FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 24030

FusionGeneSummary for NELL1_SMCO4

check button Fusion gene summary
Fusion gene informationFusion gene name: NELL1_SMCO4
Fusion gene ID: 24030
HgeneTgene
Gene symbol

NELL1

SMCO4

Gene ID

4745

56935

Gene nameneural EGFL like 1single-pass membrane protein with coiled-coil domains 4
SynonymsIDH3GL|NRP1C11orf75|FN5
Cytomap

11p15.1

11q21

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C-binding protein NELL1nel-related protein 1neural epidermal growth factor-like 1single-pass membrane and coiled-coil domain-containing protein 4UPF0443 protein C11orf75
Modification date2018051920180519
UniProtAcc

Q92832

Q9NRQ5

Ensembl transtripts involved in fusion geneENST00000298925, ENST00000357134, 
ENST00000325319, ENST00000532434, 
ENST00000529218, 		ENST00000525141, 
ENST00000298966, ENST00000527149, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 2 X 3=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NELL1 [Title/Abstract] AND SMCO4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNELL1

GO:0010468

regulation of gene expression

21723284

HgeneNELL1

GO:0030501

positive regulation of bone mineralization

21723284

HgeneNELL1

GO:0033689

negative regulation of osteoblast proliferation

21723284

HgeneNELL1

GO:0045669

positive regulation of osteoblast differentiation

21723284

HgeneNELL1

GO:1903363

negative regulation of cellular protein catabolic process

21723284


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-ER-A19H-06ANELL1chr11

20907086

+SMCO4chr11

93232514

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000298925ENST00000525141NELL1chr11

20907086

+SMCO4chr11

93232514

-
5CDS-5UTRENST00000298925ENST00000298966NELL1chr11

20907086

+SMCO4chr11

93232514

-
5CDS-5UTRENST00000298925ENST00000527149NELL1chr11

20907086

+SMCO4chr11

93232514

-
In-frameENST00000357134ENST00000525141NELL1chr11

20907086

+SMCO4chr11

93232514

-
5CDS-5UTRENST00000357134ENST00000298966NELL1chr11

20907086

+SMCO4chr11

93232514

-
5CDS-5UTRENST00000357134ENST00000527149NELL1chr11

20907086

+SMCO4chr11

93232514

-
In-frameENST00000325319ENST00000525141NELL1chr11

20907086

+SMCO4chr11

93232514

-
5CDS-5UTRENST00000325319ENST00000298966NELL1chr11

20907086

+SMCO4chr11

93232514

-
5CDS-5UTRENST00000325319ENST00000527149NELL1chr11

20907086

+SMCO4chr11

93232514

-
In-frameENST00000532434ENST00000525141NELL1chr11

20907086

+SMCO4chr11

93232514

-
5CDS-5UTRENST00000532434ENST00000298966NELL1chr11

20907086

+SMCO4chr11

93232514

-
5CDS-5UTRENST00000532434ENST00000527149NELL1chr11

20907086

+SMCO4chr11

93232514

-
intron-3CDSENST00000529218ENST00000525141NELL1chr11

20907086

+SMCO4chr11

93232514

-
intron-5UTRENST00000529218ENST00000298966NELL1chr11

20907086

+SMCO4chr11

93232514

-
intron-5UTRENST00000529218ENST00000527149NELL1chr11

20907086

+SMCO4chr11

93232514

-

Top

FusionProtFeatures for NELL1_SMCO4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NELL1

Q92832

SMCO4

Q9NRQ5

Plays a role in the control of cell growth anddifferentiation. Promotes osteoblast cell differentiation andterminal mineralization. {ECO:0000269|PubMed:21723284}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMCO4chr11:20907086chr11:93232514ENST00000298966-039_31-5160Coiled coilOntology_term=ECO:0000255
TgeneSMCO4chr11:20907086chr11:93232514ENST00000525141--129_31-3260Coiled coilOntology_term=ECO:0000255
TgeneSMCO4chr11:20907086chr11:93232514ENST00000527149-039_31-5160Coiled coilOntology_term=ECO:0000255
TgeneSMCO4chr11:20907086chr11:93232514ENST00000298966-0332_52-5160TransmembraneHelical
TgeneSMCO4chr11:20907086chr11:93232514ENST00000525141--1232_52-3260TransmembraneHelical
TgeneSMCO4chr11:20907086chr11:93232514ENST00000527149-0332_52-5160TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNELL1chr11:20907086chr11:93232514ENST00000357134+520271_332201811DomainVWFC 1
HgeneNELL1chr11:20907086chr11:93232514ENST00000357134+520434_475201811DomainEGF-like 1%3B calcium-binding
HgeneNELL1chr11:20907086chr11:93232514ENST00000357134+520476_516201811DomainEGF-like 2%3B calcium-binding
HgeneNELL1chr11:20907086chr11:93232514ENST00000357134+520517_547201811DomainEGF-like 3
HgeneNELL1chr11:20907086chr11:93232514ENST00000357134+520549_587201811DomainEGF-like 4%3B calcium-binding
HgeneNELL1chr11:20907086chr11:93232514ENST00000357134+520596_631201811DomainEGF-like 5%3B calcium-binding
HgeneNELL1chr11:20907086chr11:93232514ENST00000357134+52064_227201811DomainNote=Laminin G-like
HgeneNELL1chr11:20907086chr11:93232514ENST00000357134+520692_750201811DomainVWFC 2
HgeneNELL1chr11:20907086chr11:93232514ENST00000532434+519271_332201764DomainVWFC 1
HgeneNELL1chr11:20907086chr11:93232514ENST00000532434+519434_475201764DomainEGF-like 1%3B calcium-binding
HgeneNELL1chr11:20907086chr11:93232514ENST00000532434+519476_516201764DomainEGF-like 2%3B calcium-binding
HgeneNELL1chr11:20907086chr11:93232514ENST00000532434+519517_547201764DomainEGF-like 3
HgeneNELL1chr11:20907086chr11:93232514ENST00000532434+519549_587201764DomainEGF-like 4%3B calcium-binding
HgeneNELL1chr11:20907086chr11:93232514ENST00000532434+519596_631201764DomainEGF-like 5%3B calcium-binding
HgeneNELL1chr11:20907086chr11:93232514ENST00000532434+51964_227201764DomainNote=Laminin G-like
HgeneNELL1chr11:20907086chr11:93232514ENST00000532434+519692_750201764DomainVWFC 2


Top

FusionGeneSequence for NELL1_SMCO4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NELL1_ENST00000298925_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_229aa
MPMDLILVVWFCVCTARTAEDMKPPVLSLIWRTRVLKSLLQQSLQGVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQD
IEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKV

>In-frame_NELL1_ENST00000357134_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_201aa
MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTIL
ATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT

>In-frame_NELL1_ENST00000325319_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_144aa
MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTIL

>In-frame_NELL1_ENST00000532434_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_201aa
MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTIL
ATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NELL1_ENST00000298925_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_687nt
ATGCCGATGGATTTGATTTTAGTTGTGTGGTTCTGTGTGTGCACTGCCAGGACAGCAGAAGATATGAAGCCACCCGTGTTATCGCTGATA
TGGAGAACTAGAGTTCTGAAGTCTCTGCTTCAGCAATCCCTTCAGGGAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATGGATATC
GTCACCGAGCTTGACCTTGTGAACACCACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTTCAAGAC
ATAGAAAGAGAGATCCATGCAGCTCCTCATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTGGCCACT
GTACAGCAGAAGCCATCCACTTCAGGAGTGATACTGTCCATTCGAGAACTGGAGCACAGCTATTTTGAACTGGAGAGCAGTGGCCTGAGG
GATGAGATTCGGTATCACTACATACACAATGGGAAGCCAAGGACAGAGGCACTTCCTTACCGCATGGCAGATGGACAATGGCACAAGGTT
GCACTGTCAGTTAGCGCCTCTCATCTCCTGCTCCATGTCGACTGTAACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACCAACCTT

>In-frame_NELL1_ENST00000357134_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_603nt
ATGCCGATGGATTTGATTTTAGTTGTGTGGTTCTGTGTGTGCACTGCCAGGACAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATG
GATATCGTCACCGAGCTTGACCTTGTGAACACCACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTT
CAAGACATAGAAAGAGAGATCCATGCAGCTCCTCATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTG
GCCACTGTACAGCAGAAGCCATCCACTTCAGGAGTGATACTGTCCATTCGAGAACTGGAGCACAGCTATTTTGAACTGGAGAGCAGTGGC
CTGAGGGATGAGATTCGGTATCACTACATACACAATGGGAAGCCAAGGACAGAGGCACTTCCTTACCGCATGGCAGATGGACAATGGCAC
AAGGTTGCACTGTCAGTTAGCGCCTCTCATCTCCTGCTCCATGTCGACTGTAACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACC

>In-frame_NELL1_ENST00000325319_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_432nt
ATGCCGATGGATTTGATTTTAGTTGTGTGGTTCTGTGTGTGCACTGCCAGGACAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATG
GATATCGTCACCGAGCTTGACCTTGTGAACACCACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTT
CAAGACATAGAAAGAGAGATCCATGCAGCTCCTCATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTG
GCCACTGTACAGCAGAAGCCATCCACTTCAGGAGTGATACTGTCCATTCGAGAACTGGAGCACAGGATTTATGAGCGTGTGATAGACCCT

>In-frame_NELL1_ENST00000532434_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_603nt
ATGCCGATGGATTTGATTTTAGTTGTGTGGTTCTGTGTGTGCACTGCCAGGACAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATG
GATATCGTCACCGAGCTTGACCTTGTGAACACCACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTT
CAAGACATAGAAAGAGAGATCCATGCAGCTCCTCATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTG
GCCACTGTACAGCAGAAGCCATCCACTTCAGGAGTGATACTGTCCATTCGAGAACTGGAGCACAGCTATTTTGAACTGGAGAGCAGTGGC
CTGAGGGATGAGATTCGGTATCACTACATACACAATGGGAAGCCAAGGACAGAGGCACTTCCTTACCGCATGGCAGATGGACAATGGCAC
AAGGTTGCACTGTCAGTTAGCGCCTCTCATCTCCTGCTCCATGTCGACTGTAACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NELL1_ENST00000298925_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_1729nt
ATATGCGAGCGCAGCACCCGGCGCTGCCGAGCCACCTCCCCCGCCGCCCGCTAGCAAGTTTGGCGGCTCCAAGCCAGGCGCGCCTCAGGA
TCCAGGCTCATTTGCTTCCACCTAGCTTCGGTGCCCCCTGCTAGGCGGGGACCCTCGAGAGCGATGCCGATGGATTTGATTTTAGTTGTG
TGGTTCTGTGTGTGCACTGCCAGGACAGCAGAAGATATGAAGCCACCCGTGTTATCGCTGATATGGAGAACTAGAGTTCTGAAGTCTCTG
CTTCAGCAATCCCTTCAGGGAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATGGATATCGTCACCGAGCTTGACCTTGTGAACACC
ACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTTCAAGACATAGAAAGAGAGATCCATGCAGCTCCT
CATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTGGCCACTGTACAGCAGAAGCCATCCACTTCAGGA
GTGATACTGTCCATTCGAGAACTGGAGCACAGCTATTTTGAACTGGAGAGCAGTGGCCTGAGGGATGAGATTCGGTATCACTACATACAC
AATGGGAAGCCAAGGACAGAGGCACTTCCTTACCGCATGGCAGATGGACAATGGCACAAGGTTGCACTGTCAGTTAGCGCCTCTCATCTC
CTGCTCCATGTCGACTGTAACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACCAACCTTCCCCCAGGAATCAATTTATGGCTTGGC
CAGCGCAACCAAAAGCATGGCTTATTCAAACAGGAATAACTCAAGTCACCTGTACTGGAAATCAGTTTGCTGAAATTAATCAACGATTCT
TGAAGTTGAAGAAAAGTTGTTCTCTCTACAGGAGGTTCCAGCCTTGGCAAGAGGAGTGTGGCCCTTCCTGGAATCCCTCTGGACACACCC
TCCTAGCATCCTCTAGGAAAGATGCGGCAGCTCAAAGGGAAGCCCAAGAAGGAGACCTCCAAGGACAAGAAGGAGCGGAAGCAAGCCATG
CAGGAGGCCCGGCAGCAGATCACTACAGTGGTGCTGCCCACGCTGGCCGTGGTCGTGCTCTTGATCGTGGTGTTTGTGTACGTGGCCACG
CGCCCCACCATCACCGAGTGAGCCCCGCAGCCGGCTGCGGACCCCATCGGCAGGGAGAGGAGGCGCGGGAGGGGGACGCAAACAAAAAAT
GGCTTTCATATTCAGAGATGTTCATGTTGCTGAGCTGTAAGCAGGAGCACCCTGTCTTCTCTGGTCTTTGACTTGATTAAAGTATCTCCG
CTTTCTTGGGAGGGAATAGGGGATGTTTTATCAGTGAATGTGCCATACACCTTATGGTCCACTTCATGTGCCTTTCAGACTTCAAAGCGC
GCGCGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTTCTTTTTCTCTCCTAAAAATCGATAAGTAGCTCCACCTGAA
GAGGGATGGAACCTCTGGGTCAGGAAACAGCTGGAATCCACACTCACCTCATTCCCATTGTTTGGATCATGCTTCTTTCCAACACGTGTT
CACAATCTCCAAAGGGACTGTATTTCTTCTCTGTGCTTAATGTGATTTGAAATATGTTGAATCAAAGTGAAATATTTATTTTTTGAATAA

>In-frame_NELL1_ENST00000357134_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_1644nt
TATGCGAGCGCAGCACCCGGCGCTGCCGAGCCACCTCCCCCGCCGCCCGCTAGCAAGTTTGGCGGCTCCAAGCCAGGCGCGCCTCAGGAT
CCAGGCTCATTTGCTTCCACCTAGCTTCGGTGCCCCCTGCTAGGCGGGGACCCTCGAGAGCGATGCCGATGGATTTGATTTTAGTTGTGT
GGTTCTGTGTGTGCACTGCCAGGACAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATGGATATCGTCACCGAGCTTGACCTTGTGA
ACACCACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTTCAAGACATAGAAAGAGAGATCCATGCAG
CTCCTCATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTGGCCACTGTACAGCAGAAGCCATCCACTT
CAGGAGTGATACTGTCCATTCGAGAACTGGAGCACAGCTATTTTGAACTGGAGAGCAGTGGCCTGAGGGATGAGATTCGGTATCACTACA
TACACAATGGGAAGCCAAGGACAGAGGCACTTCCTTACCGCATGGCAGATGGACAATGGCACAAGGTTGCACTGTCAGTTAGCGCCTCTC
ATCTCCTGCTCCATGTCGACTGTAACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACCAACCTTCCCCCAGGAATCAATTTATGGC
TTGGCCAGCGCAACCAAAAGCATGGCTTATTCAAACAGGAATAACTCAAGTCACCTGTACTGGAAATCAGTTTGCTGAAATTAATCAACG
ATTCTTGAAGTTGAAGAAAAGTTGTTCTCTCTACAGGAGGTTCCAGCCTTGGCAAGAGGAGTGTGGCCCTTCCTGGAATCCCTCTGGACA
CACCCTCCTAGCATCCTCTAGGAAAGATGCGGCAGCTCAAAGGGAAGCCCAAGAAGGAGACCTCCAAGGACAAGAAGGAGCGGAAGCAAG
CCATGCAGGAGGCCCGGCAGCAGATCACTACAGTGGTGCTGCCCACGCTGGCCGTGGTCGTGCTCTTGATCGTGGTGTTTGTGTACGTGG
CCACGCGCCCCACCATCACCGAGTGAGCCCCGCAGCCGGCTGCGGACCCCATCGGCAGGGAGAGGAGGCGCGGGAGGGGGACGCAAACAA
AAAATGGCTTTCATATTCAGAGATGTTCATGTTGCTGAGCTGTAAGCAGGAGCACCCTGTCTTCTCTGGTCTTTGACTTGATTAAAGTAT
CTCCGCTTTCTTGGGAGGGAATAGGGGATGTTTTATCAGTGAATGTGCCATACACCTTATGGTCCACTTCATGTGCCTTTCAGACTTCAA
AGCGCGCGCGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTTCTTTTTCTCTCCTAAAAATCGATAAGTAGCTCCAC
CTGAAGAGGGATGGAACCTCTGGGTCAGGAAACAGCTGGAATCCACACTCACCTCATTCCCATTGTTTGGATCATGCTTCTTTCCAACAC
GTGTTCACAATCTCCAAAGGGACTGTATTTCTTCTCTGTGCTTAATGTGATTTGAAATATGTTGAATCAAAGTGAAATATTTATTTTTTG

>In-frame_NELL1_ENST00000325319_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_1462nt
AGCACCCGGCGCTGCCGAGCCACCTCCCCCGCCGCCCGCTAGCAAGTTTGGCGGCTCCAAGCCAGGCGCGCCTCAGGATCCAGGCTCATT
TGCTTCCACCTAGCTTCGGTGCCCCCTGCTAGGCGGGGACCCTCGAGAGCGATGCCGATGGATTTGATTTTAGTTGTGTGGTTCTGTGTG
TGCACTGCCAGGACAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATGGATATCGTCACCGAGCTTGACCTTGTGAACACCACCCTT
GGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTTCAAGACATAGAAAGAGAGATCCATGCAGCTCCTCATGTG
AGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTGGCCACTGTACAGCAGAAGCCATCCACTTCAGGAGTGATA
CTGTCCATTCGAGAACTGGAGCACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACCAACCTTCCCCCAGGAATCAATTTATGGCTT
GGCCAGCGCAACCAAAAGCATGGCTTATTCAAACAGGAATAACTCAAGTCACCTGTACTGGAAATCAGTTTGCTGAAATTAATCAACGAT
TCTTGAAGTTGAAGAAAAGTTGTTCTCTCTACAGGAGGTTCCAGCCTTGGCAAGAGGAGTGTGGCCCTTCCTGGAATCCCTCTGGACACA
CCCTCCTAGCATCCTCTAGGAAAGATGCGGCAGCTCAAAGGGAAGCCCAAGAAGGAGACCTCCAAGGACAAGAAGGAGCGGAAGCAAGCC
ATGCAGGAGGCCCGGCAGCAGATCACTACAGTGGTGCTGCCCACGCTGGCCGTGGTCGTGCTCTTGATCGTGGTGTTTGTGTACGTGGCC
ACGCGCCCCACCATCACCGAGTGAGCCCCGCAGCCGGCTGCGGACCCCATCGGCAGGGAGAGGAGGCGCGGGAGGGGGACGCAAACAAAA
AATGGCTTTCATATTCAGAGATGTTCATGTTGCTGAGCTGTAAGCAGGAGCACCCTGTCTTCTCTGGTCTTTGACTTGATTAAAGTATCT
CCGCTTTCTTGGGAGGGAATAGGGGATGTTTTATCAGTGAATGTGCCATACACCTTATGGTCCACTTCATGTGCCTTTCAGACTTCAAAG
CGCGCGCGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTTCTTTTTCTCTCCTAAAAATCGATAAGTAGCTCCACCT
GAAGAGGGATGGAACCTCTGGGTCAGGAAACAGCTGGAATCCACACTCACCTCATTCCCATTGTTTGGATCATGCTTCTTTCCAACACGT
GTTCACAATCTCCAAAGGGACTGTATTTCTTCTCTGTGCTTAATGTGATTTGAAATATGTTGAATCAAAGTGAAATATTTATTTTTTGAA

>In-frame_NELL1_ENST00000532434_chr11_20907086_+_SMCO4_ENST00000525141_chr11_93232514_-_1555nt
TCCAGGCTCATTTGCTTCCACCTAGCTTCGGTGCCCCCTGCTAGGCGGGGACCCTCGAGAGCGATGCCGATGGATTTGATTTTAGTTGTG
TGGTTCTGTGTGTGCACTGCCAGGACAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATGGATATCGTCACCGAGCTTGACCTTGTG
AACACCACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTTCAAGACATAGAAAGAGAGATCCATGCA
GCTCCTCATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTGGCCACTGTACAGCAGAAGCCATCCACT
TCAGGAGTGATACTGTCCATTCGAGAACTGGAGCACAGCTATTTTGAACTGGAGAGCAGTGGCCTGAGGGATGAGATTCGGTATCACTAC
ATACACAATGGGAAGCCAAGGACAGAGGCACTTCCTTACCGCATGGCAGATGGACAATGGCACAAGGTTGCACTGTCAGTTAGCGCCTCT
CATCTCCTGCTCCATGTCGACTGTAACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACCAACCTTCCCCCAGGAATCAATTTATGG
CTTGGCCAGCGCAACCAAAAGCATGGCTTATTCAAACAGGAATAACTCAAGTCACCTGTACTGGAAATCAGTTTGCTGAAATTAATCAAC
GATTCTTGAAGTTGAAGAAAAGTTGTTCTCTCTACAGGAGGTTCCAGCCTTGGCAAGAGGAGTGTGGCCCTTCCTGGAATCCCTCTGGAC
ACACCCTCCTAGCATCCTCTAGGAAAGATGCGGCAGCTCAAAGGGAAGCCCAAGAAGGAGACCTCCAAGGACAAGAAGGAGCGGAAGCAA
GCCATGCAGGAGGCCCGGCAGCAGATCACTACAGTGGTGCTGCCCACGCTGGCCGTGGTCGTGCTCTTGATCGTGGTGTTTGTGTACGTG
GCCACGCGCCCCACCATCACCGAGTGAGCCCCGCAGCCGGCTGCGGACCCCATCGGCAGGGAGAGGAGGCGCGGGAGGGGGACGCAAACA
AAAAATGGCTTTCATATTCAGAGATGTTCATGTTGCTGAGCTGTAAGCAGGAGCACCCTGTCTTCTCTGGTCTTTGACTTGATTAAAGTA
TCTCCGCTTTCTTGGGAGGGAATAGGGGATGTTTTATCAGTGAATGTGCCATACACCTTATGGTCCACTTCATGTGCCTTTCAGACTTCA
AAGCGCGCGCGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTTCTTTTTCTCTCCTAAAAATCGATAAGTAGCTCCA
CCTGAAGAGGGATGGAACCTCTGGGTCAGGAAACAGCTGGAATCCACACTCACCTCATTCCCATTGTTTGGATCATGCTTCTTTCCAACA
CGTGTTCACAATCTCCAAAGGGACTGTATTTCTTCTCTGTGCTTAATGTGATTTGAAATATGTTGAATCAAAGTGAAATATTTATTTTTT


Top

FusionGenePPI for NELL1_SMCO4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NELL1ATXN7, CACNA1A, ATN1, GFI1B, EGFR, MATN2, PFKP, FBXO27, PXDN, ZNF260, TRMT2B, EMILIN2, TP53RK, TIMP3, EGFL7, C4orf48, POLRMT, TYW3, LTBP4, CEP44, FBLN1, LAMB2, OBSL1, C10orf88, CHEK1, TRIM25SMCO4BNIP3L, KRT40, CCDC155, SYNE4, KRTAP10-7, KRTAP10-3, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NELL1_SMCO4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NELL1_SMCO4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNELL1C0010278Craniosynostosis1CTD_human
HgeneNELL1C0041696Unipolar Depression1PSYGENET
HgeneNELL1C0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneNELL1C1269683Major Depressive Disorder1PSYGENET