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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23997

FusionGeneSummary for NEK10_DCUN1D4

check button Fusion gene summary
Fusion gene informationFusion gene name: NEK10_DCUN1D4
Fusion gene ID: 23997
HgeneTgene
Gene symbol

NEK10

DCUN1D4

Gene ID

152110

23142

Gene nameNIMA related kinase 10defective in cullin neddylation 1 domain containing 4
Synonyms--
Cytomap

3p24.1

4q12

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Nek10NIMA (never in mitosis gene a)- related kinase 10never in mitosis A-related kinase 10nimA-related protein kinase 10DCN1-like protein 4DCN1, defective in cullin neddylation 1, domain containing 4DCUN1 domain-containing protein 4defective in cullin neddylation protein 1-like protein 4
Modification date2018052220180523
UniProtAcc

Q6ZWH5

Q92564

Ensembl transtripts involved in fusion geneENST00000429845, ENST00000357467, 
ENST00000341435, ENST00000295720, 
ENST00000383771, ENST00000383770, 
ENST00000498182, 
ENST00000381441, 
ENST00000334635, ENST00000513800, 
ENST00000381437, ENST00000451288, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 2=18
# samples 43
** MAII scorelog2(4/4*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NEK10 [Title/Abstract] AND DCUN1D4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEK10

GO:0006468

protein phosphorylation

20956560

HgeneNEK10

GO:0031954

positive regulation of protein autophosphorylation

20956560


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA119783NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000429845ENST00000381441NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
5UTR-intronENST00000429845ENST00000334635NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
5UTR-intronENST00000429845ENST00000513800NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
5UTR-intronENST00000429845ENST00000381437NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
5UTR-intronENST00000429845ENST00000451288NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000357467ENST00000381441NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000357467ENST00000334635NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000357467ENST00000513800NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000357467ENST00000381437NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000357467ENST00000451288NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
5UTR-intronENST00000341435ENST00000381441NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
5UTR-intronENST00000341435ENST00000334635NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
5UTR-intronENST00000341435ENST00000513800NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
5UTR-intronENST00000341435ENST00000381437NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
5UTR-intronENST00000341435ENST00000451288NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000295720ENST00000381441NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000295720ENST00000334635NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000295720ENST00000513800NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000295720ENST00000381437NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000295720ENST00000451288NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383771ENST00000381441NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383771ENST00000334635NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383771ENST00000513800NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383771ENST00000381437NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383771ENST00000451288NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383770ENST00000381441NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383770ENST00000334635NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383770ENST00000513800NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383770ENST00000381437NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000383770ENST00000451288NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000498182ENST00000381441NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000498182ENST00000334635NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000498182ENST00000513800NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000498182ENST00000381437NEK10chr3

27410715

-DCUN1D4chr4

52726708

+
intron-intronENST00000498182ENST00000451288NEK10chr3

27410715

-DCUN1D4chr4

52726708

+

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FusionProtFeatures for NEK10_DCUN1D4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEK10

Q6ZWH5

DCUN1D4

Q92564


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEK10_DCUN1D4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEK10_DCUN1D4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEK10_DCUN1D4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEK10_DCUN1D4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource