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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24016

FusionGeneSummary for NEK7_INTS7

check button Fusion gene summary
Fusion gene informationFusion gene name: NEK7_INTS7
Fusion gene ID: 24016
HgeneTgene
Gene symbol

NEK7

INTS7

Gene ID

140609

25896

Gene nameNIMA related kinase 7integrator complex subunit 7
Synonyms-C1orf73|INT7
Cytomap

1q31.3

1q32.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Nek7NIMA (never in mitosis gene a)-related kinase 7never in mitosis A-related kinase 7nimA-related protein kinase 7integrator complex subunit 7
Modification date2018052220180523
UniProtAcc

Q8TDX7

Q9NVH2

Ensembl transtripts involved in fusion geneENST00000367385, ENST00000538004, 
ENST00000367383, ENST00000417895, 
ENST00000469606, ENST00000366994, 
ENST00000366993, ENST00000366992, 
ENST00000440600, 
Fusion gene scores* DoF score8 X 4 X 6=1925 X 5 X 5=125
# samples 86
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEK7 [Title/Abstract] AND INTS7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEK7

GO:0006468

protein phosphorylation

12840024

TgeneINTS7

GO:0016180

snRNA processing

16239144

TgeneINTS7

GO:0071479

cellular response to ionizing radiation

21659603


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-OK-A5Q2-01ANEK7chr1

198233365

+INTS7chr1

212115453

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000367385ENST00000469606NEK7chr1

198233365

+INTS7chr1

212115453

-
5CDS-5UTRENST00000367385ENST00000366994NEK7chr1

198233365

+INTS7chr1

212115453

-
5CDS-5UTRENST00000367385ENST00000366993NEK7chr1

198233365

+INTS7chr1

212115453

-
5CDS-5UTRENST00000367385ENST00000366992NEK7chr1

198233365

+INTS7chr1

212115453

-
5CDS-5UTRENST00000367385ENST00000440600NEK7chr1

198233365

+INTS7chr1

212115453

-
5CDS-5UTRENST00000538004ENST00000469606NEK7chr1

198233365

+INTS7chr1

212115453

-
5CDS-5UTRENST00000538004ENST00000366994NEK7chr1

198233365

+INTS7chr1

212115453

-
5CDS-5UTRENST00000538004ENST00000366993NEK7chr1

198233365

+INTS7chr1

212115453

-
5CDS-5UTRENST00000538004ENST00000366992NEK7chr1

198233365

+INTS7chr1

212115453

-
5CDS-5UTRENST00000538004ENST00000440600NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000367383ENST00000469606NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000367383ENST00000366994NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000367383ENST00000366993NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000367383ENST00000366992NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000367383ENST00000440600NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000417895ENST00000469606NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000417895ENST00000366994NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000417895ENST00000366993NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000417895ENST00000366992NEK7chr1

198233365

+INTS7chr1

212115453

-
intron-5UTRENST00000417895ENST00000440600NEK7chr1

198233365

+INTS7chr1

212115453

-

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FusionProtFeatures for NEK7_INTS7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEK7

Q8TDX7

INTS7

Q9NVH2

Protein kinase which plays an important role in mitoticcell cycle progression. Required for microtubule nucleationactivity of the centrosome, robust mitotic spindle formation andcytokinesis. Phosphorylates RPS6KB1. {ECO:0000269|PubMed:17101132,ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEK7_INTS7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEK7_INTS7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEK7NEK6, NEK9, TNF, NFATC1, LAMP3, ZNF669, ZNF214, PCDHGB1, IL13RA2, P4HA2, SLC39A9, ZNF331, DPH3, LLGL2, GPR107, ZNF556, PTPN21, ANKS3, ANKS6, SCYL1, P4HB, RREB1, EML4, CBS, NEK8, DYNLL1, PLK1, WDR19, IFT122, WDR35, TRIM25, TERF1, NEK7INTS7RPAP2, INTS1, INTS3, INTS5, INTS6, SHFM1, INTS10, CTDP1, INTS2, INTS8, PAXIP1, SOX2, DCP2, SSBP1, HLA-DPA1, SPACA1, NRG1, SLAMF1, DLK1, TMEFF1, PRKCSH, VSIG4, FNDC4, FAF2, C7orf26, CPSF3L, ASUN, FGD1, HNRNPD, PML, RALA, BUB3, VPS26A, CKAP5, SYNCRIP, KIF1C, GOLT1B, ANLN, ACTR5, SCN3B, VSIG1, CD79B, PDCD1, TOR1AIP2, CLEC14A, PMEL, NTRK3, MGRN1, TNFRSF17, IL13RA2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEK7_INTS7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEK7_INTS7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEK7C0043094Weight Gain1CTD_human