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Fusion gene ID: 24076 |
FusionGeneSummary for NEXN_AK5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEXN_AK5 | Fusion gene ID: 24076 | Hgene | Tgene | Gene symbol | NEXN | AK5 | Gene ID | 91624 | 26289 |
| Gene name | nexilin F-actin binding protein | adenylate kinase 5 | |
| Synonyms | CMH20|NELIN | AK6 | |
| Cytomap | 1p31.1 | 1p31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nexilin | adenylate kinase isoenzyme 5AK 5ATP-AMP transphosphorylase 5adenylate kinase 6 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q0ZGT2 | Q9Y6K8 | |
| Ensembl transtripts involved in fusion gene | ENST00000457030, ENST00000330010, ENST00000294624, ENST00000334785, ENST00000480732, | ENST00000354567, ENST00000344720, ENST00000317704, ENST00000478255, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 5 X 3 X 4=60 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEXN [Title/Abstract] AND AK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NEXN | GO:0030334 | regulation of cell migration | 15823560 |
| Tgene | AK5 | GO:0006165 | nucleoside diphosphate phosphorylation | 23416111 |
| Tgene | AK5 | GO:0009142 | nucleoside triphosphate biosynthetic process | 23416111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-B6-A0X1-01A | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000457030 | ENST00000354567 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| In-frame | ENST00000457030 | ENST00000344720 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000457030 | ENST00000317704 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000457030 | ENST00000478255 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| In-frame | ENST00000330010 | ENST00000354567 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| In-frame | ENST00000330010 | ENST00000344720 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000330010 | ENST00000317704 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000330010 | ENST00000478255 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| intron-3CDS | ENST00000294624 | ENST00000354567 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| intron-3CDS | ENST00000294624 | ENST00000344720 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| intron-intron | ENST00000294624 | ENST00000317704 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| intron-intron | ENST00000294624 | ENST00000478255 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| In-frame | ENST00000334785 | ENST00000354567 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| In-frame | ENST00000334785 | ENST00000344720 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000334785 | ENST00000317704 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 5CDS-intron | ENST00000334785 | ENST00000478255 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 3UTR-3CDS | ENST00000480732 | ENST00000354567 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 3UTR-3CDS | ENST00000480732 | ENST00000344720 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 3UTR-intron | ENST00000480732 | ENST00000317704 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
| 3UTR-intron | ENST00000480732 | ENST00000478255 | NEXN | chr1 | 78399164 | + | AK5 | chr1 | 77949002 | + |
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FusionProtFeatures for NEXN_AK5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEXN | AK5 |
| Nucleoside monophosphate (NMP) kinase that catalyzes thereversible transfer of the terminal phosphate group betweennucleoside triphosphates and monophosphates. Active on AMP anddAMP with ATP as a donor. When GTP is used as phosphate donor, theenzyme phosphorylates AMP, CMP, and to a small extent dCMP. Alsodisplays broad nucleoside diphosphate kinase activity.{ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 386_391 | 327 | 537 | Nucleotide binding | ATP 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 433_435 | 327 | 537 | Nucleotide binding | AMP 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 462_465 | 327 | 537 | Nucleotide binding | AMP 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 386_391 | 353 | 563 | Nucleotide binding | ATP 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 433_435 | 353 | 563 | Nucleotide binding | AMP 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 462_465 | 353 | 563 | Nucleotide binding | AMP 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 377_559 | 327 | 537 | Region | Adenylate kinase 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 406_435 | 327 | 537 | Region | NMPbind 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 499_509 | 327 | 537 | Region | LID 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 377_559 | 353 | 563 | Region | Adenylate kinase 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 406_435 | 353 | 563 | Region | NMPbind 2 |
| Tgene | >AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 499_509 | 353 | 563 | Region | LID 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NEXN | chr1:78399164 | chr1:77949002 | ENST00000330010 | + | 9 | 12 | 43_575 | 353 | 612 | Compositional bias | Glu-rich |
| Hgene | >NEXN | chr1:78399164 | chr1:77949002 | ENST00000334785 | + | 10 | 13 | 43_575 | 417 | 676 | Compositional bias | Glu-rich |
| Hgene | >NEXN | chr1:78399164 | chr1:77949002 | ENST00000457030 | + | 9 | 13 | 43_575 | 403 | 663 | Compositional bias | Glu-rich |
| Hgene | >NEXN | chr1:78399164 | chr1:77949002 | ENST00000330010 | + | 9 | 12 | 582_670 | 353 | 612 | Domain | Ig-like |
| Hgene | >NEXN | chr1:78399164 | chr1:77949002 | ENST00000334785 | + | 10 | 13 | 582_670 | 417 | 676 | Domain | Ig-like |
| Hgene | >NEXN | chr1:78399164 | chr1:77949002 | ENST00000457030 | + | 9 | 13 | 582_670 | 403 | 663 | Domain | Ig-like |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 142_147 | 327 | 537 | Nucleotide binding | ATP 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 191_193 | 327 | 537 | Nucleotide binding | AMP 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 219_222 | 327 | 537 | Nucleotide binding | AMP 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 142_147 | 353 | 563 | Nucleotide binding | ATP 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 191_193 | 353 | 563 | Nucleotide binding | AMP 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 219_222 | 353 | 563 | Nucleotide binding | AMP 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 133_316 | 327 | 537 | Region | Adenylate kinase 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 162_193 | 327 | 537 | Region | NMPbind 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000344720 | + | 7 | 14 | 256_266 | 327 | 537 | Region | LID 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 133_316 | 353 | 563 | Region | Adenylate kinase 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 162_193 | 353 | 563 | Region | NMPbind 1 |
| Tgene | AK5 | chr1:78399164 | chr1:77949002 | ENST00000354567 | + | 7 | 14 | 256_266 | 353 | 563 | Region | LID 1 |
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FusionGeneSequence for NEXN_AK5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NEXN_ENST00000457030_chr1_78399164_+_AK5_ENST00000354567_chr1_77949002_+_613aa MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKV EKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQEGDDSLLITVVPVKSYKTSGKMKKNFEDLEK EREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEA RRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKL EINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKY GFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSA >In-frame_NEXN_ENST00000457030_chr1_78399164_+_AK5_ENST00000344720_chr1_77949002_+_613aa MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKV EKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQEGDDSLLITVVPVKSYKTSGKMKKNFEDLEK EREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEA RRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKL EINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKY GFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSA >In-frame_NEXN_ENST00000330010_chr1_78399164_+_AK5_ENST00000354567_chr1_77949002_+_563aa MNDISQKAEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDIN NTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSP GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEAR RRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNV FGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVA SLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHK >In-frame_NEXN_ENST00000330010_chr1_78399164_+_AK5_ENST00000344720_chr1_77949002_+_563aa MNDISQKAEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDIN NTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSP GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEAR RRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNV FGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVA SLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHK >In-frame_NEXN_ENST00000334785_chr1_78399164_+_AK5_ENST00000354567_chr1_77949002_+_627aa MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKV EKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYK TSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEM YKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPG SGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRR >In-frame_NEXN_ENST00000334785_chr1_78399164_+_AK5_ENST00000344720_chr1_77949002_+_627aa MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKV EKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYK TSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEM YKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPG SGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NEXN_ENST00000457030_chr1_78399164_+_AK5_ENST00000354567_chr1_77949002_+_1839nt ATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACCTATGTACCAAAACTTGGCAAGGGTGAT GTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGAGACGAAAAACAAAGAAGAAAAGAACAA TATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAAAGTA GAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAAGAGA ACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACAGGAA GGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAA GAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGT CTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTG GAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCA AGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTT GAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTT GCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTG GAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAG AAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATG GAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATAT GGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAA CGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATT GACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCA GACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCC TACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTT >In-frame_NEXN_ENST00000457030_chr1_78399164_+_AK5_ENST00000344720_chr1_77949002_+_1839nt ATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACCTATGTACCAAAACTTGGCAAGGGTGAT GTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGAGACGAAAAACAAAGAAGAAAAGAACAA TATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAAAGTA GAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAAGAGA ACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACAGGAA GGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAA GAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGT CTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTG GAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCA AGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTT GAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTT GCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTG GAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAG AAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATG GAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATAT GGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAA CGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATT GACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCA GACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCC TACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTT >In-frame_NEXN_ENST00000330010_chr1_78399164_+_AK5_ENST00000354567_chr1_77949002_+_1689nt ATGAATGATATTTCCCAAAAGGCTGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAAAGTAGAAAAGGCTTAT GTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAAGAGAACGGAGGAGGAA CGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACAGATTGAGGACATAAAC AATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAAACATCTGGAAAA ATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATAAGATATGAAGAA CAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAATCACTTTCTCCC GGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCAAGAAAACGTTTA GAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAAATTTTTAAAGGG TACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAAGAAGAAGCCAGA AGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATGTATAAGACAATC TCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAACGACGAACAGAG GAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGACCAGTTAAATGTA TTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGC ACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAA AGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCC AGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCA CAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACC ACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAG >In-frame_NEXN_ENST00000330010_chr1_78399164_+_AK5_ENST00000344720_chr1_77949002_+_1689nt ATGAATGATATTTCCCAAAAGGCTGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAAAGTAGAAAAGGCTTAT GTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAAGAGAACGGAGGAGGAA CGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACAGATTGAGGACATAAAC AATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAAACATCTGGAAAA ATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATAAGATATGAAGAA CAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAATCACTTTCTCCC GGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCAAGAAAACGTTTA GAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAAATTTTTAAAGGG TACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAAGAAGAAGCCAGA AGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATGTATAAGACAATC TCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAACGACGAACAGAG GAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGACCAGTTAAATGTA TTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGC ACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAA AGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCC AGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCA CAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACC ACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAG >In-frame_NEXN_ENST00000334785_chr1_78399164_+_AK5_ENST00000354567_chr1_77949002_+_1881nt ATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACCTATGTACCAAAACTTGGCAAGGGTGAT GTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGAGACGAAAAACAAAGAAGAAAAGAACAA TATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAAAGTA GAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAAGAGA ACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACAGATT GAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAA ACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATA AGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAA TCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCA AGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAA ATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAA GAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATG TATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAA CGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGAC CAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGC TCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCA TCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAG GCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGG ATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCT GTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACA >In-frame_NEXN_ENST00000334785_chr1_78399164_+_AK5_ENST00000344720_chr1_77949002_+_1881nt ATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACCTATGTACCAAAACTTGGCAAGGGTGAT GTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGAGACGAAAAACAAAGAAGAAAAGAACAA TATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAAAGTA GAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAAGAGA ACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACAGATT GAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAA ACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATA AGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAA TCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCA AGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAA ATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAA GAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATG TATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAA CGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGAC CAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGC TCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCA TCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAG GCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGG ATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCT GTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NEXN_ENST00000457030_chr1_78399164_+_AK5_ENST00000354567_chr1_77949002_+_3432nt AACAGCTGCAGCCGGCGCTGGGCCCGCCTGGAATGCGGGAACAGGCTGCACACCAGGACTTTTATGGAAACTTGCTGCTGGAGACGGCGG CGGCGGCGGCGGCAGCGGCAGCCAGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCA GGCGGGACGCGCACAGTCCCTCCACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATA ATCAGCCCAAGACCACATAGAGCAAACATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACC TATGTACCAAAACTTGGCAAGGGTGATGTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGA GACGAAAAACAAAGAAGAAAAGAACAATATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGAT GATGAGGAAGATGTATCTTCTAAAGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAA CAAAGACAAGAGGAACAAAGGAAGAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGT GAATTAGCAAAAAGGGCTGAACAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAAACATCTGGAAAAATG AAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATAAGATATGAAGAACAA CGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAATCACTTTCTCCCGGA AAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCAAGAAAACGTTTAGAA GAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAAATTTTTAAAGGGTAC CGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAAGAAGAAGCCAGAAGG AGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATGTATAAGACAATCTCT CAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAACGACGAACAGAGGAG GAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGACCAGTTAAATGTATTT GGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGCACA CAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGA AGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCCAGC CTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAG TTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACCACC AAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATA AATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCAAAAATGCATGTTTGTTAGA ATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCGCCCCCACCAACCACCACCT CCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGTGTATTTGGGACTATATCAA CCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTCAGAGCTAGTCAGTACATGA ACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCCTCTCATTAAGCATCCCTAA CCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGCATCTTCCTTTGGTGTCTGG CTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACATGATATAGAGGCATCAAGC AAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGTTAGTCATCAGTAACCTTCT CTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTGTAACCTAGTCTCTTCTCTA CATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTTGCTATTTCATTCATTGGGC ACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAATACCCTAACAAACCTGATG TGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTTTGCAAACCTTGTCATACCC ATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTGTAAAATCAGAGCTGCTTAT ATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATTTTTTTTTTTTTCTTCAATG GCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGATATGTACAAATAAAATAAA >In-frame_NEXN_ENST00000457030_chr1_78399164_+_AK5_ENST00000344720_chr1_77949002_+_3428nt AACAGCTGCAGCCGGCGCTGGGCCCGCCTGGAATGCGGGAACAGGCTGCACACCAGGACTTTTATGGAAACTTGCTGCTGGAGACGGCGG CGGCGGCGGCGGCAGCGGCAGCCAGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCA GGCGGGACGCGCACAGTCCCTCCACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATA ATCAGCCCAAGACCACATAGAGCAAACATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACC TATGTACCAAAACTTGGCAAGGGTGATGTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGA GACGAAAAACAAAGAAGAAAAGAACAATATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGAT GATGAGGAAGATGTATCTTCTAAAGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAA CAAAGACAAGAGGAACAAAGGAAGAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGT GAATTAGCAAAAAGGGCTGAACAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAAACATCTGGAAAAATG AAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATAAGATATGAAGAACAA CGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAATCACTTTCTCCCGGA AAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCAAGAAAACGTTTAGAA GAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAAATTTTTAAAGGGTAC CGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAAGAAGAAGCCAGAAGG AGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATGTATAAGACAATCTCT CAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAACGACGAACAGAGGAG GAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGACCAGTTAAATGTATTT GGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGCACA CAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGA AGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCCAGC CTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAG TTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACCACC AAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATA AATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCAAAAATGCATGTTTGTTAGA ATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCGCCCCCACCAACCACCACCT CCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGTGTATTTGGGACTATATCAA CCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTCAGAGCTAGTCAGTACATGA ACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCCTCTCATTAAGCATCCCTAA CCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGCATCTTCCTTTGGTGTCTGG CTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACATGATATAGAGGCATCAAGC AAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGTTAGTCATCAGTAACCTTCT CTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTGTAACCTAGTCTCTTCTCTA CATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTTGCTATTTCATTCATTGGGC ACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAATACCCTAACAAACCTGATG TGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTTTGCAAACCTTGTCATACCC ATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTGTAAAATCAGAGCTGCTTAT ATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATTTTTTTTTTTTTCTTCAATG GCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGATATGTACAAATAAAATAAA >In-frame_NEXN_ENST00000330010_chr1_78399164_+_AK5_ENST00000354567_chr1_77949002_+_3282nt AACAGCTGCAGCCGGCGCTGGGCCCGCCTGGAATGCGGGAACAGGCTGCACACCAGGACTTTTATGGAAACTTGCTGCTGGAGACGGCGG CGGCGGCGGCGGCAGCGGCAGCCAGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCA GGCGGGACGCGCACAGTCCCTCCACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATA ATCAGCCCAAGACCACATAGAGCAAACATGAATGATATTTCCCAAAAGGCTGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGAT GTATCTTCTAAAGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAG GAACAAAGGAAGAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAA AGGGCTGAACAGATTGAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCT GTCAAATCATATAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAG GAAGATAAAAGAATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGT GAAGCAAAAAAAGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAA GCTGAAGAGGAAGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAAC CAAGACACAGCAAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAA AAAAGGAAAGCAGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGAT GACTCCCCAGAGATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAA ATGGAAGAAGAAAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATG GGAGAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATA ATTGGTGGTCCTGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTG CGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTG GAGCTCCTGAAGGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAA GAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGC CGGAGCAGCCTGCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTAC TACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATT TTCTGAAGGCAAAAATGCATGTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTT TTGTGTCACCGCCCCCACCAACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAA TCATGCATGGTGTATTTGGGACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGC AGGCCACACTCAGAGCTAGTCAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCA TCTGGTTCTCCTCTCATTAAGCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGA CAGCCCTGGGCATCTTCCTTTGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAA TGCCTTGTACATGATATAGAGGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGT AAAACCCAGGTTAGTCATCAGTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCT GATAAATTGTGTAACCTAGTCTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGC ATGAGATATTTGCTATTTCATTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGC AAGTAAAAAAATACCCTAACAAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCT TTCCAGGAGTTTGCAAACCTTGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTA TCAATCAGTTGTAAAATCAGAGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGT TTGCATGAATTTTTTTTTTTTTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTT >In-frame_NEXN_ENST00000330010_chr1_78399164_+_AK5_ENST00000344720_chr1_77949002_+_3278nt AACAGCTGCAGCCGGCGCTGGGCCCGCCTGGAATGCGGGAACAGGCTGCACACCAGGACTTTTATGGAAACTTGCTGCTGGAGACGGCGG CGGCGGCGGCGGCAGCGGCAGCCAGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCA GGCGGGACGCGCACAGTCCCTCCACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATA ATCAGCCCAAGACCACATAGAGCAAACATGAATGATATTTCCCAAAAGGCTGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGAT GTATCTTCTAAAGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAG GAACAAAGGAAGAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAA AGGGCTGAACAGATTGAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCT GTCAAATCATATAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAG GAAGATAAAAGAATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGT GAAGCAAAAAAAGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAA GCTGAAGAGGAAGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAAC CAAGACACAGCAAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAA AAAAGGAAAGCAGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGAT GACTCCCCAGAGATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAA ATGGAAGAAGAAAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATG GGAGAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATA ATTGGTGGTCCTGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTG CGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTG GAGCTCCTGAAGGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAA GAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGC CGGAGCAGCCTGCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTAC TACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATT TTCTGAAGGCAAAAATGCATGTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTT TTGTGTCACCGCCCCCACCAACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAA TCATGCATGGTGTATTTGGGACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGC AGGCCACACTCAGAGCTAGTCAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCA TCTGGTTCTCCTCTCATTAAGCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGA CAGCCCTGGGCATCTTCCTTTGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAA TGCCTTGTACATGATATAGAGGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGT AAAACCCAGGTTAGTCATCAGTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCT GATAAATTGTGTAACCTAGTCTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGC ATGAGATATTTGCTATTTCATTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGC AAGTAAAAAAATACCCTAACAAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCT TTCCAGGAGTTTGCAAACCTTGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTA TCAATCAGTTGTAAAATCAGAGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGT TTGCATGAATTTTTTTTTTTTTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTT >In-frame_NEXN_ENST00000334785_chr1_78399164_+_AK5_ENST00000354567_chr1_77949002_+_3361nt AGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCAGGCGGGACGCGCACAGTCCCTCC ACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATAATCAGCCCAAGACCACATAGAGC AAACATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACCTATGTACCAAAACTTGGCAAGGG TGATGTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGAGACGAAAAACAAAGAAGAAAAGA ACAATATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAA AGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAA GAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACA GATTGAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATA TAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAG AATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAA AGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGA AGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGC AAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGC AGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGA GATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGA AAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGA TGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCC TGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACT GGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAA GGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACG CAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCT GCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAA AACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCA AAAATGCATGTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCG CCCCCACCAACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGT GTATTTGGGACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTC AGAGCTAGTCAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCC TCTCATTAAGCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGC ATCTTCCTTTGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACA TGATATAGAGGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGT TAGTCATCAGTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTG TAACCTAGTCTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTT GCTATTTCATTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAA TACCCTAACAAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTT TGCAAACCTTGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTG TAAAATCAGAGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATT TTTTTTTTTTTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGA >In-frame_NEXN_ENST00000334785_chr1_78399164_+_AK5_ENST00000344720_chr1_77949002_+_3357nt AGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCAGGCGGGACGCGCACAGTCCCTCC ACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATAATCAGCCCAAGACCACATAGAGC AAACATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACCTATGTACCAAAACTTGGCAAGGG TGATGTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGAGACGAAAAACAAAGAAGAAAAGA ACAATATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAA AGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAA GAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACA GATTGAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATA TAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAG AATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAA AGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGA AGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGC AAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGC AGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGA GATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGA AAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGA TGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCC TGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACT GGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAA GGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACG CAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCT GCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAA AACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCA AAAATGCATGTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCG CCCCCACCAACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGT GTATTTGGGACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTC AGAGCTAGTCAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCC TCTCATTAAGCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGC ATCTTCCTTTGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACA TGATATAGAGGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGT TAGTCATCAGTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTG TAACCTAGTCTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTT GCTATTTCATTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAA TACCCTAACAAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTT TGCAAACCTTGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTG TAAAATCAGAGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATT TTTTTTTTTTTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGA |
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FusionGenePPI for NEXN_AK5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEXN | CALM1, CUL1, PAN2, LGR4, HSPB1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO5C, MYO19, MYO18A, TRIM15, GSN, MYO1B, ACTB, PPP1R9A, ACTA2, ACTBL2, ANK3, ACTR10, CPVL, MYO1D, FBXO34, FBXO46, G3BP1, FAM107A, TES | AK5 | C7orf26, CPNE6, NUCKS1, STRN4, TRIM46, UGDH, RNF114, CEBPA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEXN_AK5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEXN_AK5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NEXN | C2751084 | Cardiomyopathy, Dilated, 1CC | 1 | CTD_human;UNIPROT |
| Hgene | NEXN | C3151267 | CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 20 | 1 | UNIPROT |
| Tgene | AK5 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
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