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Fusion gene ID: 23997 |
FusionGeneSummary for NEK10_DCUN1D4 |
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Fusion gene information | Fusion gene name: NEK10_DCUN1D4 | Fusion gene ID: 23997 | Hgene | Tgene | Gene symbol | NEK10 | DCUN1D4 | Gene ID | 152110 | 23142 |
Gene name | NIMA related kinase 10 | defective in cullin neddylation 1 domain containing 4 | |
Synonyms | - | - | |
Cytomap | 3p24.1 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase Nek10NIMA (never in mitosis gene a)- related kinase 10never in mitosis A-related kinase 10nimA-related protein kinase 10 | DCN1-like protein 4DCN1, defective in cullin neddylation 1, domain containing 4DCUN1 domain-containing protein 4defective in cullin neddylation protein 1-like protein 4 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q6ZWH5 | Q92564 | |
Ensembl transtripts involved in fusion gene | ENST00000429845, ENST00000357467, ENST00000341435, ENST00000295720, ENST00000383771, ENST00000383770, ENST00000498182, | ENST00000381441, ENST00000334635, ENST00000513800, ENST00000381437, ENST00000451288, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
# samples | 4 | 3 | |
** MAII score | log2(4/4*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NEK10 [Title/Abstract] AND DCUN1D4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NEK10 | GO:0006468 | protein phosphorylation | 20956560 |
Hgene | NEK10 | GO:0031954 | positive regulation of protein autophosphorylation | 20956560 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA119783 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000429845 | ENST00000381441 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
5UTR-intron | ENST00000429845 | ENST00000334635 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
5UTR-intron | ENST00000429845 | ENST00000513800 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
5UTR-intron | ENST00000429845 | ENST00000381437 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
5UTR-intron | ENST00000429845 | ENST00000451288 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000357467 | ENST00000381441 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000357467 | ENST00000334635 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000357467 | ENST00000513800 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000357467 | ENST00000381437 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000357467 | ENST00000451288 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
5UTR-intron | ENST00000341435 | ENST00000381441 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
5UTR-intron | ENST00000341435 | ENST00000334635 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
5UTR-intron | ENST00000341435 | ENST00000513800 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
5UTR-intron | ENST00000341435 | ENST00000381437 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
5UTR-intron | ENST00000341435 | ENST00000451288 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000295720 | ENST00000381441 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000295720 | ENST00000334635 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000295720 | ENST00000513800 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000295720 | ENST00000381437 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000295720 | ENST00000451288 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383771 | ENST00000381441 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383771 | ENST00000334635 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383771 | ENST00000513800 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383771 | ENST00000381437 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383771 | ENST00000451288 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383770 | ENST00000381441 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383770 | ENST00000334635 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383770 | ENST00000513800 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383770 | ENST00000381437 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000383770 | ENST00000451288 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000498182 | ENST00000381441 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000498182 | ENST00000334635 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000498182 | ENST00000513800 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000498182 | ENST00000381437 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
intron-intron | ENST00000498182 | ENST00000451288 | NEK10 | chr3 | 27410715 | - | DCUN1D4 | chr4 | 52726708 | + |
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FusionProtFeatures for NEK10_DCUN1D4 |
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Hgene | Tgene |
NEK10 | DCUN1D4 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NEK10_DCUN1D4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NEK10_DCUN1D4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEK10_DCUN1D4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEK10_DCUN1D4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |