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Fusion gene ID: 23988 |
FusionGeneSummary for NEGR1_CYP2J2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEGR1_CYP2J2 | Fusion gene ID: 23988 | Hgene | Tgene | Gene symbol | NEGR1 | CYP2J2 | Gene ID | 257194 | 1573 |
| Gene name | neuronal growth regulator 1 | cytochrome P450 family 2 subfamily J member 2 | |
| Synonyms | DMML2433|IGLON4|KILON|Ntra | CPJ2|CYPIIJ2 | |
| Cytomap | 1p31.1 | 1p32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuronal growth regulator 1IgLON family member 4a kindred of IgLONneurotractin | cytochrome P450 2J2arachidonic acid epoxygenasecytochrome P450, family 2, subfamily J, polypeptide 2cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2flavoprotein-linked monooxygenasemicrosomal monooxygenase | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q7Z3B1 | P51589 | |
| Ensembl transtripts involved in fusion gene | ENST00000357731, ENST00000306821, ENST00000434200, ENST00000467479, | ENST00000371204, ENST00000492633, | |
| Fusion gene scores | * DoF score | 7 X 3 X 6=126 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NEGR1 [Title/Abstract] AND CYP2J2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CYP2J2 | GO:0019373 | epoxygenase P450 pathway | 11901223 |
| Tgene | CYP2J2 | GO:0043651 | linoleic acid metabolic process | 11901223 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A3ET-06A | NEGR1 | chr1 | 72748002 | - | CYP2J2 | chr1 | 60381772 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000357731 | ENST00000371204 | NEGR1 | chr1 | 72748002 | - | CYP2J2 | chr1 | 60381772 | - |
| 5CDS-intron | ENST00000357731 | ENST00000492633 | NEGR1 | chr1 | 72748002 | - | CYP2J2 | chr1 | 60381772 | - |
| intron-3CDS | ENST00000306821 | ENST00000371204 | NEGR1 | chr1 | 72748002 | - | CYP2J2 | chr1 | 60381772 | - |
| intron-intron | ENST00000306821 | ENST00000492633 | NEGR1 | chr1 | 72748002 | - | CYP2J2 | chr1 | 60381772 | - |
| In-frame | ENST00000434200 | ENST00000371204 | NEGR1 | chr1 | 72748002 | - | CYP2J2 | chr1 | 60381772 | - |
| 5CDS-intron | ENST00000434200 | ENST00000492633 | NEGR1 | chr1 | 72748002 | - | CYP2J2 | chr1 | 60381772 | - |
| intron-3CDS | ENST00000467479 | ENST00000371204 | NEGR1 | chr1 | 72748002 | - | CYP2J2 | chr1 | 60381772 | - |
| intron-intron | ENST00000467479 | ENST00000492633 | NEGR1 | chr1 | 72748002 | - | CYP2J2 | chr1 | 60381772 | - |
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FusionProtFeatures for NEGR1_CYP2J2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEGR1 | CYP2J2 |
| May be involved in cell-adhesion. May function as atrans-neural growth-promoting factor in regenerative axonsprouting in the mammalian brain (By similarity). {ECO:0000250}. | This enzyme metabolizes arachidonic acid predominantlyvia a NADPH-dependent olefin epoxidation to all four regioisomericcis-epoxyeicosatrienoic acids. One of the predominant enzymesresponsible for the epoxidation of endogenous cardiac arachidonicacid pools. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NEGR1 | chr1:72748002 | chr1:60381772 | ENST00000357731 | - | 1 | 7 | 139_221 | 58 | 355 | Domain | Note=Ig-like C2-type 2 |
| Hgene | >NEGR1 | chr1:72748002 | chr1:60381772 | ENST00000357731 | - | 1 | 7 | 225_313 | 58 | 355 | Domain | Note=Ig-like C2-type 3 |
| Hgene | >NEGR1 | chr1:72748002 | chr1:60381772 | ENST00000357731 | - | 1 | 7 | 38_134 | 58 | 355 | Domain | Note=Ig-like C2-type 1 |
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FusionGeneSequence for NEGR1_CYP2J2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NEGR1_ENST00000357731_chr1_72748002_-_CYP2J2_ENST00000371204_chr1_60381772_-_491aa MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLSLXRNMGTFLAWSLVTYLQFLLLACPXSKKPL STWTKTLGTAPXPLCENISLRKMDXLCQVARHGRSKEGSLXQHXGTLVXERRAXRNAFRRRPNTSLKQXKRRTDSLLTLISRSTMQFPIS FAPSPSENALSTRIVGFSSCXSYXMKSHTWRLQRHASSTMSFHGXXNSCLDPTKLSSATGKNXNCLFLIXLTNTERIGILQKQETLLMLT LKKCQSTQAILLQVSMKKTSSAAPWTSSLPEPRQLPQLCDGLCFIWPSTQKSKKKYKLRLTEXLARGSSRAQPPGSPCPTPMLSSMRCRE WATSSPXTFPGKXQLIPLWLGTTCPRVPXSXPIXRRCTGTPQSGPPLTHSIRTIFWRMDSLRKGKPLCLSQXESGHASENSWPGLSCLFS >In-frame_NEGR1_ENST00000434200_chr1_72748002_-_CYP2J2_ENST00000371204_chr1_60381772_-_489aa MMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLSLXRNMGTFLAWSLVTYLQFLLLACPXSKKPLST WTKTLGTAPXPLCENISLRKMDXLCQVARHGRSKEGSLXQHXGTLVXERRAXRNAFRRRPNTSLKQXKRRTDSLLTLISRSTMQFPISFA PSPSENALSTRIVGFSSCXSYXMKSHTWRLQRHASSTMSFHGXXNSCLDPTKLSSATGKNXNCLFLIXLTNTERIGILQKQETLLMLTLK KCQSTQAILLQVSMKKTSSAAPWTSSLPEPRQLPQLCDGLCFIWPSTQKSKKKYKLRLTEXLARGSSRAQPPGSPCPTPMLSSMRCREWA TSSPXTFPGKXQLIPLWLGTTCPRVPXSXPIXRRCTGTPQSGPPLTHSIRTIFWRMDSLRKGKPLCLSQXESGHASENSWPGLSCLFSSL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NEGR1_ENST00000357731_chr1_72748002_-_CYP2J2_ENST00000371204_chr1_60381772_-_1475nt ATGGACATGATGCTGTTGGTGCAGGGTGCTTGTTGCTCGAACCAGTGGCTGGCGGCGGTGCTCCTCAGCCTGTGCTGCCTGCTACCCTCC TGCCTCCCGGCTGGACAGAGTGTGGACTTCCCCTGGGCGGCCGTGGACAACATGATGGTCAGAAAAGGGGACACGGCGGTGCTTAGTTTG TGAAGAAATATGGGAACCTTTTTAGCTTGGAGCTTGGTGACATATCTGCAGTTCTTATTACTGGCTTGCCCTTAATCAAAGAAGCCCTTA TCCACATGGACCAAAACTTTGGGAACCGCCCCGTGACCCCTATGCGAGAACATATCTTTAAGAAAAATGGATTGATTATGTCAAGTGGCC AGGCATGGAAGGAGCAAAGAAGGTTCACTCTGACAGCACTAAGGAACTTTGGTTTAGGAAAGAAGAGCTTAGAGGAACGCATTCAGGAGG AGGCCCAACACCTCACTGAAGCAATAAAAGAGGAGAACGGACAGCCTTTTGACCCTCATTTCAAGATCAACAATGCAGTTTCCAATATCA TTTGCTCCATCACCTTCGGAGAACGCTTTGAGTACCAGGATAGTTGGTTTCAGCAGCTGCTGAAGTTACTAGATGAAGTCACATACTTGG AGGCTTCAAAGACATGCCAGCTCTACAATGTCTTTCCATGGATAATGAAATTCCTGCCTGGACCCCACCAAACTCTCTTCAGCAACTGGA AAAAACTGAAATTGTTTGTTTCTCATATGATTGACAAACACAGAAAGGATTGGAATCCTGCAGAAACAAGAGACTTTATTGATGCTTACC TTAAAGAAATGTCAAAGCACACAGGCAATCCTACTTCAAGTTTCCATGAAGAAAACCTCATCTGCAGCACCCTGGACCTCTTCTTTGCCG GAACCGAGACAACTTCCACAACTCTGCGATGGGCTCTGCTTTATATGGCCCTCTACCCAGAAATCCAAGAAAAAGTACAAGCTGAGATTG ACAGAGTGATTGGCCAGGGGCAGCAGCCGAGCACAGCCGCCCGGGAGTCCATGCCCTACACCAATGCTGTCATCCATGAGGTGCAGAGAA TGGGCAACATCATCCCCCTGAACGTTCCCAGGGAAGTGACAGTTGATACCACTTTGGCTGGGTACCACCTGCCCAAGGGTACCATGATCC TGACCAATTTGACGGCGCTGCACAGGGACCCCACAGAGTGGGCCACCCCTGACACATTCAATCCGGACCATTTTCTGGAGAATGGACAGT TTAAGAAAAGGGAAGCCTTTATGCCTTTCTCAATAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCAGGACTGAGCTGTTTATTTTCT TCACTTCCCTTATGCAAAAATTTACCTTCAGGCCCCCAAACAATGAGAAGCTGAGCCTGAAGTTTAGAATGGGTATCACCATTTCCCCAG >In-frame_NEGR1_ENST00000434200_chr1_72748002_-_CYP2J2_ENST00000371204_chr1_60381772_-_1469nt ATGATGCTGTTGGTGCAGGGTGCTTGTTGCTCGAACCAGTGGCTGGCGGCGGTGCTCCTCAGCCTGTGCTGCCTGCTACCCTCCTGCCTC CCGGCTGGACAGAGTGTGGACTTCCCCTGGGCGGCCGTGGACAACATGATGGTCAGAAAAGGGGACACGGCGGTGCTTAGTTTGTGAAGA AATATGGGAACCTTTTTAGCTTGGAGCTTGGTGACATATCTGCAGTTCTTATTACTGGCTTGCCCTTAATCAAAGAAGCCCTTATCCACA TGGACCAAAACTTTGGGAACCGCCCCGTGACCCCTATGCGAGAACATATCTTTAAGAAAAATGGATTGATTATGTCAAGTGGCCAGGCAT GGAAGGAGCAAAGAAGGTTCACTCTGACAGCACTAAGGAACTTTGGTTTAGGAAAGAAGAGCTTAGAGGAACGCATTCAGGAGGAGGCCC AACACCTCACTGAAGCAATAAAAGAGGAGAACGGACAGCCTTTTGACCCTCATTTCAAGATCAACAATGCAGTTTCCAATATCATTTGCT CCATCACCTTCGGAGAACGCTTTGAGTACCAGGATAGTTGGTTTCAGCAGCTGCTGAAGTTACTAGATGAAGTCACATACTTGGAGGCTT CAAAGACATGCCAGCTCTACAATGTCTTTCCATGGATAATGAAATTCCTGCCTGGACCCCACCAAACTCTCTTCAGCAACTGGAAAAAAC TGAAATTGTTTGTTTCTCATATGATTGACAAACACAGAAAGGATTGGAATCCTGCAGAAACAAGAGACTTTATTGATGCTTACCTTAAAG AAATGTCAAAGCACACAGGCAATCCTACTTCAAGTTTCCATGAAGAAAACCTCATCTGCAGCACCCTGGACCTCTTCTTTGCCGGAACCG AGACAACTTCCACAACTCTGCGATGGGCTCTGCTTTATATGGCCCTCTACCCAGAAATCCAAGAAAAAGTACAAGCTGAGATTGACAGAG TGATTGGCCAGGGGCAGCAGCCGAGCACAGCCGCCCGGGAGTCCATGCCCTACACCAATGCTGTCATCCATGAGGTGCAGAGAATGGGCA ACATCATCCCCCTGAACGTTCCCAGGGAAGTGACAGTTGATACCACTTTGGCTGGGTACCACCTGCCCAAGGGTACCATGATCCTGACCA ATTTGACGGCGCTGCACAGGGACCCCACAGAGTGGGCCACCCCTGACACATTCAATCCGGACCATTTTCTGGAGAATGGACAGTTTAAGA AAAGGGAAGCCTTTATGCCTTTCTCAATAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCAGGACTGAGCTGTTTATTTTCTTCACTT CCCTTATGCAAAAATTTACCTTCAGGCCCCCAAACAATGAGAAGCTGAGCCTGAAGTTTAGAATGGGTATCACCATTTCCCCAGTCAGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NEGR1_ENST00000357731_chr1_72748002_-_CYP2J2_ENST00000371204_chr1_60381772_-_2058nt GAAGAGGAGGAGGGGAGGCAAAAACACCGAAAAACAAAAAGAGAGAAACAACACCCAACAACTGGGGTGGGGGGAAGAAAGAAAGAAAAG AAACCCACCCACCCACCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATCCTGTGGCGCGCCGCCTGGTTCCCGGGAAGACTCGCCAG CACCAGGGGGTGGGGGAGTGCGAGCTGAAAGCTGCTGGAGAGTGAGCAGCCCTAGCAGGGATGGACATGATGCTGTTGGTGCAGGGTGCT TGTTGCTCGAACCAGTGGCTGGCGGCGGTGCTCCTCAGCCTGTGCTGCCTGCTACCCTCCTGCCTCCCGGCTGGACAGAGTGTGGACTTC CCCTGGGCGGCCGTGGACAACATGATGGTCAGAAAAGGGGACACGGCGGTGCTTAGTTTGTGAAGAAATATGGGAACCTTTTTAGCTTGG AGCTTGGTGACATATCTGCAGTTCTTATTACTGGCTTGCCCTTAATCAAAGAAGCCCTTATCCACATGGACCAAAACTTTGGGAACCGCC CCGTGACCCCTATGCGAGAACATATCTTTAAGAAAAATGGATTGATTATGTCAAGTGGCCAGGCATGGAAGGAGCAAAGAAGGTTCACTC TGACAGCACTAAGGAACTTTGGTTTAGGAAAGAAGAGCTTAGAGGAACGCATTCAGGAGGAGGCCCAACACCTCACTGAAGCAATAAAAG AGGAGAACGGACAGCCTTTTGACCCTCATTTCAAGATCAACAATGCAGTTTCCAATATCATTTGCTCCATCACCTTCGGAGAACGCTTTG AGTACCAGGATAGTTGGTTTCAGCAGCTGCTGAAGTTACTAGATGAAGTCACATACTTGGAGGCTTCAAAGACATGCCAGCTCTACAATG TCTTTCCATGGATAATGAAATTCCTGCCTGGACCCCACCAAACTCTCTTCAGCAACTGGAAAAAACTGAAATTGTTTGTTTCTCATATGA TTGACAAACACAGAAAGGATTGGAATCCTGCAGAAACAAGAGACTTTATTGATGCTTACCTTAAAGAAATGTCAAAGCACACAGGCAATC CTACTTCAAGTTTCCATGAAGAAAACCTCATCTGCAGCACCCTGGACCTCTTCTTTGCCGGAACCGAGACAACTTCCACAACTCTGCGAT GGGCTCTGCTTTATATGGCCCTCTACCCAGAAATCCAAGAAAAAGTACAAGCTGAGATTGACAGAGTGATTGGCCAGGGGCAGCAGCCGA GCACAGCCGCCCGGGAGTCCATGCCCTACACCAATGCTGTCATCCATGAGGTGCAGAGAATGGGCAACATCATCCCCCTGAACGTTCCCA GGGAAGTGACAGTTGATACCACTTTGGCTGGGTACCACCTGCCCAAGGGTACCATGATCCTGACCAATTTGACGGCGCTGCACAGGGACC CCACAGAGTGGGCCACCCCTGACACATTCAATCCGGACCATTTTCTGGAGAATGGACAGTTTAAGAAAAGGGAAGCCTTTATGCCTTTCT CAATAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCAGGACTGAGCTGTTTATTTTCTTCACTTCCCTTATGCAAAAATTTACCTTCA GGCCCCCAAACAATGAGAAGCTGAGCCTGAAGTTTAGAATGGGTATCACCATTTCCCCAGTCAGTCACCGCCTCTGCGCTGTTCCTCAGG TGTAATATTGTTAAGAAAGAAAGGGGCAAGGAAAGTAAGAAGACATGGCACGTGTTCTGAAACCACTGGTGTCTGCTCAGATGTGTTGGG ACAAAATGAAAGTGACTTTCAAGAAAGATCAGAGGAATTTGACTCAGAGAAAACTAGATCCAAATCCCAGCTCTACTGTCTCGTCCGAAT TAGCCTTGGGAAAATCATTTATATGCTAAATAATTTACCTTTTTATCTAGGAGATGAAAAGAGGATAATGTTTCCTTCCATAAAGAAAGT >In-frame_NEGR1_ENST00000434200_chr1_72748002_-_CYP2J2_ENST00000371204_chr1_60381772_-_1812nt ATGATGCTGTTGGTGCAGGGTGCTTGTTGCTCGAACCAGTGGCTGGCGGCGGTGCTCCTCAGCCTGTGCTGCCTGCTACCCTCCTGCCTC CCGGCTGGACAGAGTGTGGACTTCCCCTGGGCGGCCGTGGACAACATGATGGTCAGAAAAGGGGACACGGCGGTGCTTAGTTTGTGAAGA AATATGGGAACCTTTTTAGCTTGGAGCTTGGTGACATATCTGCAGTTCTTATTACTGGCTTGCCCTTAATCAAAGAAGCCCTTATCCACA TGGACCAAAACTTTGGGAACCGCCCCGTGACCCCTATGCGAGAACATATCTTTAAGAAAAATGGATTGATTATGTCAAGTGGCCAGGCAT GGAAGGAGCAAAGAAGGTTCACTCTGACAGCACTAAGGAACTTTGGTTTAGGAAAGAAGAGCTTAGAGGAACGCATTCAGGAGGAGGCCC AACACCTCACTGAAGCAATAAAAGAGGAGAACGGACAGCCTTTTGACCCTCATTTCAAGATCAACAATGCAGTTTCCAATATCATTTGCT CCATCACCTTCGGAGAACGCTTTGAGTACCAGGATAGTTGGTTTCAGCAGCTGCTGAAGTTACTAGATGAAGTCACATACTTGGAGGCTT CAAAGACATGCCAGCTCTACAATGTCTTTCCATGGATAATGAAATTCCTGCCTGGACCCCACCAAACTCTCTTCAGCAACTGGAAAAAAC TGAAATTGTTTGTTTCTCATATGATTGACAAACACAGAAAGGATTGGAATCCTGCAGAAACAAGAGACTTTATTGATGCTTACCTTAAAG AAATGTCAAAGCACACAGGCAATCCTACTTCAAGTTTCCATGAAGAAAACCTCATCTGCAGCACCCTGGACCTCTTCTTTGCCGGAACCG AGACAACTTCCACAACTCTGCGATGGGCTCTGCTTTATATGGCCCTCTACCCAGAAATCCAAGAAAAAGTACAAGCTGAGATTGACAGAG TGATTGGCCAGGGGCAGCAGCCGAGCACAGCCGCCCGGGAGTCCATGCCCTACACCAATGCTGTCATCCATGAGGTGCAGAGAATGGGCA ACATCATCCCCCTGAACGTTCCCAGGGAAGTGACAGTTGATACCACTTTGGCTGGGTACCACCTGCCCAAGGGTACCATGATCCTGACCA ATTTGACGGCGCTGCACAGGGACCCCACAGAGTGGGCCACCCCTGACACATTCAATCCGGACCATTTTCTGGAGAATGGACAGTTTAAGA AAAGGGAAGCCTTTATGCCTTTCTCAATAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCAGGACTGAGCTGTTTATTTTCTTCACTT CCCTTATGCAAAAATTTACCTTCAGGCCCCCAAACAATGAGAAGCTGAGCCTGAAGTTTAGAATGGGTATCACCATTTCCCCAGTCAGTC ACCGCCTCTGCGCTGTTCCTCAGGTGTAATATTGTTAAGAAAGAAAGGGGCAAGGAAAGTAAGAAGACATGGCACGTGTTCTGAAACCAC TGGTGTCTGCTCAGATGTGTTGGGACAAAATGAAAGTGACTTTCAAGAAAGATCAGAGGAATTTGACTCAGAGAAAACTAGATCCAAATC CCAGCTCTACTGTCTCGTCCGAATTAGCCTTGGGAAAATCATTTATATGCTAAATAATTTACCTTTTTATCTAGGAGATGAAAAGAGGAT AATGTTTCCTTCCATAAAGAAAGTTCTTGTAAGAATCAAAAGAAATGGTGAGCTTTAAGTGGTTTGTAAACCATAAAACACATCATAAAA |
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FusionGenePPI for NEGR1_CYP2J2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEGR1 | NTM, LSAMP, NEGR1 | CYP2J2 | TCEB1, ZBTB25, FAM63B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEGR1_CYP2J2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEGR1_CYP2J2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NEGR1 | C0028754 | Obesity | 1 | CTD_human |
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