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Fusion gene ID: 23972 |
FusionGeneSummary for NEDD8-MDP1_ARV1 |
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Fusion gene information | Fusion gene name: NEDD8-MDP1_ARV1 | Fusion gene ID: 23972 | Hgene | Tgene | Gene symbol | NEDD8-MDP1 | ARV1 | Gene ID | 100528064 | 64801 |
Gene name | NEDD8-MDP1 readthrough | ARV1 homolog, fatty acid homeostasis modulator | |
Synonyms | - | EIEE38 | |
Cytomap | 14q12 | 1q42.2 | |
Type of gene | protein-coding | protein-coding | |
Description | NEDD8-MDP1 proteinNEDD8-MDP1 read-through transcript | protein ARV1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9H2C2 | ||
Ensembl transtripts involved in fusion gene | ENST00000534348, ENST00000604306, | ENST00000497753, ENST00000310256, ENST00000366658, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 4 X 2=32 |
# samples | 3 | 4 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NEDD8-MDP1 [Title/Abstract] AND ARV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CA309107 | NEDD8-MDP1 | chr14 | 24701536 | + | ARV1 | chr1 | 231131614 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000534348 | ENST00000497753 | NEDD8-MDP1 | chr14 | 24701536 | + | ARV1 | chr1 | 231131614 | - |
intron-3UTR | ENST00000534348 | ENST00000310256 | NEDD8-MDP1 | chr14 | 24701536 | + | ARV1 | chr1 | 231131614 | - |
intron-3UTR | ENST00000534348 | ENST00000366658 | NEDD8-MDP1 | chr14 | 24701536 | + | ARV1 | chr1 | 231131614 | - |
intron-3UTR | ENST00000604306 | ENST00000497753 | NEDD8-MDP1 | chr14 | 24701536 | + | ARV1 | chr1 | 231131614 | - |
intron-3UTR | ENST00000604306 | ENST00000310256 | NEDD8-MDP1 | chr14 | 24701536 | + | ARV1 | chr1 | 231131614 | - |
intron-3UTR | ENST00000604306 | ENST00000366658 | NEDD8-MDP1 | chr14 | 24701536 | + | ARV1 | chr1 | 231131614 | - |
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FusionProtFeatures for NEDD8-MDP1_ARV1 |
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Hgene | Tgene |
NEDD8-MDP1 | ARV1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NEDD8-MDP1_ARV1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NEDD8-MDP1_ARV1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEDD8-MDP1_ARV1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEDD8-MDP1_ARV1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |