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Fusion gene ID: 23996 |
FusionGeneSummary for NEIL3_AGA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEIL3_AGA | Fusion gene ID: 23996 | Hgene | Tgene | Gene symbol | NEIL3 | AGA | Gene ID | 55247 | 175 |
| Gene name | nei like DNA glycosylase 3 | aspartylglucosaminidase | |
| Synonyms | FGP2|FPG2|NEI3|ZGRF3|hFPG2|hNEI3 | AGU|ASRG|GA | |
| Cytomap | 4q34.3 | 4q34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | endonuclease 8-like 3DNA glycosylase FPG2DNA glycosylase hFPG2DNA glycosylase/AP lyase Neil3endonuclease VIII-like 3nei endonuclease VIII-like 3nei-like protein 3zinc finger, GRF-type containing 3 | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginaseN4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidaseaspartylglucosylamine deaspartylaseglycosylasparaginase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TAT5 | P20933 | |
| Ensembl transtripts involved in fusion gene | ENST00000264596, | ENST00000264595, ENST00000506853, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NEIL3 [Title/Abstract] AND AGA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NEIL3 | GO:0006284 | base-excision repair | 23755964 |
| Tgene | AGA | GO:0006517 | protein deglycosylation | 1281977 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-KQ-A41P-01A | NEIL3 | chr4 | 178272703 | + | AGA | chr4 | 178352962 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264596 | ENST00000264595 | NEIL3 | chr4 | 178272703 | + | AGA | chr4 | 178352962 | - |
| 5CDS-intron | ENST00000264596 | ENST00000506853 | NEIL3 | chr4 | 178272703 | + | AGA | chr4 | 178352962 | - |
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FusionProtFeatures for NEIL3_AGA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEIL3 | AGA |
| DNA glycosylase which prefers single-stranded DNA(ssDNA), or partially ssDNA structures such as bubble and forkstructures, to double-stranded DNA (dsDNA). In vitro, displaysstrong glycosylase activity towards the hydantoin lesionsspiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in bothssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoGdetected. Also shows weak DNA-(apurinic or apyrimidinic site)lyase activity. In vivo, appears to be the primary enzyme involvedin removing Sp and Gh from ssDNA in neonatal tissues. Seems to bean important facilitator of cell proliferation in certainpopulations, for example neural stem/progenitor cells and tumorcells, suggesting a role in replication-associated DNA repair.{ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:19170771,ECO:0000269|PubMed:22569481, ECO:0000269|PubMed:23755964}. | Cleaves the GlcNAc-Asn bond which joins oligosaccharidesto the peptide of asparagine-linked glycoproteins.{ECO:0000269|PubMed:1703489, ECO:0000269|PubMed:1904874,ECO:0000269|PubMed:2401370}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NEIL3 | chr4:178272703 | chr4:178352962 | ENST00000264596 | + | 7 | 10 | 247_281 | 346 | 606 | Zinc finger | FPG-type |
| Hgene | NEIL3 | chr4:178272703 | chr4:178352962 | ENST00000264596 | + | 7 | 10 | 317_346 | 346 | 606 | Zinc finger | RanBP2-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | AGA | chr4:178272703 | chr4:178352962 | ENST00000264595 | - | 7 | 9 | 234_237 | 313 | 347 | Region | Substrate binding |
| Tgene | AGA | chr4:178272703 | chr4:178352962 | ENST00000264595 | - | 7 | 9 | 257_260 | 313 | 347 | Region | Substrate binding |
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FusionGeneSequence for NEIL3_AGA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NEIL3_AGA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEIL3 | TP53, TWIST1, ROCK1, SFSWAP, SLC2A1, SMARCA4, BCL7C, SLC25A13, SF3B2, NNT, GLTSCR1, GPATCH4, CDKN2AIP, PRPF40A, HMCES, ENY2, RBM25, RSBN1L | AGA | AGA, ALB, FBXO6, MOB4, HBA2, HBB, IGHG1, ZER1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEIL3_AGA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEIL3_AGA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | AGA | C0268225 | Aspartylglucosaminuria | 4 | CTD_human;HPO;ORPHANET;UNIPROT |
| Tgene | AGA | C0036341 | Schizophrenia | 1 | PSYGENET |
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