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Fusion gene ID: 24021 |
FusionGeneSummary for NEK9_TMED10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEK9_TMED10 | Fusion gene ID: 24021 | Hgene | Tgene | Gene symbol | NEK9 | TMED10 | Gene ID | 91754 | 10972 |
| Gene name | NIMA related kinase 9 | transmembrane p24 trafficking protein 10 | |
| Synonyms | APUG|LCCS10|NC|NERCC|NERCC1 | P24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1 | |
| Cytomap | 14q24.3 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase Nek9NIMA (never in mitosis gene a)- related kinase 9nercc1 kinasenimA-related protein kinase 9 | transmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q8TD19 | P49755 | |
| Ensembl transtripts involved in fusion gene | ENST00000238616, ENST00000555763, | ENST00000303575, ENST00000557670, | |
| Fusion gene scores | * DoF score | 2 X 5 X 2=20 | 6 X 4 X 4=96 |
| # samples | 5 | 6 | |
| ** MAII score | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEK9 [Title/Abstract] AND TMED10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TMED10 | GO:0006886 | intracellular protein transport | 20427317 |
| Tgene | TMED10 | GO:0035964 | COPI-coated vesicle budding | 10052452 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-B6-A0RT-01A | NEK9 | chr14 | 75593406 | - | TMED10 | chr14 | 75602589 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000238616 | ENST00000303575 | NEK9 | chr14 | 75593406 | - | TMED10 | chr14 | 75602589 | - |
| 5CDS-5UTR | ENST00000238616 | ENST00000557670 | NEK9 | chr14 | 75593406 | - | TMED10 | chr14 | 75602589 | - |
| intron-3CDS | ENST00000555763 | ENST00000303575 | NEK9 | chr14 | 75593406 | - | TMED10 | chr14 | 75602589 | - |
| intron-5UTR | ENST00000555763 | ENST00000557670 | NEK9 | chr14 | 75593406 | - | TMED10 | chr14 | 75602589 | - |
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FusionProtFeatures for NEK9_TMED10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEK9 | TMED10 |
| Pleiotropic regulator of mitotic progression,participating in the control of spindle dynamics and chromosomeseparation. Phosphorylates different histones, myelin basicprotein, beta-casein, and BICD2. Phosphorylates histone H3 onserine and threonine residues and beta-casein on serine residues.Important for G1/S transition and S phase progression.Phosphorylates NEK6 and NEK7 and stimulates their activity byreleasing the autoinhibitory functions of Tyr-108 and Tyr-97respectively. {ECO:0000269|PubMed:12840024,ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817}. | Involved in vesicular protein trafficking. Mainlyfunctions in the early secretory pathway. Thought to act as cargoreceptor at the lumenal side for incorporation of secretory cargomolecules into transport vesicles and to be involved in vesiclecoat formation at the cytoplasmic side. In COPII vesicle-mediatedanterograde transport involved in the transport of GPI-anchoredproteins and proposed to act together with TMED2 as their cargoreceptor; the function specifically implies SEC24C and SEC24D ofthe COPII vesicle coat and lipid raft-like microdomains of the ER.Recognizes GPI anchors structural remodeled in the ER by PGAP1 andMPPE1 (By similarity). In COPI vesicle-mediated retrogradetransport involved in the biogenesis of COPI vesicles and vesiclecoat recruitment. On Golgi membranes, acts as primary receptor forARF1-GDP which is involved in COPI-vesicle formation. Increasescoatomer-dependent GTPase-activating activity of ARFGAP2. Involvedin trafficking of G protein-coupled receptors (GPCRs). RegulatesF2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to theplasma membrane thus contributing to receptor resensitization.Involved in trafficking of amyloid beta A4 protein and solubleAPP-beta release (independent of modulation of gamma-secretaseactivity). As part of the presenilin-dependent gamma-secretasecomplex regulates gamma-cleavages of the amyloid beta A4 proteinto yield amyloid-beta 40 (Abeta40). Involved in organization ofthe Golgi apparatus. {ECO:0000250, ECO:0000269|PubMed:10052452,ECO:0000269|PubMed:11726511, ECO:0000269|PubMed:16641999,ECO:0000269|PubMed:17288597, ECO:0000269|PubMed:19296914,ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 58_66 | 73 | 980 | Nucleotide binding | ATP |
| Tgene | >TMED10 | chr14:75593406 | chr14:75602589 | ENST00000303575 | - | 2 | 5 | 211_219 | 137 | 220 | Motif | Note=COPI vesicle coat-binding |
| Tgene | >TMED10 | chr14:75593406 | chr14:75602589 | ENST00000303575 | - | 2 | 5 | 147_178 | 137 | 220 | Region | Note=Required for TMED10 and TMED2 cis-Golgi network localization |
| Tgene | >TMED10 | chr14:75593406 | chr14:75602589 | ENST00000303575 | - | 2 | 5 | 186_206 | 137 | 220 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 892_939 | 73 | 980 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 752_760 | 73 | 980 | Compositional bias | Note=Poly-Gly |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 765_888 | 73 | 980 | Compositional bias | Note=Pro/Ser/Thr-rich |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 52_308 | 73 | 980 | Domain | Protein kinase |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 388_444 | 73 | 980 | Repeat | Note=RCC1 1 |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 445_498 | 73 | 980 | Repeat | Note=RCC1 2 |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 499_550 | 73 | 980 | Repeat | Note=RCC1 3 |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 551_615 | 73 | 980 | Repeat | Note=RCC1 4 |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 616_668 | 73 | 980 | Repeat | Note=RCC1 5 |
| Hgene | >NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 669_726 | 73 | 980 | Repeat | Note=RCC1 6 |
| Tgene | TMED10 | chr14:75593406 | chr14:75602589 | ENST00000303575 | - | 2 | 5 | 41_193 | 137 | 220 | Domain | GOLD |
| Tgene | TMED10 | chr14:75593406 | chr14:75602589 | ENST00000303575 | - | 2 | 5 | 32_185 | 137 | 220 | Topological domain | Lumenal |
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FusionGeneSequence for NEK9_TMED10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NEK9_TMED10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEK9 | NEK6, GABARAPL2, SSRP1, NEK7, RAN, GABARAPL1, DYNLL1, CHEK1, NSMAF, MYC, HSP90AA1, CAP1, SPDL1, MCM5, REPIN1, MDM2, HUWE1, MAFF, NTRK1, CSN2, NEK8, BICD2, MED4, XPO1, BAG3, TUBA1C, ATOH1, RNF19B, DYNLL2 | TMED10 | GORASP2, RYK, CDK2, COPA, COPB1, COPB2, COPG1, ARCN1, COPE, COPZ1, TMED9, SEC22B, VAMP2, PTRF, NIT2, S100A16, PRDX6, EIF3C, VCP, ATF2, SEC23B, UBL4A, DHODH, FBXO6, ASB8, RNF2, TMED1, GOLGB1, TMED4, TMED2, TMED7, TMED3, TMED5, EMC7, EPHX1, LMAN1, LMAN2, NAGLU, KRAS, COPG2, TCTN1, RAB5C, CDKN2AIP, RAB1A, TSSC1, LIPG, FGF3, PTPRO, COX15, HSD17B10, PDHA1, SDHA, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | TMED10 | chr14:75593406 | chr14:75602589 | ENST00000303575 | - | 2 | 5 | 207_219 | 137 | 220 | ARF1 |
| Tgene | TMED10 | chr14:75593406 | chr14:75602589 | ENST00000303575 | - | 2 | 5 | 204_219 | 137 | 220 | COPG1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NEK9 | chr14:75593406 | chr14:75602589 | ENST00000238616 | - | 1 | 22 | 732_891 | 73 | 980 | NEK6 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEK9_TMED10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEK9_TMED10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NEK9 | C3280309 | ARTHROGRYPOSIS, PERTHES DISEASE, AND UPWARD GAZE PALSY | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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