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Fusion gene ID: 23974 |
FusionGeneSummary for NEDD8-MDP1_NDRG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEDD8-MDP1_NDRG1 | Fusion gene ID: 23974 | Hgene | Tgene | Gene symbol | NEDD8-MDP1 | NDRG1 | Gene ID | 100528064 | 10397 |
| Gene name | NEDD8-MDP1 readthrough | N-myc downstream regulated 1 | |
| Synonyms | - | CAP43|CMT4D|DRG-1|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5 | |
| Cytomap | 14q12 | 8q24.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NEDD8-MDP1 proteinNEDD8-MDP1 read-through transcript | protein NDRG1N-myc downstream-regulated gene 1 proteindifferentiation-related gene 1 proteinnickel-specific induction protein Cap43protein regulated by oxygen-1reducing agents and tunicamycin-responsive protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q92597 | ||
| Ensembl transtripts involved in fusion gene | ENST00000534348, ENST00000604306, | ENST00000323851, ENST00000354944, ENST00000521414, ENST00000537882, ENST00000414097, ENST00000518176, ENST00000522476, ENST00000518066, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 8 X 9 X 2=144 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEDD8-MDP1 [Title/Abstract] AND NDRG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CD693882 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000534348 | ENST00000323851 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-3UTR | ENST00000534348 | ENST00000354944 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-5UTR | ENST00000534348 | ENST00000521414 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-3UTR | ENST00000534348 | ENST00000537882 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-3UTR | ENST00000534348 | ENST00000414097 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-intron | ENST00000534348 | ENST00000518176 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-intron | ENST00000534348 | ENST00000522476 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-intron | ENST00000534348 | ENST00000518066 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-3UTR | ENST00000604306 | ENST00000323851 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-3UTR | ENST00000604306 | ENST00000354944 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-5UTR | ENST00000604306 | ENST00000521414 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-3UTR | ENST00000604306 | ENST00000537882 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-3UTR | ENST00000604306 | ENST00000414097 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-intron | ENST00000604306 | ENST00000518176 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-intron | ENST00000604306 | ENST00000522476 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
| intron-intron | ENST00000604306 | ENST00000518066 | NEDD8-MDP1 | chr14 | 24686262 | - | NDRG1 | chr8 | 134249937 | - |
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FusionProtFeatures for NEDD8-MDP1_NDRG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEDD8-MDP1 | NDRG1 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Stress-responsive protein involved in hormone responses,cell growth, and differentiation. Acts as a tumor suppressor inmany cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in celltrafficking, notably of the Schwann cell, and is necessary for themaintenance and development of the peripheral nerve myelin sheath.Required for vesicular recycling of CDH1 and TF. May also functionin lipid trafficking. Protects cells from spindle disruptiondamage. Functions in p53/TP53-dependent mitotic spindlecheckpoint. Regulates microtubule dynamics and maintains euploidy.{ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670,ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NEDD8-MDP1_NDRG1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NEDD8-MDP1_NDRG1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEDD8-MDP1_NDRG1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEDD8-MDP1_NDRG1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NDRG1 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Tgene | NDRG1 | C0004114 | Astrocytoma | 1 | CTD_human |
| Tgene | NDRG1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | NDRG1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | NDRG1 | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | NDRG1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | NDRG1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | NDRG1 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | NDRG1 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | NDRG1 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Tgene | NDRG1 | C0029295 | Oropharyngeal Neoplasms | 1 | CTD_human |
| Tgene | NDRG1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | NDRG1 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Tgene | NDRG1 | C0206658 | Smooth Muscle Tumor | 1 | CTD_human |
| Tgene | NDRG1 | C0206734 | Hemangioblastoma | 1 | CTD_human |
| Tgene | NDRG1 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
| Tgene | NDRG1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
| Tgene | NDRG1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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