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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 23959

FusionGeneSummary for NEDD4L_MORC3

check button Fusion gene summary
Fusion gene informationFusion gene name: NEDD4L_MORC3
Fusion gene ID: 23959
HgeneTgene
Gene symbol

NEDD4L

MORC3

Gene ID

23327

23515

Gene nameneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseMORC family CW-type zinc finger 3
SynonymsNEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2NXP2|ZCW5|ZCWCC3
Cytomap

18q21.31

21q22.12

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lubiquitin-protein ligase Rsp5MORC family CW-type zinc finger protein 3nuclear matrix protein 2nuclear matrix protein NXP2zinc finger CW-type coiled-coil domain protein 3zinc finger, CW type with coiled-coil domain 3
Modification date2018052320180522
UniProtAcc

Q96PU5

Q14149

Ensembl transtripts involved in fusion geneENST00000356462, ENST00000400345, 
ENST00000589054, ENST00000256832, 
ENST00000382850, ENST00000256830, 
ENST00000588516, ENST00000456986, 
ENST00000435432, ENST00000357895, 
ENST00000586263, ENST00000456173, 
ENST00000431212, 		ENST00000400485, 
ENST00000487909, 
Fusion gene scores* DoF score18 X 11 X 9=17825 X 5 X 3=75
# samples 205
** MAII scorelog2(20/1782*10)=-3.1554254317472
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEDD4L [Title/Abstract] AND MORC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

HgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

HgeneNEDD4L

GO:0010038

response to metal ion

11244092

HgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

HgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

HgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

HgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

HgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

HgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

HgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

HgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

HgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

HgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

HgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

HgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910

TgeneMORC3

GO:0006468

protein phosphorylation

17332504

TgeneMORC3

GO:0007569

cell aging

17332504

TgeneMORC3

GO:0018105

peptidyl-serine phosphorylation

17332504

TgeneMORC3

GO:0048147

negative regulation of fibroblast proliferation

17332504

TgeneMORC3

GO:0050821

protein stabilization

17332504

TgeneMORC3

GO:0051457

maintenance of protein location in nucleus

17332504


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A8IL-01ANEDD4Lchr18

55833093

+MORC3chr21

37728918

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356462ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5CDS-3UTRENST00000356462ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
In-frameENST00000400345ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5CDS-3UTRENST00000400345ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
intron-3CDSENST00000589054ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
intron-3UTRENST00000589054ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5UTR-3CDSENST00000256832ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5UTR-3UTRENST00000256832ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
In-frameENST00000382850ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5CDS-3UTRENST00000382850ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
In-frameENST00000256830ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5CDS-3UTRENST00000256830ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
3UTR-3CDSENST00000588516ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
3UTR-3UTRENST00000588516ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5UTR-3CDSENST00000456986ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5UTR-3UTRENST00000456986ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5UTR-3CDSENST00000435432ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5UTR-3UTRENST00000435432ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
In-frameENST00000357895ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5CDS-3UTRENST00000357895ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
In-frameENST00000586263ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
5CDS-3UTRENST00000586263ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
intron-3CDSENST00000456173ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
intron-3UTRENST00000456173ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
intron-3CDSENST00000431212ENST00000400485NEDD4Lchr18

55833093

+MORC3chr21

37728918

+
intron-3UTRENST00000431212ENST00000487909NEDD4Lchr18

55833093

+MORC3chr21

37728918

+

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FusionProtFeatures for NEDD4L_MORC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEDD4L

Q96PU5

MORC3

Q14149

Nuclear factor which forms MORC3-NBs (nuclear bodies)via an ATP-dependent mechanism (PubMed:20501696). SumoylatedMORC3-NBs can also associate with PML-NBs (PubMed:20501696).Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity(PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May berequired for influenza A transcription during viral infection(PubMed:26202233). {ECO:0000269|PubMed:11927593,ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696,ECO:0000269|PubMed:26202233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMORC3chr18:55833093chr21:37728918ENST00000400485+817686_877367940Coiled coilOntology_term=ECO:0000255
TgeneMORC3chr18:55833093chr21:37728918ENST00000400485+817500_591367940RegionRNA binding
TgeneMORC3chr18:55833093chr21:37728918ENST00000400485+817404_454367940Zinc fingerCW-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000256830+228193_22640872DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000256830+228385_41840872DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000256830+228497_53040872DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000256830+228548_58140872DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000256830+228640_97440872DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000256830+2287_10940872DomainC2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000356462+229193_22640912DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000356462+229385_41840912DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000356462+229497_53040912DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000356462+229548_58140912DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000356462+229640_97440912DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000356462+2297_10940912DomainC2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000357895+231193_22632968DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000357895+231385_41832968DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000357895+231497_53032968DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000357895+231548_58132968DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000357895+231640_97432968DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000357895+2317_10932968DomainC2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000382850+230193_22640956DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000382850+230385_41840956DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000382850+230497_53040956DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000382850+230548_58140956DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000382850+230640_97440956DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000382850+2307_10940956DomainC2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000400345+231193_22640976DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000400345+231385_41840976DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000400345+231497_53040976DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000400345+231548_58140976DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000400345+231640_97440976DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000400345+2317_10940976DomainC2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000431212+130193_226-155855DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000431212+130385_418-155855DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000431212+130497_530-155855DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000431212+130548_581-155855DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000431212+130640_974-155855DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000431212+1307_109-155855DomainC2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000435432+231193_226-107835DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000435432+231385_418-107835DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000435432+231497_530-107835DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000435432+231548_581-107835DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000435432+231640_974-107835DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000435432+2317_109-107835DomainC2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456173+129193_226-195835DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456173+129385_418-195835DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456173+129497_530-195835DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456173+129548_581-195835DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456173+129640_974-195835DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456173+1297_109-195835DomainC2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456986+231193_226-81855DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456986+231385_418-81855DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456986+231497_530-81855DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456986+231548_581-81855DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456986+231640_974-81855DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000456986+2317_109-81855DomainC2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000586263+230193_22632948DomainWW 1
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000586263+230385_41832948DomainWW 2
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000586263+230497_53032948DomainWW 3
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000586263+230548_58132948DomainWW 4
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000586263+230640_97432948DomainHECT
HgeneNEDD4Lchr18:55833093chr21:37728918ENST00000586263+2307_10932948DomainC2
TgeneMORC3chr18:55833093chr21:37728918ENST00000400485+817326_353367940RegionNuclear matrix binding


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FusionGeneSequence for NEDD4L_MORC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NEDD4L_ENST00000356462_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_613aa
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACL
KWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKES
VPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMK
SEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDK
SADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQAL
EEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQ

>In-frame_NEDD4L_ENST00000400345_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_613aa
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACL
KWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKES
VPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMK
SEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDK
SADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQAL
EEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQ

>In-frame_NEDD4L_ENST00000382850_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_613aa
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACL
KWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKES
VPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMK
SEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDK
SADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQAL
EEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQ

>In-frame_NEDD4L_ENST00000256830_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_613aa
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACL
KWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKES
VPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMK
SEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDK
SADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQAL
EEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQ

>In-frame_NEDD4L_ENST00000357895_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_605aa
MRRLAFEQGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDG
MDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSE
GTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQ
GGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQ
LQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKK
QCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTS

>In-frame_NEDD4L_ENST00000586263_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_605aa
MRRLAFEQGESRILRVKVVSGIDLAKKDIFGARLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDG
MDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSE
GTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQ
GGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQ
LQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKK
QCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NEDD4L_ENST00000356462_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_1839nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTG
AAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTA
AAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAG
GTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGA
CAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGT
GTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAG
AGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTT
TATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAA
TCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACC
TCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGAC
GAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAA
TCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGT
CATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCC
ACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTG
GAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGT
GAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTT
GAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAG
ACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTT
AACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGA

>In-frame_NEDD4L_ENST00000400345_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_1839nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTG
AAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTA
AAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAG
GTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGA
CAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGT
GTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAG
AGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTT
TATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAA
TCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACC
TCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGAC
GAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAA
TCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGT
CATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCC
ACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTG
GAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGT
GAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTT
GAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAG
ACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTT
AACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGA

>In-frame_NEDD4L_ENST00000382850_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_1839nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTG
AAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTA
AAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAG
GTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGA
CAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGT
GTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAG
AGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTT
TATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAA
TCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACC
TCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGAC
GAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAA
TCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGT
CATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCC
ACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTG
GAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGT
GAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTT
GAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAG
ACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTT
AACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGA

>In-frame_NEDD4L_ENST00000256830_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_1839nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTG
AAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTA
AAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAG
GTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGA
CAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGT
GTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAG
AGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTT
TATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAA
TCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACC
TCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGAC
GAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAA
TCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGT
CATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCC
ACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTG
GAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGT
GAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTT
GAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAG
ACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTT
AACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGA

>In-frame_NEDD4L_ENST00000357895_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_1815nt
ATGAGACGTCTCGCATTTGAGCAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTT
GGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTA
AATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGG
ATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAG
GATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACCGGAAATGATCCCTCGGATT
AATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAA
GGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTT
TCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGATGATGATGATGAA
GATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGAACAGAGTCACGTTGAGCAA
GGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATCATCCCGATGCGACCAGGGA
AATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTAAGAAATGATGCA
GTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGCAGATGATGCAGGCTGCCAA
TTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATATGTTTACTGATCAAATCAAA
GTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTA
CTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAA
CAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAG
CTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCA
CAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGCAACAGATGTTTCAACATCA
AGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATG
ATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAA

>In-frame_NEDD4L_ENST00000586263_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_1815nt
ATGAGACGTCTCGCATTTGAGCAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTT
GGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTA
AATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGG
ATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAG
GATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACCGGAAATGATCCCTCGGATT
AATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAA
GGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTT
TCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGATGATGATGATGAA
GATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGAACAGAGTCACGTTGAGCAA
GGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATCATCCCGATGCGACCAGGGA
AATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTAAGAAATGATGCA
GTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGCAGATGATGCAGGCTGCCAA
TTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATATGTTTACTGATCAAATCAAA
GTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTA
CTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAA
CAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAG
CTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCA
CAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGCAACAGATGTTTCAACATCA
AGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATG
ATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_NEDD4L_ENST00000356462_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_3483nt
GCGCCGCCGCCGCGCGCAGTGAGAGGCGCCGGGGCTGCCGCCCGGTGCTCGGCGCGCTCTCGGGAGCCGCCCGCCCGCTGGTCCCGCAGC
CTTCCGGGAGGAAGCGGTGCCGGCAGCGTCCAGGGCGCGCTCTCGGGCACCCTCACCTGCCGGCGCCCGGCCGCTTACCCGGCAGGGCGT
GCGCAGGGTAGGGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCA
GACCCCGCGCGGGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTC
AGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAAT
GATTACTGGAATGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACA
TGGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCT
GACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACC
AACAAGGAAAAATTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCA
AGCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAA
GTTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTG
AGTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCA
GTAGATCATGATATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGT
GGCCAGACTGGTTCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTT
AAAAAAGAAGAAACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACAT
GAAACCCAGGAAACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAA
AAAGAGAATTATAAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTT
AAGAAAGAAACTTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATG
GTATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAG
TGTTCCAATAATGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAG
AGGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAA
CAGTTAAAATCTACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGC
CTCAAACTCCGATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTT
GATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAGTATATGTTATGTAAGATAAAATATT
TGCTCAATTCTTTTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGGCAACAGACTGAAAACCATAATCTTT
ACTGTATTCTATGCATTCAAATGTGGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCA
GCTGAAGCTAACTCATGACTCTGTTTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGT
TTTTCACCAAGAGCTTTTCAGGTTGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTAT
GCCATAATACAAATGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACA
ACTCTGGTTATAAGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGTAAGCAAA
AACCAACTCCATTTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATAGAATGAAGAAACAGTCT
TTAACAGAAAAAAGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGCTGTTTAGTCAGCATGAAGTGGGCAT
GATAATTTTTTAATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCT
TTCTCAAACAATACTACATACCTTTTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATA
GTATTACATGCCATAAAATACTATGCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTA
TATATAAGAACCATATTTTCCACAACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAA
CATTCAATCCGTTCATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGC
AAATAAATGAAGATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATTGTAATTT

>In-frame_NEDD4L_ENST00000400345_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_3472nt
GCGCGCAGTGAGAGGCGCCGGGGCTGCCGCCCGGTGCTCGGCGCGCTCTCGGGAGCCGCCCGCCCGCTGGTCCCGCAGCCTTCCGGGAGG
AAGCGGTGCCGGCAGCGTCCAGGGCGCGCTCTCGGGCACCCTCACCTGCCGGCGCCCGGCCGCTTACCCGGCAGGGCGTGCGCAGGGTAG
GGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCAGACCCCGCGCG
GGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGT
TGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAA
TGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTG
TGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTT
CAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAA
ATTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTC
TCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCA
GTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTT
TGAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGA
TATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGG
TTCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGA
AACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGA
AACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTA
TAAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAAC
TTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTA
TCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAA
TGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTA
TAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATC
TACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCG
ATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGA
TGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAGTATATGTTATGTAAGATAAAATATTTGCTCAATTCT
TTTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGGCAACAGACTGAAAACCATAATCTTTACTGTATTCTA
TGCATTCAAATGTGGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAA
CTCATGACTCTGTTTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAG
AGCTTTTCAGGTTGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTATGCCATAATACA
AATGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACAACTCTGGTTAT
AAGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGTAAGCAAAAACCAACTCCA
TTTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAA
AAGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGCTGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTT
AATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAA
TACTACATACCTTTTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATAGTATTACATGC
CATAAAATACTATGCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTATATATAAGAAC
CATATTTTCCACAACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAACATTCAATCCG
TTCATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAA
GATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATTGTAATTTCCCAAATTTTA

>In-frame_NEDD4L_ENST00000382850_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_3302nt
CGCAGGGTAGGGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCAG
ACCCCGCGCGGGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCA
GAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATG
ATTACTGGAATGAAATGAAAGTGAAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACAT
GGGTTCAGTGTGATGCCTGTCTAAAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTG
ACCCACAGTTCAGAAATTGTGAGGTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCA
ACAAGGAAAAATTCAGGATCAGACAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAA
GCTTTTCTTCTCCTAAGGAAAGTGTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAG
TTCCACCTCAGTCTGAACCTGAGAGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGA
GTAGTCAGTTTGAAAATTCAGTTTATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAG
TAGATCATGATATTGACATGAAATCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTG
GCCAGACTGGTTCAACAAGCACCTCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTA
AAAAAGAAGAAACTGTTGAAGACGAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATG
AAACCCAGGAAACCACCGATAAATCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAA
AAGAGAATTATAAAAGACAGTGTCATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTA
AGAAAGAAACTTGCCATCAGTCCACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGG
TATCTCAGTATCAGCAAGCTTTGGAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGT
GTTCCAATAATGAGAGTAAAAGTGAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGA
GGGACCAGTATAAAAGTGAGGTTGAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAAC
AGTTAAAATCTACAAATCAACAGACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCC
TCAAACTCCGATCTCTTCGAGTTAACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTG
ATGTAGTTGATGAGATTTTAGGACAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAGTATATGTTATGTAAGATAAAATATTT
GCTCAATTCTTTTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGGCAACAGACTGAAAACCATAATCTTTA
CTGTATTCTATGCATTCAAATGTGGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCAG
CTGAAGCTAACTCATGACTCTGTTTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGTT
TTTCACCAAGAGCTTTTCAGGTTGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTATG
CCATAATACAAATGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACAA
CTCTGGTTATAAGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGTAAGCAAAA
ACCAACTCCATTTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATAGAATGAAGAAACAGTCTT
TAACAGAAAAAAGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGCTGTTTAGTCAGCATGAAGTGGGCATG
ATAATTTTTTAATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCTT
TCTCAAACAATACTACATACCTTTTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATAG
TATTACATGCCATAAAATACTATGCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTAT
ATATAAGAACCATATTTTCCACAACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAAC
ATTCAATCCGTTCATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGCA
AATAAATGAAGATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATTGTAATTTC

>In-frame_NEDD4L_ENST00000256830_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_3189nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTG
AAGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTA
AAGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAG
GTTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGA
CAACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGT
GTTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAG
AGCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTT
TATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAA
TCAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACC
TCATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGAC
GAGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAA
TCTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGT
CATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCC
ACTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTG
GAAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGT
GAAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTT
GAATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAG
ACGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTT
AACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGA
CAAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAGTATATGTTATGTAAGATAAAATATTTGCTCAATTCTTTTGGTTGTACAG
CTTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGGCAACAGACTGAAAACCATAATCTTTACTGTATTCTATGCATTCAAATGT
GGTCACAAATATTGTGGACACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAACTCATGACTCTGT
TTTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGAGCTTTTCAGGTT
GCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAAATGGAAATGTTA
CCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACAACTCTGGTTATAAGTGAATTGAGC
ATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGTAAGCAAAAACCAACTCCATTTTGCCAGGATT
TTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAAAAGGTATTGAAAT
ATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGCTGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTAATATTTCTTTTT
GTGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAATACTACATACCTT
TTATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATAGTATTACATGCCATAAAATACTAT
GCTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTATATATAAGAACCATATTTTCCACA
ACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGTTCATTTTGTATG
TATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAAGATTGTTTTTATT
TGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATTGTAATTTCCCAAATTTTAAAATATCTTATAA

>In-frame_NEDD4L_ENST00000357895_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_3368nt
GCCATTTCCAGAGAGGAACAACCGTGTAGACTGCTTTCCTGGGAGTCAAGTTAAAACTTCTCTCCTGTGACCTTGTCACCCGGCAGTGGA
AAGTTACCCTTGGCTGCAGCCACGACTTCCGCATACTCTTCAGAACTTGCTCTGCCCTTGAGTTTTCCAGCTTTCCTTTAATGCACTAAA
CCTTTAATATTGTATTCTCCTAAATGAGACGTCTCGCATTTGAGCAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTG
ATCTCGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGA
AGAAAAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAA
AGTGGCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGG
TTCCAGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGAC
AACCGGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTG
TTCCAAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGA
GCAACAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTT
ATAAAGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAAT
CAGAACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCT
CATCATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACG
AGATAGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAAT
CTGCAGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTC
ATATGTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCA
CTGAAACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGG
AAGAAATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTG
AAATGGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTG
AATTGCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGA
CGGCAACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTA
ACGTAGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGAC
AAGTTGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAGTATATGTTATGTAAGATAAAATATTTGCTCAATTCTTTTGGTTGTACAGC
TTTCAAAATATAATTAATTTTGTTTTATAGATATGATAGGCAACAGACTGAAAACCATAATCTTTACTGTATTCTATGCATTCAAATGTG
GTCACAAATATTGTGGACACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAACTCATGACTCTGTT
TTGAATGTAAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGAGCTTTTCAGGTTG
CCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAAATGGAAATGTTAC
CTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACAACTCTGGTTATAAGTGAATTGAGCA
TTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGTAAGCAAAAACCAACTCCATTTTGCCAGGATTT
TGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAAAAGGTATTGAAATA
TTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGCTGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTAATATTTCTTTTTG
TGAAATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAATACTACATACCTTT
TATTATATTACAAACCTAAGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATAGTATTACATGCCATAAAATACTATG
CTTTATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTATATATAAGAACCATATTTTCCACAA
CTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGTTCATTTTGTATGT
ATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAAGATTGTTTTTATTT
GCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATTGTAATTTCCCAAATTTTAAAATATCTTATAAT

>In-frame_NEDD4L_ENST00000586263_chr18_55833093_+_MORC3_ENST00000400485_chr21_37728918_+_3364nt
TTTCCAGAGAGGAACAACCGTGTAGACTGCTTTCCTGGGAGTCAAGTTAAAACTTCTCTCCTGTGACCTTGTCACCCGGCAGTGGAAAGT
TACCCTTGGCTGCAGCCACGACTTCCGCATACTCTTCAGAACTTGCTCTGCCCTTGAGTTTTCCAGCTTTCCTTTAATGCACTAAACCTT
TAATATTGTATTCTCCTAAATGAGACGTCTCGCATTTGAGCAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCT
CGCCAAAAAGGACATCTTTGGAGCCAGACTTACAATAACAGCACTAGGAGAAAAGCTGAATGATTACTGGAATGAAATGAAAGTGAAGAA
AAATACAGAATATCCTCTAAATTTGCCAGTTGAAGATATACAGAAGCGTCCTGATCAGACATGGGTTCAGTGTGATGCCTGTCTAAAGTG
GCGGAAATTACCTGATGGGATGGATCAACTTCCTGAAAAATGGTATTGCTCCAATAACCCTGACCCACAGTTCAGAAATTGTGAGGTTCC
AGAAGAACCTGAAGATGAGGATTTGGTACATCCCACTTATGAAAAAACCTACAAAAAGACCAACAAGGAAAAATTCAGGATCAGACAACC
GGAAATGATCCCTCGGATTAATGCTGAACTGTTGTTTCGGCCAACTGCTCTTTCAACTCCAAGCTTTTCTTCTCCTAAGGAAAGTGTTCC
AAGAAGACATCTTTCAGAAGGAACAAATTCTTATGCGACAAGACTTCTAAATAATCATCAAGTTCCACCTCAGTCTGAACCTGAGAGCAA
CAGCTTGAAACGGAGACTTTCTACTCGTTCCTCAATTTTGAATGCAAAGAATCGGAGATTGAGTAGTCAGTTTGAAAATTCAGTTTATAA
AGGTGATGATGATGATGAAGATGTCATCATCTTAGAAGAAAACAGTACCCCCAAACCTGCAGTAGATCATGATATTGACATGAAATCAGA
ACAGAGTCACGTTGAGCAAGGTGGTGTTCAGGTTGAGTTTGTGGGTGACAGTGAACCTTGTGGCCAGACTGGTTCAACAAGCACCTCATC
ATCCCGATGCGACCAGGGAAATACTGCAGCTACCCAGACTGAAGTACCAAGTTTAGTTGTTAAAAAAGAAGAAACTGTTGAAGACGAGAT
AGACGTAAGAAATGATGCAGTGATTCTGCCCTCCTGTGTAGAAGCTGAAGCAAAGATACATGAAACCCAGGAAACCACCGATAAATCTGC
AGATGATGCAGGCTGCCAATTACAAGAACTGAGAAACCAGCTACTCCTTGTCACTGAGGAAAAAGAGAATTATAAAAGACAGTGTCATAT
GTTTACTGATCAAATCAAAGTGTTACAACAGAGGATACTAGAAATGAATGACAAGTATGTTAAGAAAGAAACTTGCCATCAGTCCACTGA
AACCGATGCTGTATTTTTACTTGAAAGTATTAATGGCAAATCTGAAAGTCCAGACCATATGGTATCTCAGTATCAGCAAGCTTTGGAAGA
AATAGAAAGGCTGAAAAAACAATGTAGTGCTTTGCAACATGTAAAGGCTGAATGCAGCCAGTGTTCCAATAATGAGAGTAAAAGTGAAAT
GGATGAGATGGCTGTGCAGCTTGACGATGTGTTTAGACAACTGGACAAATGCAGTATTGAGAGGGACCAGTATAAAAGTGAGGTTGAATT
GCTGGAAATGGAAAAGTCACAAATCCGTTCACAGTGTGAAGAACTCAAAACTGAAGTAGAACAGTTAAAATCTACAAATCAACAGACGGC
AACAGATGTTTCAACATCAAGTAACATTGAGGAGTCTGTAAATCATATGGATGGAGAAAGCCTCAAACTCCGATCTCTTCGAGTTAACGT
AGGACAACTGCTGGCTATGATTGTGCCTGATCTTGATCTTCAGCAAGTGAATTACGATGTTGATGTAGTTGATGAGATTTTAGGACAAGT
TGTTGAACAAATGAGTGAAATCAGTAGTACTTAAAGTATATGTTATGTAAGATAAAATATTTGCTCAATTCTTTTGGTTGTACAGCTTTC
AAAATATAATTAATTTTGTTTTATAGATATGATAGGCAACAGACTGAAAACCATAATCTTTACTGTATTCTATGCATTCAAATGTGGTCA
CAAATATTGTGGACACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAACTCATGACTCTGTTTTGA
ATGTAAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGAGCTTTTCAGGTTGCCCC
TAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAAATGGAAATGTTACCTTT
GATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACAACTCTGGTTATAAGTGAATTGAGCATTAA
TGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGTAAGCAAAAACCAACTCCATTTTGCCAGGATTTTGTT
GTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATAGAATGAAGAAACAGTCTTTAACAGAAAAAAGGTATTGAAATATTAA
ATGGCCACCAAGTTTACTTTGAAGCCCATTTTTGGCTGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTAATATTTCTTTTTGTGAA
ATTTCCTGTACAGCCTTTTGTAGGATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAATACTACATACCTTTTATT
ATATTACAAACCTAAGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATAGTATTACATGCCATAAAATACTATGCTTT
ATTGGTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTATATATAAGAACCATATTTTCCACAACTAA
AATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGTTCATTTTGTATGTATGC
TTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGCAAATAAATGAAGATTGTTTTTATTTGCCT
GATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATTGTAATTTCCCAAATTTTAAAATATCTTATAATAAAA


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FusionGenePPI for NEDD4L_MORC3


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEDD4LSFN, NR3C1, ARHGDIA, SCNN1A, SCNN1B, SCNN1G, NEDD4L, AMOT, YWHAG, YWHAZ, PSMD4, YWHAB, TNK2, OCLN, APBB1, TOLLIP, NDFIP1, KCNB1, MAPKAPK3, CLIC2, EFEMP2, HGS, NDFIP2, MAP3K3, VDAC2, ZDHHC3, CAMK1D, RANBP10, CDK5, ABL1, MAGEB1, DMTN, AICDA, MARK2, KCNAB1, FKBP3, DAPK3, BRAF, MAP3K5, DDX54, ZAK, KCNAB3, NTRK1, CUEDC1, RPS6KB2, ABL2, CACNB1, YY1, MAP3K2, BBX, PRKX, ACVR1B, ADAP2, BMPR1A, AKT3, MINK1, AURKC, NSRP1, WIBG, SGK2, UBAC1, RPL30, MERTK, SRMS, SERPINF1, DYRK3, IFRD2, SCD, ROBO3, TRIM41, TMA16, TAF1B, SPAG8, STAC, H1F0, PRR16, KIFC3, RASL10B, PRRG1, CDK3, KCNAB2, FGF12, RNF7, APEX2, MRPL19, TGFB1I1, TBC1D7, NHP2, TMEM55A, CYP26B1, DECR2, SENP2, SIVA1, RASL11B, MAP2, STK40, NUDT16L1, C7orf50, TCEAL2, ZC3HAV1L, MOB3A, TARBP2, ZADH2, WBP2, ELAVL1, YWHAH, SGK1, RAF1, TSC22D3, WNK4, WNK1, IKBKB, SMAD7, AMOTL1, UBE2D2, UBC, SMAD2, SMAD3, YWHAQ, NPC2, MT2A, ATP1B1, CYBRD1, SLC7A7, PBX1, ACY3, HAX1, KIF3B, KCNH2, CAV3, UBE2L3, UBE2K, UBE2D1, UBE2E3, UBE2J2, CDC34, ARRDC3, ARRDC4, MED28, FBXL15, LAPTM5, RNF11, KCNQ1, SGK3, UBE2D3, NOTCH1, AATF, GORAB, UBE2N, HCN1, SMAD6, SLC9A3, SNCA, WNK3, PTCH1, DAZAP2, MOV10, CCDC8, FAM189B, PRRG3, TMEM51, TMEM171, SUSD6, FAM189A2, WBP1, ARRDC1, TMEM92, TMEM52B, LDLRAD4, XPO1, LITAF, SLC22A11, SLC22A8, RHOB, CRYAB, GRB10, KCNA3, ULK1, ERBB3, PTK2B, GRIA1, ILDR1, TNFAIP3, TNFRSF19, LPAR1, EDEM3, TRIM25, SCN5A, UBE2E1, UBE2E2, UBE2L6MORC3RAD23A, ROR1, KPNA2, HIST1H2BG, HIST1H3A, HTT, SNTB1, MOGS, DYNLL1, CRIPT, TRIB1, SYNE2, DEPDC1, DOCK8, RDH10, C6orf141, UBC, DYNLL2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEDD4L_MORC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEDD4L_MORC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEDD4LC0020538Hypertensive disease2CTD_human
HgeneNEDD4LC0008925Cleft Palate1CTD_human
HgeneNEDD4LC0014175Endometriosis1CTD_human
HgeneNEDD4LC0039075Syndactyly1CTD_human
HgeneNEDD4LC1868720Periventricular Nodular Heterotopia1CTD_human;ORPHANET