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Fusion gene ID: 24008 |
FusionGeneSummary for NEK4_SETD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEK4_SETD2 | Fusion gene ID: 24008 | Hgene | Tgene | Gene symbol | NEK4 | SETD2 | Gene ID | 6787 | 29072 |
| Gene name | NIMA related kinase 4 | SET domain containing 2 | |
| Synonyms | NRK2|STK2|pp12301 | HBP231|HIF-1|HIP-1|HSPC069|HYPB|KMT3A|LLS|SET2|p231HBP | |
| Cytomap | 3p21.1 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase Nek4NIMA (never in mitosis gene a)-related kinase 4never in mitosis A-related kinase 4nimA-related protein kinase 4serine/threonine kinase 2serine/threonine protein kinase-2serine/threonine-protein kinase NRK2serine/ | histone-lysine N-methyltransferase SETD2huntingtin interacting protein 1huntingtin yeast partner Bhuntingtin-interacting protein Blysine N-methyltransferase 3Aprotein-lysine N-methyltransferase SETD2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P51957 | Q9BYW2 | |
| Ensembl transtripts involved in fusion gene | ENST00000233027, ENST00000535191, ENST00000383721, | ENST00000409792, ENST00000492397, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 6=216 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/216*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEK4 [Title/Abstract] AND SETD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SETD2 | GO:0010569 | regulation of double-strand break repair via homologous recombination | 24843002 |
| Tgene | SETD2 | GO:0018023 | peptidyl-lysine trimethylation | 27518565 |
| Tgene | SETD2 | GO:0018026 | peptidyl-lysine monomethylation | 28753426 |
| Tgene | SETD2 | GO:0032465 | regulation of cytokinesis | 27518565 |
| Tgene | SETD2 | GO:0032727 | positive regulation of interferon-alpha production | 28753426 |
| Tgene | SETD2 | GO:0034340 | response to type I interferon | 28753426 |
| Tgene | SETD2 | GO:0051607 | defense response to virus | 28753426 |
| Tgene | SETD2 | GO:0097198 | histone H3-K36 trimethylation | 23043551|24843002|26002201|27474439|28753426 |
| Tgene | SETD2 | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
| Tgene | SETD2 | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 27518565 |
| Tgene | SETD2 | GO:1905634 | regulation of protein localization to chromatin | 24843002 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-A1AF-01A | NEK4 | chr3 | 52771602 | - | SETD2 | chr3 | 47108608 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000233027 | ENST00000409792 | NEK4 | chr3 | 52771602 | - | SETD2 | chr3 | 47108608 | - |
| 5CDS-5UTR | ENST00000233027 | ENST00000492397 | NEK4 | chr3 | 52771602 | - | SETD2 | chr3 | 47108608 | - |
| In-frame | ENST00000535191 | ENST00000409792 | NEK4 | chr3 | 52771602 | - | SETD2 | chr3 | 47108608 | - |
| 5CDS-5UTR | ENST00000535191 | ENST00000492397 | NEK4 | chr3 | 52771602 | - | SETD2 | chr3 | 47108608 | - |
| intron-3CDS | ENST00000383721 | ENST00000409792 | NEK4 | chr3 | 52771602 | - | SETD2 | chr3 | 47108608 | - |
| intron-5UTR | ENST00000383721 | ENST00000492397 | NEK4 | chr3 | 52771602 | - | SETD2 | chr3 | 47108608 | - |
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FusionProtFeatures for NEK4_SETD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEK4 | SETD2 |
| Protein kinase that seems to act exclusively uponthreonine residues (By similarity). Required for normal entry intoproliferative arrest after a limited number of cell divisions,also called replicative senescence. Required for normal cell cyclearrest in response to double-stranded DNA damage.{ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NEK4 | chr3:52771602 | chr3:47108608 | ENST00000233027 | - | 15 | 16 | 6_261 | 811 | 842 | Domain | Protein kinase |
| Hgene | NEK4 | chr3:52771602 | chr3:47108608 | ENST00000535191 | - | 14 | 15 | 6_261 | 722 | 753 | Domain | Protein kinase |
| Hgene | NEK4 | chr3:52771602 | chr3:47108608 | ENST00000233027 | - | 15 | 16 | 12_20 | 811 | 842 | Nucleotide binding | ATP |
| Hgene | NEK4 | chr3:52771602 | chr3:47108608 | ENST00000535191 | - | 14 | 15 | 12_20 | 722 | 753 | Nucleotide binding | ATP |
| Tgene | >SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 2117_2146 | 2020 | 2565 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 2149_2232 | 2020 | 2565 | Compositional bias | Note=Pro-rich |
| Tgene | >SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 2266_2365 | 2020 | 2565 | Compositional bias | Note=Gln-rich |
| Tgene | >SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 2389_2422 | 2020 | 2565 | Domain | WW |
| Tgene | >SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 2137_2366 | 2020 | 2565 | Region | Low charge region |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NEK4 | chr3:52771602 | chr3:47108608 | ENST00000383721 | - | 1 | 14 | 6_261 | -65 | 782 | Domain | Protein kinase |
| Hgene | >NEK4 | chr3:52771602 | chr3:47108608 | ENST00000383721 | - | 1 | 14 | 12_20 | -65 | 782 | Nucleotide binding | ATP |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 166_247 | 2020 | 2565 | Compositional bias | Note=Pro-rich |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 385_456 | 2020 | 2565 | Compositional bias | Note=Arg-rich |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 1494_1548 | 2020 | 2565 | Domain | AWS |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 1550_1667 | 2020 | 2565 | Domain | SET |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 1674_1690 | 2020 | 2565 | Domain | Post-SET |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 1560_1562 | 2020 | 2565 | Region | S-adenosyl-L-methionine binding |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 1603_1605 | 2020 | 2565 | Region | S-adenosyl-L-methionine binding |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 1628_1629 | 2020 | 2565 | Region | S-adenosyl-L-methionine binding |
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FusionGeneSequence for NEK4_SETD2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NEK4_ENST00000233027_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_1356aa MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGD LYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLE ATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKE QKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSS SGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDR EEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTSKKKVR IKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCS PAPYDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSVSVQQQYSPA QSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLP PPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTAEADTSSELAKK SKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKE >In-frame_NEK4_ENST00000535191_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_1267aa MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFS NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFL EATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTEL ATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIK EQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQK RREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMS SSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLD SKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFD REEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTSKKKV RIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVC SPAPYDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSVSVQQQYSP AQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDL PPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTAEADTSSELAK KSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NEK4_ENST00000233027_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_4068nt ATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTGACGCTTGTGAAGCACCGGCGGGACGGCAAG CAGTATGTCATCAAAAAACTGAACCTCCGAAATGCCTCTAGCCGAGAGCGGCGAGCTGCTGAACAGGAAGCCCAGCTCTTGTCTCAGTTG AAGCATCCCAACATTGTCACCTACAAGGAGTCATGGGAAGGAGGAGATGGTCTGCTCTACATTGTCATGGGCTTCTGTGAAGGAGGTGAT TTGTACCGAAAGCTCAAGGAGCAGAAAGGGCAGCTTCTGCCTGAGAATCAGGTGGTAGAGTGGTTTGTACAGATCGCCATGGCTTTGCAG TATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACAAGAACAAACATCATCAAAGTAGGGGACCTA GGAATTGCCCGAGTGTTAGAGAACCACTGTGACATGGCTAGCACCCTCATTGGCACACCCTACTACATGAGCCCTGAATTGTTCTCAAAC AAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCCACCTTGAAGCATGCTTTCAATGCAAAAGAT ATGAATTCTTTAGTTTATCGGATTATTGAAGGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAGAGCTGGCAGAACTGATAAGAACA ATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTATATAAAGCGGCAAATCTCCTTCTTTTTGGAG GCCACAAAGATAAAAACCTCCAAAAATAACATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTACAGTGGTTTCTGGAGAGGCAGAA TCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATAATGGGTGAAGGCAAATGTTTGTCCCAGGAG AAACCCAGGGCCTCTGGTCTCTTGAAGTCACCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACTTGAGCAATACCACAGAACTAGCC ACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGATGGCTTTGTTCAGGAGAATCAGCCAAGATAT TTGGATGCCTCTAATGAGTTAGGAGGTATATGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGGACAACACTAAATCCAGTGCCCAG CCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCAGTGAAGCCTCTGCAGCCCCTAATCAAAGAA CAAAAGCCAAAGGACCAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTCACAGCAACCTCCGCCTCCTGGGT TCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCCAGGATCAAGTTGCTGGTGAATGTATT ATAGAAAAACAGGGCAGAATCCACCCAGATTTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGTCTCGACAGCGACGGCAAAAGAGG AGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTCCAAGAGTCGCCTCCTCGATTTTTGCCTTCT CATCCCATTGTTGGGAAAGTGGATGTCACATCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGGTCACTGGGTCTGTGAGCAGTTCA AGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGACTAAAGCAGTCACAGGAAGAAATGTCCTCT TCAGGCCCTTCAGTGAGGAAAGCGTCTCTGAGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACCAGCCCTTGCCTGCCCGACGGCTC TCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAGTTAAGTTCTTCTACAAGTTCAACTGATAAG TCAGATGGGGATTACGGGGAAGGGAAAGGTCAGACAAATGAAATTAATGCCTTGGTACAATTGATGACTCAGACCCTGAAACTGGATTCT AAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGGAAATATCGGGACACACTGATACTTCATGGG AAGGTTGCAGAAGAGGCAGAGGAAATCCATTTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTGAAAAGATCAGGAGACTAGTTGAA GTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGATCTTTTGGAGGAGGAGGATGAATTTGATAGA GAGGAGGTATATCGAATTCCAAAGAAAAGTCAAACTGAAAAGGAAAACACAACAACTGAACGAGGAAGGGATGCTGTTGGCTTCAGAGAT CAAACACCTGCCCCGAAGACTCCTAATAGGTCAAGAGAGAGAGACCCAGACAAGCAAACTCAAAATAAAGAGAAAAGGAAACGAAGAAGC TCCCTCTCACCACCCTCTTCTGCCTATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACACCAACTTCTAAAAAGAAAGTACGA ATTAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAACGGGAGGCTCAGAAACAACAGCAA CAGATGCAGAACCTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATCATCCCTTTGCTGGTTACCCACCA GGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCCCACACCCAGCATGGACCCAGTGTGTTCT CCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCTACAGAACCCCTTTCTGCCCCTCCACCAGTACCAGTGGTGCCACATGTG GCAGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACTCCAGCGTTGCTGTCTTGCCAGTG CCGGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTGTACAGCAGCAGTACTCTCCTGCA CAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCACCTTATTCACAGACAACTCCACCAATT GTACAGAGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGGCAACAGATTTTCACAGCTCATCCACAAGGAGTGGTGGTACAGCCAGCC GCAGCAGTGACTACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGACAAATAATCTCTTGGATCTGCCG CCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGATCCAGAAGGGAAGATTTATTACTACCAT GTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCCTTGAGCATGAAGCTGAGATGGACCTG GGAACTCCAACATATGATGAAAACCCCATGAAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAA AGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATT ACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGAC CTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAG >In-frame_NEK4_ENST00000535191_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_3801nt ATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTGACGCTTGTGAAGCACCGGCGGGACGGCAAG CAGTATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACAAGAACAAACATCATCAAAGTAGGGGAC CTAGGAATTGCCCGAGTGTTAGAGAACCACTGTGACATGGCTAGCACCCTCATTGGCACACCCTACTACATGAGCCCTGAATTGTTCTCA AACAAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCCACCTTGAAGCATGCTTTCAATGCAAAA GATATGAATTCTTTAGTTTATCGGATTATTGAAGGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAGAGCTGGCAGAACTGATAAGA ACAATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTATATAAAGCGGCAAATCTCCTTCTTTTTG GAGGCCACAAAGATAAAAACCTCCAAAAATAACATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTACAGTGGTTTCTGGAGAGGCA GAATCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATAATGGGTGAAGGCAAATGTTTGTCCCAG GAGAAACCCAGGGCCTCTGGTCTCTTGAAGTCACCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACTTGAGCAATACCACAGAACTA GCCACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGATGGCTTTGTTCAGGAGAATCAGCCAAGA TATTTGGATGCCTCTAATGAGTTAGGAGGTATATGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGGACAACACTAAATCCAGTGCC CAGCCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCAGTGAAGCCTCTGCAGCCCCTAATCAAA GAACAAAAGCCAAAGGACCAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTCACAGCAACCTCCGCCTCCTG GGTTCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCCAGGATCAAGTTGCTGGTGAATGT ATTATAGAAAAACAGGGCAGAATCCACCCAGATTTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGTCTCGACAGCGACGGCAAAAG AGGAGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTCCAAGAGTCGCCTCCTCGATTTTTGCCT TCTCATCCCATTGTTGGGAAAGTGGATGTCACATCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGGTCACTGGGTCTGTGAGCAGT TCAAGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGACTAAAGCAGTCACAGGAAGAAATGTCC TCTTCAGGCCCTTCAGTGAGGAAAGCGTCTCTGAGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACCAGCCCTTGCCTGCCCGACGG CTCTCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAGTTAAGTTCTTCTACAAGTTCAACTGAT AAGTCAGATGGGGATTACGGGGAAGGGAAAGGTCAGACAAATGAAATTAATGCCTTGGTACAATTGATGACTCAGACCCTGAAACTGGAT TCTAAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGGAAATATCGGGACACACTGATACTTCAT GGGAAGGTTGCAGAAGAGGCAGAGGAAATCCATTTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTGAAAAGATCAGGAGACTAGTT GAAGTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGATCTTTTGGAGGAGGAGGATGAATTTGAT AGAGAGGAGGTATATCGAATTCCAAAGAAAAGTCAAACTGAAAAGGAAAACACAACAACTGAACGAGGAAGGGATGCTGTTGGCTTCAGA GATCAAACACCTGCCCCGAAGACTCCTAATAGGTCAAGAGAGAGAGACCCAGACAAGCAAACTCAAAATAAAGAGAAAAGGAAACGAAGA AGCTCCCTCTCACCACCCTCTTCTGCCTATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACACCAACTTCTAAAAAGAAAGTA CGAATTAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAACGGGAGGCTCAGAAACAACAG CAACAGATGCAGAACCTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATCATCCCTTTGCTGGTTACCCA CCAGGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCCCACACCCAGCATGGACCCAGTGTGT TCTCCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCTACAGAACCCCTTTCTGCCCCTCCACCAGTACCAGTGGTGCCACAT GTGGCAGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACTCCAGCGTTGCTGTCTTGCCA GTGCCGGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTGTACAGCAGCAGTACTCTCCT GCACAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCACCTTATTCACAGACAACTCCACCA ATTGTACAGAGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGGCAACAGATTTTCACAGCTCATCCACAAGGAGTGGTGGTACAGCCA GCCGCAGCAGTGACTACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGACAAATAATCTCTTGGATCTG CCGCCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGATCCAGAAGGGAAGATTTATTACTAC CATGTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCCTTGAGCATGAAGCTGAGATGGAC CTGGGAACTCCAACATATGATGAAAACCCCATGAAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAG AAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGA ATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAG GACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NEK4_ENST00000233027_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_4675nt AGCATGCGCAGAACTGCTCCCGGCCCGGATCGCTATGGCAGCGGCGTCGTCGCGGGCCGGGCCCCAGCAATCCCGCCCGGGCCCGGCTGC CTCAACAGCCGCCCCCACTGCCCCCTCTCGGGCATGAACCGAGCTTCTTGTTGCCGCCCGCTGCCCTACCCGCCGCTGCCGCCGCATCCC GACTCTGGGCCAGCGCTGGGAACATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTGACGCTTG TGAAGCACCGGCGGGACGGCAAGCAGTATGTCATCAAAAAACTGAACCTCCGAAATGCCTCTAGCCGAGAGCGGCGAGCTGCTGAACAGG AAGCCCAGCTCTTGTCTCAGTTGAAGCATCCCAACATTGTCACCTACAAGGAGTCATGGGAAGGAGGAGATGGTCTGCTCTACATTGTCA TGGGCTTCTGTGAAGGAGGTGATTTGTACCGAAAGCTCAAGGAGCAGAAAGGGCAGCTTCTGCCTGAGAATCAGGTGGTAGAGTGGTTTG TACAGATCGCCATGGCTTTGCAGTATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACAAGAACAA ACATCATCAAAGTAGGGGACCTAGGAATTGCCCGAGTGTTAGAGAACCACTGTGACATGGCTAGCACCCTCATTGGCACACCCTACTACA TGAGCCCTGAATTGTTCTCAAACAAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCCACCTTGA AGCATGCTTTCAATGCAAAAGATATGAATTCTTTAGTTTATCGGATTATTGAAGGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAG AGCTGGCAGAACTGATAAGAACAATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTATATAAAGC GGCAAATCTCCTTCTTTTTGGAGGCCACAAAGATAAAAACCTCCAAAAATAACATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTA CAGTGGTTTCTGGAGAGGCAGAATCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATAATGGGTG AAGGCAAATGTTTGTCCCAGGAGAAACCCAGGGCCTCTGGTCTCTTGAAGTCACCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACT TGAGCAATACCACAGAACTAGCCACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGATGGCTTTG TTCAGGAGAATCAGCCAAGATATTTGGATGCCTCTAATGAGTTAGGAGGTATATGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGG ACAACACTAAATCCAGTGCCCAGCCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCAGTGAAGC CTCTGCAGCCCCTAATCAAAGAACAAAAGCCAAAGGACCAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTC ACAGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCCAGG ATCAAGTTGCTGGTGAATGTATTATAGAAAAACAGGGCAGAATCCACCCAGATTTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGT CTCGACAGCGACGGCAAAAGAGGAGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTCCAAGAGT CGCCTCCTCGATTTTTGCCTTCTCATCCCATTGTTGGGAAAGTGGATGTCACATCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGG TCACTGGGTCTGTGAGCAGTTCAAGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGACTAAAGC AGTCACAGGAAGAAATGTCCTCTTCAGGCCCTTCAGTGAGGAAAGCGTCTCTGAGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACC AGCCCTTGCCTGCCCGACGGCTCTCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAGTTAAGTT CTTCTACAAGTTCAACTGATAAGTCAGATGGGGATTACGGGGAAGGGAAAGGTCAGACAAATGAAATTAATGCCTTGGTACAATTGATGA CTCAGACCCTGAAACTGGATTCTAAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGGAAATATC GGGACACACTGATACTTCATGGGAAGGTTGCAGAAGAGGCAGAGGAAATCCATTTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTG AAAAGATCAGGAGACTAGTTGAAGTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGATCTTTTGG AGGAGGAGGATGAATTTGATAGAGAGGAGGTATATCGAATTCCAAAGAAAAGTCAAACTGAAAAGGAAAACACAACAACTGAACGAGGAA GGGATGCTGTTGGCTTCAGAGATCAAACACCTGCCCCGAAGACTCCTAATAGGTCAAGAGAGAGAGACCCAGACAAGCAAACTCAAAATA AAGAGAAAAGGAAACGAAGAAGCTCCCTCTCACCACCCTCTTCTGCCTATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACAC CAACTTCTAAAAAGAAAGTACGAATTAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAAC GGGAGGCTCAGAAACAACAGCAACAGATGCAGAACCTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATC ATCCCTTTGCTGGTTACCCACCAGGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCCCACAC CCAGCATGGACCCAGTGTGTTCTCCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCTACAGAACCCCTTTCTGCCCCTCCAC CAGTACCAGTGGTGCCACATGTGGCAGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACT CCAGCGTTGCTGTCTTGCCAGTGCCGGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTG TACAGCAGCAGTACTCTCCTGCACAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCACCTT ATTCACAGACAACTCCACCAATTGTACAGAGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGGCAACAGATTTTCACAGCTCATCCAC AAGGAGTGGTGGTACAGCCAGCCGCAGCAGTGACTACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGA CAAATAATCTCTTGGATCTGCCGCCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGATCCAG AAGGGAAGATTTATTACTACCATGTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCCTTG AGCATGAAGCTGAGATGGACCTGGGAACTCCAACATATGATGAAAACCCCATGAAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACA CCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAAC CTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAGCTGA AGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAGTTTG GGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGGTCAGGTAAGACAGACTCTAG GGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCTGGGGAATTCAACCCTGCAGA TGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGCATGTGGTTAGAAGCCATCAGAGGTG CAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCCTTGGCGGTGCTGTCAGCGCACAGACCCATG >In-frame_NEK4_ENST00000535191_chr3_52771602_-_SETD2_ENST00000409792_chr3_47108608_-_4315nt AACAGCCGCCCCCACTGCCCCCTCTCGGGCATGAACCGAGCTTCTTGTTGCCGCCCGCTGCCCTACCCGCCGCTGCCGCCGCATCCCGAC TCTGGGCCAGCGCTGGGAACATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTGACGCTTGTGA AGCACCGGCGGGACGGCAAGCAGTATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACAAGAACAA ACATCATCAAAGTAGGGGACCTAGGAATTGCCCGAGTGTTAGAGAACCACTGTGACATGGCTAGCACCCTCATTGGCACACCCTACTACA TGAGCCCTGAATTGTTCTCAAACAAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCCACCTTGA AGCATGCTTTCAATGCAAAAGATATGAATTCTTTAGTTTATCGGATTATTGAAGGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAG AGCTGGCAGAACTGATAAGAACAATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTATATAAAGC GGCAAATCTCCTTCTTTTTGGAGGCCACAAAGATAAAAACCTCCAAAAATAACATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTA CAGTGGTTTCTGGAGAGGCAGAATCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATAATGGGTG AAGGCAAATGTTTGTCCCAGGAGAAACCCAGGGCCTCTGGTCTCTTGAAGTCACCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACT TGAGCAATACCACAGAACTAGCCACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGATGGCTTTG TTCAGGAGAATCAGCCAAGATATTTGGATGCCTCTAATGAGTTAGGAGGTATATGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGG ACAACACTAAATCCAGTGCCCAGCCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCAGTGAAGC CTCTGCAGCCCCTAATCAAAGAACAAAAGCCAAAGGACCAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTC ACAGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCACGCCCAGG ATCAAGTTGCTGGTGAATGTATTATAGAAAAACAGGGCAGAATCCACCCAGATTTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGT CTCGACAGCGACGGCAAAAGAGGAGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTCCAAGAGT CGCCTCCTCGATTTTTGCCTTCTCATCCCATTGTTGGGAAAGTGGATGTCACATCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGG TCACTGGGTCTGTGAGCAGTTCAAGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGACTAAAGC AGTCACAGGAAGAAATGTCCTCTTCAGGCCCTTCAGTGAGGAAAGCGTCTCTGAGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACC AGCCCTTGCCTGCCCGACGGCTCTCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAGTTAAGTT CTTCTACAAGTTCAACTGATAAGTCAGATGGGGATTACGGGGAAGGGAAAGGTCAGACAAATGAAATTAATGCCTTGGTACAATTGATGA CTCAGACCCTGAAACTGGATTCTAAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGGAAATATC GGGACACACTGATACTTCATGGGAAGGTTGCAGAAGAGGCAGAGGAAATCCATTTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTG AAAAGATCAGGAGACTAGTTGAAGTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGATCTTTTGG AGGAGGAGGATGAATTTGATAGAGAGGAGGTATATCGAATTCCAAAGAAAAGTCAAACTGAAAAGGAAAACACAACAACTGAACGAGGAA GGGATGCTGTTGGCTTCAGAGATCAAACACCTGCCCCGAAGACTCCTAATAGGTCAAGAGAGAGAGACCCAGACAAGCAAACTCAAAATA AAGAGAAAAGGAAACGAAGAAGCTCCCTCTCACCACCCTCTTCTGCCTATGAGCGGGGAACAAAAAGGCCAGATGACAGATATGATACAC CAACTTCTAAAAAGAAAGTACGAATTAAAGACCGCAATAAACTTTCTACAGAGGAACGCCGGAAGTTGTTTGAGCAAGAGGTGGCTCAAC GGGAGGCTCAGAAACAACAGCAACAGATGCAGAACCTGGGAATGACATCACCACTGCCCTATGACTCTCTTGGTTATAATGCCCCGCATC ATCCCTTTGCTGGTTACCCACCAGGTTATCCCATGCAGGCCTATGTGGATCCCAGCAACCCTAATGCTGGAAAGGTGCTCCTGCCCACAC CCAGCATGGACCCAGTGTGTTCTCCTGCTCCTTATGATCATGCTCAGCCCTTGGTGGGACATTCTACAGAACCCCTTTCTGCCCCTCCAC CAGTACCAGTGGTGCCACATGTGGCAGCTCCTGTGGAAGTTTCCAGTTCCCAGTATGTGGCCCAGAGTGATGGTGTAGTACACCAAGACT CCAGCGTTGCTGTCTTGCCAGTGCCGGCCCCCGGCCCAGTTCAGGGACAGAATTATAGTGTTTGGGATTCAAACCAACAGTCTGTCAGTG TACAGCAGCAGTACTCTCCTGCACAGTCTCAAGCAACCATATATTATCAAGGACAGACATGTCCAACAGTCTATGGTGTGACATCACCTT ATTCACAGACAACTCCACCAATTGTACAGAGTTATGCCCAGCCAAGTCTTCAGTATATCCAGGGGCAACAGATTTTCACAGCTCATCCAC AAGGAGTGGTGGTACAGCCAGCCGCAGCAGTGACTACAATAGTTGCACCAGGGCAGCCTCAGCCCTTGCAGCCATCTGAAATGGTTGTGA CAAATAATCTCTTGGATCTGCCGCCCCCCTCTCCTCCCAAACCAAAAACCATTGTCTTACCTCCCAACTGGAAGACAGCTCGAGATCCAG AAGGGAAGATTTATTACTACCATGTGATCACAAGGCAGACTCAGTGGGATCCTCCTACTTGGGAAAGCCCAGGAGATGATGCCAGCCTTG AGCATGAAGCTGAGATGGACCTGGGAACTCCAACATATGATGAAAACCCCATGAAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACA CCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAAC CTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAGCTGA AGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAGTTTG GGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGGTCAGGTAAGACAGACTCTAG GGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCTGGGGAATTCAACCCTGCAGA TGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGCATGTGGTTAGAAGCCATCAGAGGTG CAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCCTTGGCGGTGCTGTCAGCGCACAGACCCATG |
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FusionGenePPI for NEK4_SETD2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEK4 | ANKRD28, C4BPB, CTDSP2, SPACA1, NRG1, DNAJB2, PLAUR, TXNDC15, HLA-B, HLA-C, SDF4, HLA-E, SKAP1, CBWD1, CBWD2, ISLR, RPGRIP1L, RPGRIP1, XPO1, C1orf85, CD79A, PCDHA12, PRKAB1, LAMP3, SLC18A1, PCDHB11, PCDHGB1, TUBA3C, TUBB1, SLC25A4, HSP90AB2P, CTNNA1, HSP90AB3P, BLM, NPHP4, RPGR | SETD2 | HTT, IWS1, TP53, HIST1H3A, SETD2, POLR2A, ELAVL1, ATXN1, CIC, CBX8, SOX2, SMAD3, SIAH2, CLK2, HIST3H3, WDR37, ARHGEF10, LUC7L, SCARA3, AURKA, EIF3I, XPO1, RASSF8, GAN, ATM, HNRNPLL, NXF2, HSPB8, RSBN1, F9, CPNE7, PIP4K2A, TRPC4AP, JMJD6, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 2457_2564 | 2020 | 2565 | POLR2A |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SETD2 | chr3:52771602 | chr3:47108608 | ENST00000409792 | - | 11 | 21 | 1418_1714 | 2020 | 2565 | TUBA1A |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEK4_SETD2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEK4_SETD2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NEK4 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | SETD2 | C0007134 | Renal Cell Carcinoma | 2 | CTD_human |
| Tgene | SETD2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | SETD2 | C0010701 | Phyllodes Tumor | 1 | CTD_human |
| Tgene | SETD2 | C0023418 | leukemia | 1 | CTD_human |
| Tgene | SETD2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | SETD2 | C0920269 | Microsatellite Instability | 1 | CTD_human |
| Tgene | SETD2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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