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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 24008

FusionGeneSummary for NEK4_SETD2

check button Fusion gene summary
Fusion gene informationFusion gene name: NEK4_SETD2
Fusion gene ID: 24008
HgeneTgene
Gene symbol

NEK4

SETD2

Gene ID

6787

29072

Gene nameNIMA related kinase 4SET domain containing 2
SynonymsNRK2|STK2|pp12301HBP231|HIF-1|HIP-1|HSPC069|HYPB|KMT3A|LLS|SET2|p231HBP
Cytomap

3p21.1

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Nek4NIMA (never in mitosis gene a)-related kinase 4never in mitosis A-related kinase 4nimA-related protein kinase 4serine/threonine kinase 2serine/threonine protein kinase-2serine/threonine-protein kinase NRK2serine/histone-lysine N-methyltransferase SETD2huntingtin interacting protein 1huntingtin yeast partner Bhuntingtin-interacting protein Blysine N-methyltransferase 3Aprotein-lysine N-methyltransferase SETD2
Modification date2018052320180519
UniProtAcc

P51957

Q9BYW2

Ensembl transtripts involved in fusion geneENST00000233027, ENST00000535191, 
ENST00000383721, 
ENST00000409792, 
ENST00000492397, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 6=216
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/216*10)=-1.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEK4 [Title/Abstract] AND SETD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSETD2

GO:0010569

regulation of double-strand break repair via homologous recombination

24843002

TgeneSETD2

GO:0018023

peptidyl-lysine trimethylation

27518565

TgeneSETD2

GO:0018026

peptidyl-lysine monomethylation

28753426

TgeneSETD2

GO:0032465

regulation of cytokinesis

27518565

TgeneSETD2

GO:0032727

positive regulation of interferon-alpha production

28753426

TgeneSETD2

GO:0034340

response to type I interferon

28753426

TgeneSETD2

GO:0051607

defense response to virus

28753426

TgeneSETD2

GO:0097198

histone H3-K36 trimethylation

23043551|24843002|26002201|27474439|28753426

TgeneSETD2

GO:0097676

histone H3-K36 dimethylation

26002201

TgeneSETD2

GO:1902850

microtubule cytoskeleton organization involved in mitosis

27518565

TgeneSETD2

GO:1905634

regulation of protein localization to chromatin

24843002


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A1AF-01ANEK4chr3

52771602

-SETD2chr3

47108608

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000233027ENST00000409792NEK4chr3

52771602

-SETD2chr3

47108608

-
5CDS-5UTRENST00000233027ENST00000492397NEK4chr3

52771602

-SETD2chr3

47108608

-
In-frameENST00000535191ENST00000409792NEK4chr3

52771602

-SETD2chr3

47108608

-
5CDS-5UTRENST00000535191ENST00000492397NEK4chr3

52771602

-SETD2chr3

47108608

-
intron-3CDSENST00000383721ENST00000409792NEK4chr3

52771602

-SETD2chr3

47108608

-
intron-5UTRENST00000383721ENST00000492397NEK4chr3

52771602

-SETD2chr3

47108608

-

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FusionProtFeatures for NEK4_SETD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEK4

P51957

SETD2

Q9BYW2

Protein kinase that seems to act exclusively uponthreonine residues (By similarity). Required for normal entry intoproliferative arrest after a limited number of cell divisions,also called replicative senescence. Required for normal cell cyclearrest in response to double-stranded DNA damage.{ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEK4chr3:52771602chr3:47108608ENST00000233027-15166_261811842DomainProtein kinase
HgeneNEK4chr3:52771602chr3:47108608ENST00000535191-14156_261722753DomainProtein kinase
HgeneNEK4chr3:52771602chr3:47108608ENST00000233027-151612_20811842Nucleotide bindingATP
HgeneNEK4chr3:52771602chr3:47108608ENST00000535191-141512_20722753Nucleotide bindingATP
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11212117_214620202565Coiled coilOntology_term=ECO:0000255
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11212149_223220202565Compositional biasNote=Pro-rich
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11212266_236520202565Compositional biasNote=Gln-rich
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11212389_242220202565DomainWW
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11212137_236620202565RegionLow charge region

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEK4chr3:52771602chr3:47108608ENST00000383721-1146_261-65782DomainProtein kinase
HgeneNEK4chr3:52771602chr3:47108608ENST00000383721-11412_20-65782Nucleotide bindingATP
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-1121166_24720202565Compositional biasNote=Pro-rich
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-1121385_45620202565Compositional biasNote=Arg-rich
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11211494_154820202565DomainAWS
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11211550_166720202565DomainSET
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11211674_169020202565DomainPost-SET
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11211560_156220202565RegionS-adenosyl-L-methionine binding
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11211603_160520202565RegionS-adenosyl-L-methionine binding
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11211628_162920202565RegionS-adenosyl-L-methionine binding


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FusionGeneSequence for NEK4_SETD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NEK4_ENST00000233027_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_1356aa
MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGD
LYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN
KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLE
ATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA
TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKE
QKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR
REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSS
SGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS
KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDR
EEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTSKKKVR
IKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCS
PAPYDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSVSVQQQYSPA
QSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLP
PPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTAEADTSSELAKK
SKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKE

>In-frame_NEK4_ENST00000535191_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_1267aa
MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFS
NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFL
EATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTEL
ATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIK
EQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQK
RREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMS
SSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLD
SKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFD
REEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTSKKKV
RIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVC
SPAPYDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSVSVQQQYSP
AQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDL
PPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTAEADTSSELAK
KSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NEK4_ENST00000233027_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_4068nt
ATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTGACGCTTGTGAAGCACCGGCGGGACGGCAAG
CAGTATGTCATCAAAAAACTGAACCTCCGAAATGCCTCTAGCCGAGAGCGGCGAGCTGCTGAACAGGAAGCCCAGCTCTTGTCTCAGTTG
AAGCATCCCAACATTGTCACCTACAAGGAGTCATGGGAAGGAGGAGATGGTCTGCTCTACATTGTCATGGGCTTCTGTGAAGGAGGTGAT
TTGTACCGAAAGCTCAAGGAGCAGAAAGGGCAGCTTCTGCCTGAGAATCAGGTGGTAGAGTGGTTTGTACAGATCGCCATGGCTTTGCAG
TATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACAAGAACAAACATCATCAAAGTAGGGGACCTA
GGAATTGCCCGAGTGTTAGAGAACCACTGTGACATGGCTAGCACCCTCATTGGCACACCCTACTACATGAGCCCTGAATTGTTCTCAAAC
AAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCCACCTTGAAGCATGCTTTCAATGCAAAAGAT
ATGAATTCTTTAGTTTATCGGATTATTGAAGGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAGAGCTGGCAGAACTGATAAGAACA
ATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTATATAAAGCGGCAAATCTCCTTCTTTTTGGAG
GCCACAAAGATAAAAACCTCCAAAAATAACATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTACAGTGGTTTCTGGAGAGGCAGAA
TCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATAATGGGTGAAGGCAAATGTTTGTCCCAGGAG
AAACCCAGGGCCTCTGGTCTCTTGAAGTCACCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACTTGAGCAATACCACAGAACTAGCC
ACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGATGGCTTTGTTCAGGAGAATCAGCCAAGATAT
TTGGATGCCTCTAATGAGTTAGGAGGTATATGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGGACAACACTAAATCCAGTGCCCAG
CCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCAGTGAAGCCTCTGCAGCCCCTAATCAAAGAA
CAAAAGCCAAAGGACCAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTCACAGCAACCTCCGCCTCCTGGGT
TCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCCAGGATCAAGTTGCTGGTGAATGTATT
ATAGAAAAACAGGGCAGAATCCACCCAGATTTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGTCTCGACAGCGACGGCAAAAGAGG
AGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTCCAAGAGTCGCCTCCTCGATTTTTGCCTTCT
CATCCCATTGTTGGGAAAGTGGATGTCACATCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGGTCACTGGGTCTGTGAGCAGTTCA
AGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGACTAAAGCAGTCACAGGAAGAAATGTCCTCT
TCAGGCCCTTCAGTGAGGAAAGCGTCTCTGAGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACCAGCCCTTGCCTGCCCGACGGCTC
TCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAGTTAAGTTCTTCTACAAGTTCAACTGATAAG
TCAGATGGGGATTACGGGGAAGGGAAAGGTCAGACAAATGAAATTAATGCCTTGGTACAATTGATGACTCAGACCCTGAAACTGGATTCT
AAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGGAAATATCGGGACACACTGATACTTCATGGG
AAGGTTGCAGAAGAGGCAGAGGAAATCCATTTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTGAAAAGATCAGGAGACTAGTTGAA
GTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGATCTTTTGGAGGAGGAGGATGAATTTGATAGA
GAGGAGGTATATCGAATTCCAAAGAAAAGTCAAACTGAAAAGGAAAACACAACAACTGAACGAGGAAGGGATGCTGTTGGCTTCAGAGAT
CAAACACCTGCCCCGAAGACTCCTAATAGGTCAAGAGAGAGAGACCCAGACAAGCAAACTCAAAATAAAGAGAAAAGGAAACGAAGAAGC
TCCCTCTCACCACCCTCTTCTGCCTATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACACCAACTTCTAAAAAGAAAGTACGA
ATTAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAACGGGAGGCTCAGAAACAACAGCAA
CAGATGCAGAACCTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATCATCCCTTTGCTGGTTACCCACCA
GGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCCCACACCCAGCATGGACCCAGTGTGTTCT
CCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCTACAGAACCCCTTTCTGCCCCTCCACCAGTACCAGTGGTGCCACATGTG
GCAGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACTCCAGCGTTGCTGTCTTGCCAGTG
CCGGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTGTACAGCAGCAGTACTCTCCTGCA
CAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCACCTTATTCACAGACAACTCCACCAATT
GTACAGAGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGGCAACAGATTTTCACAGCTCATCCACAAGGAGTGGTGGTACAGCCAGCC
GCAGCAGTGACTACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGACAAATAATCTCTTGGATCTGCCG
CCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGATCCAGAAGGGAAGATTTATTACTACCAT
GTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCCTTGAGCATGAAGCTGAGATGGACCTG
GGAACTCCAACATATGATGAAAACCCCATGAAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAA
AGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATT
ACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGAC
CTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAG

>In-frame_NEK4_ENST00000535191_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_3801nt
ATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTGACGCTTGTGAAGCACCGGCGGGACGGCAAG
CAGTATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACAAGAACAAACATCATCAAAGTAGGGGAC
CTAGGAATTGCCCGAGTGTTAGAGAACCACTGTGACATGGCTAGCACCCTCATTGGCACACCCTACTACATGAGCCCTGAATTGTTCTCA
AACAAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCCACCTTGAAGCATGCTTTCAATGCAAAA
GATATGAATTCTTTAGTTTATCGGATTATTGAAGGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAGAGCTGGCAGAACTGATAAGA
ACAATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTATATAAAGCGGCAAATCTCCTTCTTTTTG
GAGGCCACAAAGATAAAAACCTCCAAAAATAACATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTACAGTGGTTTCTGGAGAGGCA
GAATCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATAATGGGTGAAGGCAAATGTTTGTCCCAG
GAGAAACCCAGGGCCTCTGGTCTCTTGAAGTCACCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACTTGAGCAATACCACAGAACTA
GCCACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGATGGCTTTGTTCAGGAGAATCAGCCAAGA
TATTTGGATGCCTCTAATGAGTTAGGAGGTATATGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGGACAACACTAAATCCAGTGCC
CAGCCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCAGTGAAGCCTCTGCAGCCCCTAATCAAA
GAACAAAAGCCAAAGGACCAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTCACAGCAACCTCCGCCTCCTG
GGTTCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCCAGGATCAAGTTGCTGGTGAATGT
ATTATAGAAAAACAGGGCAGAATCCACCCAGATTTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGTCTCGACAGCGACGGCAAAAG
AGGAGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTCCAAGAGTCGCCTCCTCGATTTTTGCCT
TCTCATCCCATTGTTGGGAAAGTGGATGTCACATCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGGTCACTGGGTCTGTGAGCAGT
TCAAGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGACTAAAGCAGTCACAGGAAGAAATGTCC
TCTTCAGGCCCTTCAGTGAGGAAAGCGTCTCTGAGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACCAGCCCTTGCCTGCCCGACGG
CTCTCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAGTTAAGTTCTTCTACAAGTTCAACTGAT
AAGTCAGATGGGGATTACGGGGAAGGGAAAGGTCAGACAAATGAAATTAATGCCTTGGTACAATTGATGACTCAGACCCTGAAACTGGAT
TCTAAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGGAAATATCGGGACACACTGATACTTCAT
GGGAAGGTTGCAGAAGAGGCAGAGGAAATCCATTTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTGAAAAGATCAGGAGACTAGTT
GAAGTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGATCTTTTGGAGGAGGAGGATGAATTTGAT
AGAGAGGAGGTATATCGAATTCCAAAGAAAAGTCAAACTGAAAAGGAAAACACAACAACTGAACGAGGAAGGGATGCTGTTGGCTTCAGA
GATCAAACACCTGCCCCGAAGACTCCTAATAGGTCAAGAGAGAGAGACCCAGACAAGCAAACTCAAAATAAAGAGAAAAGGAAACGAAGA
AGCTCCCTCTCACCACCCTCTTCTGCCTATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACACCAACTTCTAAAAAGAAAGTA
CGAATTAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAACGGGAGGCTCAGAAACAACAG
CAACAGATGCAGAACCTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATCATCCCTTTGCTGGTTACCCA
CCAGGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCCCACACCCAGCATGGACCCAGTGTGT
TCTCCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCTACAGAACCCCTTTCTGCCCCTCCACCAGTACCAGTGGTGCCACAT
GTGGCAGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACTCCAGCGTTGCTGTCTTGCCA
GTGCCGGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTGTACAGCAGCAGTACTCTCCT
GCACAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCACCTTATTCACAGACAACTCCACCA
ATTGTACAGAGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGGCAACAGATTTTCACAGCTCATCCACAAGGAGTGGTGGTACAGCCA
GCCGCAGCAGTGACTACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGACAAATAATCTCTTGGATCTG
CCGCCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGATCCAGAAGGGAAGATTTATTACTAC
CATGTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCCTTGAGCATGAAGCTGAGATGGAC
CTGGGAACTCCAACATATGATGAAAACCCCATGAAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAG
AAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGA
ATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAG
GACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_NEK4_ENST00000233027_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_4675nt
AGCATGCGCAGAACTGCTCCCGGCCCGGATCGCTATGGCAGCGGCGTCGTCGCGGGCCGGGCCCCAGCAATCCCGCCCGGGCCCGGCTGC
CTCAACAGCCGCCCCCACTGCCCCCTCTCGGGCATGAACCGAGCTTCTTGTTGCCGCCCGCTGCCCTACCCGCCGCTGCCGCCGCATCCC
GACTCTGGGCCAGCGCTGGGAACATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTGACGCTTG
TGAAGCACCGGCGGGACGGCAAGCAGTATGTCATCAAAAAACTGAACCTCCGAAATGCCTCTAGCCGAGAGCGGCGAGCTGCTGAACAGG
AAGCCCAGCTCTTGTCTCAGTTGAAGCATCCCAACATTGTCACCTACAAGGAGTCATGGGAAGGAGGAGATGGTCTGCTCTACATTGTCA
TGGGCTTCTGTGAAGGAGGTGATTTGTACCGAAAGCTCAAGGAGCAGAAAGGGCAGCTTCTGCCTGAGAATCAGGTGGTAGAGTGGTTTG
TACAGATCGCCATGGCTTTGCAGTATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACAAGAACAA
ACATCATCAAAGTAGGGGACCTAGGAATTGCCCGAGTGTTAGAGAACCACTGTGACATGGCTAGCACCCTCATTGGCACACCCTACTACA
TGAGCCCTGAATTGTTCTCAAACAAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCCACCTTGA
AGCATGCTTTCAATGCAAAAGATATGAATTCTTTAGTTTATCGGATTATTGAAGGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAG
AGCTGGCAGAACTGATAAGAACAATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTATATAAAGC
GGCAAATCTCCTTCTTTTTGGAGGCCACAAAGATAAAAACCTCCAAAAATAACATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTA
CAGTGGTTTCTGGAGAGGCAGAATCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATAATGGGTG
AAGGCAAATGTTTGTCCCAGGAGAAACCCAGGGCCTCTGGTCTCTTGAAGTCACCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACT
TGAGCAATACCACAGAACTAGCCACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGATGGCTTTG
TTCAGGAGAATCAGCCAAGATATTTGGATGCCTCTAATGAGTTAGGAGGTATATGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGG
ACAACACTAAATCCAGTGCCCAGCCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCAGTGAAGC
CTCTGCAGCCCCTAATCAAAGAACAAAAGCCAAAGGACCAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTC
ACAGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCCAGG
ATCAAGTTGCTGGTGAATGTATTATAGAAAAACAGGGCAGAATCCACCCAGATTTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGT
CTCGACAGCGACGGCAAAAGAGGAGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTCCAAGAGT
CGCCTCCTCGATTTTTGCCTTCTCATCCCATTGTTGGGAAAGTGGATGTCACATCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGG
TCACTGGGTCTGTGAGCAGTTCAAGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGACTAAAGC
AGTCACAGGAAGAAATGTCCTCTTCAGGCCCTTCAGTGAGGAAAGCGTCTCTGAGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACC
AGCCCTTGCCTGCCCGACGGCTCTCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAGTTAAGTT
CTTCTACAAGTTCAACTGATAAGTCAGATGGGGATTACGGGGAAGGGAAAGGTCAGACAAATGAAATTAATGCCTTGGTACAATTGATGA
CTCAGACCCTGAAACTGGATTCTAAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGGAAATATC
GGGACACACTGATACTTCATGGGAAGGTTGCAGAAGAGGCAGAGGAAATCCATTTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTG
AAAAGATCAGGAGACTAGTTGAAGTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGATCTTTTGG
AGGAGGAGGATGAATTTGATAGAGAGGAGGTATATCGAATTCCAAAGAAAAGTCAAACTGAAAAGGAAAACACAACAACTGAACGAGGAA
GGGATGCTGTTGGCTTCAGAGATCAAACACCTGCCCCGAAGACTCCTAATAGGTCAAGAGAGAGAGACCCAGACAAGCAAACTCAAAATA
AAGAGAAAAGGAAACGAAGAAGCTCCCTCTCACCACCCTCTTCTGCCTATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACAC
CAACTTCTAAAAAGAAAGTACGAATTAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAAC
GGGAGGCTCAGAAACAACAGCAACAGATGCAGAACCTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATC
ATCCCTTTGCTGGTTACCCACCAGGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCCCACAC
CCAGCATGGACCCAGTGTGTTCTCCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCTACAGAACCCCTTTCTGCCCCTCCAC
CAGTACCAGTGGTGCCACATGTGGCAGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACT
CCAGCGTTGCTGTCTTGCCAGTGCCGGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTG
TACAGCAGCAGTACTCTCCTGCACAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCACCTT
ATTCACAGACAACTCCACCAATTGTACAGAGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGGCAACAGATTTTCACAGCTCATCCAC
AAGGAGTGGTGGTACAGCCAGCCGCAGCAGTGACTACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGA
CAAATAATCTCTTGGATCTGCCGCCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGATCCAG
AAGGGAAGATTTATTACTACCATGTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCCTTG
AGCATGAAGCTGAGATGGACCTGGGAACTCCAACATATGATGAAAACCCCATGAAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACA
CCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAAC
CTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAGCTGA
AGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAGTTTG
GGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGGTCAGGTAAGACAGACTCTAG
GGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCTGGGGAATTCAACCCTGCAGA
TGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGCATGTGGTTAGAAGCCATCAGAGGTG
CAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCCTTGGCGGTGCTGTCAGCGCACAGACCCATG

>In-frame_NEK4_ENST00000535191_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_4315nt
AACAGCCGCCCCCACTGCCCCCTCTCGGGCATGAACCGAGCTTCTTGTTGCCGCCCGCTGCCCTACCCGCCGCTGCCGCCGCATCCCGAC
TCTGGGCCAGCGCTGGGAACATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTGACGCTTGTGA
AGCACCGGCGGGACGGCAAGCAGTATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACAAGAACAA
ACATCATCAAAGTAGGGGACCTAGGAATTGCCCGAGTGTTAGAGAACCACTGTGACATGGCTAGCACCCTCATTGGCACACCCTACTACA
TGAGCCCTGAATTGTTCTCAAACAAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCCACCTTGA
AGCATGCTTTCAATGCAAAAGATATGAATTCTTTAGTTTATCGGATTATTGAAGGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAG
AGCTGGCAGAACTGATAAGAACAATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTATATAAAGC
GGCAAATCTCCTTCTTTTTGGAGGCCACAAAGATAAAAACCTCCAAAAATAACATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTA
CAGTGGTTTCTGGAGAGGCAGAATCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATAATGGGTG
AAGGCAAATGTTTGTCCCAGGAGAAACCCAGGGCCTCTGGTCTCTTGAAGTCACCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACT
TGAGCAATACCACAGAACTAGCCACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGATGGCTTTG
TTCAGGAGAATCAGCCAAGATATTTGGATGCCTCTAATGAGTTAGGAGGTATATGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGG
ACAACACTAAATCCAGTGCCCAGCCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCAGTGAAGC
CTCTGCAGCCCCTAATCAAAGAACAAAAGCCAAAGGACCAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTC
ACAGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCCAGG
ATCAAGTTGCTGGTGAATGTATTATAGAAAAACAGGGCAGAATCCACCCAGATTTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGT
CTCGACAGCGACGGCAAAAGAGGAGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTCCAAGAGT
CGCCTCCTCGATTTTTGCCTTCTCATCCCATTGTTGGGAAAGTGGATGTCACATCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGG
TCACTGGGTCTGTGAGCAGTTCAAGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGACTAAAGC
AGTCACAGGAAGAAATGTCCTCTTCAGGCCCTTCAGTGAGGAAAGCGTCTCTGAGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACC
AGCCCTTGCCTGCCCGACGGCTCTCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAGTTAAGTT
CTTCTACAAGTTCAACTGATAAGTCAGATGGGGATTACGGGGAAGGGAAAGGTCAGACAAATGAAATTAATGCCTTGGTACAATTGATGA
CTCAGACCCTGAAACTGGATTCTAAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGGAAATATC
GGGACACACTGATACTTCATGGGAAGGTTGCAGAAGAGGCAGAGGAAATCCATTTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTG
AAAAGATCAGGAGACTAGTTGAAGTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGATCTTTTGG
AGGAGGAGGATGAATTTGATAGAGAGGAGGTATATCGAATTCCAAAGAAAAGTCAAACTGAAAAGGAAAACACAACAACTGAACGAGGAA
GGGATGCTGTTGGCTTCAGAGATCAAACACCTGCCCCGAAGACTCCTAATAGGTCAAGAGAGAGAGACCCAGACAAGCAAACTCAAAATA
AAGAGAAAAGGAAACGAAGAAGCTCCCTCTCACCACCCTCTTCTGCCTATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACAC
CAACTTCTAAAAAGAAAGTACGAATTAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAAC
GGGAGGCTCAGAAACAACAGCAACAGATGCAGAACCTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATC
ATCCCTTTGCTGGTTACCCACCAGGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCCCACAC
CCAGCATGGACCCAGTGTGTTCTCCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCTACAGAACCCCTTTCTGCCCCTCCAC
CAGTACCAGTGGTGCCACATGTGGCAGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACT
CCAGCGTTGCTGTCTTGCCAGTGCCGGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTG
TACAGCAGCAGTACTCTCCTGCACAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCACCTT
ATTCACAGACAACTCCACCAATTGTACAGAGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGGCAACAGATTTTCACAGCTCATCCAC
AAGGAGTGGTGGTACAGCCAGCCGCAGCAGTGACTACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGA
CAAATAATCTCTTGGATCTGCCGCCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGATCCAG
AAGGGAAGATTTATTACTACCATGTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCCTTG
AGCATGAAGCTGAGATGGACCTGGGAACTCCAACATATGATGAAAACCCCATGAAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACA
CCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAAC
CTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAGCTGA
AGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAGTTTG
GGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGGTCAGGTAAGACAGACTCTAG
GGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCTGGGGAATTCAACCCTGCAGA
TGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGCATGTGGTTAGAAGCCATCAGAGGTG
CAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCCTTGGCGGTGCTGTCAGCGCACAGACCCATG


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FusionGenePPI for NEK4_SETD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEK4ANKRD28, C4BPB, CTDSP2, SPACA1, NRG1, DNAJB2, PLAUR, TXNDC15, HLA-B, HLA-C, SDF4, HLA-E, SKAP1, CBWD1, CBWD2, ISLR, RPGRIP1L, RPGRIP1, XPO1, C1orf85, CD79A, PCDHA12, PRKAB1, LAMP3, SLC18A1, PCDHB11, PCDHGB1, TUBA3C, TUBB1, SLC25A4, HSP90AB2P, CTNNA1, HSP90AB3P, BLM, NPHP4, RPGRSETD2HTT, IWS1, TP53, HIST1H3A, SETD2, POLR2A, ELAVL1, ATXN1, CIC, CBX8, SOX2, SMAD3, SIAH2, CLK2, HIST3H3, WDR37, ARHGEF10, LUC7L, SCARA3, AURKA, EIF3I, XPO1, RASSF8, GAN, ATM, HNRNPLL, NXF2, HSPB8, RSBN1, F9, CPNE7, PIP4K2A, TRPC4AP, JMJD6, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11212457_256420202565POLR2A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSETD2chr3:52771602chr3:47108608ENST00000409792-11211418_171420202565TUBA1A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEK4_SETD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEK4_SETD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEK4C0005586Bipolar Disorder2PSYGENET
TgeneSETD2C0007134Renal Cell Carcinoma2CTD_human
TgeneSETD2C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneSETD2C0010701Phyllodes Tumor1CTD_human
TgeneSETD2C0023418leukemia1CTD_human
TgeneSETD2C0345967Malignant mesothelioma1CTD_human
TgeneSETD2C0920269Microsatellite Instability1CTD_human
TgeneSETD2C1458155Mammary Neoplasms1CTD_human