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Fusion gene ID: 24006 |
FusionGeneSummary for NEK3_GXYLT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEK3_GXYLT2 | Fusion gene ID: 24006 | Hgene | Tgene | Gene symbol | NEK3 | GXYLT2 | Gene ID | 4752 | 727936 |
| Gene name | NIMA related kinase 3 | glucoside xylosyltransferase 2 | |
| Synonyms | HSPK36 | GLT8D4 | |
| Cytomap | 13q14.3 | 3p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase Nek3HSPK 36NIMA (never in mitosis gene a)-related kinase 3glycogen synthase A kinasehydroxyalkyl-protein kinasenever in mitosis A-related kinase 3nimA-related protein kinase 3phosphorylase B kinase kinase | glucoside xylosyltransferase 2glycosyltransferase 8 domain containing 4glycosyltransferase 8 domain-containing protein 4 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P51956 | A0PJZ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000378101, ENST00000339406, ENST00000452082, ENST00000400357, | ENST00000389617, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 3 X 4=60 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEK3 [Title/Abstract] AND GXYLT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GXYLT2 | GO:0016266 | O-glycan processing | 19940119 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EB-A44R-06A | NEK3 | chr13 | 52722550 | - | GXYLT2 | chr3 | 73006380 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000378101 | ENST00000389617 | NEK3 | chr13 | 52722550 | - | GXYLT2 | chr3 | 73006380 | + |
| In-frame | ENST00000339406 | ENST00000389617 | NEK3 | chr13 | 52722550 | - | GXYLT2 | chr3 | 73006380 | + |
| In-frame | ENST00000452082 | ENST00000389617 | NEK3 | chr13 | 52722550 | - | GXYLT2 | chr3 | 73006380 | + |
| In-frame | ENST00000400357 | ENST00000389617 | NEK3 | chr13 | 52722550 | - | GXYLT2 | chr3 | 73006380 | + |
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FusionProtFeatures for NEK3_GXYLT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEK3 | GXYLT2 |
| Protein kinase which influences neuronal morphogenesisand polarity through effects on microtubules. Regulatesmicrotubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancercells through mechanisms involving RAC1 activation andphosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286,ECO:0000269|PubMed:17297458}. | Glycosyltransferase which elongates the O-linked glucoseattached to EGF-like repeats in the extracellular domain of Notchproteins by catalyzing the addition of xylose.{ECO:0000269|PubMed:19940119}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NEK3 | chr13:52722550 | chr3:73006380 | ENST00000400357 | - | 7 | 14 | 10_18 | 201 | 490 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NEK3 | chr13:52722550 | chr3:73006380 | ENST00000400357 | - | 7 | 14 | 4_257 | 201 | 490 | Domain | Protein kinase |
| Tgene | GXYLT2 | chr13:52722550 | chr3:73006380 | ENST00000389617 | + | 3 | 7 | 68_98 | 284 | 444 | Compositional bias | Note=Arg-rich |
| Tgene | GXYLT2 | chr13:52722550 | chr3:73006380 | ENST00000389617 | + | 3 | 7 | 1_4 | 284 | 444 | Topological domain | Cytoplasmic |
| Tgene | GXYLT2 | chr13:52722550 | chr3:73006380 | ENST00000389617 | + | 3 | 7 | 26_443 | 284 | 444 | Topological domain | Lumenal |
| Tgene | GXYLT2 | chr13:52722550 | chr3:73006380 | ENST00000389617 | + | 3 | 7 | 5_25 | 284 | 444 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for NEK3_GXYLT2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NEK3_ENST00000378101_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_361aa MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLTIVMEYCDGGDLMQK IKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTTVGTPTTVPPEIWENLPTN NKSDIWSLGCILTELCTLKHPNSMIPTGLAWEDMLYPLYQKYKNAITWGDQDLLNIIFTFNPECLTVFPCQWNYRPDHCMYGSNCREAEH EGVSVLHGNRGVYHDDKQPTFRALTEAIRDFPFQDNLFQSMTYPLQLKFLETVHTLCGRIPQVFLKQIEKTMKRATEKHVIIHVGPNQMH >In-frame_NEK3_ENST00000339406_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_361aa MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLTIVMEYCDGGDLMQK IKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTTVGTPTTVPPEIWENLPTN NKSDIWSLGCILTELCTLKHPNSMIPTGLAWEDMLYPLYQKYKNAITWGDQDLLNIIFTFNPECLTVFPCQWNYRPDHCMYGSNCREAEH EGVSVLHGNRGVYHDDKQPTFRALTEAIRDFPFQDNLFQSMTYPLQLKFLETVHTLCGRIPQVFLKQIEKTMKRATEKHVIIHVGPNQMH >In-frame_NEK3_ENST00000452082_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_382aa MQFGRAHGDCVSGAQLCGCPSMDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESF EAEGHLTIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFA CTTVGTPTTVPPEIWENLPTNNKSDIWSLGCILTELCTLKHPNSMIPTGLAWEDMLYPLYQKYKNAITWGDQDLLNIIFTFNPECLTVFP CQWNYRPDHCMYGSNCREAEHEGVSVLHGNRGVYHDDKQPTFRALTEAIRDFPFQDNLFQSMTYPLQLKFLETVHTLCGRIPQVFLKQIE >In-frame_NEK3_ENST00000400357_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_361aa MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLTIVMEYCDGGDLMQK IKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTTVGTPTTVPPEIWENLPTN NKSDIWSLGCILTELCTLKHPNSMIPTGLAWEDMLYPLYQKYKNAITWGDQDLLNIIFTFNPECLTVFPCQWNYRPDHCMYGSNCREAEH EGVSVLHGNRGVYHDDKQPTFRALTEAIRDFPFQDNLFQSMTYPLQLKFLETVHTLCGRIPQVFLKQIEKTMKRATEKHVIIHVGPNQMH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NEK3_ENST00000378101_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_1083nt ATGGATGACTACATGGTCCTGAGAATGATTGGGGAGGGCTCCTTCGGCAGAGCTCTTTTGGTTCAGCATGAAAGCAGTAATCAGATGTTT GCCATGAAAGAAATAAGGCTTCCCAAGTCTTTCTCTAATACACAGAATTCTAGGAAGGAGGCTGTTCTTTTAGCCAAAATGAAACACCCT AATATTGTTGCCTTCAAAGAATCATTTGAAGCTGAAGGACACTTGTATATTGTGATGGAATACTGTGATGGAGGGGATCTAATGCAAAAG ATTAAACAGCAGAAAGGAAAGTTATTTCCTGAAGACATGATACTTAATTGGTTTACCCAAATGTGCCTTGGAGTAAATCACATTCACAAG AAACGTGTGCTACACAGAGATATCAAGTCCAAGAATATCTTCCTCACTCAGAATGGAAAAGTGAAATTGGGAGACTTTGGATCTGCCCGT CTTCTCTCCAATCCGATGGCATTTGCTTGTACCTATGTGGGAACTCCTTATTATGTGCCTCCAGAAATTTGGGAAAACCTGCCTTATAAC AATAAAAGTGACATCTGGTCCTTGGGTTGCATCCTGTATGAACTCTGTACCCTTAAGCATCCAAACAGCATGATTCCAACAGGCCTGGCT TGGGAGGACATGTTGTACCCTCTGTACCAGAAGTACAAGAATGCCATCACGTGGGGAGACCAGGATTTATTAAATATTATTTTTTATTTC AACCCAGAGTGTCTCTATGTATTCCCCTGCCAGTGGAACTACCGTCCCGATCACTGCATGTACGGAAGCAACTGCAGAGAGGCTGAGCAT GAAGGTGTGTCTGTTCTGCATGGAAACCGAGGCGTCTACCATGACGATAAGCAACCAACGTTCAGAGCACTCTATGAAGCAATACGGGAT TTTCCCTTTCAAGACAATCTCTTTCAATCCATGTATTACCCCCTTCAGCTGAAGTTTTTGGAGACTGTGCACACTTTATGTGGACGAATC CCGCAAGTTTTTCTGAAGCAAATTGAGAAAACAATGAAAAGGGCTTATGAGAAACACGTCATCATCCATGTTGGCCCCAACCAGATGCAC >In-frame_NEK3_ENST00000339406_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_1083nt ATGGATGACTACATGGTCCTGAGAATGATTGGGGAGGGCTCCTTCGGCAGAGCTCTTTTGGTTCAGCATGAAAGCAGTAATCAGATGTTT GCCATGAAAGAAATAAGGCTTCCCAAGTCTTTCTCTAATACACAGAATTCTAGGAAGGAGGCTGTTCTTTTAGCCAAAATGAAACACCCT AATATTGTTGCCTTCAAAGAATCATTTGAAGCTGAAGGACACTTGTATATTGTGATGGAATACTGTGATGGAGGGGATCTAATGCAAAAG ATTAAACAGCAGAAAGGAAAGTTATTTCCTGAAGACATGATACTTAATTGGTTTACCCAAATGTGCCTTGGAGTAAATCACATTCACAAG AAACGTGTGCTACACAGAGATATCAAGTCCAAGAATATCTTCCTCACTCAGAATGGAAAAGTGAAATTGGGAGACTTTGGATCTGCCCGT CTTCTCTCCAATCCGATGGCATTTGCTTGTACCTATGTGGGAACTCCTTATTATGTGCCTCCAGAAATTTGGGAAAACCTGCCTTATAAC AATAAAAGTGACATCTGGTCCTTGGGTTGCATCCTGTATGAACTCTGTACCCTTAAGCATCCAAACAGCATGATTCCAACAGGCCTGGCT TGGGAGGACATGTTGTACCCTCTGTACCAGAAGTACAAGAATGCCATCACGTGGGGAGACCAGGATTTATTAAATATTATTTTTTATTTC AACCCAGAGTGTCTCTATGTATTCCCCTGCCAGTGGAACTACCGTCCCGATCACTGCATGTACGGAAGCAACTGCAGAGAGGCTGAGCAT GAAGGTGTGTCTGTTCTGCATGGAAACCGAGGCGTCTACCATGACGATAAGCAACCAACGTTCAGAGCACTCTATGAAGCAATACGGGAT TTTCCCTTTCAAGACAATCTCTTTCAATCCATGTATTACCCCCTTCAGCTGAAGTTTTTGGAGACTGTGCACACTTTATGTGGACGAATC CCGCAAGTTTTTCTGAAGCAAATTGAGAAAACAATGAAAAGGGCTTATGAGAAACACGTCATCATCCATGTTGGCCCCAACCAGATGCAC >In-frame_NEK3_ENST00000452082_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_1146nt ATGCAGTTTGGGAGAGCCCATGGTGACTGCGTGAGTGGAGCCCAGCTGTGTGGATGCCCCAGCATGGATGACTACATGGTCCTGAGAATG ATTGGGGAGGGCTCCTTCGGCAGAGCTCTTTTGGTTCAGCATGAAAGCAGTAATCAGATGTTTGCCATGAAAGAAATAAGGCTTCCCAAG TCTTTCTCTAATACACAGAATTCTAGGAAGGAGGCTGTTCTTTTAGCCAAAATGAAACACCCTAATATTGTTGCCTTCAAAGAATCATTT GAAGCTGAAGGACACTTGTATATTGTGATGGAATACTGTGATGGAGGGGATCTAATGCAAAAGATTAAACAGCAGAAAGGAAAGTTATTT CCTGAAGACATGATACTTAATTGGTTTACCCAAATGTGCCTTGGAGTAAATCACATTCACAAGAAACGTGTGCTACACAGAGATATCAAG TCCAAGAATATCTTCCTCACTCAGAATGGAAAAGTGAAATTGGGAGACTTTGGATCTGCCCGTCTTCTCTCCAATCCGATGGCATTTGCT TGTACCTATGTGGGAACTCCTTATTATGTGCCTCCAGAAATTTGGGAAAACCTGCCTTATAACAATAAAAGTGACATCTGGTCCTTGGGT TGCATCCTGTATGAACTCTGTACCCTTAAGCATCCAAACAGCATGATTCCAACAGGCCTGGCTTGGGAGGACATGTTGTACCCTCTGTAC CAGAAGTACAAGAATGCCATCACGTGGGGAGACCAGGATTTATTAAATATTATTTTTTATTTCAACCCAGAGTGTCTCTATGTATTCCCC TGCCAGTGGAACTACCGTCCCGATCACTGCATGTACGGAAGCAACTGCAGAGAGGCTGAGCATGAAGGTGTGTCTGTTCTGCATGGAAAC CGAGGCGTCTACCATGACGATAAGCAACCAACGTTCAGAGCACTCTATGAAGCAATACGGGATTTTCCCTTTCAAGACAATCTCTTTCAA TCCATGTATTACCCCCTTCAGCTGAAGTTTTTGGAGACTGTGCACACTTTATGTGGACGAATCCCGCAAGTTTTTCTGAAGCAAATTGAG >In-frame_NEK3_ENST00000400357_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_1083nt ATGGATGACTACATGGTCCTGAGAATGATTGGGGAGGGCTCCTTCGGCAGAGCTCTTTTGGTTCAGCATGAAAGCAGTAATCAGATGTTT GCCATGAAAGAAATAAGGCTTCCCAAGTCTTTCTCTAATACACAGAATTCTAGGAAGGAGGCTGTTCTTTTAGCCAAAATGAAACACCCT AATATTGTTGCCTTCAAAGAATCATTTGAAGCTGAAGGACACTTGTATATTGTGATGGAATACTGTGATGGAGGGGATCTAATGCAAAAG ATTAAACAGCAGAAAGGAAAGTTATTTCCTGAAGACATGATACTTAATTGGTTTACCCAAATGTGCCTTGGAGTAAATCACATTCACAAG AAACGTGTGCTACACAGAGATATCAAGTCCAAGAATATCTTCCTCACTCAGAATGGAAAAGTGAAATTGGGAGACTTTGGATCTGCCCGT CTTCTCTCCAATCCGATGGCATTTGCTTGTACCTATGTGGGAACTCCTTATTATGTGCCTCCAGAAATTTGGGAAAACCTGCCTTATAAC AATAAAAGTGACATCTGGTCCTTGGGTTGCATCCTGTATGAACTCTGTACCCTTAAGCATCCAAACAGCATGATTCCAACAGGCCTGGCT TGGGAGGACATGTTGTACCCTCTGTACCAGAAGTACAAGAATGCCATCACGTGGGGAGACCAGGATTTATTAAATATTATTTTTTATTTC AACCCAGAGTGTCTCTATGTATTCCCCTGCCAGTGGAACTACCGTCCCGATCACTGCATGTACGGAAGCAACTGCAGAGAGGCTGAGCAT GAAGGTGTGTCTGTTCTGCATGGAAACCGAGGCGTCTACCATGACGATAAGCAACCAACGTTCAGAGCACTCTATGAAGCAATACGGGAT TTTCCCTTTCAAGACAATCTCTTTCAATCCATGTATTACCCCCTTCAGCTGAAGTTTTTGGAGACTGTGCACACTTTATGTGGACGAATC CCGCAAGTTTTTCTGAAGCAAATTGAGAAAACAATGAAAAGGGCTTATGAGAAACACGTCATCATCCATGTTGGCCCCAACCAGATGCAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NEK3_ENST00000378101_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_3085nt CGCCGCCTTGGGGTCTGGGCGCGCGGTGCCGTGGGGGTCAGCAGGGCGGAGCGGCTTTTCCAGGAGAAAGGGCCCTCACGGGTGAGCGGG GCGACTGGGCTCCCCCGCGGTGCAGTTGCCCCGCGGGCGCCGGCCCCGGCTCAACGGATTCTTCTCGCTCGCTGCCCGGAAAGAACCATT TGGGAGAGCCCATGGTGACTGCGTGAGTGGAGCCCAGCTGTGTGGATGCCCCAGCATGGATGACTACATGGTCCTGAGAATGATTGGGGA GGGCTCCTTCGGCAGAGCTCTTTTGGTTCAGCATGAAAGCAGTAATCAGATGTTTGCCATGAAAGAAATAAGGCTTCCCAAGTCTTTCTC TAATACACAGAATTCTAGGAAGGAGGCTGTTCTTTTAGCCAAAATGAAACACCCTAATATTGTTGCCTTCAAAGAATCATTTGAAGCTGA AGGACACTTGTATATTGTGATGGAATACTGTGATGGAGGGGATCTAATGCAAAAGATTAAACAGCAGAAAGGAAAGTTATTTCCTGAAGA CATGATACTTAATTGGTTTACCCAAATGTGCCTTGGAGTAAATCACATTCACAAGAAACGTGTGCTACACAGAGATATCAAGTCCAAGAA TATCTTCCTCACTCAGAATGGAAAAGTGAAATTGGGAGACTTTGGATCTGCCCGTCTTCTCTCCAATCCGATGGCATTTGCTTGTACCTA TGTGGGAACTCCTTATTATGTGCCTCCAGAAATTTGGGAAAACCTGCCTTATAACAATAAAAGTGACATCTGGTCCTTGGGTTGCATCCT GTATGAACTCTGTACCCTTAAGCATCCAAACAGCATGATTCCAACAGGCCTGGCTTGGGAGGACATGTTGTACCCTCTGTACCAGAAGTA CAAGAATGCCATCACGTGGGGAGACCAGGATTTATTAAATATTATTTTTTATTTCAACCCAGAGTGTCTCTATGTATTCCCCTGCCAGTG GAACTACCGTCCCGATCACTGCATGTACGGAAGCAACTGCAGAGAGGCTGAGCATGAAGGTGTGTCTGTTCTGCATGGAAACCGAGGCGT CTACCATGACGATAAGCAACCAACGTTCAGAGCACTCTATGAAGCAATACGGGATTTTCCCTTTCAAGACAATCTCTTTCAATCCATGTA TTACCCCCTTCAGCTGAAGTTTTTGGAGACTGTGCACACTTTATGTGGACGAATCCCGCAAGTTTTTCTGAAGCAAATTGAGAAAACAAT GAAAAGGGCTTATGAGAAACACGTCATCATCCATGTTGGCCCCAACCAGATGCACTGAATATTTTGTCTTGTTGCAAGTCAATTAGGTGT CTTGTGACCAAGGAAATACTAATCTCTAAGCTGCCTGGGTCTTTTTGTGTGAATATTTAATGGTGCTCCATGACTGTTGAGTTTTAAAAA CCTCGTTAAATTTTGCCAAATCAGTTGCCCCCAAAAGGGAATATGCTTTTCCTTATTTTTTTTTCTAAAATGCTATTTATCTCTAAGGAA AAAAAAAAAAGACTATTACTCATTTAACATTGTTTAAGCAGGTTGAGCTAGCTGTGAAAATAGCTTTTGTGAGCCTTCTAATTCCTAAAC GTCTGAGACCATTTCAGTGGCACCTGAGGTGTTATATTGATCTAGCATTCCTGAGACTCTTTCTATGCAACTGACTCCCCCACACCCGTG TTATAAAAGTAATACACACTTTTGAAACAGAGAGACACACTTGTAGAGCATATGGGTCAAGGGCTCAACATCAAGATTAGATTAGCCATA ATCCTATTGACCAGTGGAAAAGATTGTTTCCATTTTAAAGCAGTTCCTTACAACCTTTTTTCTCTACTTTTGCATTTTCCACTCTAACAC ACATCTAAAACAGGTAATCTCAGTAAAAGCTGGCCTTTTTGCTGAGATTTTTATGTGGGAGACTAAAATATTAGATGAGATGATTATGTG TACAGAATTTTATTTAAAATACATCTGAGAGAATCATTCAGATACTTGGGTAGTGTTAAAGGATGAAGCATGTATCTGGGGGTATTTCTT CTTTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAATCTCACTCTGTAGCCCAGGCTAGAATGCAGTGGCAGGATCTCG GCTCACTGCAGCTTCCACCTCCTGGGTTCAAGTGATTCTCATGCCTCAGCCTCCCCAGTAGCTGGGATTACAAGTGTGTGCCACCACACC CGGCTAATTTTTGTATTTTTAGTAGAGACACGGTTTTACCATGTTGGCCAGGCTGGTCTTGATCTCCAGACCTCAAGTGATCTGCCTGCC TCAGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGCCACTGCACTCAGCCAATCTGGGAGTATTTCTAAAGAAAAAAATTACTTTGATTT GTGGAGGACTAAATCATAATACATTTCTATGCAACAATAGCTTCTGAGAGGAAATTCAGGAATGTTTGTGTTTACCACAGACAAAAACAT TTGATCTGTTAATCATCAGTAGCTGTGGTCATCTCTCTTTCTTAAACTCTTGGGCAATGGGTGGAAATCAGAGACCAACTTCAAATTTAA TGTGTAAAAAACAAATAGTTCAGCTGCTTCTATTGGTAAGAAAATTCAACTTCCTACCAGCCTTAGAAAGGTCTCTTTAAACAATTTCTT TCCCCCTAGGGTTACCTAGCTGGTCCATACAGGTTTTATCACCTCACTGCAAGGAGGAAGTTGAATATTCTGTTCCCCACGGGGATCTGG CTTAATCCCTAGTTGCTCATATAGTTGGTATCAGCATAGCAATATTTTGCATAATGCTTTATTTTTCTCAAATGACTATTGCATAGATGA TCTTGATATTTGCAACAGCCTAGTGGATTTGGTAGGGTCCTGAATCATCTCTATAAGGCAAACAAGGAAATTGTAACACAAAGAAATAAA CATATTGAATATAATTGCTATTCTGTAAGACATACAGTCTGTGTAAGATGTATCTTATTTACAGAGACATTTTTGAAAATTAAAATATTA >In-frame_NEK3_ENST00000339406_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_3226nt CACATAGCTAGTAAGTTCTAGCTAGCACTGAGTGCTGTGCCCGTGAAATTTATCTACATAGGCTTTCACTTAACCTGCAGACAGAACTCA GTTAGTCGGGGACAATTTCCCTCAATGTTAACAGCACTGTTCCACCGCAACGTGGAACAACAGCTTTAAAACGTGCTCTTCGTAGGCCCG GCTACTCCAAGAACAGTGCCTCCCGCCAGACCCAGGCGGCTTCCTTCACCCGCAACCCGAGAGACGACCCGCCGGGCCCGCCCCGCGGAA GCCGCCGGTTGCCAGGCCAAGGAGTGGACTAGGGTCGCCGGGGAAGCGGTTTGGGAGAGCCCATGGTGACTGCGTGAGTGGAGCCCAGCT GTGTGGATGCCCCAGCATGGATGACTACATGGTCCTGAGAATGATTGGGGAGGGCTCCTTCGGCAGAGCTCTTTTGGTTCAGCATGAAAG CAGTAATCAGATGTTTGCCATGAAAGAAATAAGGCTTCCCAAGTCTTTCTCTAATACACAGAATTCTAGGAAGGAGGCTGTTCTTTTAGC CAAAATGAAACACCCTAATATTGTTGCCTTCAAAGAATCATTTGAAGCTGAAGGACACTTGTATATTGTGATGGAATACTGTGATGGAGG GGATCTAATGCAAAAGATTAAACAGCAGAAAGGAAAGTTATTTCCTGAAGACATGATACTTAATTGGTTTACCCAAATGTGCCTTGGAGT AAATCACATTCACAAGAAACGTGTGCTACACAGAGATATCAAGTCCAAGAATATCTTCCTCACTCAGAATGGAAAAGTGAAATTGGGAGA CTTTGGATCTGCCCGTCTTCTCTCCAATCCGATGGCATTTGCTTGTACCTATGTGGGAACTCCTTATTATGTGCCTCCAGAAATTTGGGA AAACCTGCCTTATAACAATAAAAGTGACATCTGGTCCTTGGGTTGCATCCTGTATGAACTCTGTACCCTTAAGCATCCAAACAGCATGAT TCCAACAGGCCTGGCTTGGGAGGACATGTTGTACCCTCTGTACCAGAAGTACAAGAATGCCATCACGTGGGGAGACCAGGATTTATTAAA TATTATTTTTTATTTCAACCCAGAGTGTCTCTATGTATTCCCCTGCCAGTGGAACTACCGTCCCGATCACTGCATGTACGGAAGCAACTG CAGAGAGGCTGAGCATGAAGGTGTGTCTGTTCTGCATGGAAACCGAGGCGTCTACCATGACGATAAGCAACCAACGTTCAGAGCACTCTA TGAAGCAATACGGGATTTTCCCTTTCAAGACAATCTCTTTCAATCCATGTATTACCCCCTTCAGCTGAAGTTTTTGGAGACTGTGCACAC TTTATGTGGACGAATCCCGCAAGTTTTTCTGAAGCAAATTGAGAAAACAATGAAAAGGGCTTATGAGAAACACGTCATCATCCATGTTGG CCCCAACCAGATGCACTGAATATTTTGTCTTGTTGCAAGTCAATTAGGTGTCTTGTGACCAAGGAAATACTAATCTCTAAGCTGCCTGGG TCTTTTTGTGTGAATATTTAATGGTGCTCCATGACTGTTGAGTTTTAAAAACCTCGTTAAATTTTGCCAAATCAGTTGCCCCCAAAAGGG AATATGCTTTTCCTTATTTTTTTTTCTAAAATGCTATTTATCTCTAAGGAAAAAAAAAAAAGACTATTACTCATTTAACATTGTTTAAGC AGGTTGAGCTAGCTGTGAAAATAGCTTTTGTGAGCCTTCTAATTCCTAAACGTCTGAGACCATTTCAGTGGCACCTGAGGTGTTATATTG ATCTAGCATTCCTGAGACTCTTTCTATGCAACTGACTCCCCCACACCCGTGTTATAAAAGTAATACACACTTTTGAAACAGAGAGACACA CTTGTAGAGCATATGGGTCAAGGGCTCAACATCAAGATTAGATTAGCCATAATCCTATTGACCAGTGGAAAAGATTGTTTCCATTTTAAA GCAGTTCCTTACAACCTTTTTTCTCTACTTTTGCATTTTCCACTCTAACACACATCTAAAACAGGTAATCTCAGTAAAAGCTGGCCTTTT TGCTGAGATTTTTATGTGGGAGACTAAAATATTAGATGAGATGATTATGTGTACAGAATTTTATTTAAAATACATCTGAGAGAATCATTC AGATACTTGGGTAGTGTTAAAGGATGAAGCATGTATCTGGGGGTATTTCTTCTTTTTCTTTCTTTCTTTTTTTTTTTTTTTTTTTTTTTG AGACGGAATCTCACTCTGTAGCCCAGGCTAGAATGCAGTGGCAGGATCTCGGCTCACTGCAGCTTCCACCTCCTGGGTTCAAGTGATTCT CATGCCTCAGCCTCCCCAGTAGCTGGGATTACAAGTGTGTGCCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACACGGTTTTAC CATGTTGGCCAGGCTGGTCTTGATCTCCAGACCTCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGCCAC TGCACTCAGCCAATCTGGGAGTATTTCTAAAGAAAAAAATTACTTTGATTTGTGGAGGACTAAATCATAATACATTTCTATGCAACAATA GCTTCTGAGAGGAAATTCAGGAATGTTTGTGTTTACCACAGACAAAAACATTTGATCTGTTAATCATCAGTAGCTGTGGTCATCTCTCTT TCTTAAACTCTTGGGCAATGGGTGGAAATCAGAGACCAACTTCAAATTTAATGTGTAAAAAACAAATAGTTCAGCTGCTTCTATTGGTAA GAAAATTCAACTTCCTACCAGCCTTAGAAAGGTCTCTTTAAACAATTTCTTTCCCCCTAGGGTTACCTAGCTGGTCCATACAGGTTTTAT CACCTCACTGCAAGGAGGAAGTTGAATATTCTGTTCCCCACGGGGATCTGGCTTAATCCCTAGTTGCTCATATAGTTGGTATCAGCATAG CAATATTTTGCATAATGCTTTATTTTTCTCAAATGACTATTGCATAGATGATCTTGATATTTGCAACAGCCTAGTGGATTTGGTAGGGTC CTGAATCATCTCTATAAGGCAAACAAGGAAATTGTAACACAAAGAAATAAACATATTGAATATAATTGCTATTCTGTAAGACATACAGTC >In-frame_NEK3_ENST00000452082_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_4144nt ATTGTGCCTTTCCTCTCTCAGGGAGTGCCAAGAAACCATCTGGTTCATGCCAGAAACTTGGGAGTCAACCTTGCCCCCTTCTCTGCTTGC CCCCCATAAATCTGCCACCACAAATCCTGTCAACTGTTCTTACATCTTTCCTTCCCATTTTTTCTGACCCCATTGCCTCCACTCTATTCC ATTTCATTATTTTCCTGCCTTTTCTATTGTTGGAGCCTCCTAACTGGCCTGTGTCTCTGAGCTGGCCTTCCTGCCCCTCCTCCACTGGTC CATTTAATCTGCAATCTGAGTGAATGTTTTTTCTAATATGCAAATATGATTATATTGCCTTCTTGGTTAAAATGCTTCAGCAGCTTGTTA CATTCTTCTTTCAATTTCTTGAACTGAATGTAATTTCTTTAGCTCTTAAATATGCAATTTCCTCTTCCTTGATTACTCTTTTCCTCCTCT TTGTCTAGCCAAGTTTCATTCATCCTTCAGGCTTCAGCTTAAATAGCCTACATTTGTTGAGGTTTATGGTTATCTCTGCATGGGATGTCC ACGTTGGCAGGGACTATGAGAGATTTTTCAGATTATAACATCTGACTCAGAGTTGGTGCTCAGTGTCTGCCTGTTGTATGTAGTATAGGG GAGGAAAAACATTTTTTCTCTGCCCTCTTAGGTTCAGTAGCTGGGCCCTGCAAAATAAACTGATGAAAGATAGATTAACAGGAAAAAAGG TTTATGCATAAATGTAAAGAAGTGGTTAGACCAGGGGGCTCATATGCCATTTTAACAAAGAGTGATAAATTATAGAGAAGTAACTAGACA AAAGTAGGGGAATGCTTCTTGGGTAAATTGTAGGAAGGTAAATATATGGCGGAAGCTAACATAAGATAAGGGTTATTCAGTAAAGTTTGT TATGTGGACTCAAGTTGGTGCCTTCCCCATTGGTAAGAGTTGCTCTCCTCTTCCTGGTACTGGAAAGGAAGACACATTTACAAATGGATA TTTATTACCTGTACATAGGAAAATTTATGCCCTGCATTTATACAAAAAAGGGAGGGCAAAGAGCAAATTGGTTTCAGCTCAAAACAATTC TTACATGAAAGTGGCATATTTTGGGGTAGCATACACTGATCCTCTTCAAAAGGAATAATTTGCTTTTCTCTTATCATGGTTATGAGAGCT ACTTTGAATTAATTTTTGCTTTTTGAAAGTACATTTAATTCTCAAATGTTTCTGCTTTTGAATGCAGTTTGGGAGAGCCCATGGTGACTG CGTGAGTGGAGCCCAGCTGTGTGGATGCCCCAGCATGGATGACTACATGGTCCTGAGAATGATTGGGGAGGGCTCCTTCGGCAGAGCTCT TTTGGTTCAGCATGAAAGCAGTAATCAGATGTTTGCCATGAAAGAAATAAGGCTTCCCAAGTCTTTCTCTAATACACAGAATTCTAGGAA GGAGGCTGTTCTTTTAGCCAAAATGAAACACCCTAATATTGTTGCCTTCAAAGAATCATTTGAAGCTGAAGGACACTTGTATATTGTGAT GGAATACTGTGATGGAGGGGATCTAATGCAAAAGATTAAACAGCAGAAAGGAAAGTTATTTCCTGAAGACATGATACTTAATTGGTTTAC CCAAATGTGCCTTGGAGTAAATCACATTCACAAGAAACGTGTGCTACACAGAGATATCAAGTCCAAGAATATCTTCCTCACTCAGAATGG AAAAGTGAAATTGGGAGACTTTGGATCTGCCCGTCTTCTCTCCAATCCGATGGCATTTGCTTGTACCTATGTGGGAACTCCTTATTATGT GCCTCCAGAAATTTGGGAAAACCTGCCTTATAACAATAAAAGTGACATCTGGTCCTTGGGTTGCATCCTGTATGAACTCTGTACCCTTAA GCATCCAAACAGCATGATTCCAACAGGCCTGGCTTGGGAGGACATGTTGTACCCTCTGTACCAGAAGTACAAGAATGCCATCACGTGGGG AGACCAGGATTTATTAAATATTATTTTTTATTTCAACCCAGAGTGTCTCTATGTATTCCCCTGCCAGTGGAACTACCGTCCCGATCACTG CATGTACGGAAGCAACTGCAGAGAGGCTGAGCATGAAGGTGTGTCTGTTCTGCATGGAAACCGAGGCGTCTACCATGACGATAAGCAACC AACGTTCAGAGCACTCTATGAAGCAATACGGGATTTTCCCTTTCAAGACAATCTCTTTCAATCCATGTATTACCCCCTTCAGCTGAAGTT TTTGGAGACTGTGCACACTTTATGTGGACGAATCCCGCAAGTTTTTCTGAAGCAAATTGAGAAAACAATGAAAAGGGCTTATGAGAAACA CGTCATCATCCATGTTGGCCCCAACCAGATGCACTGAATATTTTGTCTTGTTGCAAGTCAATTAGGTGTCTTGTGACCAAGGAAATACTA ATCTCTAAGCTGCCTGGGTCTTTTTGTGTGAATATTTAATGGTGCTCCATGACTGTTGAGTTTTAAAAACCTCGTTAAATTTTGCCAAAT CAGTTGCCCCCAAAAGGGAATATGCTTTTCCTTATTTTTTTTTCTAAAATGCTATTTATCTCTAAGGAAAAAAAAAAAAGACTATTACTC ATTTAACATTGTTTAAGCAGGTTGAGCTAGCTGTGAAAATAGCTTTTGTGAGCCTTCTAATTCCTAAACGTCTGAGACCATTTCAGTGGC ACCTGAGGTGTTATATTGATCTAGCATTCCTGAGACTCTTTCTATGCAACTGACTCCCCCACACCCGTGTTATAAAAGTAATACACACTT TTGAAACAGAGAGACACACTTGTAGAGCATATGGGTCAAGGGCTCAACATCAAGATTAGATTAGCCATAATCCTATTGACCAGTGGAAAA GATTGTTTCCATTTTAAAGCAGTTCCTTACAACCTTTTTTCTCTACTTTTGCATTTTCCACTCTAACACACATCTAAAACAGGTAATCTC AGTAAAAGCTGGCCTTTTTGCTGAGATTTTTATGTGGGAGACTAAAATATTAGATGAGATGATTATGTGTACAGAATTTTATTTAAAATA CATCTGAGAGAATCATTCAGATACTTGGGTAGTGTTAAAGGATGAAGCATGTATCTGGGGGTATTTCTTCTTTTTCTTTCTTTCTTTTTT TTTTTTTTTTTTTTTTTGAGACGGAATCTCACTCTGTAGCCCAGGCTAGAATGCAGTGGCAGGATCTCGGCTCACTGCAGCTTCCACCTC CTGGGTTCAAGTGATTCTCATGCCTCAGCCTCCCCAGTAGCTGGGATTACAAGTGTGTGCCACCACACCCGGCTAATTTTTGTATTTTTA GTAGAGACACGGTTTTACCATGTTGGCCAGGCTGGTCTTGATCTCCAGACCTCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGG ATTACAAGTGTGAGCCACTGCACTCAGCCAATCTGGGAGTATTTCTAAAGAAAAAAATTACTTTGATTTGTGGAGGACTAAATCATAATA CATTTCTATGCAACAATAGCTTCTGAGAGGAAATTCAGGAATGTTTGTGTTTACCACAGACAAAAACATTTGATCTGTTAATCATCAGTA GCTGTGGTCATCTCTCTTTCTTAAACTCTTGGGCAATGGGTGGAAATCAGAGACCAACTTCAAATTTAATGTGTAAAAAACAAATAGTTC AGCTGCTTCTATTGGTAAGAAAATTCAACTTCCTACCAGCCTTAGAAAGGTCTCTTTAAACAATTTCTTTCCCCCTAGGGTTACCTAGCT GGTCCATACAGGTTTTATCACCTCACTGCAAGGAGGAAGTTGAATATTCTGTTCCCCACGGGGATCTGGCTTAATCCCTAGTTGCTCATA TAGTTGGTATCAGCATAGCAATATTTTGCATAATGCTTTATTTTTCTCAAATGACTATTGCATAGATGATCTTGATATTTGCAACAGCCT AGTGGATTTGGTAGGGTCCTGAATCATCTCTATAAGGCAAACAAGGAAATTGTAACACAAAGAAATAAACATATTGAATATAATTGCTAT TCTGTAAGACATACAGTCTGTGTAAGATGTATCTTATTTACAGAGACATTTTTGAAAATTAAAATATTAAATACTTTTTGTTATATAGAG >In-frame_NEK3_ENST00000400357_chr13_52722550_-_GXYLT2_ENST00000389617_chr3_73006380_+_4144nt ATTGTGCCTTTCCTCTCTCAGGGAGTGCCAAGAAACCATCTGGTTCATGCCAGAAACTTGGGAGTCAACCTTGCCCCCTTCTCTGCTTGC CCCCCATAAATCTGCCACCACAAATCCTGTCAACTGTTCTTACATCTTTCCTTCCCATTTTTTCTGACCCCATTGCCTCCACTCTATTCC ATTTCATTATTTTCCTGCCTTTTCTATTGTTGGAGCCTCCTAACTGGCCTGTGTCTCTGAGCTGGCCTTCCTGCCCCTCCTCCACTGGTC CATTTAATCTGCAATCTGAGTGAATGTTTTTTCTAATATGCAAATATGATTATATTGCCTTCTTGGTTAAAATGCTTCAGCAGCTTGTTA CATTCTTCTTTCAATTTCTTGAACTGAATGTAATTTCTTTAGCTCTTAAATATGCAATTTCCTCTTCCTTGATTACTCTTTTCCTCCTCT TTGTCTAGCCAAGTTTCATTCATCCTTCAGGCTTCAGCTTAAATAGCCTACATTTGTTGAGGTTTATGGTTATCTCTGCATGGGATGTCC ACGTTGGCAGGGACTATGAGAGATTTTTCAGATTATAACATCTGACTCAGAGTTGGTGCTCAGTGTCTGCCTGTTGTATGTAGTATAGGG GAGGAAAAACATTTTTTCTCTGCCCTCTTAGGTTCAGTAGCTGGGCCCTGCAAAATAAACTGATGAAAGATAGATTAACAGGAAAAAAGG TTTATGCATAAATGTAAAGAAGTGGTTAGACCAGGGGGCTCATATGCCATTTTAACAAAGAGTGATAAATTATAGAGAAGTAACTAGACA AAAGTAGGGGAATGCTTCTTGGGTAAATTGTAGGAAGGTAAATATATGGCGGAAGCTAACATAAGATAAGGGTTATTCAGTAAAGTTTGT TATGTGGACTCAAGTTGGTGCCTTCCCCATTGGTAAGAGTTGCTCTCCTCTTCCTGGTACTGGAAAGGAAGACACATTTACAAATGGATA TTTATTACCTGTACATAGGAAAATTTATGCCCTGCATTTATACAAAAAAGGGAGGGCAAAGAGCAAATTGGTTTCAGCTCAAAACAATTC TTACATGAAAGTGGCATATTTTGGGGTAGCATACACTGATCCTCTTCAAAAGGAATAATTTGCTTTTCTCTTATCATGGTTATGAGAGCT ACTTTGAATTAATTTTTGCTTTTTGAAAGTACATTTAATTCTCAAATGTTTCTGCTTTTGAATGCAGTTTGGGAGAGCCCATGGTGACTG CGTGAGTGGAGCCCAGCTGTGTGGATGCCCCAGCATGGATGACTACATGGTCCTGAGAATGATTGGGGAGGGCTCCTTCGGCAGAGCTCT TTTGGTTCAGCATGAAAGCAGTAATCAGATGTTTGCCATGAAAGAAATAAGGCTTCCCAAGTCTTTCTCTAATACACAGAATTCTAGGAA GGAGGCTGTTCTTTTAGCCAAAATGAAACACCCTAATATTGTTGCCTTCAAAGAATCATTTGAAGCTGAAGGACACTTGTATATTGTGAT GGAATACTGTGATGGAGGGGATCTAATGCAAAAGATTAAACAGCAGAAAGGAAAGTTATTTCCTGAAGACATGATACTTAATTGGTTTAC CCAAATGTGCCTTGGAGTAAATCACATTCACAAGAAACGTGTGCTACACAGAGATATCAAGTCCAAGAATATCTTCCTCACTCAGAATGG AAAAGTGAAATTGGGAGACTTTGGATCTGCCCGTCTTCTCTCCAATCCGATGGCATTTGCTTGTACCTATGTGGGAACTCCTTATTATGT GCCTCCAGAAATTTGGGAAAACCTGCCTTATAACAATAAAAGTGACATCTGGTCCTTGGGTTGCATCCTGTATGAACTCTGTACCCTTAA GCATCCAAACAGCATGATTCCAACAGGCCTGGCTTGGGAGGACATGTTGTACCCTCTGTACCAGAAGTACAAGAATGCCATCACGTGGGG AGACCAGGATTTATTAAATATTATTTTTTATTTCAACCCAGAGTGTCTCTATGTATTCCCCTGCCAGTGGAACTACCGTCCCGATCACTG CATGTACGGAAGCAACTGCAGAGAGGCTGAGCATGAAGGTGTGTCTGTTCTGCATGGAAACCGAGGCGTCTACCATGACGATAAGCAACC AACGTTCAGAGCACTCTATGAAGCAATACGGGATTTTCCCTTTCAAGACAATCTCTTTCAATCCATGTATTACCCCCTTCAGCTGAAGTT TTTGGAGACTGTGCACACTTTATGTGGACGAATCCCGCAAGTTTTTCTGAAGCAAATTGAGAAAACAATGAAAAGGGCTTATGAGAAACA CGTCATCATCCATGTTGGCCCCAACCAGATGCACTGAATATTTTGTCTTGTTGCAAGTCAATTAGGTGTCTTGTGACCAAGGAAATACTA ATCTCTAAGCTGCCTGGGTCTTTTTGTGTGAATATTTAATGGTGCTCCATGACTGTTGAGTTTTAAAAACCTCGTTAAATTTTGCCAAAT CAGTTGCCCCCAAAAGGGAATATGCTTTTCCTTATTTTTTTTTCTAAAATGCTATTTATCTCTAAGGAAAAAAAAAAAAGACTATTACTC ATTTAACATTGTTTAAGCAGGTTGAGCTAGCTGTGAAAATAGCTTTTGTGAGCCTTCTAATTCCTAAACGTCTGAGACCATTTCAGTGGC ACCTGAGGTGTTATATTGATCTAGCATTCCTGAGACTCTTTCTATGCAACTGACTCCCCCACACCCGTGTTATAAAAGTAATACACACTT TTGAAACAGAGAGACACACTTGTAGAGCATATGGGTCAAGGGCTCAACATCAAGATTAGATTAGCCATAATCCTATTGACCAGTGGAAAA GATTGTTTCCATTTTAAAGCAGTTCCTTACAACCTTTTTTCTCTACTTTTGCATTTTCCACTCTAACACACATCTAAAACAGGTAATCTC AGTAAAAGCTGGCCTTTTTGCTGAGATTTTTATGTGGGAGACTAAAATATTAGATGAGATGATTATGTGTACAGAATTTTATTTAAAATA CATCTGAGAGAATCATTCAGATACTTGGGTAGTGTTAAAGGATGAAGCATGTATCTGGGGGTATTTCTTCTTTTTCTTTCTTTCTTTTTT TTTTTTTTTTTTTTTTTGAGACGGAATCTCACTCTGTAGCCCAGGCTAGAATGCAGTGGCAGGATCTCGGCTCACTGCAGCTTCCACCTC CTGGGTTCAAGTGATTCTCATGCCTCAGCCTCCCCAGTAGCTGGGATTACAAGTGTGTGCCACCACACCCGGCTAATTTTTGTATTTTTA GTAGAGACACGGTTTTACCATGTTGGCCAGGCTGGTCTTGATCTCCAGACCTCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGG ATTACAAGTGTGAGCCACTGCACTCAGCCAATCTGGGAGTATTTCTAAAGAAAAAAATTACTTTGATTTGTGGAGGACTAAATCATAATA CATTTCTATGCAACAATAGCTTCTGAGAGGAAATTCAGGAATGTTTGTGTTTACCACAGACAAAAACATTTGATCTGTTAATCATCAGTA GCTGTGGTCATCTCTCTTTCTTAAACTCTTGGGCAATGGGTGGAAATCAGAGACCAACTTCAAATTTAATGTGTAAAAAACAAATAGTTC AGCTGCTTCTATTGGTAAGAAAATTCAACTTCCTACCAGCCTTAGAAAGGTCTCTTTAAACAATTTCTTTCCCCCTAGGGTTACCTAGCT GGTCCATACAGGTTTTATCACCTCACTGCAAGGAGGAAGTTGAATATTCTGTTCCCCACGGGGATCTGGCTTAATCCCTAGTTGCTCATA TAGTTGGTATCAGCATAGCAATATTTTGCATAATGCTTTATTTTTCTCAAATGACTATTGCATAGATGATCTTGATATTTGCAACAGCCT AGTGGATTTGGTAGGGTCCTGAATCATCTCTATAAGGCAAACAAGGAAATTGTAACACAAAGAAATAAACATATTGAATATAATTGCTAT TCTGTAAGACATACAGTCTGTGTAAGATGTATCTTATTTACAGAGACATTTTTGAAAATTAAAATATTAAATACTTTTTGTTATATAGAG |
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FusionGenePPI for NEK3_GXYLT2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEK3 | HDAC6, NMNAT1, BPGM, CDCA8, VSIG4, CDK13, TNFSF8, CPNE2 | GXYLT2 | FBL, SRPK2, MGAT4C, CD70, NEUROG3, HLA-DPA1, SCGB2A2, KCNC4, KLRG2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NEK3 | chr13:52722550 | chr3:73006380 | ENST00000400357 | - | 7 | 14 | 1_285 | 201 | 490 | VAV2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEK3_GXYLT2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEK3_GXYLT2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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