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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24049

FusionGeneSummary for NEO1_NEO1

check button Fusion gene summary
Fusion gene informationFusion gene name: NEO1_NEO1
Fusion gene ID: 24049
HgeneTgene
Gene symbol

NEO1

NEO1

Gene ID

4756

4756

Gene nameneogenin 1neogenin 1
SynonymsIGDCC2|NGN|NTN1R2IGDCC2|NGN|NTN1R2
Cytomap

15q24.1

15q24.1

Type of geneprotein-codingprotein-coding
Descriptionneogeninimmunoglobulin superfamily DCC subclass member 2neogenin homolog 1neogeninimmunoglobulin superfamily DCC subclass member 2neogenin homolog 1
Modification date2018051920180519
UniProtAcc

Q92859

Q92859

Ensembl transtripts involved in fusion geneENST00000339362, ENST00000261908, 
ENST00000558964, ENST00000560262, 
ENST00000560352, 		ENST00000339362, 
ENST00000261908, ENST00000558964, 
ENST00000560262, ENST00000560352, 
Fusion gene scores* DoF score6 X 3 X 4=724 X 4 X 3=48
# samples 75
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NEO1 [Title/Abstract] AND NEO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA578152NEO1chr15

73528707

+NEO1chr15

73418823

-
ChiTaRS3.1AW973832NEO1chr15

73528707

+NEO1chr15

73418823

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000339362ENST00000339362NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000339362ENST00000261908NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000339362ENST00000558964NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000339362ENST00000560262NEO1chr15

73528707

+NEO1chr15

73418823

-
5CDS-intronENST00000339362ENST00000560352NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000261908ENST00000339362NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000261908ENST00000261908NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000261908ENST00000558964NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000261908ENST00000560262NEO1chr15

73528707

+NEO1chr15

73418823

-
5CDS-intronENST00000261908ENST00000560352NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000558964ENST00000339362NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000558964ENST00000261908NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000558964ENST00000558964NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000558964ENST00000560262NEO1chr15

73528707

+NEO1chr15

73418823

-
5CDS-intronENST00000558964ENST00000560352NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000560262ENST00000339362NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000560262ENST00000261908NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000560262ENST00000558964NEO1chr15

73528707

+NEO1chr15

73418823

-
Frame-shiftENST00000560262ENST00000560262NEO1chr15

73528707

+NEO1chr15

73418823

-
5CDS-intronENST00000560262ENST00000560352NEO1chr15

73528707

+NEO1chr15

73418823

-
3UTR-3CDSENST00000560352ENST00000339362NEO1chr15

73528707

+NEO1chr15

73418823

-
3UTR-3CDSENST00000560352ENST00000261908NEO1chr15

73528707

+NEO1chr15

73418823

-
3UTR-3CDSENST00000560352ENST00000558964NEO1chr15

73528707

+NEO1chr15

73418823

-
3UTR-3CDSENST00000560352ENST00000560262NEO1chr15

73528707

+NEO1chr15

73418823

-
3UTR-intronENST00000560352ENST00000560352NEO1chr15

73528707

+NEO1chr15

73418823

-

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FusionProtFeatures for NEO1_NEO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEO1

Q92859

NEO1

Q92859

Multi-functional cell surface receptor regulating celladhesion in many diverse developmental processes, including neuraltube and mammary gland formation, myogenesis and angiogenesis.Receptor for members of the BMP, netrin, and repulsive guidancemolecule (RGM) families. Netrin-Neogenin interactions result in achemoattractive axon guidance response and cell-cell adhesion, theinteraction between NEO1/Neogenin and RGMa and RGMb induces achemorepulsive response. {ECO:0000269|PubMed:21149453}. Multi-functional cell surface receptor regulating celladhesion in many diverse developmental processes, including neuraltube and mammary gland formation, myogenesis and angiogenesis.Receptor for members of the BMP, netrin, and repulsive guidancemolecule (RGM) families. Netrin-Neogenin interactions result in achemoattractive axon guidance response and cell-cell adhesion, theinteraction between NEO1/Neogenin and RGMa and RGMb induces achemorepulsive response. {ECO:0000269|PubMed:21149453}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEO1_NEO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEO1_NEO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEO1_NEO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEO1_NEO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource