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Fusion gene ID: 24022 |
FusionGeneSummary for NELFA_POLN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NELFA_POLN | Fusion gene ID: 24022 | Hgene | Tgene | Gene symbol | NELFA | POLN | Gene ID | 7469 | 353497 |
| Gene name | negative elongation factor complex member A | DNA polymerase nu | |
| Synonyms | NELF-A|P/OKcl.15|WHSC2 | POL4P | |
| Cytomap | 4p16.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | negative elongation factor Awolf-Hirschhorn syndrome candidate 2 protein | DNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9H3P2 | Q7Z5Q5 | |
| Ensembl transtripts involved in fusion gene | ENST00000382882, ENST00000411638, ENST00000542778, | ENST00000382865, ENST00000511885, ENST00000515357, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 12 X 7 X 9=756 |
| # samples | 2 | 12 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(12/756*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NELFA [Title/Abstract] AND POLN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | POLN | GO:0019985 | translesion synthesis | 20102227 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A09N-01A | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000382882 | ENST00000382865 | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
| In-frame | ENST00000382882 | ENST00000511885 | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
| 5CDS-5UTR | ENST00000382882 | ENST00000515357 | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
| In-frame | ENST00000411638 | ENST00000382865 | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
| In-frame | ENST00000411638 | ENST00000511885 | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
| 5CDS-5UTR | ENST00000411638 | ENST00000515357 | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
| 5UTR-3CDS | ENST00000542778 | ENST00000382865 | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
| 5UTR-3CDS | ENST00000542778 | ENST00000511885 | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
| 5UTR-5UTR | ENST00000542778 | ENST00000515357 | NELFA | chr4 | 2010477 | - | POLN | chr4 | 2210214 | - |
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FusionProtFeatures for NELFA_POLN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NELFA | POLN |
| Essential component of the NELF complex, a complex thatnegatively regulates the elongation of transcription by RNApolymerase II. The NELF complex, which acts via an associationwith the DSIF complex and causes transcriptional pausing, iscounteracted by the P-TEFb kinase complex. The NELF complex isinvolved in HIV-1 latency possibly involving recruitment of PCF11to paused RNA polymerase II. In vitro, the NELFA:NELFCD subcomplexbinds to ssDNA and ssRNA in a sequence- and structure-dependentmanner. Probably required to interact with the RNA polymerase IIcomplex. {ECO:0000269|PubMed:10199401,ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062,ECO:0000305}. | DNA polymerase with very low fidelity that catalyzesconsiderable misincorporation by inserting dTTP opposite a Gtemplate, and dGTP opposite a T template (PubMed:16787914,PubMed:17118716). Is the least accurate of the DNA polymerase Afamily (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can performaccurate translesion DNA synthesis (TLS) past a 5S-thymine glycol.Can perform efficient strand displacement past a nick or a gap andgives rise to an amount of product similar to that on non-damagedtemplate. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dTregardless of template sequence (PubMed:25775266). May play a rolein TLS during interstrand cross-link (ICL) repair(PubMed:19908865). May be involved in TLS when genomic replicationis blocked by extremely large major groove DNA lesions. Mayfunction in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linkingagents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates inFANCD2-mediated repair. Forms a complex with HELQ helicase thatparticipates in homologous recombination (HR) repair and isessential for cellular protection against DNA cross-links(PubMed:19995904). {ECO:0000269|PubMed:16787914,ECO:0000269|PubMed:17118716, ECO:0000269|PubMed:19908865,ECO:0000269|PubMed:19995904, ECO:0000269|PubMed:20102227,ECO:0000269|PubMed:25775266}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NELFA | chr4:2010477 | chr4:2210214 | ENST00000382882 | - | 1 | 11 | 89_248 | 81 | 540 | Domain | HDAg |
| Hgene | >NELFA | chr4:2010477 | chr4:2210214 | ENST00000411638 | - | 1 | 11 | 89_248 | 70 | 529 | Domain | HDAg |
| Hgene | >NELFA | chr4:2010477 | chr4:2210214 | ENST00000382882 | - | 1 | 11 | 125_188 | 81 | 540 | Region | NELF-C/D-binding |
| Hgene | >NELFA | chr4:2010477 | chr4:2210214 | ENST00000382882 | - | 1 | 11 | 189_248 | 81 | 540 | Region | RNAPII-binding |
| Hgene | >NELFA | chr4:2010477 | chr4:2210214 | ENST00000411638 | - | 1 | 11 | 125_188 | 70 | 529 | Region | NELF-C/D-binding |
| Hgene | >NELFA | chr4:2010477 | chr4:2210214 | ENST00000411638 | - | 1 | 11 | 189_248 | 70 | 529 | Region | RNAPII-binding |
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FusionGeneSequence for NELFA_POLN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NELFA_ENST00000382882_chr4_2010477_-_POLN_ENST00000382865_chr4_2210214_-_911aa MPGQRRALSPKMASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVDEDLKSLRSQT SRGSAKLSPQSFSVRLTDQLSADQKQKSISSLTLSSCLIPQYNQEASVLQKKGHKRKHFLMENINNENKGSINLKRKHITYNNLSEKTSK QMALEEDTDDAEGYLNSGNSGALKKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSSVRGIVVLVKRQAEGGHG CPDAPACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPR IAAWLIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMES HAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPK IILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFL AADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLES FLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQ IHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPGSPASTQPP >In-frame_NELFA_ENST00000382882_chr4_2010477_-_POLN_ENST00000511885_chr4_2210214_-_911aa MPGQRRALSPKMASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVDEDLKSLRSQT SRGSAKLSPQSFSVRLTDQLSADQKQKSISSLTLSSCLIPQYNQEASVLQKKGHKRKHFLMENINNENKGSINLKRKHITYNNLSEKTSK QMALEEDTDDAEGYLNSGNSGALKKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSSVRGIVVLVKRQAEGGHG CPDAPACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPR IAAWLIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMES HAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPK IILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFL AADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLES FLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQ IHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPGSPASTQPP >In-frame_NELFA_ENST00000411638_chr4_2010477_-_POLN_ENST00000382865_chr4_2210214_-_900aa MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVDEDLKSLRSQTSRGSAKLSPQS FSVRLTDQLSADQKQKSISSLTLSSCLIPQYNQEASVLQKKGHKRKHFLMENINNENKGSINLKRKHITYNNLSEKTSKQMALEEDTDDA EGYLNSGNSGALKKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSSVRGIVVLVKRQAEGGHGCPDAPACGPVL EGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAWLIDPSDA TPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEME KTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKI KSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRI LTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDF ARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVED PQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPGSPASTQPPPLHFSPSFCLX >In-frame_NELFA_ENST00000411638_chr4_2010477_-_POLN_ENST00000511885_chr4_2210214_-_900aa MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVDEDLKSLRSQTSRGSAKLSPQS FSVRLTDQLSADQKQKSISSLTLSSCLIPQYNQEASVLQKKGHKRKHFLMENINNENKGSINLKRKHITYNNLSEKTSKQMALEEDTDDA EGYLNSGNSGALKKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSSVRGIVVLVKRQAEGGHGCPDAPACGPVL EGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAWLIDPSDA TPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEME KTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKI KSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRI LTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDF ARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVED PQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPGSPASTQPPPLHFSPSFCLX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NELFA_ENST00000382882_chr4_2010477_-_POLN_ENST00000382865_chr4_2210214_-_2733nt ATGCCGGGGCAGCGGCGCGCGCTTTCCCCCAAGATGGCGTCCATGCGGGAGAGCGACACGGGCCTGTGGCTGCACAACAAGCTGGGGGCC ACGGACGAGCTGTGGGCGCCGCCCAGCATCGCGTCCCTGCTCACGGCCGCGGTCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCG TCGGCAGTGAAGCTCAAGTTGCTACTCGGGACGCTGCACCTCCCGCGCCGCACGGTGGACGAGGATCTTAAATCTTTAAGAAGTCAGACA TCAAGAGGTTCTGCCAAGCTGTCTCCTCAGTCCTTCAGTGTCAGGCTCACAGATCAGCTGTCTGCTGACCAAAAACAGAAGAGCATCAGC TCATTGACTCTTTCAAGTTGTTTAATTCCACAGTATAATCAAGAGGCTTCAGTTCTACAGAAAAAGGGGCATAAAAGAAAGCATTTCCTA ATGGAGAATATAAATAATGAAAATAAAGGAAGCATTAATCTTAAAAGAAAACATATTACATATAATAATTTGTCAGAGAAAACAAGTAAA CAAATGGCATTGGAAGAAGATACTGATGACGCCGAAGGCTACCTAAATTCTGGGAACTCAGGAGCATTGAAAAAACATTTTTGTGATATT AGGCATTTGGATGATTGGGCAAAAAGCCAGCTGATTGAAATGCTCAAACAGGCAGCAGCCCTGGTGATAACTGTGATGTATACTGATGGT TCCACCCAGCTAGGAGCTGACCAGACCCCCGTTTCTTCTGTTAGAGGAATTGTGGTGTTAGTAAAACGCCAAGCAGAGGGTGGCCATGGC TGTCCAGATGCCCCGGCCTGTGGTCCTGTTCTGGAGGGCTTTGTGTCAGATGATCCATGCATCTACATTCAAATAGAGCACTCTGCTATC TGGGACCAAGAACAGGAGGCACATCAACAATTTGCCCGGAACGTGCTATTTCAAACAATGAAATGTAAATGTCCTGTTATTTGTTTTAAT GCTAAGGATTTTGTGAGAATAGTGCTGCAGTTTTTTGGCAATGATGGCAGTTGGAAGCATGTTGCTGATTTTATAGGGCTAGATCCCAGA ATTGCTGCATGGCTTATAGATCCTAGTGATGCCACACCCTCTTTTGAAGATTTAGTAGAAAAATACTGTGAAAAATCCATTACAGTTAAA GTGAACAGCACATATGGAAATTCCTCAAGAAATATTGTGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGAC CTTTGCTCTAAACTGAAGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGC CATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTT GTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGG AACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAG ATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCT ACATGGAATCAGACTGGAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACT ACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTA GCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGA GATGATGTATTTTCTACTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTG GTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGT TTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGC AGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGC TCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAG ATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAG GTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAG GCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCA >In-frame_NELFA_ENST00000382882_chr4_2010477_-_POLN_ENST00000511885_chr4_2210214_-_2733nt ATGCCGGGGCAGCGGCGCGCGCTTTCCCCCAAGATGGCGTCCATGCGGGAGAGCGACACGGGCCTGTGGCTGCACAACAAGCTGGGGGCC ACGGACGAGCTGTGGGCGCCGCCCAGCATCGCGTCCCTGCTCACGGCCGCGGTCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCG TCGGCAGTGAAGCTCAAGTTGCTACTCGGGACGCTGCACCTCCCGCGCCGCACGGTGGACGAGGATCTTAAATCTTTAAGAAGTCAGACA TCAAGAGGTTCTGCCAAGCTGTCTCCTCAGTCCTTCAGTGTCAGGCTCACAGATCAGCTGTCTGCTGACCAAAAACAGAAGAGCATCAGC TCATTGACTCTTTCAAGTTGTTTAATTCCACAGTATAATCAAGAGGCTTCAGTTCTACAGAAAAAGGGGCATAAAAGAAAGCATTTCCTA ATGGAGAATATAAATAATGAAAATAAAGGAAGCATTAATCTTAAAAGAAAACATATTACATATAATAATTTGTCAGAGAAAACAAGTAAA CAAATGGCATTGGAAGAAGATACTGATGACGCCGAAGGCTACCTAAATTCTGGGAACTCAGGAGCATTGAAAAAACATTTTTGTGATATT AGGCATTTGGATGATTGGGCAAAAAGCCAGCTGATTGAAATGCTCAAACAGGCAGCAGCCCTGGTGATAACTGTGATGTATACTGATGGT TCCACCCAGCTAGGAGCTGACCAGACCCCCGTTTCTTCTGTTAGAGGAATTGTGGTGTTAGTAAAACGCCAAGCAGAGGGTGGCCATGGC TGTCCAGATGCCCCGGCCTGTGGTCCTGTTCTGGAGGGCTTTGTGTCAGATGATCCATGCATCTACATTCAAATAGAGCACTCTGCTATC TGGGACCAAGAACAGGAGGCACATCAACAATTTGCCCGGAACGTGCTATTTCAAACAATGAAATGTAAATGTCCTGTTATTTGTTTTAAT GCTAAGGATTTTGTGAGAATAGTGCTGCAGTTTTTTGGCAATGATGGCAGTTGGAAGCATGTTGCTGATTTTATAGGGCTAGATCCCAGA ATTGCTGCATGGCTTATAGATCCTAGTGATGCCACACCCTCTTTTGAAGATTTAGTAGAAAAATACTGTGAAAAATCCATTACAGTTAAA GTGAACAGCACATATGGAAATTCCTCAAGAAATATTGTGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGAC CTTTGCTCTAAACTGAAGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGC CATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTT GTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGG AACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAG ATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCT ACATGGAATCAGACTGGAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACT ACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTA GCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGA GATGATGTATTTTCTACTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTG GTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGT TTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGC AGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGC TCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAG ATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAG GTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAG GCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCA >In-frame_NELFA_ENST00000411638_chr4_2010477_-_POLN_ENST00000382865_chr4_2210214_-_2700nt ATGGCGTCCATGCGGGAGAGCGACACGGGCCTGTGGCTGCACAACAAGCTGGGGGCCACGGACGAGCTGTGGGCGCCGCCCAGCATCGCG TCCCTGCTCACGGCCGCGGTCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCGTCGGCAGTGAAGCTCAAGTTGCTACTCGGGACG CTGCACCTCCCGCGCCGCACGGTGGACGAGGATCTTAAATCTTTAAGAAGTCAGACATCAAGAGGTTCTGCCAAGCTGTCTCCTCAGTCC TTCAGTGTCAGGCTCACAGATCAGCTGTCTGCTGACCAAAAACAGAAGAGCATCAGCTCATTGACTCTTTCAAGTTGTTTAATTCCACAG TATAATCAAGAGGCTTCAGTTCTACAGAAAAAGGGGCATAAAAGAAAGCATTTCCTAATGGAGAATATAAATAATGAAAATAAAGGAAGC ATTAATCTTAAAAGAAAACATATTACATATAATAATTTGTCAGAGAAAACAAGTAAACAAATGGCATTGGAAGAAGATACTGATGACGCC GAAGGCTACCTAAATTCTGGGAACTCAGGAGCATTGAAAAAACATTTTTGTGATATTAGGCATTTGGATGATTGGGCAAAAAGCCAGCTG ATTGAAATGCTCAAACAGGCAGCAGCCCTGGTGATAACTGTGATGTATACTGATGGTTCCACCCAGCTAGGAGCTGACCAGACCCCCGTT TCTTCTGTTAGAGGAATTGTGGTGTTAGTAAAACGCCAAGCAGAGGGTGGCCATGGCTGTCCAGATGCCCCGGCCTGTGGTCCTGTTCTG GAGGGCTTTGTGTCAGATGATCCATGCATCTACATTCAAATAGAGCACTCTGCTATCTGGGACCAAGAACAGGAGGCACATCAACAATTT GCCCGGAACGTGCTATTTCAAACAATGAAATGTAAATGTCCTGTTATTTGTTTTAATGCTAAGGATTTTGTGAGAATAGTGCTGCAGTTT TTTGGCAATGATGGCAGTTGGAAGCATGTTGCTGATTTTATAGGGCTAGATCCCAGAATTGCTGCATGGCTTATAGATCCTAGTGATGCC ACACCCTCTTTTGAAGATTTAGTAGAAAAATACTGTGAAAAATCCATTACAGTTAAAGTGAACAGCACATATGGAAATTCCTCAAGAAAT ATTGTGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGAAGGATTATGGTTTATGG CAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAG AAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAAT AACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATAC CCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATC AAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGA CTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAG ATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATT CTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGG AAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAG CGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTC GCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCAT GACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATC CATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGAT CCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCC CTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACT GAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAG >In-frame_NELFA_ENST00000411638_chr4_2010477_-_POLN_ENST00000511885_chr4_2210214_-_2700nt ATGGCGTCCATGCGGGAGAGCGACACGGGCCTGTGGCTGCACAACAAGCTGGGGGCCACGGACGAGCTGTGGGCGCCGCCCAGCATCGCG TCCCTGCTCACGGCCGCGGTCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCGTCGGCAGTGAAGCTCAAGTTGCTACTCGGGACG CTGCACCTCCCGCGCCGCACGGTGGACGAGGATCTTAAATCTTTAAGAAGTCAGACATCAAGAGGTTCTGCCAAGCTGTCTCCTCAGTCC TTCAGTGTCAGGCTCACAGATCAGCTGTCTGCTGACCAAAAACAGAAGAGCATCAGCTCATTGACTCTTTCAAGTTGTTTAATTCCACAG TATAATCAAGAGGCTTCAGTTCTACAGAAAAAGGGGCATAAAAGAAAGCATTTCCTAATGGAGAATATAAATAATGAAAATAAAGGAAGC ATTAATCTTAAAAGAAAACATATTACATATAATAATTTGTCAGAGAAAACAAGTAAACAAATGGCATTGGAAGAAGATACTGATGACGCC GAAGGCTACCTAAATTCTGGGAACTCAGGAGCATTGAAAAAACATTTTTGTGATATTAGGCATTTGGATGATTGGGCAAAAAGCCAGCTG ATTGAAATGCTCAAACAGGCAGCAGCCCTGGTGATAACTGTGATGTATACTGATGGTTCCACCCAGCTAGGAGCTGACCAGACCCCCGTT TCTTCTGTTAGAGGAATTGTGGTGTTAGTAAAACGCCAAGCAGAGGGTGGCCATGGCTGTCCAGATGCCCCGGCCTGTGGTCCTGTTCTG GAGGGCTTTGTGTCAGATGATCCATGCATCTACATTCAAATAGAGCACTCTGCTATCTGGGACCAAGAACAGGAGGCACATCAACAATTT GCCCGGAACGTGCTATTTCAAACAATGAAATGTAAATGTCCTGTTATTTGTTTTAATGCTAAGGATTTTGTGAGAATAGTGCTGCAGTTT TTTGGCAATGATGGCAGTTGGAAGCATGTTGCTGATTTTATAGGGCTAGATCCCAGAATTGCTGCATGGCTTATAGATCCTAGTGATGCC ACACCCTCTTTTGAAGATTTAGTAGAAAAATACTGTGAAAAATCCATTACAGTTAAAGTGAACAGCACATATGGAAATTCCTCAAGAAAT ATTGTGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGAAGGATTATGGTTTATGG CAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAG AAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAAT AACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATAC CCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATC AAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGA CTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAG ATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATT CTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGG AAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAG CGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTC GCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCAT GACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATC CATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGAT CCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCC CTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACT GAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NELFA_ENST00000382882_chr4_2010477_-_POLN_ENST00000382865_chr4_2210214_-_4047nt GTGACTTCCGCAGGACTGCCAAGTTCAAGCCGCCAGGGCCAGGGCACTGCTAGCAGCTGGGCTGAGCCCTGTTCTCCCGGCGTTCCCACC GCCCAGTGGCAATAGCTGTGAACGGCGGCAGGAGCATGGCAGTGGAACAATAAGGAAAAGATCTTTTAAAAAAAAGATATAATACAGAAG CCAAGCAAGGCGGCCCCGACCTGTAACCCCAGCACTCTGGGAGGCAGAGGCGGGCGGGCGGATCGCTTGAGCCCAGGAGTTTGAGACCAG CCTGGCCAACATAGGAAGGCCTCGTCAAAAAGACAAAAGGGTAAAACGAATTTAATAAAATGAAGTTTAACTTTTACTCATGTTTGTATC TAATGACAAGCTTTTAAAACTGAAAAGTTCACTACTGGCTCCTGCCTGGCGGCTCCAGCCCGACTGGGGGCCGGGGCCTCCCTGCACTGT GGGGTCACGAGTGCCCCTGGACAGCTCCCGAGCGCCCTCCGACCCGCATGCTCAGCGCAGCCCCGTCGGCGGCGCGCCACGGGCAGAGCG GGCTCAGCGGGGGACGGAAGCTCAGCGCTGCGACCGGGATCCCGCAGGCTCGCTCCGCAGGGCCGCGGCTCCTCTCCGTGCAGGTGCTGG GCCCGCGGGGGCGGGGCGTCCACACGGTCCGCGCCGAGACCCAAGCGGGGAAAAAGCGAAGAGCGGACAGCGGGGCAGGTGCCACAGGGA GCCTCCGCCCCACCGCGCGAGCAGCAAGTCTGCGGCGCTTGACACCTGCACTGCGAATGCCAGGCCGCAGCCCGGGCTCCCAAGACGCGA ATACGCGCGCCTGCTCGTGACGTCATTTTTTGCGGTCTTCCCGAGAGCCAGCAGAGGGCGCCGCCATGATGTTTTACGGAAGCCGATAGT CCTTGCTCAGCGGCACCCCGTCCTTCCGGCTCTCGGCTTTGCCACAAAGCTTCCCGAAGACGCGGCCGCTACCCGGAGACGCGGTCGCCA CCCAGAAGCGCTCTCCCGGGAAGCCCCGCTCGTGGGACCGCGCCACCTGCGCCGCCTCTGCGGCCCGCAGCCCGACGGGCGCCGCCATGT TGGGGTCCTAGCGAGGGACGCGTAGGTGTCTTCATAAGATGCCGGGGCAGCGGCGCGCGCTTTCCCCCAAGATGGCGTCCATGCGGGAGA GCGACACGGGCCTGTGGCTGCACAACAAGCTGGGGGCCACGGACGAGCTGTGGGCGCCGCCCAGCATCGCGTCCCTGCTCACGGCCGCGG TCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCGTCGGCAGTGAAGCTCAAGTTGCTACTCGGGACGCTGCACCTCCCGCGCCGCA CGGTGGACGAGGATCTTAAATCTTTAAGAAGTCAGACATCAAGAGGTTCTGCCAAGCTGTCTCCTCAGTCCTTCAGTGTCAGGCTCACAG ATCAGCTGTCTGCTGACCAAAAACAGAAGAGCATCAGCTCATTGACTCTTTCAAGTTGTTTAATTCCACAGTATAATCAAGAGGCTTCAG TTCTACAGAAAAAGGGGCATAAAAGAAAGCATTTCCTAATGGAGAATATAAATAATGAAAATAAAGGAAGCATTAATCTTAAAAGAAAAC ATATTACATATAATAATTTGTCAGAGAAAACAAGTAAACAAATGGCATTGGAAGAAGATACTGATGACGCCGAAGGCTACCTAAATTCTG GGAACTCAGGAGCATTGAAAAAACATTTTTGTGATATTAGGCATTTGGATGATTGGGCAAAAAGCCAGCTGATTGAAATGCTCAAACAGG CAGCAGCCCTGGTGATAACTGTGATGTATACTGATGGTTCCACCCAGCTAGGAGCTGACCAGACCCCCGTTTCTTCTGTTAGAGGAATTG TGGTGTTAGTAAAACGCCAAGCAGAGGGTGGCCATGGCTGTCCAGATGCCCCGGCCTGTGGTCCTGTTCTGGAGGGCTTTGTGTCAGATG ATCCATGCATCTACATTCAAATAGAGCACTCTGCTATCTGGGACCAAGAACAGGAGGCACATCAACAATTTGCCCGGAACGTGCTATTTC AAACAATGAAATGTAAATGTCCTGTTATTTGTTTTAATGCTAAGGATTTTGTGAGAATAGTGCTGCAGTTTTTTGGCAATGATGGCAGTT GGAAGCATGTTGCTGATTTTATAGGGCTAGATCCCAGAATTGCTGCATGGCTTATAGATCCTAGTGATGCCACACCCTCTTTTGAAGATT TAGTAGAAAAATACTGTGAAAAATCCATTACAGTTAAAGTGAACAGCACATATGGAAATTCCTCAAGAAATATTGTGAATCAGAATGTAC GTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGAAGGATTATGGTTTATGGCAACTATTTCGTACTTTGG AGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTG GGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACCAGCTTCGAGAGATCC TCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAG TGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATG GATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTA ATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGA GGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTACACATTTATCTGGAG ATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAAC AGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTG GAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCC AGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCAC AAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGG CTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTG CAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTG CCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCC TGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAG GAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTG >In-frame_NELFA_ENST00000382882_chr4_2010477_-_POLN_ENST00000511885_chr4_2210214_-_4047nt GTGACTTCCGCAGGACTGCCAAGTTCAAGCCGCCAGGGCCAGGGCACTGCTAGCAGCTGGGCTGAGCCCTGTTCTCCCGGCGTTCCCACC GCCCAGTGGCAATAGCTGTGAACGGCGGCAGGAGCATGGCAGTGGAACAATAAGGAAAAGATCTTTTAAAAAAAAGATATAATACAGAAG CCAAGCAAGGCGGCCCCGACCTGTAACCCCAGCACTCTGGGAGGCAGAGGCGGGCGGGCGGATCGCTTGAGCCCAGGAGTTTGAGACCAG CCTGGCCAACATAGGAAGGCCTCGTCAAAAAGACAAAAGGGTAAAACGAATTTAATAAAATGAAGTTTAACTTTTACTCATGTTTGTATC TAATGACAAGCTTTTAAAACTGAAAAGTTCACTACTGGCTCCTGCCTGGCGGCTCCAGCCCGACTGGGGGCCGGGGCCTCCCTGCACTGT GGGGTCACGAGTGCCCCTGGACAGCTCCCGAGCGCCCTCCGACCCGCATGCTCAGCGCAGCCCCGTCGGCGGCGCGCCACGGGCAGAGCG GGCTCAGCGGGGGACGGAAGCTCAGCGCTGCGACCGGGATCCCGCAGGCTCGCTCCGCAGGGCCGCGGCTCCTCTCCGTGCAGGTGCTGG GCCCGCGGGGGCGGGGCGTCCACACGGTCCGCGCCGAGACCCAAGCGGGGAAAAAGCGAAGAGCGGACAGCGGGGCAGGTGCCACAGGGA GCCTCCGCCCCACCGCGCGAGCAGCAAGTCTGCGGCGCTTGACACCTGCACTGCGAATGCCAGGCCGCAGCCCGGGCTCCCAAGACGCGA ATACGCGCGCCTGCTCGTGACGTCATTTTTTGCGGTCTTCCCGAGAGCCAGCAGAGGGCGCCGCCATGATGTTTTACGGAAGCCGATAGT CCTTGCTCAGCGGCACCCCGTCCTTCCGGCTCTCGGCTTTGCCACAAAGCTTCCCGAAGACGCGGCCGCTACCCGGAGACGCGGTCGCCA CCCAGAAGCGCTCTCCCGGGAAGCCCCGCTCGTGGGACCGCGCCACCTGCGCCGCCTCTGCGGCCCGCAGCCCGACGGGCGCCGCCATGT TGGGGTCCTAGCGAGGGACGCGTAGGTGTCTTCATAAGATGCCGGGGCAGCGGCGCGCGCTTTCCCCCAAGATGGCGTCCATGCGGGAGA GCGACACGGGCCTGTGGCTGCACAACAAGCTGGGGGCCACGGACGAGCTGTGGGCGCCGCCCAGCATCGCGTCCCTGCTCACGGCCGCGG TCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCGTCGGCAGTGAAGCTCAAGTTGCTACTCGGGACGCTGCACCTCCCGCGCCGCA CGGTGGACGAGGATCTTAAATCTTTAAGAAGTCAGACATCAAGAGGTTCTGCCAAGCTGTCTCCTCAGTCCTTCAGTGTCAGGCTCACAG ATCAGCTGTCTGCTGACCAAAAACAGAAGAGCATCAGCTCATTGACTCTTTCAAGTTGTTTAATTCCACAGTATAATCAAGAGGCTTCAG TTCTACAGAAAAAGGGGCATAAAAGAAAGCATTTCCTAATGGAGAATATAAATAATGAAAATAAAGGAAGCATTAATCTTAAAAGAAAAC ATATTACATATAATAATTTGTCAGAGAAAACAAGTAAACAAATGGCATTGGAAGAAGATACTGATGACGCCGAAGGCTACCTAAATTCTG GGAACTCAGGAGCATTGAAAAAACATTTTTGTGATATTAGGCATTTGGATGATTGGGCAAAAAGCCAGCTGATTGAAATGCTCAAACAGG CAGCAGCCCTGGTGATAACTGTGATGTATACTGATGGTTCCACCCAGCTAGGAGCTGACCAGACCCCCGTTTCTTCTGTTAGAGGAATTG TGGTGTTAGTAAAACGCCAAGCAGAGGGTGGCCATGGCTGTCCAGATGCCCCGGCCTGTGGTCCTGTTCTGGAGGGCTTTGTGTCAGATG ATCCATGCATCTACATTCAAATAGAGCACTCTGCTATCTGGGACCAAGAACAGGAGGCACATCAACAATTTGCCCGGAACGTGCTATTTC AAACAATGAAATGTAAATGTCCTGTTATTTGTTTTAATGCTAAGGATTTTGTGAGAATAGTGCTGCAGTTTTTTGGCAATGATGGCAGTT GGAAGCATGTTGCTGATTTTATAGGGCTAGATCCCAGAATTGCTGCATGGCTTATAGATCCTAGTGATGCCACACCCTCTTTTGAAGATT TAGTAGAAAAATACTGTGAAAAATCCATTACAGTTAAAGTGAACAGCACATATGGAAATTCCTCAAGAAATATTGTGAATCAGAATGTAC GTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGAAGGATTATGGTTTATGGCAACTATTTCGTACTTTGG AGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTG GGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACCAGCTTCGAGAGATCC TCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAG TGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATG GATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTA ATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGA GGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTACACATTTATCTGGAG ATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAAC AGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTG GAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCC AGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCAC AAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGG CTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTG CAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTG CCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCC TGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAG GAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTG >In-frame_NELFA_ENST00000411638_chr4_2010477_-_POLN_ENST00000382865_chr4_2210214_-_2912nt CGCGCTTTCCCCCAAGATGGCGTCCATGCGGGAGAGCGACACGGGCCTGTGGCTGCACAACAAGCTGGGGGCCACGGACGAGCTGTGGGC GCCGCCCAGCATCGCGTCCCTGCTCACGGCCGCGGTCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCGTCGGCAGTGAAGCTCAA GTTGCTACTCGGGACGCTGCACCTCCCGCGCCGCACGGTGGACGAGGATCTTAAATCTTTAAGAAGTCAGACATCAAGAGGTTCTGCCAA GCTGTCTCCTCAGTCCTTCAGTGTCAGGCTCACAGATCAGCTGTCTGCTGACCAAAAACAGAAGAGCATCAGCTCATTGACTCTTTCAAG TTGTTTAATTCCACAGTATAATCAAGAGGCTTCAGTTCTACAGAAAAAGGGGCATAAAAGAAAGCATTTCCTAATGGAGAATATAAATAA TGAAAATAAAGGAAGCATTAATCTTAAAAGAAAACATATTACATATAATAATTTGTCAGAGAAAACAAGTAAACAAATGGCATTGGAAGA AGATACTGATGACGCCGAAGGCTACCTAAATTCTGGGAACTCAGGAGCATTGAAAAAACATTTTTGTGATATTAGGCATTTGGATGATTG GGCAAAAAGCCAGCTGATTGAAATGCTCAAACAGGCAGCAGCCCTGGTGATAACTGTGATGTATACTGATGGTTCCACCCAGCTAGGAGC TGACCAGACCCCCGTTTCTTCTGTTAGAGGAATTGTGGTGTTAGTAAAACGCCAAGCAGAGGGTGGCCATGGCTGTCCAGATGCCCCGGC CTGTGGTCCTGTTCTGGAGGGCTTTGTGTCAGATGATCCATGCATCTACATTCAAATAGAGCACTCTGCTATCTGGGACCAAGAACAGGA GGCACATCAACAATTTGCCCGGAACGTGCTATTTCAAACAATGAAATGTAAATGTCCTGTTATTTGTTTTAATGCTAAGGATTTTGTGAG AATAGTGCTGCAGTTTTTTGGCAATGATGGCAGTTGGAAGCATGTTGCTGATTTTATAGGGCTAGATCCCAGAATTGCTGCATGGCTTAT AGATCCTAGTGATGCCACACCCTCTTTTGAAGATTTAGTAGAAAAATACTGTGAAAAATCCATTACAGTTAAAGTGAACAGCACATATGG AAATTCCTCAAGAAATATTGTGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGAA GGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAA CAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTT TCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAAC GGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAG GCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGG AACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAA AGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACA GATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTAC TCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTA TGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAA GAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCC AAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTG CAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCT GTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCT GCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCC AGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCC TTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTC TGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTG >In-frame_NELFA_ENST00000411638_chr4_2010477_-_POLN_ENST00000511885_chr4_2210214_-_2912nt CGCGCTTTCCCCCAAGATGGCGTCCATGCGGGAGAGCGACACGGGCCTGTGGCTGCACAACAAGCTGGGGGCCACGGACGAGCTGTGGGC GCCGCCCAGCATCGCGTCCCTGCTCACGGCCGCGGTCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCGTCGGCAGTGAAGCTCAA GTTGCTACTCGGGACGCTGCACCTCCCGCGCCGCACGGTGGACGAGGATCTTAAATCTTTAAGAAGTCAGACATCAAGAGGTTCTGCCAA GCTGTCTCCTCAGTCCTTCAGTGTCAGGCTCACAGATCAGCTGTCTGCTGACCAAAAACAGAAGAGCATCAGCTCATTGACTCTTTCAAG TTGTTTAATTCCACAGTATAATCAAGAGGCTTCAGTTCTACAGAAAAAGGGGCATAAAAGAAAGCATTTCCTAATGGAGAATATAAATAA TGAAAATAAAGGAAGCATTAATCTTAAAAGAAAACATATTACATATAATAATTTGTCAGAGAAAACAAGTAAACAAATGGCATTGGAAGA AGATACTGATGACGCCGAAGGCTACCTAAATTCTGGGAACTCAGGAGCATTGAAAAAACATTTTTGTGATATTAGGCATTTGGATGATTG GGCAAAAAGCCAGCTGATTGAAATGCTCAAACAGGCAGCAGCCCTGGTGATAACTGTGATGTATACTGATGGTTCCACCCAGCTAGGAGC TGACCAGACCCCCGTTTCTTCTGTTAGAGGAATTGTGGTGTTAGTAAAACGCCAAGCAGAGGGTGGCCATGGCTGTCCAGATGCCCCGGC CTGTGGTCCTGTTCTGGAGGGCTTTGTGTCAGATGATCCATGCATCTACATTCAAATAGAGCACTCTGCTATCTGGGACCAAGAACAGGA GGCACATCAACAATTTGCCCGGAACGTGCTATTTCAAACAATGAAATGTAAATGTCCTGTTATTTGTTTTAATGCTAAGGATTTTGTGAG AATAGTGCTGCAGTTTTTTGGCAATGATGGCAGTTGGAAGCATGTTGCTGATTTTATAGGGCTAGATCCCAGAATTGCTGCATGGCTTAT AGATCCTAGTGATGCCACACCCTCTTTTGAAGATTTAGTAGAAAAATACTGTGAAAAATCCATTACAGTTAAAGTGAACAGCACATATGG AAATTCCTCAAGAAATATTGTGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGAA GGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAA CAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTT TCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAAC GGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAG GCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGG AACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAA AGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACA GATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTAC TCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTA TGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAA GAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCC AAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTG CAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCT GTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCT GCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCC AGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCC TTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTC TGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTG |
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FusionGenePPI for NELFA_POLN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NELFA | NELFE, NELFB, NELFCD, POLR2A, TCEA2, ATP1A1, APP, POLR2C, YWHAB, HECW2, SIAH1, PRR22, NXF1, NTRK1, POLR2B, SUPT5H, NCBP1, ATL2, INTS12, WIBG, FEZ1, PROSER2, MCM9, IGHMBP2, TMOD4 | POLN | ATR, FANCD2, POLDIP2, FANCA, FANCG, PCNA, FANCI, RAD51, HELQ, RAD18, BRCA1, BARD1, PALB2, BRCA2, BRIP1, RBBP8 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NELFA_POLN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NELFA_POLN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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