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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 23950

FusionGeneSummary for NEDD4L_ALPK2

check button Fusion gene summary
Fusion gene informationFusion gene name: NEDD4L_ALPK2
Fusion gene ID: 23950
HgeneTgene
Gene symbol

NEDD4L

ALPK2

Gene ID

23327

115701

Gene nameneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligasealpha kinase 2
SynonymsNEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2HAK
Cytomap

18q21.31

18q21.31-q21.32

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lubiquitin-protein ligase Rsp5alpha-protein kinase 2heart alpha-kinaseheart alpha-protein kinase
Modification date2018052320180329
UniProtAcc

Q96PU5

Q86TB3

Ensembl transtripts involved in fusion geneENST00000356462, ENST00000400345, 
ENST00000589054, ENST00000256832, 
ENST00000382850, ENST00000256830, 
ENST00000588516, ENST00000456986, 
ENST00000435432, ENST00000357895, 
ENST00000586263, ENST00000456173, 
ENST00000431212, 
ENST00000361673, 
ENST00000587399, 
Fusion gene scores* DoF score18 X 11 X 9=17821 X 2 X 1=2
# samples 202
** MAII scorelog2(20/1782*10)=-3.1554254317472
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/2*10)=3.32192809488736
Context

PubMed: NEDD4L [Title/Abstract] AND ALPK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

HgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

HgeneNEDD4L

GO:0010038

response to metal ion

11244092

HgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

HgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

HgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

HgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

HgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

HgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

HgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

HgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

HgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

HgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

HgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

HgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-VQ-A8PD-01ANEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
TCGALDSTADTCGA-VQ-A8PX-01ANEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356462ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000356462ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
Frame-shiftENST00000400345ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000400345ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
Frame-shiftENST00000589054ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000589054ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5UTR-3CDSENST00000256832ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5UTR-intronENST00000256832ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
Frame-shiftENST00000382850ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000382850ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
Frame-shiftENST00000256830ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000256830ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000588516ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000588516ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000456986ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000456986ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000435432ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000435432ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000357895ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000357895ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000586263ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000586263ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000456173ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000456173ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000431212ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000431212ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
In-frameENST00000356462ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000356462ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000400345ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000400345ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
intron-3CDSENST00000589054ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
intron-intronENST00000589054ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000256832ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000256832ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000382850ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000382850ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000256830ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000256830ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
intron-3CDSENST00000588516ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
intron-intronENST00000588516ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000456986ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000456986ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000435432ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000435432ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000357895ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000357895ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000586263ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000586263ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000456173ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000456173ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000431212ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000431212ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-

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FusionProtFeatures for NEDD4L_ALPK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEDD4L

Q96PU5

ALPK2

Q86TB3

Kinase that recognizes phosphorylation sites in whichthe surrounding peptides have an alpha-helical conformation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000256830+1828193_226583872DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000256830+1828385_418583872DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000256830+1828497_530583872DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000256830+1828548_581583872DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000256830+18287_109583872DomainC2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000356462+1929193_226623912DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000356462+1929385_418623912DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000356462+1929497_530623912DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000356462+1929548_581623912DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000356462+19297_109623912DomainC2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000357895+2131193_226679968DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000357895+2131385_418679968DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000357895+2131497_530679968DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000357895+2131548_581679968DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000357895+21317_109679968DomainC2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000382850+2030193_226667956DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000382850+2030385_418667956DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000382850+2030497_530667956DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000382850+2030548_581667956DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000382850+20307_109667956DomainC2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000400345+2131193_226687976DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000400345+2131385_418687976DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000400345+2131497_530687976DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000400345+2131548_581687976DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000400345+21317_109687976DomainC2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000431212+2030193_226566855DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000431212+2030385_418566855DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000431212+2030497_530566855DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000431212+20307_109566855DomainC2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000435432+2131193_226546835DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000435432+2131385_418546835DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000435432+2131497_530546835DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000435432+21317_109546835DomainC2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456173+1929193_226546835DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456173+1929385_418546835DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456173+1929497_530546835DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456173+19297_109546835DomainC2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456986+2131193_226566855DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456986+2131385_418566855DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456986+2131497_530566855DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456986+21317_109566855DomainC2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000586263+2030193_226659948DomainWW 1
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000586263+2030385_418659948DomainWW 2
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000586263+2030497_530659948DomainWW 3
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000586263+2030548_581659948DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000586263+20307_109659948DomainC2
TgeneALPK2chr18:56033460chr18:56191294ENST00000361673-5131901_213318332171DomainAlpha-type protein kinase

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000256830+1828640_974583872DomainHECT
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000356462+1929640_974623912DomainHECT
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000357895+2131640_974679968DomainHECT
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000382850+2030640_974667956DomainHECT
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000400345+2131640_974687976DomainHECT
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000431212+2030548_581566855DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000431212+2030640_974566855DomainHECT
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000435432+2131548_581546835DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000435432+2131640_974546835DomainHECT
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456173+1929548_581546835DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456173+1929640_974546835DomainHECT
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456986+2131548_581566855DomainWW 4
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000456986+2131640_974566855DomainHECT
HgeneNEDD4Lchr18:56033460chr18:56191294ENST00000586263+2030640_974659948DomainHECT
TgeneALPK2chr18:56033460chr18:56191294ENST00000361673-5131644_164918332171Compositional biasNote=Poly-Ser
TgeneALPK2chr18:56033460chr18:56191294ENST00000361673-51310_11418332171DomainNote=Ig-like 1
TgeneALPK2chr18:56033460chr18:56191294ENST00000361673-5131786_187418332171DomainNote=Ig-like 2


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FusionGeneSequence for NEDD4L_ALPK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NEDD4L_ENST00000356462_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_961aa
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLL
FEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVP
EPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDG
ASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPF
FIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYF
RKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATAGDNST
VSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIATEELHFGEGVH
RKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRP
ENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMT

>In-frame_NEDD4L_ENST00000400345_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_1025aa
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLL
FEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVP
EPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPA
GRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSP
TVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKT
SLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEE
SYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGK
VTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKV
HNAIAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGK
EINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNN

>In-frame_NEDD4L_ENST00000256832_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_885aa
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT
TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPKA
VPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYY
GLFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRG
QIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFG
EVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATL

>In-frame_NEDD4L_ENST00000382850_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_1005aa
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLL
FEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVP
EPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAY
VHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAV
KDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHL
DGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWI
EFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQD
TKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYK
LAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQH
WVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMT

>In-frame_NEDD4L_ENST00000256830_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_921aa
MATGLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLL
FEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSN
DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVP
EPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPGAKDS
PVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW
EERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVL
KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQ
LSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDEL
IQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQK
CCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKV

>In-frame_NEDD4L_ENST00000456986_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_904aa
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGW
EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS
KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
GVAREWFFLLSKEMFNPYYGLFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQ
LIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQNT
ARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLL
VTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMTIKKAGPETPGE

>In-frame_NEDD4L_ENST00000435432_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_884aa
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT
TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV
PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
LFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQ
IATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGE
VPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLA

>In-frame_NEDD4L_ENST00000357895_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_1017aa
MRRLAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENR
LTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE
ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISE
EVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTV
TGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPL
EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLG
PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSV
KRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLT
AEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGT
RNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRE
SEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPS

>In-frame_NEDD4L_ENST00000586263_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_997aa
MRRLAFEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENR
LTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQE
ELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISE
EVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLP
SGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQ
SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYID
HNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGL
DYGGVAREWFFLLSKEMFNPYYGLFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIE
FSQLIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYV
QNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSG
CLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMTIKKAGPET

>In-frame_NEDD4L_ENST00000456173_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_884aa
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT
TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV
PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
LFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQ
IATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGE
VPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLA

>In-frame_NEDD4L_ENST00000431212_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_904aa
MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGW
EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS
KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
GVAREWFFLLSKEMFNPYYGLFEYSATAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQ
LIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQNT
ARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLL
VTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMTIKKAGPETPGE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NEDD4L_ENST00000356462_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_2883nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTG
GTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTA
TTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCA
ACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATG
GCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAAT
GACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTAC
TATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATC
AACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCC
GAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCT
CGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATT
CAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCTTGCAGAAGATGGT
GCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTA
TCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCT
TACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTC
TTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCC
AATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACT
CAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTC
AGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGA
ATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCC
AGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACT
GTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAA
TTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTC
AAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCAC
CGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATT
GCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTAT
TATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCT
GAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTC
TTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGAC
ATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACC
TTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAG
AAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGCGAAAAGAAAACC

>In-frame_NEDD4L_ENST00000400345_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3075nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTG
GTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTA
TTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCA
ACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATG
GCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAAT
GACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTAC
TATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATC
AACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCC
GAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCT
CGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATT
CAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCT
GGGAGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGC
TGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTT
GCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCA
ACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCA
CAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAAC
GGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACA
TCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAAT
AGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAA
TATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAG
TCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTAT
GGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGG
GACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAA
GTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGC
CAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGA
GAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTG
CACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAAT
ACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTT
ATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAA
GAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTC
CTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAAC
TGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAAC
AACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGC

>In-frame_NEDD4L_ENST00000256832_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_2655nt
ATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCC
TATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGAC
TCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTAT
GTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAAC
CAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAG
CCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGG
ACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAA
AGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCATCAGTGGCCTATGTA
CATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACA
ACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATC
CGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAA
GACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCC
GGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAA
TTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGAT
GGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGAAAGCT
GTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATG
AAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATT
GAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTAC
GGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTAT
TACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGAT
ACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGT
CAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTC
AAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAA
CTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGA
GAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAA
TTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCAC
TGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTG
GCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAA
ATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACA

>In-frame_NEDD4L_ENST00000382850_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3015nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTG
GTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTA
TTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCA
ACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATG
GCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAAT
GACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTAC
TATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATC
AACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCC
GAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCT
CGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATT
CAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCATCAGTGGCCTAT
GTACATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACC
ACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAG
ATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTG
AAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCA
CCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTG
AAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTG
GATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCT
GTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATG
AAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATT
GAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTAC
GGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTAT
TACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGAT
ACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGT
CAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTC
AAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAA
CTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGA
GAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAA
TTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCAC
TGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTG
GCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAA
ATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACA

>In-frame_NEDD4L_ENST00000256830_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_2763nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTG
GTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTA
TTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCA
ACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATG
GCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAAT
GACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTAC
TATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATC
AACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCC
GAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCT
CGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATT
CAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGGGTGCCAAGGACTCA
CCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTC
ACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACC
TGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGG
GAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCA
GCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATC
CCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTA
AAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAG
ATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCG
AAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAG
CTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTT
GGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCAC
GGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTC
ATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAG
CCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAG
GAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAA
TGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGAC
GTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAG
TGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTT

>In-frame_NEDD4L_ENST00000456986_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_2712nt
ATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCC
TATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGAC
TCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTAT
GTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAAC
CAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAG
CCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGG
ACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAA
AGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCTGGG
AGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGG
GAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCA
GAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACA
GTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAG
CCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGC
CGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCT
TTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGC
AAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATAT
GACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCC
TATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGG
GGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGAC
AACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTG
ACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAA
CTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAA
GGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCAC
AATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACT
GCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATC
CATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAA
ATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTG
GTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGT
TCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAAC
CAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGCGAA

>In-frame_NEDD4L_ENST00000435432_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_2652nt
ATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCC
TATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGAC
TCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTAT
GTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAAC
CAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAG
CCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGG
ACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAA
AGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCATCAGTGGCCTATGTA
CATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACA
ACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATC
CGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAA
GACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCC
GGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAA
TTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGAT
GGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTC
CCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAA
CTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAG
TTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGC
CTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTAC
TGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACT
AAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAG
ATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAA
CCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTC
GCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAA
GTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTT
GTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGG
GTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCT
AAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATG
CTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATA

>In-frame_NEDD4L_ENST00000357895_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3051nt
ATGAGACGTCTCGCATTTGAGCAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTT
GGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAG
ACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGA
CTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTT
AAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGT
CAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAG
GAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACC
ACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGC
TTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAG
GAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCA
GAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTG
AGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCTGGGAGAGCGCGTTCATCAACTGTC
ACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAG
GGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCA
GCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTG
GAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCC
AAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCAT
AACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGC
CCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGAC
CCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTA
AAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTG
AAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTC
TTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCC
ATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACA
GCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTC
CTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTC
CGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACC
AGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATC
TACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATC
CCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAA
TCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTA
GGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAG
TTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGC

>In-frame_NEDD4L_ENST00000586263_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_2991nt
ATGAGACGTCTCGCATTTGAGCAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTT
GGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAG
ACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGA
CTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTT
AAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGT
CAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAG
GAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACC
ACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGC
TTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAG
GAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCA
GAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTG
AGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCT
TCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATG
CAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGC
TCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAG
TCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCG
CCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCA
AAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGAT
CATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAG
CAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTT
GAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTT
GACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACT
GCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTAC
GGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAA
TTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCAC
TTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTT
AAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTT
CAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATT
TTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGAT
GGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGC
TGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAA
GGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAA
AACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACC

>In-frame_NEDD4L_ENST00000456173_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_2652nt
ATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCC
TATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGAC
TCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTAT
GTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAAC
CAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAG
CCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGG
ACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAA
AGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCATCAGTGGCCTATGTA
CATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACA
ACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATC
CGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAA
GACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCC
GGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAA
TTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGAT
GGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTC
CCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAA
CTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAG
TTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGC
CTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTAC
TGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACT
AAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAG
ATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAA
CCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTC
GCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAA
GTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTT
GTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGG
GTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCT
AAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATG
CTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATA

>In-frame_NEDD4L_ENST00000431212_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_2712nt
ATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCC
TATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGAC
TCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTAT
GTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAAC
CAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAG
CCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGG
ACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAA
AGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCTGGG
AGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGG
GAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCA
GAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACA
GTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAG
CCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGC
CGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCT
TTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGC
AAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATAT
GACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCC
TATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGG
GGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGAC
AACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTG
ACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAA
CTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAA
GGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCAC
AATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACT
GCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATC
CATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAA
ATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTG
GTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGT
TCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAAC
CAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGCGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_NEDD4L_ENST00000356462_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3753nt
GCGCCGCCGCCGCGCGCAGTGAGAGGCGCCGGGGCTGCCGCCCGGTGCTCGGCGCGCTCTCGGGAGCCGCCCGCCCGCTGGTCCCGCAGC
CTTCCGGGAGGAAGCGGTGCCGGCAGCGTCCAGGGCGCGCTCTCGGGCACCCTCACCTGCCGGCGCCCGGCCGCTTACCCGGCAGGGCGT
GCGCAGGGTAGGGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCA
GACCCCGCGCGGGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTC
AGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCG
GATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTA
AACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTT
AGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTT
AAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCAT
GGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAA
GTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAG
TCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAG
CCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCC
CCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAAT
GGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCAT
CTACCACCGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGC
CTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAAC
CCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGG
ATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATG
CGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTAT
ATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAA
TTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAAC
ATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAA
GGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCT
GCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAAC
AGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAG
ATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAG
CTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGT
GTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGC
TATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATT
CCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATC
AGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACA
AGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGA
TTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCC
CTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCT
GAGACCCCAGGCGAAAAGAAAACCTAACGTCCCTGGGTAACCTAATGGCCACTGGCTAGCAGCACACAATCTCGCCAGGGAAAATCTGAG
GCCACACAGGAGAGAATATACAGCCTGCAGAGAGTGCGTGGCAATCCTTACTCCCAGCCGACTGTGCGCCAAGATGCTTCTAAACCCATC
ACCTGCTGTCTTCACTCAAATGATTTCAGAACAGGATTTGCGACCAGGTTTATGGGGAGATTGAATCAACGATTGGTCTCAAAGACAGTC
CATTCTTTATATACATGTTTAGCATTTTTACCAACCTCACATCATGTGTATATTTGTGTATTTGCACATGGTTGTGCTGTCGAGGACCTG
GTGCTGAGAAGAGTCTGTTCACAGCCAAAATTCTTCCCACTGTCATTCCTAACCTGGGATTTCTAGACACATCCTGCTGTGATGTAAACA
GAAATCACGAATTCGCTCACTGGATCAAGTTGTTCCACTGGTGTCTAATACGCTATTGTTGCCGGAGGTGGGTTCTGTGACGTGAAGCCA

>In-frame_NEDD4L_ENST00000400345_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3934nt
GCGCGCAGTGAGAGGCGCCGGGGCTGCCGCCCGGTGCTCGGCGCGCTCTCGGGAGCCGCCCGCCCGCTGGTCCCGCAGCCTTCCGGGAGG
AAGCGGTGCCGGCAGCGTCCAGGGCGCGCTCTCGGGCACCCTCACCTGCCGGCGCCCGGCCGCTTACCCGGCAGGGCGTGCGCAGGGTAG
GGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCAGACCCCGCGCG
GGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGT
TGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAG
AGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAA
TCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCC
GACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTT
GCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGT
TGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTT
AGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAA
CATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGG
CGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGC
CTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTT
CAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCC
CAGTGCCCCAGCTGGGAGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGG
TCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACC
TATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAG
CCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAA
CCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAG
GATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATAT
GCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTA
TATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGA
ATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAA
CATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAA
AGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTC
TGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAA
CAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGA
GATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGA
GCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTG
TGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATG
CTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCAT
TCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCAT
CAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAAC
AAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGG
ATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATC
CCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCC
TGAGACCCCAGGCGAAAAGAAAACCTAACGTCCCTGGGTAACCTAATGGCCACTGGCTAGCAGCACACAATCTCGCCAGGGAAAATCTGA
GGCCACACAGGAGAGAATATACAGCCTGCAGAGAGTGCGTGGCAATCCTTACTCCCAGCCGACTGTGCGCCAAGATGCTTCTAAACCCAT
CACCTGCTGTCTTCACTCAAATGATTTCAGAACAGGATTTGCGACCAGGTTTATGGGGAGATTGAATCAACGATTGGTCTCAAAGACAGT
CCATTCTTTATATACATGTTTAGCATTTTTACCAACCTCACATCATGTGTATATTTGTGTATTTGCACATGGTTGTGCTGTCGAGGACCT
GGTGCTGAGAAGAGTCTGTTCACAGCCAAAATTCTTCCCACTGTCATTCCTAACCTGGGATTTCTAGACACATCCTGCTGTGATGTAAAC
AGAAATCACGAATTCGCTCACTGGATCAAGTTGTTCCACTGGTGTCTAATACGCTATTGTTGCCGGAGGTGGGTTCTGTGACGTGAAGCC

>In-frame_NEDD4L_ENST00000256832_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3868nt
GAGAGGCGCCGGGGCTGCCGCCCGGTGCTCGGCGCGCTCTCGGGAGCCGCCCGCCCGCTGGTCCCGCAGCCTTCCGGGAGGAAGCGGTGC
CGGCAGCGTCCAGGGCGCGCTCTCGGGCACCCTCACCTGCCGGCGCCCGGCCGCTTACCCGGCAGGGCGTGCGCAGGGTAGGGTGCGGGA
CCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCAGACCCCGCGCGGGGCGCCGG
CTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGG
AATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGC
TTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACT
CCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGA
TCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAA
AATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTC
AAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAAC
TTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACA
GATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGT
CCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGG
ATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTT
GATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCATCAGTGGC
CTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCG
AACCACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCC
TCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGC
TGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTT
GCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACG
TTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCA
CTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCC
GAAAGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTT
TGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACT
GTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCC
CTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGG
ACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCG
CCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCT
GCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCC
TGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAA
CTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGG
CTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGAT
TGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTT
CCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGC
AACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTA
TTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTC
TATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGCGAAAAGAAAACCTAACGTCCCTGGGTAACCTAATGGCCACTGGCTAGCAGCAC
ACAATCTCGCCAGGGAAAATCTGAGGCCACACAGGAGAGAATATACAGCCTGCAGAGAGTGCGTGGCAATCCTTACTCCCAGCCGACTGT
GCGCCAAGATGCTTCTAAACCCATCACCTGCTGTCTTCACTCAAATGATTTCAGAACAGGATTTGCGACCAGGTTTATGGGGAGATTGAA
TCAACGATTGGTCTCAAAGACAGTCCATTCTTTATATACATGTTTAGCATTTTTACCAACCTCACATCATGTGTATATTTGTGTATTTGC
ACATGGTTGTGCTGTCGAGGACCTGGTGCTGAGAAGAGTCTGTTCACAGCCAAAATTCTTCCCACTGTCATTCCTAACCTGGGATTTCTA
GACACATCCTGCTGTGATGTAAACAGAAATCACGAATTCGCTCACTGGATCAAGTTGTTCCACTGGTGTCTAATACGCTATTGTTGCCGG

>In-frame_NEDD4L_ENST00000382850_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3704nt
CGCAGGGTAGGGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCAG
ACCCCGCGCGGGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCA
GAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGG
ATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAA
ACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTA
GTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTA
AGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATG
GATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAG
TGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGT
CGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGC
CCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCC
CACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATG
GGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATC
TACCACCGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACT
ATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTA
ACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGG
ACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACA
AAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTA
CAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTG
GCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGA
ACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTG
ATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATG
TCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCA
AAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCA
GTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCA
AACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCT
ACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGA
TGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATG
AGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAG
CACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAG
TGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTC
AGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAA
CTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTAC
ACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCA
AAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGCGAAAAGAAAACCTAACGTCCCTGGGTAACCTAATGGC
CACTGGCTAGCAGCACACAATCTCGCCAGGGAAAATCTGAGGCCACACAGGAGAGAATATACAGCCTGCAGAGAGTGCGTGGCAATCCTT
ACTCCCAGCCGACTGTGCGCCAAGATGCTTCTAAACCCATCACCTGCTGTCTTCACTCAAATGATTTCAGAACAGGATTTGCGACCAGGT
TTATGGGGAGATTGAATCAACGATTGGTCTCAAAGACAGTCCATTCTTTATATACATGTTTAGCATTTTTACCAACCTCACATCATGTGT
ATATTTGTGTATTTGCACATGGTTGTGCTGTCGAGGACCTGGTGCTGAGAAGAGTCTGTTCACAGCCAAAATTCTTCCCACTGTCATTCC
TAACCTGGGATTTCTAGACACATCCTGCTGTGATGTAAACAGAAATCACGAATTCGCTCACTGGATCAAGTTGTTCCACTGGTGTCTAAT
ACGCTATTGTTGCCGGAGGTGGGTTCTGTGACGTGAAGCCATTTCCCATCATTCAACAGCCAGTTACAATTTTCTGTTTAATTAAATTCA

>In-frame_NEDD4L_ENST00000256830_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3339nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATT
GATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTG
GTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTA
TTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCA
ACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATG
GCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAAT
GACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTAC
TATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATC
AACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCC
GAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCT
CGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATT
CAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGGGTGCCAAGGACTCA
CCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTC
ACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACC
TGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGG
GAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCA
GCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATC
CCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTA
AAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAG
ATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCG
AAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAG
CTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTT
GGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCAC
GGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTC
ATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAG
CCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAG
GAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAA
TGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGAC
GTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAG
TGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTT
CAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGCGAAAAGAAAACCTAACGTCCCTGGGTAACCTAATGGCCACTG
GCTAGCAGCACACAATCTCGCCAGGGAAAATCTGAGGCCACACAGGAGAGAATATACAGCCTGCAGAGAGTGCGTGGCAATCCTTACTCC
CAGCCGACTGTGCGCCAAGATGCTTCTAAACCCATCACCTGCTGTCTTCACTCAAATGATTTCAGAACAGGATTTGCGACCAGGTTTATG
GGGAGATTGAATCAACGATTGGTCTCAAAGACAGTCCATTCTTTATATACATGTTTAGCATTTTTACCAACCTCACATCATGTGTATATT
TGTGTATTTGCACATGGTTGTGCTGTCGAGGACCTGGTGCTGAGAAGAGTCTGTTCACAGCCAAAATTCTTCCCACTGTCATTCCTAACC
TGGGATTTCTAGACACATCCTGCTGTGATGTAAACAGAAATCACGAATTCGCTCACTGGATCAAGTTGTTCCACTGGTGTCTAATACGCT
ATTGTTGCCGGAGGTGGGTTCTGTGACGTGAAGCCATTTCCCATCATTCAACAGCCAGTTACAATTTTCTGTTTAATTAAATTCATATTT

>In-frame_NEDD4L_ENST00000456986_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3888nt
ATTTTGACCGCTATTTAGAAGAGTGACCTCATAAATCTTTTAGCAAAGTAGACACACATACCTACCACATTTCTTAAAAGTAGATTCGTA
TTTTGATTTGAGATTGTTGAAAAGCATGGTATGTTTGGAGTGCACTTAGTTATGTCCCATCTCATAAAGACTGTTGAGCTCTCTGCACTG
CTGATGATGAAGCATTGCATGAACCCAGAAAACGGGGATGCCAAAGCACAGGGCTTAGGTGCTGTTCCTTGCGTCATCAGCAGAGGTCTG
TCCACTTTGTAGAAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGT
GATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAAC
CCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGA
GACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTT
CTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAA
GAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCT
CCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGG
CACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCC
CGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAAT
ATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTA
AGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGC
AGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCTGGGAGAGCGCGTTCATCAACTGTCACGGGTGGT
GAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACA
TACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAAC
AGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCC
AAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAA
CACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAG
ACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCT
CCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTG
CAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCT
GCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCA
GATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTG
TCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAA
GCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTT
CTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGAC
AGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACA
GTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAAT
GATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCT
GAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCT
ACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCT
GGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAG
CTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCA
CTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAA
AGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGCGAAAAGAAAACCTAACGTCCCTGGGTAACCTAA
TGGCCACTGGCTAGCAGCACACAATCTCGCCAGGGAAAATCTGAGGCCACACAGGAGAGAATATACAGCCTGCAGAGAGTGCGTGGCAAT
CCTTACTCCCAGCCGACTGTGCGCCAAGATGCTTCTAAACCCATCACCTGCTGTCTTCACTCAAATGATTTCAGAACAGGATTTGCGACC
AGGTTTATGGGGAGATTGAATCAACGATTGGTCTCAAAGACAGTCCATTCTTTATATACATGTTTAGCATTTTTACCAACCTCACATCAT
GTGTATATTTGTGTATTTGCACATGGTTGTGCTGTCGAGGACCTGGTGCTGAGAAGAGTCTGTTCACAGCCAAAATTCTTCCCACTGTCA
TTCCTAACCTGGGATTTCTAGACACATCCTGCTGTGATGTAAACAGAAATCACGAATTCGCTCACTGGATCAAGTTGTTCCACTGGTGTC
TAATACGCTATTGTTGCCGGAGGTGGGTTCTGTGACGTGAAGCCATTTCCCATCATTCAACAGCCAGTTACAATTTTCTGTTTAATTAAA

>In-frame_NEDD4L_ENST00000435432_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3858nt
GCCATTTCCAGAGAGGAACAACCGTGTAGACTGCTTTCCTGGGAGTCAAGTTAAAACTTCTCTCCTGTGACCTTGTCACCCGGCAGTGGA
AAGTTACCCTTGGCTGCAGCCACGACTTCCGCATACTCTTCAGAACTTGCTCTGCCCTTGAGTTTTCCAGCTTTCCTTTAATGCACTAAA
CCTTTAATATTGTATTCTCCTAAATGAGACGTCTCGCATTTGAGCAGGTAACACTCGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTT
TCTGGAATTGATCTCGCCAAAAAGGACATCTTTGGAGCCAGCTTCTGCTCCATTGCTGTTGAACTTTTTTTTGGTCGTGACATCAGAAAA
ATAACCAAGTGTGAGTCTGATAATAGCAATGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTC
CAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTT
GAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACC
ATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCC
TATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGAC
TCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTAT
GTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAAC
CAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAG
CCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGG
ACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAA
AGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCATCAGTGGCCTATGTA
CATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACA
ACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATC
CGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAA
GACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCC
GGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAA
TTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGAT
GGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTC
CCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAA
CTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAG
TTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGC
CTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTAC
TGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACT
AAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAG
ATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAA
CCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTC
GCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAA
GTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTT
GTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGG
GTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCT
AAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATG
CTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATA
AAGAAGGCAGGGCCTGAGACCCCAGGCGAAAAGAAAACCTAACGTCCCTGGGTAACCTAATGGCCACTGGCTAGCAGCACACAATCTCGC
CAGGGAAAATCTGAGGCCACACAGGAGAGAATATACAGCCTGCAGAGAGTGCGTGGCAATCCTTACTCCCAGCCGACTGTGCGCCAAGAT
GCTTCTAAACCCATCACCTGCTGTCTTCACTCAAATGATTTCAGAACAGGATTTGCGACCAGGTTTATGGGGAGATTGAATCAACGATTG
GTCTCAAAGACAGTCCATTCTTTATATACATGTTTAGCATTTTTACCAACCTCACATCATGTGTATATTTGTGTATTTGCACATGGTTGT
GCTGTCGAGGACCTGGTGCTGAGAAGAGTCTGTTCACAGCCAAAATTCTTCCCACTGTCATTCCTAACCTGGGATTTCTAGACACATCCT
GCTGTGATGTAAACAGAAATCACGAATTCGCTCACTGGATCAAGTTGTTCCACTGGTGTCTAATACGCTATTGTTGCCGGAGGTGGGTTC

>In-frame_NEDD4L_ENST00000357895_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3830nt
GCCATTTCCAGAGAGGAACAACCGTGTAGACTGCTTTCCTGGGAGTCAAGTTAAAACTTCTCTCCTGTGACCTTGTCACCCGGCAGTGGA
AAGTTACCCTTGGCTGCAGCCACGACTTCCGCATACTCTTCAGAACTTGCTCTGCCCTTGAGTTTTCCAGCTTTCCTTTAATGCACTAAA
CCTTTAATATTGTATTCTCCTAAATGAGACGTCTCGCATTTGAGCAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTG
ATCTCGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGG
TCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTAT
TTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAA
CCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGG
CCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATG
ACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACT
ATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCA
ACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCG
AGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTC
GGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTC
AAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCAGTGCCCCAGCTG
GGAGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCT
GGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTG
CAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAA
CAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCAC
AGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACG
GCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACAT
CTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATA
GCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAAT
ATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGT
CCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATG
GGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGG
ACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAG
TGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCC
AACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAG
AAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGC
ACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATA
CTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTA
TCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAG
AAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCC
TGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACT
GTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACA
ACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGCG
AAAAGAAAACCTAACGTCCCTGGGTAACCTAATGGCCACTGGCTAGCAGCACACAATCTCGCCAGGGAAAATCTGAGGCCACACAGGAGA
GAATATACAGCCTGCAGAGAGTGCGTGGCAATCCTTACTCCCAGCCGACTGTGCGCCAAGATGCTTCTAAACCCATCACCTGCTGTCTTC
ACTCAAATGATTTCAGAACAGGATTTGCGACCAGGTTTATGGGGAGATTGAATCAACGATTGGTCTCAAAGACAGTCCATTCTTTATATA
CATGTTTAGCATTTTTACCAACCTCACATCATGTGTATATTTGTGTATTTGCACATGGTTGTGCTGTCGAGGACCTGGTGCTGAGAAGAG
TCTGTTCACAGCCAAAATTCTTCCCACTGTCATTCCTAACCTGGGATTTCTAGACACATCCTGCTGTGATGTAAACAGAAATCACGAATT
CGCTCACTGGATCAAGTTGTTCCACTGGTGTCTAATACGCTATTGTTGCCGGAGGTGGGTTCTGTGACGTGAAGCCATTTCCCATCATTC

>In-frame_NEDD4L_ENST00000586263_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3766nt
TTTCCAGAGAGGAACAACCGTGTAGACTGCTTTCCTGGGAGTCAAGTTAAAACTTCTCTCCTGTGACCTTGTCACCCGGCAGTGGAAAGT
TACCCTTGGCTGCAGCCACGACTTCCGCATACTCTTCAGAACTTGCTCTGCCCTTGAGTTTTCCAGCTTTCCTTTAATGCACTAAACCTT
TAATATTGTATTCTCCTAAATGAGACGTCTCGCATTTGAGCAGGGAGAGTCCCGTATTCTCAGAGTAAAAGTTGTTTCTGGAATTGATCT
CGCCAAAAAGGACATCTTTGGAGCCAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCA
GACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGA
AGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACCAT
GGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTA
TATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTC
GGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGT
CAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAACCA
GGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCC
TTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGAC
CAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAG
AGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCATCAGTGGCCTATGTACA
TACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAAC
TTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCG
CCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGA
CACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGG
CTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATT
TCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGG
CCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCC
TTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACT
TCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTT
TGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCT
CTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTG
CTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAA
AGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGAT
CGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACC
TGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGC
TGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGT
ACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGT
GAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGT
GTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAA
AGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCT
GGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAA
GAAGGCAGGGCCTGAGACCCCAGGCGAAAAGAAAACCTAACGTCCCTGGGTAACCTAATGGCCACTGGCTAGCAGCACACAATCTCGCCA
GGGAAAATCTGAGGCCACACAGGAGAGAATATACAGCCTGCAGAGAGTGCGTGGCAATCCTTACTCCCAGCCGACTGTGCGCCAAGATGC
TTCTAAACCCATCACCTGCTGTCTTCACTCAAATGATTTCAGAACAGGATTTGCGACCAGGTTTATGGGGAGATTGAATCAACGATTGGT
CTCAAAGACAGTCCATTCTTTATATACATGTTTAGCATTTTTACCAACCTCACATCATGTGTATATTTGTGTATTTGCACATGGTTGTGC
TGTCGAGGACCTGGTGCTGAGAAGAGTCTGTTCACAGCCAAAATTCTTCCCACTGTCATTCCTAACCTGGGATTTCTAGACACATCCTGC
TGTGATGTAAACAGAAATCACGAATTCGCTCACTGGATCAAGTTGTTCCACTGGTGTCTAATACGCTATTGTTGCCGGAGGTGGGTTCTG

>In-frame_NEDD4L_ENST00000456173_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3813nt
ACTTCCGTGTTCCCCACATTTGAATTTGCTCCCGATTCGAGAGAGGCAGGCATCCGCGGCAGCAGCTTCCAACCCAGACAGGCTTAAGCC
GCGCGAGGGTGCCCGGGTGGGTGGCTGCGCAGGGCCCTACCTGGGCGGGAGCGGCTGCAGAGCCCTGTCCACGCGGTGCCTCCCCAGCAC
GGCACCTCCCACTCCAGGCTGTTGGTTACCTGGCCGGGAGCTGGCGGAGACCAGGATTTCTCCTCGCCGCCGTTGCTGTTGTTAGGGGAA
ACAGACCATCTGCATCTAGACCTGCCTCTCTCTCCGCTCCCCACTTCAGACGAGCTCTTCCTGCCTGGAATCTGTGATCCGTATGTGAAA
CTTTCATTGTACGTAGCGGATGAGAATAGAGAACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAA
GAATTTTATTTCAGGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGC
CAGGTGGACGTGCCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGA
AGTCATAAGTCTCGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAG
AGGGATGACATGGAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCT
CCCGGGTGGGAAGAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTG
ATGGACGTGTCCTCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGC
GAAGACTTGGAGCCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCT
CTCGGTCTGGCTCTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAG
ATCACTCCAGACTCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCA
GTTGCAGAACAGGGCCATCTACCACCGCCATCAGTGGCCTATGTACATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGAT
GCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCC
GGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCC
CCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAAC
TCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATT
GATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGAC
CTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGG
GAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAG
AAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATG
TCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAA
TGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTGCCACTGCAGGGGACAACTCCACTGTTTCC
TTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACAGCTACGGAAAAGTGACTGCTGAATTTAAC
CTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGATTGAATTCAGCCAACTCATCTTCAAAGAA
GACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGCTGCACTTTGGAGAAGGGGTTCACCGCAAA
GCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTGTGCTTAAGGTGCACAATGCCATTGCCTAT
GGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCTATGTTCAAAATACTGCCAGGTATTATGCC
AAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTCCTATTTTTCTTATCCATCGGCCTGAGAAC
AATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCAGGGATGGGAAAGAAATAAACTTCTTGAGA
AGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAAGTGGCTGCCTCCTGGTGACGGACATGCAA
GGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGATTTAAAGGCAACTGTTCCATGACCTTCATT
GATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCCTTCAAAACAACAACCAGAAACAGAAGCAG
CCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTGAGACCCCAGGCGAAAAGAAAACCTAACGT
CCCTGGGTAACCTAATGGCCACTGGCTAGCAGCACACAATCTCGCCAGGGAAAATCTGAGGCCACACAGGAGAGAATATACAGCCTGCAG
AGAGTGCGTGGCAATCCTTACTCCCAGCCGACTGTGCGCCAAGATGCTTCTAAACCCATCACCTGCTGTCTTCACTCAAATGATTTCAGA
ACAGGATTTGCGACCAGGTTTATGGGGAGATTGAATCAACGATTGGTCTCAAAGACAGTCCATTCTTTATATACATGTTTAGCATTTTTA
CCAACCTCACATCATGTGTATATTTGTGTATTTGCACATGGTTGTGCTGTCGAGGACCTGGTGCTGAGAAGAGTCTGTTCACAGCCAAAA
TTCTTCCCACTGTCATTCCTAACCTGGGATTTCTAGACACATCCTGCTGTGATGTAAACAGAAATCACGAATTCGCTCACTGGATCAAGT
TGTTCCACTGGTGTCTAATACGCTATTGTTGCCGGAGGTGGGTTCTGTGACGTGAAGCCATTTCCCATCATTCAACAGCCAGTTACAATT

>In-frame_NEDD4L_ENST00000431212_chr18_56033460_+_ALPK2_ENST00000361673_chr18_56191294_-_3752nt
ATCAGTATAAGTAGCGAGCTGGGCGCATTCCTTCTCAGTTGTGTTAAAACTTGCTGGTATTCCCCCGGTATCAGCAGAGGTGTGTACGGG
CACTGCTTTAAAACTGGGAAGGAGGAAGACGAGGCCAGGGAGCCGGAGGGTCACCAAGGTAGATTTCCAGCAGCGCTAGTCCAGCTGAAC
ACTTTCCAGCCTTGTTTTTCAGCAGCTTTGAGGAAAAGTATAGTGATCCGTATGTGAAACTTTCATTGTACGTAGCGGATGAGAATAGAG
AACTTGCTTTGGTCCAGACAAAAACAATTAAAAAGACACTGAACCCAAAATGGAATGAAGAATTTTATTTCAGGGTAAACCCATCTAATC
ACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTGCCCCTTAGTCACCTTCCGA
CAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCTCGAGTTAAGGGATTTTTGC
GATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATGGAGCATGGATGGGAAGTTG
TTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAAGAAAAAGTGGACAATTTAG
GCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCCTCGGAGTCGGACAATAACA
TCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAGCCCGAGCCCTCGGAGGGCG
GGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCTCTGCCCCCACCACCGGCCT
CCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGACTCCAATGGGGAACAGTTCA
GCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAGGGCCATCTACCACCGCCCA
GTGCCCCAGCTGGGAGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTATGTACATACCACGCCGGGTC
TGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACCACAACTTGGACTCGACCTA
TCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCTCGTAGCC
TCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTTTCCAACC
CACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAAATGAGGA
TAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTACATATGC
GGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACGTTTTATA
TTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCCAGAGAAT
TTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGAAATAACA
TATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCAGAGAAAG
GTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAGTACTCTG
CCACTGCAGGGGACAACTCCACTGTTTCCTTTGCCATCGTGCAAGCCAGTCCGAAGGACCAGGGACTCTATTACTGCTGCATCAAGAACA
GCTACGGAAAAGTGACTGCTGAATTTAACCTCACAGCTGAAGTTCTCAAACAGCTGTCAAGTCGCCAGGATACTAAAGGATGTGAAGAGA
TTGAATTCAGCCAACTCATCTTCAAAGAAGACTTCCTCCATGACAGCTACTTTGGGGGCCGCCTGCGTGGTCAGATCGCCACGGAGGAGC
TGCACTTTGGAGAAGGGGTTCACCGCAAAGCCTTCCGCAGCACAGTGATGCACGGCCTCATGCCTGTCTTCAAACCTGGCCATGCCTGTG
TGCTTAAGGTGCACAATGCCATTGCCTATGGGACCAGAAATAATGATGAGCTCATCCAAAGGAACTACAAACTCGCTGCCCAGGAATGCT
ATGTTCAAAATACTGCCAGGTATTATGCCAAGATCTACGCTGCTGAAGCACAGCCTCTGGAAGGCTTTGGAGAAGTACCTGAGATCATTC
CTATTTTTCTTATCCATCGGCCTGAGAACAATATCCCGTATGCTACAGTGGAGGAGGAGCTGATTGGAGAATTTGTGAAGTATTCCATCA
GGGATGGGAAAGAAATAAACTTCTTGAGAAGAGAATCAGAAGCTGGTCAGAAATGTTGCACCTTCCAGCACTGGGTGTACCAGAAAACAA
GTGGCTGCCTCCTGGTGACGGACATGCAAGGTGTAGGAATGAAGCTAACTGACGTTGGCATAGCAACGCTGGCTAAAGGGTACAAGGGAT
TTAAAGGCAACTGTTCCATGACCTTCATTGATCAGTTTAAAGCACTACACCAGTGTAACAAGTATTGCAAAATGCTGGGACTGAAATCCC
TTCAAAACAACAACCAGAAACAGAAGCAGCCGAGCATTGGGAAAAGCAAAGTTCAAACAAACTCTATGACAATAAAGAAGGCAGGGCCTG
AGACCCCAGGCGAAAAGAAAACCTAACGTCCCTGGGTAACCTAATGGCCACTGGCTAGCAGCACACAATCTCGCCAGGGAAAATCTGAGG
CCACACAGGAGAGAATATACAGCCTGCAGAGAGTGCGTGGCAATCCTTACTCCCAGCCGACTGTGCGCCAAGATGCTTCTAAACCCATCA
CCTGCTGTCTTCACTCAAATGATTTCAGAACAGGATTTGCGACCAGGTTTATGGGGAGATTGAATCAACGATTGGTCTCAAAGACAGTCC
ATTCTTTATATACATGTTTAGCATTTTTACCAACCTCACATCATGTGTATATTTGTGTATTTGCACATGGTTGTGCTGTCGAGGACCTGG
TGCTGAGAAGAGTCTGTTCACAGCCAAAATTCTTCCCACTGTCATTCCTAACCTGGGATTTCTAGACACATCCTGCTGTGATGTAAACAG
AAATCACGAATTCGCTCACTGGATCAAGTTGTTCCACTGGTGTCTAATACGCTATTGTTGCCGGAGGTGGGTTCTGTGACGTGAAGCCAT


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FusionGenePPI for NEDD4L_ALPK2


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEDD4LSFN, NR3C1, ARHGDIA, SCNN1A, SCNN1B, SCNN1G, NEDD4L, AMOT, YWHAG, YWHAZ, PSMD4, YWHAB, TNK2, OCLN, APBB1, TOLLIP, NDFIP1, KCNB1, MAPKAPK3, CLIC2, EFEMP2, HGS, NDFIP2, MAP3K3, VDAC2, ZDHHC3, CAMK1D, RANBP10, CDK5, ABL1, MAGEB1, DMTN, AICDA, MARK2, KCNAB1, FKBP3, DAPK3, BRAF, MAP3K5, DDX54, ZAK, KCNAB3, NTRK1, CUEDC1, RPS6KB2, ABL2, CACNB1, YY1, MAP3K2, BBX, PRKX, ACVR1B, ADAP2, BMPR1A, AKT3, MINK1, AURKC, NSRP1, WIBG, SGK2, UBAC1, RPL30, MERTK, SRMS, SERPINF1, DYRK3, IFRD2, SCD, ROBO3, TRIM41, TMA16, TAF1B, SPAG8, STAC, H1F0, PRR16, KIFC3, RASL10B, PRRG1, CDK3, KCNAB2, FGF12, RNF7, APEX2, MRPL19, TGFB1I1, TBC1D7, NHP2, TMEM55A, CYP26B1, DECR2, SENP2, SIVA1, RASL11B, MAP2, STK40, NUDT16L1, C7orf50, TCEAL2, ZC3HAV1L, MOB3A, TARBP2, ZADH2, WBP2, ELAVL1, YWHAH, SGK1, RAF1, TSC22D3, WNK4, WNK1, IKBKB, SMAD7, AMOTL1, UBE2D2, UBC, SMAD2, SMAD3, YWHAQ, NPC2, MT2A, ATP1B1, CYBRD1, SLC7A7, PBX1, ACY3, HAX1, KIF3B, KCNH2, CAV3, UBE2L3, UBE2K, UBE2D1, UBE2E3, UBE2J2, CDC34, ARRDC3, ARRDC4, MED28, FBXL15, LAPTM5, RNF11, KCNQ1, SGK3, UBE2D3, NOTCH1, AATF, GORAB, UBE2N, HCN1, SMAD6, SLC9A3, SNCA, WNK3, PTCH1, DAZAP2, MOV10, CCDC8, FAM189B, PRRG3, TMEM51, TMEM171, SUSD6, FAM189A2, WBP1, ARRDC1, TMEM92, TMEM52B, LDLRAD4, XPO1, LITAF, SLC22A11, SLC22A8, RHOB, CRYAB, GRB10, KCNA3, ULK1, ERBB3, PTK2B, GRIA1, ILDR1, TNFAIP3, TNFRSF19, LPAR1, EDEM3, TRIM25, SCN5A, UBE2E1, UBE2E2, UBE2L6ALPK2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEDD4L_ALPK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEDD4L_ALPK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEDD4LC0020538Hypertensive disease2CTD_human
HgeneNEDD4LC0008925Cleft Palate1CTD_human
HgeneNEDD4LC0014175Endometriosis1CTD_human
HgeneNEDD4LC0039075Syndactyly1CTD_human
HgeneNEDD4LC1868720Periventricular Nodular Heterotopia1CTD_human;ORPHANET