FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 23998

FusionGeneSummary for NEK10_QKI

check button Fusion gene summary
Fusion gene informationFusion gene name: NEK10_QKI
Fusion gene ID: 23998
HgeneTgene
Gene symbol

NEK10

QKI

Gene ID

152110

9444

Gene nameNIMA related kinase 10QKI, KH domain containing RNA binding
Synonyms-Hqk|QK|QK1|QK3|hqkI
Cytomap

3p24.1

6q26

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Nek10NIMA (never in mitosis gene a)- related kinase 10never in mitosis A-related kinase 10nimA-related protein kinase 10protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
Modification date2018052220180522
UniProtAcc

Q6ZWH5

Q96PU8

Ensembl transtripts involved in fusion geneENST00000429845, ENST00000357467, 
ENST00000341435, ENST00000295720, 
ENST00000383771, ENST00000383770, 
ENST00000498182, 		ENST00000275262, 
ENST00000392127, ENST00000453779, 
ENST00000361752, ENST00000361195, 
ENST00000424802, 
Fusion gene scores* DoF score2 X 2 X 1=413 X 14 X 6=1092
# samples 418
** MAII scorelog2(4/4*10)=3.32192809488736log2(18/1092*10)=-2.60090404459018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEK10 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEK10

GO:0006468

protein phosphorylation

20956560

HgeneNEK10

GO:0031954

positive regulation of protein autophosphorylation

20956560


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF142421NEK10chr3

27258070

-QKIchr6

163836232

+
ChiTaRS3.1AF142417NEK10chr3

27258070

-QKIchr6

163836232

+
ChiTaRS3.1AF142420NEK10chr3

27258070

-QKIchr6

163836232

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000429845ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000429845ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000357467ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000341435ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000295720ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383771ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000383770ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000275262NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000392127NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000453779NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000361752NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000361195NEK10chr3

27258070

-QKIchr6

163836232

+
intron-3CDSENST00000498182ENST00000424802NEK10chr3

27258070

-QKIchr6

163836232

+

Top

FusionProtFeatures for NEK10_QKI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEK10

Q6ZWH5

QKI

Q96PU8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NEK10_QKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NEK10_QKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NEK10_QKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NEK10_QKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneQKIC0036341Schizophrenia5PSYGENET
TgeneQKIC0017638Glioma1CTD_human
TgeneQKIC0041696Unipolar Depression1PSYGENET
TgeneQKIC1269683Major Depressive Disorder1PSYGENET