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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23971

FusionGeneSummary for NEDD4_RFX7

check button Fusion gene summary
Fusion gene informationFusion gene name: NEDD4_RFX7
Fusion gene ID: 23971
HgeneTgene
Gene symbol

NEDD4

RFX7

Gene ID

4734

64864

Gene nameneural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligaseregulatory factor X7
SynonymsNEDD4-1|RPF1RFXDC2
Cytomap

15q21.3

15q21.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase NEDD4HECT-type E3 ubiquitin transferase NEDD4cell proliferation-inducing gene 53 proteinreceptor-potentiating factor 1DNA-binding protein RFX7regulatory factor X domain containing 2regulatory factor X domain-containing protein 2regulatory factor X, 7
Modification date2018052720180523
UniProtAcc

P46934

Q2KHR2

Ensembl transtripts involved in fusion geneENST00000435532, ENST00000338963, 
ENST00000508342, ENST00000506154, 
ENST00000508075, 
ENST00000422057, 
ENST00000317318, ENST00000423270, 
ENST00000559447, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 3=48
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NEDD4 [Title/Abstract] AND RFX7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEDD4

GO:0006511

ubiquitin-dependent protein catabolic process

20086093

HgeneNEDD4

GO:0006622

protein targeting to lysosome

17116753

HgeneNEDD4

GO:0007041

lysosomal transport

18544533

HgeneNEDD4

GO:0010766

negative regulation of sodium ion transport

10642508

HgeneNEDD4

GO:0016567

protein ubiquitination

17996703|18305167|25631046|26280536

HgeneNEDD4

GO:0031623

receptor internalization

18544533

HgeneNEDD4

GO:0032801

receptor catabolic process

18544533

HgeneNEDD4

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneNEDD4

GO:0042391

regulation of membrane potential

17289006

HgeneNEDD4

GO:0042921

glucocorticoid receptor signaling pathway

8649367

HgeneNEDD4

GO:0045732

positive regulation of protein catabolic process

14973438

HgeneNEDD4

GO:0046824

positive regulation of nucleocytoplasmic transport

17218261

HgeneNEDD4

GO:0050847

progesterone receptor signaling pathway

8649367

HgeneNEDD4

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

HgeneNEDD4

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

10642508


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0FW-01ANEDD4chr15

56258671

-RFX7chr15

56379707

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000435532ENST00000422057NEDD4chr15

56258671

-RFX7chr15

56379707

-
5CDS-intronENST00000435532ENST00000317318NEDD4chr15

56258671

-RFX7chr15

56379707

-
5CDS-intronENST00000435532ENST00000423270NEDD4chr15

56258671

-RFX7chr15

56379707

-
5CDS-intronENST00000435532ENST00000559447NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-3CDSENST00000338963ENST00000422057NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000338963ENST00000317318NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000338963ENST00000423270NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000338963ENST00000559447NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-3CDSENST00000508342ENST00000422057NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000508342ENST00000317318NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000508342ENST00000423270NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000508342ENST00000559447NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-3CDSENST00000506154ENST00000422057NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000506154ENST00000317318NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000506154ENST00000423270NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000506154ENST00000559447NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-3CDSENST00000508075ENST00000422057NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000508075ENST00000317318NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000508075ENST00000423270NEDD4chr15

56258671

-RFX7chr15

56379707

-
intron-intronENST00000508075ENST00000559447NEDD4chr15

56258671

-RFX7chr15

56379707

-

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FusionProtFeatures for NEDD4_RFX7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEDD4

P46934

RFX7

Q2KHR2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRFX7chr15:56258671chr15:56379707ENST00000317318-010538_54101374Compositional biasNote=Poly-Ser
TgeneRFX7chr15:56258671chr15:56379707ENST00000423270-09538_54101461Compositional biasNote=Poly-Ser
TgeneRFX7chr15:56258671chr15:56379707ENST00000317318-01011_8601374DNA bindingRFX-type winged-helix
TgeneRFX7chr15:56258671chr15:56379707ENST00000423270-0911_8601461DNA bindingRFX-type winged-helix

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEDD4chr15:56258671chr15:56379707ENST00000338963-12268_215-1001248Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56258671chr15:56379707ENST00000435532-22968_21539901Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56258671chr15:56379707ENST00000506154-12568_215-931304Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56258671chr15:56379707ENST00000508342-12568_215-1001320Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56258671chr15:56379707ENST00000338963-122610_643-1001248DomainWW 1
HgeneNEDD4chr15:56258671chr15:56379707ENST00000338963-122767_800-1001248DomainWW 2
HgeneNEDD4chr15:56258671chr15:56379707ENST00000338963-122840_873-1001248DomainWW 3
HgeneNEDD4chr15:56258671chr15:56379707ENST00000338963-122892_925-1001248DomainWW 4
HgeneNEDD4chr15:56258671chr15:56379707ENST00000338963-122984_1318-1001248DomainHECT
HgeneNEDD4chr15:56258671chr15:56379707ENST00000435532-229610_64339901DomainWW 1
HgeneNEDD4chr15:56258671chr15:56379707ENST00000435532-229767_80039901DomainWW 2
HgeneNEDD4chr15:56258671chr15:56379707ENST00000435532-229840_87339901DomainWW 3
HgeneNEDD4chr15:56258671chr15:56379707ENST00000435532-229892_92539901DomainWW 4
HgeneNEDD4chr15:56258671chr15:56379707ENST00000435532-229984_131839901DomainHECT
HgeneNEDD4chr15:56258671chr15:56379707ENST00000506154-125610_643-931304DomainWW 1
HgeneNEDD4chr15:56258671chr15:56379707ENST00000506154-125767_800-931304DomainWW 2
HgeneNEDD4chr15:56258671chr15:56379707ENST00000506154-125840_873-931304DomainWW 3
HgeneNEDD4chr15:56258671chr15:56379707ENST00000506154-125892_925-931304DomainWW 4
HgeneNEDD4chr15:56258671chr15:56379707ENST00000506154-125984_1318-931304DomainHECT
HgeneNEDD4chr15:56258671chr15:56379707ENST00000508342-125610_643-1001320DomainWW 1
HgeneNEDD4chr15:56258671chr15:56379707ENST00000508342-125767_800-1001320DomainWW 2
HgeneNEDD4chr15:56258671chr15:56379707ENST00000508342-125840_873-1001320DomainWW 3
HgeneNEDD4chr15:56258671chr15:56379707ENST00000508342-125892_925-1001320DomainWW 4
HgeneNEDD4chr15:56258671chr15:56379707ENST00000508342-125984_1318-1001320DomainHECT


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FusionGeneSequence for NEDD4_RFX7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NEDD4_ENST00000435532_chr15_56258671_-_RFX7_ENST00000422057_chr15_56379707_-_53aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NEDD4_ENST00000435532_chr15_56258671_-_RFX7_ENST00000422057_chr15_56379707_-_161nt
ATGGCAACTTGCGCGGTGGAGGTGTTCGGGCTCCTGGAGGACGAGGAAAATTCACGAATTGTGAGAGTAAGAGTTATAGCCGGAATAGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NEDD4_ENST00000435532_chr15_56258671_-_RFX7_ENST00000422057_chr15_56379707_-_352nt
GGCCTTTTCCCGCCGCGCTGCCGGGTGCCGCTAGTGCCCGCTCGCCGCGGGAGGCGCTGCTGTCGCTGAGGGAGCGCCTCCTCCTCTTCC
TCCAACTCTTCCCCGCCTCCTCCCGCTTCTCCTCCTCCTCCTCCACAGTTGCCTGCCCTGGGCGGGGGCGAGCGCGTCCGGTTTGCTGGA
AGCGTTCGGAAATGGCAACTTGCGCGGTGGAGGTGTTCGGGCTCCTGGAGGACGAGGAAAATTCACGAATTGTGAGAGTAAGAGTTATAG


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FusionGenePPI for NEDD4_RFX7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEDD4UBE2D2, CBLB, PMEPA1, NDFIP2, SGK1, IGF1R, UBE2D3, UBE2E1, UBE2L3, SCNN1A, SCNN1B, SCNN1G, HGS, N4BP3, CDC25C, SCAMP3, AP1G2, ARRB2, ARRB1, TTYH3, TTYH2, PTEN, NEDD4, ISG15, POLR2A, LAPTM5, GGA3, SLC6A3, PDCD6IP, GABARAP, GABARAPL1, GABARAPL2, MLANA, TP73, SMAD2, SMAD3, SMAD6, SMAD7, SMURF2, SKIL, SCN5A, NTRK1, CPSF6, UBAP2L, GRB10, GJA1, RAPGEF2, GRIA1, SLC12A3, FGFR1, DCUN1D1, SLC38A3, SCN8A, EPS15, SLC11A2, TNK2, TNIK, RAP2A, MTMR4, RNF11, ARRDC3, ADRB2, SLC9A1, RASGEF1A, UBOX5, RANBP10, CAMK1D, ABL2, MAPKAPK3, YY1, WBP2, RTF1, EGFR, ANKRD13D, TRIM52, TRIM44, BAIAP2, PLK2, CUEDC1, FLT1, RAD51AP1, SAMSN1, LUC7L2, CLIC2, CALCOCO1, FYN, MAP3K3, ABL1, CDK5, STK31, AKT1, MARK2, ERMN, SGK2, PRKX, MAP3K5, MAP3K2, TOM1L2, RPS6KB1, C11orf63, TOM1, MARK4, RPS6KA3, PDGFRB, SPANXN3, GBA, AKT3, DDX54, FGFR2, GRK7, SFTPC, CFTR, SNCA, PSMD4, SPRY2, SPRY1, UBC, ERBB4, ERG, KCNQ1, ARRDC1, TEAD2, SMAD1, AMPD2, BMPR1A, TSTA3, FGF12, FKBP3, KCNAB1, KCNAB2, MAP4K5, MOB3A, NHP2, NSRP1, RNF7, EBAG9, MRPL19, RASL11B, SAAL1, KIAA1598, SIVA1, SYT1, TCP11L1, TBC1D7, TCEANC, WIBG, YES1, ASPSCR1, HMCES, FGF21, RBCK1, IRS1, KIFC3, SP140L, PARP16, PRR16, RPAP3, SLC23A2, SEPT9, TAF1B, PRRG1, UBE2M, SRMS, CDK5R1, CAMK4, FES, PLK1, TBK1, STK24, STK25, STK26, RPS6KA4, RAF1, GRK4, WEE1, CLK3, EPHA5, STK4, AURKC, SYK, DYRK4, PKN2, PRKG2, FLT4, CAMKK2, SULF1, RFT1, MAP2, ANXA9, RAC1, DVL1, AMOT, SLC5A7, TSG101, JUN, KIF26B, LAPTM4A, LAPTM4B, RPSA, IL2RB, IL2RG, LITAF, BECN1, ANXA13, TRPV6, NFE2, LRRK1, MDM2, BRCA2, UBE2D1, DMD, MGRN1, FBXL15, SMAD5, PPARG, GRIN2D, GRIN2A, URI1, POLR2B, POLR2C, POLR2E, POLR3A, RUVBL1, SMARCC1, ARID1A, THRAP3, CPSF1, NUDT21, DDX3X, DHX30, RPAP2, HNRNPK, HNRNPL, HNRNPU, HNRNPUL1, PRPF8, SRSF7, EPRS, RPS3A, DIAPH1, AMOTL1, RAPGEF6, POLR2M, CAD, CUL1, BTRC, FBXL18, RBX1, SKP1, CSNK1D, ERBB3, CCNH, GUCD1, YOD1, SMO, PTCH1, CUL5, SRC, MYCN, LATS1, FAM189B, TMEM51, TMEM171, FAM189A2, WBP1, TMEM255A, TMEM92, TMEM52B, LDLRAD4, ABCB1, IMPDH2, PAX7, SAV1, LATS2, PDLIM7, GLIS3, HSF1, ABCG1, IRS2, IFITM3, NDFIP1, THOC1, SUV420H2, DDIT4, PTK2B, MAP1LC3B, ILDR1, OCLN, TNFRSF19, PRRG3, SUSD6, ERRFI1, PIP5K1C, SLC22A6RFX7ANKRA2, RFXANK, OTUB1, RFX5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEDD4_RFX7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEDD4_RFX7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEDD4C0005586Bipolar Disorder1PSYGENET
HgeneNEDD4C0022548Keloid1CTD_human
HgeneNEDD4C0038325Stevens-Johnson Syndrome1CTD_human
HgeneNEDD4C0151744Myocardial Ischemia1CTD_human