAMF1, VSIG4, TGOLN2, HTR6, NOSIP, KRAS, CLK1, CDC5L, APP, YWHAH, PML, TRAF6, PTEN, SDC2, EGFR, CD79B, P4HA3, SCN3B, VSIG1, SIGLECL1, EPHA1, FAM174A, KCTD3, KIF13B, ZBTB21, KSR1, CGN, GIGYF1, LRFN1, RTKN, MAST3, DENND1A, SH3PXD2A, SRGAP2, DENND4C, PPM1H, EIF4E2, SIPA1L1, LIMA1, RALGPS2, MAGI1, CBY1, TESK2, CDC25C, DCLK1, GIGYF2, HDAC4, LPIN3, ZNF638, CAMSAP2, NADK, MAPKAP1, SRSF12, RASAL2, SYDE1, KIAA1804, TIAM1, AGAP1, CDC25B, CDK16, SH3RF3, PHLDB2, PLEKHA7, KIF1C, OSBPL6, FAM110B, USP21, NAV1, TANC2, PTPN13, FAM53C, ANKRD34A, STARD13, PTPN14, GAB2, DENND4A, INPP5E, TOP1, TOP2A, TOP3A, NRASMAP2K4FLNC, SPAG9, MAPK8, MAP4K2, MAP2K7, MAP3K8, AKT1, MAPK8IP3, MAP3K11, MAP3K4, ARRB2, MAP3K2, MAP3K1, NPHS1, ITCH, MAPK9, BLNK, PML, MAPK10, MAP3K5, MAP2K6, MAP2K4, MAPK14, MAP3K3, LRRK2, APP, JUN, MAP3K7, ARRB1, MAPK1, GCH1, GEMIN5, RBBP8, EGFR, MAP3K10, NBR1, KTI12, VASP, FLNB, CDC5L, UBC, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NF1_MAP2K4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NF1_MAP2K4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNF1C0027831Neurofibromatosis 134CTD_human;ORPHANET;UNIPROT
HgeneNF1C2931482Neurofibromatosis-Noonan syndrome5CTD_human;ORPHANET;UNIPROT
HgeneNF1C0349639Juvenile Myelomonocytic Leukemia3CTD_human;HPO;ORPHANET
HgeneNF1C0004114Astrocytoma2CTD_human;HPO
HgeneNF1C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneNF1C0025202melanoma2CTD_human
HgeneNF1C0206727Nerve Sheath Tumors2CTD_human
HgeneNF1C0001430Adenoma1CTD_human
HgeneNF1C0004352Autistic Disorder1CTD_human
HgeneNF1C0016057Fibrosarcoma1CTD_human
HgeneNF1C0017636Glioblastoma1CTD_human
HgeneNF1C0017638Glioma1CTD_human
HgeneNF1C0023186Learning Disorders1CTD_human
HgeneNF1C0023827liposarcoma1CTD_human
HgeneNF1C0027809Neurilemmoma1CTD_human
HgeneNF1C0027830neurofibroma1CTD_human
HgeneNF1C0027962Melanocytic nevus1CTD_human
HgeneNF1C0031511Pheochromocytoma1CTD_human
HgeneNF1C0162678Neurofibromatoses1CTD_human;HPO
HgeneNF1C1261473Sarcoma1CTD_human
HgeneNF1C1834235NEUROFIBROMATOSIS, FAMILIAL SPINAL1CTD_human;UNIPROT
HgeneNF1C3714756Intellectual Disability1CTD_human;HPO