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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23929

FusionGeneSummary for NEBL_CAMK1D

check button Fusion gene summary
Fusion gene informationFusion gene name: NEBL_CAMK1D
Fusion gene ID: 23929
HgeneTgene
Gene symbol

NEBL

CAMK1D

Gene ID

10529

57118

Gene namenebulettecalcium/calmodulin dependent protein kinase ID
SynonymsLASP2|LNEBLCKLiK|CaM-K1|CaMKID
Cytomap

10p12.31

10p13

Type of geneprotein-codingprotein-coding
DescriptionnebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk proteincalcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta
Modification date2018052320180523
UniProtAcc

O76041

Q8IU85

Ensembl transtripts involved in fusion geneENST00000377122, ENST00000417816, 
ENST00000377159, ENST00000377119, 
ENST00000464278, 
ENST00000378847, 
ENST00000487696, ENST00000378845, 
Fusion gene scores* DoF score8 X 7 X 4=2248 X 9 X 6=432
# samples 1010
** MAII scorelog2(10/224*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEBL [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAMK1D

GO:0032793

positive regulation of CREB transcription factor activity

16324104


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-A8HD-01ANEBLchr10

21461312

-CAMK1Dchr10

12595224

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000377122ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377122ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377122ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
In-frameENST00000417816ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
5CDS-intronENST00000417816ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
5CDS-intronENST00000417816ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-3CDSENST00000377159ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377159ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377159ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-3CDSENST00000377119ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377119ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377119ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-3CDSENST00000464278ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000464278ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000464278ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+

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FusionProtFeatures for NEBL_CAMK1D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEBL

O76041

CAMK1D

Q8IU85

Binds to actin and plays an important role in theassembly of the Z-disk. May functionally link sarcomeric actin tothe desmin intermediate filaments in the heart muscle sarcomeres(PubMed:27733623). Isoform 2 might play a role in the assembly offocal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028,ECO:0000269|PubMed:27733623}. Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascadeand, upon calcium influx, activates CREB-dependent genetranscription, regulates calcium-mediated granulocyte function andrespiratory burst and promotes basal dendritic growth ofhippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratoryburst. Activates the transcription factor CREB1 in hippocampalneuron nuclei. May play a role in apoptosis of erythroleukemiacells. In vitro, phosphorylates transcription factor CREM isoformBeta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691,ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEBL_CAMK1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NEBL_ENST00000417816_chr10_21461312_-_CAMK1D_ENST00000378847_chr10_12595224_+_410aa
MNPQCARCGKVVTPTEKVNCLDKTWHKGCFHCEVCKMALNMNNYKGTEKKPTCNAGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSI
ENEIAVLRKIKHENIVALEDITESPNHLYLVMQLVSGGELFDRIVEKGFTTEKDASTLIRQVLDAVYTLHRMGIVHRDLKPENLLYYSQD
EESKIMISDFGLSKMEGKGDVMSTACGTPGTVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFTDENDSKLFEQILKAETEFDSPYWD
DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NEBL_ENST00000417816_chr10_21461312_-_CAMK1D_ENST00000378847_chr10_12595224_+_1230nt
ATGAACCCCCAGTGCGCCCGTTGCGGAAAAGTCGTGTATCCCACCGAGAAAGTCAACTGCCTGGATAAGTATTGGCATAAAGGATGTTTC
CATTGTGAGGTCTGCAAGATGGCACTCAACATGAACAACTACAAAGGCTATGAAAAGAAGCCCTATTGTAATGCCGGGGCCTTTTCCGAA
GTGGTTTTAGCTGAAGAGAAGGCAACTGGCAAGCTCTTTGCTGTGAAGTGTATCCCTAAGAAGGCGCTGAAGGGCAAGGAAAGCAGCATA
GAGAATGAGATAGCCGTCCTGAGAAAGATTAAGCATGAAAATATTGTTGCCCTGGAAGACATTTATGAAAGCCCAAATCACCTGTACTTG
GTCATGCAGCTGGTGTCCGGTGGAGAGCTGTTTGACCGGATAGTGGAGAAGGGGTTTTATACAGAGAAGGATGCCAGCACTCTGATCCGC
CAAGTCTTGGACGCCGTGTACTATCTCCACAGAATGGGCATCGTCCACAGAGACCTCAAGCCCGAAAATCTCTTGTACTACAGTCAAGAT
GAGGAGTCCAAAATAATGATCAGTGACTTTGGATTGTCAAAAATGGAGGGCAAAGGAGATGTGATGTCCACTGCCTGTGGAACTCCAGGC
TATGTCGCTCCTGAAGTCCTCGCCCAGAAACCTTACAGCAAAGCCGTTGACTGCTGGTCCATCGGAGTGATTGCCTACATCTTGCTCTGC
GGCTACCCTCCTTTTTATGATGAAAATGACTCCAAGCTCTTTGAGCAGATCCTCAAGGCGGAATATGAGTTTGACTCTCCCTACTGGGAT
GACATCTCCGACTCTGCAAAAGACTTCATTCGGAACCTGATGGAGAAGGACCCGAATAAAAGATACACGTGTGAGCAGGCAGCTCGGCAC
CCATGGATCGCTGGTGACACAGCCCTCAACAAAAACATCCACGAGTCCGTCAGCGCCCAGATCCGGAAAAACTTTGCCAAGAGCAAATGG
AGACAAGCATTTAATGCCACGGCCGTCGTCAGACATATGAGAAAACTACACCTCGGCAGCAGCCTGGACAGTTCAAATGCAAGTGTTTCG
AGCAGCCTCAGTTTGGCCAGCCAAAAAGACTGTCTGGCACCTTCCACGCTCTGTAGTTTCATTTCTTCTTCGTCGGGGGTCTCAGGAGTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_NEBL_ENST00000417816_chr10_21461312_-_CAMK1D_ENST00000378847_chr10_12595224_+_8243nt
CCTGCGCGGCGGCGGCGGCGAGGCGGGGGAGCGAGTGAGCGCGAGGGGCGGGCGCGAGTGACTGTGTGAGTCACCCGTACCTGGAGTGCG
AGCGACGCAGAGCCAGCGGCGCGGAGCCGGAGCCGGAGCCGAGACCCAGCGCCTGCGAGCCCGAGAGCGCGGCCGGCCCCAGGCGCCAGG
CCCCGTCGCCCTCCCCGTGCACTCACCCGTGGCCCGGCGCCGACTCCCTACCCGGCGCCCGCCGCCCGCAGCCCTCCCGCCTGCCAGGAG
GCGGTGCGGGGCTCGCCGGGGGATGTCACAGCGGCTCCTGGGAGCCAGCAGCCGCCGCCGCCGCCGCCCCCGGGAACCGCGATCATGAAC
CCCCAGTGCGCCCGTTGCGGAAAAGTCGTGTATCCCACCGAGAAAGTCAACTGCCTGGATAAGTATTGGCATAAAGGATGTTTCCATTGT
GAGGTCTGCAAGATGGCACTCAACATGAACAACTACAAAGGCTATGAAAAGAAGCCCTATTGTAATGCCGGGGCCTTTTCCGAAGTGGTT
TTAGCTGAAGAGAAGGCAACTGGCAAGCTCTTTGCTGTGAAGTGTATCCCTAAGAAGGCGCTGAAGGGCAAGGAAAGCAGCATAGAGAAT
GAGATAGCCGTCCTGAGAAAGATTAAGCATGAAAATATTGTTGCCCTGGAAGACATTTATGAAAGCCCAAATCACCTGTACTTGGTCATG
CAGCTGGTGTCCGGTGGAGAGCTGTTTGACCGGATAGTGGAGAAGGGGTTTTATACAGAGAAGGATGCCAGCACTCTGATCCGCCAAGTC
TTGGACGCCGTGTACTATCTCCACAGAATGGGCATCGTCCACAGAGACCTCAAGCCCGAAAATCTCTTGTACTACAGTCAAGATGAGGAG
TCCAAAATAATGATCAGTGACTTTGGATTGTCAAAAATGGAGGGCAAAGGAGATGTGATGTCCACTGCCTGTGGAACTCCAGGCTATGTC
GCTCCTGAAGTCCTCGCCCAGAAACCTTACAGCAAAGCCGTTGACTGCTGGTCCATCGGAGTGATTGCCTACATCTTGCTCTGCGGCTAC
CCTCCTTTTTATGATGAAAATGACTCCAAGCTCTTTGAGCAGATCCTCAAGGCGGAATATGAGTTTGACTCTCCCTACTGGGATGACATC
TCCGACTCTGCAAAAGACTTCATTCGGAACCTGATGGAGAAGGACCCGAATAAAAGATACACGTGTGAGCAGGCAGCTCGGCACCCATGG
ATCGCTGGTGACACAGCCCTCAACAAAAACATCCACGAGTCCGTCAGCGCCCAGATCCGGAAAAACTTTGCCAAGAGCAAATGGAGACAA
GCATTTAATGCCACGGCCGTCGTCAGACATATGAGAAAACTACACCTCGGCAGCAGCCTGGACAGTTCAAATGCAAGTGTTTCGAGCAGC
CTCAGTTTGGCCAGCCAAAAAGACTGTCTGGCACCTTCCACGCTCTGTAGTTTCATTTCTTCTTCGTCGGGGGTCTCAGGAGTTGGAGCC
GAGCGGAGACCCAGGCCCACCACTGTGACGGCAGTGCACTCTGGAAGCAAGTGACTGGCCCTGGAGGTGGGGCCCGGGGTCGGGGCTGGG
GAAGGGGAGCCCCAGGGTCGCCAGAGCCGCGAGCCACTCCAGCGAGACCCCACCTTGCATGGTGCCCCTTCCTGCATAGGACTGGAAGAC
CGAAGTTTTTTTATGGCCATATTTTCTACTGCAATTCTGAAGTGTTCATTTCTCACAAACTGTACTGACTCGAGGGGCGCTGATTTCATA
GGATCTGGTGCTGTATATACGAATCTTGCAAAGCTCTAACTGAACGGACCTTCTTATTCCTCTCCCCTAACACCATCGTTTCCACTCTTC
TCAGTGTAGGTAACCGTCTATGGTGTGTTTTTTCATTAATGACAAAAAAAAAAAGGTTTCAACTGGATTATTTAAATATTGGTAAATATT
GTGCATTAGGGTTTGTTTTTCCTTTTAAGAAGTATGTCCTTTGTATCTCTAAGTTACATGACCTATATCTTTTCCTCTTTAATAGTAGTT
TTATGTTAACCTTTAAGAGATTTGTTTTTCCTCAAAGGAGAATTTAAAGGTATTTTTTAAAATTCTAATAAGAGGATCAGCCGGGTGCAA
TGACTCATGCCTGTAATCCCAGCACGTTGGGAGGCCAAGTCGGGCGGATCACAAGGTCAGGAGATCAAGGCCATCCTGGCCAACATGGTG
AAACCCCACGTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCACACACCTGTAGTCCCGGCTACTCGGGAGGCTGAGGCAGGAG
AATTGCTTGAACCCGGGAGACGGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCA
AAAAAAAAAAAAAAAATTCTAACAAGAGGATCATGAATCTGTCTCCAAGGCTAAGAGTGCCCTTCACCTCTACTCCTTCTGTTTCTCTCC
CCTTCCCCAGGAGGAGGGGCCCCTCAGTTCTGCGAGGCTCTCTTCTCTGCGGGGGACTTTGGTAGAGAATCTGCACAGAGCCTTTGCTGG
CAACCCATCCAGCAGAACCCACACCCACCAGAGACCCTAGAGGCCTCTTGCCATCAGCAACCAGAAATAAGCCTGCTCCCCCGAGACGCA
GGGCTCAGCTTCACAGGCCAGACTTGCTGTGAGTGAGATGCCCACACTGCAGAGATGCAGGACCCTCCCTTGCAAAAGGAACCAGCTGCC
ATGTTGCTGAAAGTGGGCCCACACACAACCCTCATTTCTCACGAGAGCTAACAGATGAAAGCTCAGCTATGCAGTGTTAAAATTCATCTC
TTTCTCTGTGGTTTTTAAAAAAATGCATTTCTAATCTTACACTTCACGTGGCCTCCAACACAAAGTTCTTTCTCCACATTTTTACCCTCT
TCTCACATGAATGTTTTCCAAGGGAAGGAAGGGAGGGAAGCAGCCTTGGGAAAGGATCCATTTCTGGTGGTAAGGAGAGGGGGCCCTGCC
AGGCTAATGGGACTTCAGCCACCACAGAGATGACCAAAGACCACCTCCGCCAGGCCCAGCCAGTGCTTGCAGCCCTCCCATTGGTCAGGG
GAGTCTAAAATCAAAGATACATGGTGGTAGGGTCACCAAACGTCCCATTTGCCCGAGACTGAAGGATTTCTCAGGCTGTGGACATTTAAT
GCCAAAACCAGGAATATCCGGGGCAAAGCAGGCTGTGTTGTTCGCCTTTGTGGAGCCAGGCAGTGTGTGGCCCAGGGAAAGCTGCGTTTC
ATGGAGGCTTCCAGGAGGCTGCCCTGTAAAGCCAGGCAGGTGGCTTCAAGTGCCATTCCTGCAAGTGCCCCTGCTTCAGCTCTCAGGCCC
ATCCAATGCCTCGAGCCCACGGGGGTGTCCCGGCAGGTCTGCGTCATCACGACCCAGTAACGCTGCTGGCTGTGTCCTCATGCCCTCTTC
CTCTGGCTGGCCAGTCATGGGAAGTCCTGTTGGTTGAGTCATCTTTGTCACTTCTACACCTTTGAGTATGTACAGGCTGAATGTTGAGTG
ATGCCCCCCCACCCTCTCAATAAACACACACACACACACACACACACACACACACACACACAATGTTATTAGGCACAGCAGCTCCATCCT
GCTCCCTGAGAATGGCAGTGCAGGCACAGAGAAGAGCAGTTGGGAAGACAGGCAGCTGGTCTACCCTGTCCCCGCACACTTCACAGGCAC
TCCACTGCTTGGCAGGAATTCTGCATGGCATCTGCCACGCATGCTCACAGGGTGAAAAATCAAGCTGTCACTCTGCAAAATCTAAAAACC
CTGGAAAGGTCTATAAGATGACATTAGACCCAGTTAAGAAGCAAGTGTCACCTGAGTTGGCCATGCAATGAATGAATATTATAAGCAGTA
TTGGAGAACTAGGCGGTTGCTTACTAAGAAGTGTCTTGGAAACATTCGAGTTCATACAGTGCATGACAAAGTAATAGAAGGCTGCAAGCG
CTGAAAATGCACCCGAATCTGGTACCTAGGATGAGTACATGAATAGTGATGAATAGCCCTTTGTGCTGTGTGCTATATACAACCATTTGC
ATTCAGAAAGCAGCATTTGAAGCTGAGTTCCATTACTGGTGATTGAAGTATTTTCAGGAGCAGATACATGTGGTGCATGTTATATGCACT
TAGTTTGAAAGTATCCCTCACCCAAAAAGTGCAGAACCTCTGAAAGGTGAGCCGTGGTGCAGGTGCCCCCCTCGCTGTTCGGGTCAGTTC
TTGGCCATGCTTGGCCTGTCACACGCCGGGTCTCAACAACATCGTGCGAGGAGACAGTGACTGGTTTCAGCCCAAGAGTCAACTGTTGAG
CATGACATCAGGAAGCCTGTACTGTCCTGATCCCACCAGGCTTGGGTTAATTTCCTATTGCTTCAGAGAAAGAGAGGCGCTCTTGTGCTT
TTGAGAGAGCTCTCATGTTAAAAAGAGGTTGTCTTTGCACTGCGCTTGGTATGATTTGTTTTCTTATAAAACAGGAAGAGAACCTAGAAT
GTGCCTTTCGTGAAGGTCTGACAAATGGGGTCTCAGAGTCCTAGGACCCGCACCAAGGTCAGAGTCCACCTGTAGAGGCTGAGCATTTCT
ACATGCACCCAGGGTGCTGGGCTGAGGCTAAGGGTGGACGCGTAGACCCCATCACAGGCTTCCTTCCTGAGCCCAAGTCCCCCATTTGGT
CACTATCCCTTCTCAGAGCAAGTGGATTCTCTTTTCCTCACTTGGAGTATTCAATGTTGAAGTAGTGGCCTGGAGTGGCCTTTCCCTCAG
CTGCCTGTCTGGGCCTCCCTGGCTTCCCGGATCTTCATCTCATACGTGAGGCAATAGGAGGAGTTTCTATTCATTGAGACAAACAGTGAG
CGGGCACCAACAGGCCAGCAGCTTGGCCCTTTTCACAGAGGTGGCCTTGGAGTCTGGAGTCTGGGCAGCTGTCTGCCTCTCTACGGCTCT
GCTTCCCAGCGGGCACACGGGTCCGGAGCCTCAGAATGAAGTGGTGCAGAGGCGCAGGGCACACCTAGGAGAAGCTCAATGACCACCAAA
GCCCTTGAGGAGAGACGGGGTTTGCTGTGTTAGAGAAATGGCAACCCCCAGGACCATGCACGGCTCTGGCAGTGCACAGTGGCTGATTTT
CACCAGTTCCTCCTACCCCTGCCTCTGTCGGAGACTAGAAAACATTCTACCCCTTCAGGTCTTCTTTTAAAAGAAAAGAGCTATGGCAAA
GCGTGCCATACAAAGTTAAAAAAAGGAAGAGTGGCTTTGCGTTCTTGACCATGGCCACAATTCTGGTCACTTCTAGCATCTGACCTTGAG
AACGGTGTAGAGTCTCTGAGCCACCGCTGGCCTTTGAGAGAGTCTCACTCTCCAGCTAGCTCTTTGTGTAGTGTCCAGGGCCCCGGCAGT
CAGGATAGAGCGAGCAAAAGAAGATGGACAGTGGACAGGGCGCAGTGGCTCACGCCTGTAATCCCAGCGCTTTGGGAGAGCGAGGCGGGC
AGATCACAAGGTCAAGAGATCAAGACCATTCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAATTAGCTGGGCATGGTG
GTGCGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGT
GCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAGATGGCCATGCTGGCCAAGGCTGGGCTCATAGGAAATATCT
GTAGTAGGATGAAAGGAATCTGGCCTAGGGAGCCCCGGACTCGGTTTACCTACCCCGTACTCATCCCACTCATCTGTCTACCCTAGTGTC
CATCATGCCCTGGATGAATCGTAGGTGGGAGGGACAGAAGCCGAGAACACCAGGCACACGGGGTGGGGGGAATGGGGGGAGCCCAGGTGA
TCCCCTTTGGAAAGTGGATTGATCCTCTCCCCTGTGGAATGACAGCTTAACCTGATTAACCCACTGGGGCTTGCTATTTTATGAGCATTT
TTAAACAGAAAGGAAAGATGATATCCCAGTGCAGGTAGACTTTATTTTTGAAAGCATCGTGGCCCCTCACCTCTCCCTCTCCCCCAGAAC
CTTGGCCAGAATTGAGTCTTCGCGTTGGGGAGGCCACGCTGGAACCATTGCTCTAGGGCTGAAGGTGGAAGTAGGGCCACTGCCGCAGCT
TCAGCCAGAGCCCTCGCTGCTTCGCAGAATTTAACAAGCACACGACTGGGATTCCTTTGGATATGAGAAAGGAAGGCAAGTGCGGGCAAA
GGGAAGCTCCTCCCGTTTTTCATAAACAGAAGTAAGATGTCCTCTTTCCCAGGTTTGCACAATCACTTCTGGCAAATTAATTGAAGGTCC
TTGAATTCAGCCAGTGCACGAAACCTTTGCATGTTCTTCTGAAACTGTACTTCTTCCCTATTCTGTCTACCCACACTCTGCGAACTTTGC
CTTTTCCTTAAACACATTCCAGACCAAACACTGTTCAGTTTGTTAAAAAAAAAAAAAAAAAAAAAAGATGTATATACCTGTATGTGATCC
ACCACCCTTTTGAGGGGCACCTGGTCCTCGGTTGGGGCTGCAGGTGTGCCTGACATTTGCAAAAGATATTCCAGTCTTTCGATGTTCAGA
ATTGAAAATGTGGAGATAGAAAAGCTCAAACAGACTCCTAAAAGGAGGGTTTCTTTCCTGAAGACTCCAAGAAAATGAGTGTGCAGATGA
GTTAGCTTGACAACCTCAACTCTGGGGAGCAGGCAGGCGGTCTGAGGAAGATAAGGGCCCACGCCCCACTCACCTGGCACCTGTTCGGTG
GTCCCGGGGCATCATGGTCTGCAGCTCTGGGCCCCCAGCCCCACTGTGAAGTCAGTCCTGCATGCTGGCCGAGGCCCGGCCACCTCCCGA
TGCCTCCAGAGTCAGTGGGAAGGAGTCAGCCCTTCCCAGACTTCCCCGCCACCTCCAGCAGGAGCAGCTCAGTTTGTGGCTCTGGGAGCT
CCGCTTTTGCAAACCCAAAAAGGCTGTGCATTTGGAAGCCAAACGCTCAGCATGCGGCTGCCGAGTCTGGTTTTGTGGACAAAGCAAACT
GTGGAATGGCTTCTCGGTGTCTGTATAAAGGGACAAACGGTTGCATTCACCCTTTGTACTATAACACCGCTTCTGCATTCGCCATATCCG
TTTTTTAACCTTTTTGTCTCCGGGGAACTTCTCATTCGATTATTATGTCTTCTGATGATTTGCCATGTTATTTTAAAGGTGATTTTATTT
TCTTATGGACAGGAAAAAAGAAAATGAGGAGGAGTTGGTTTTACTCTTAGAGATAAGACTTCAGCAGGGGCTCAGAAACCCCAAACTCTA
GTTAAATTGCTTCTCGGAGGAAAATCTTAATCTAGACAGATTCAGATTCCCAGGCTCTCCTGGAAGCCCTGCACTTCAGGGCACAGGGGC
CCTGGGACGTGGTTGGCAGCCAGGCTGCGAGAGAGCTAAAAAGGAACAAGAACATCAGCTCGGATGTTTGTCTCTCAGCCCTGACACCTG
CCACTCTCCTTCCCGGGGCACTTGGCCCTATCAGAGGGACATGAAATGCTGTCCGAATGGTGGCAGAAATGCAGCGACATTGCATGCAGC
AGAGTCTTTGCTTCGAAAGATGGGGCGCCATGTTTCAGAGAACATTTATCTTAGTCCCACGTTCAGGTGAGAAGACCTCAAAGGTACCCT
CTGTCCAGAATAAACATTGGAACAATCTCTCAATTGGCTTTTGTCACTACACATAATGTAATCTCCCTTCTTTCAGCTCCCCCAACAGTG
AGCATGCTTCCCAAAAAATTACAACATCAAAACCAGGAATGTCCCCGCATCTACTATTACCAGGCTTGCAATTGGTTCAATTTTCCCATA
AAAACATGTTTGTCCAAAAGAAGGGAAACTGTGAATTTATTCCATGCATGTAATAAACTCTGCAAGAAGTTTAACCCACATAGGTTTGCG
GCACTGCAAAATTGTTCATGGGTCTATGTAGCAAATGATTCTCTGCCTTGACAATCATGTATACATATCAAGATTTCTATCATAATGATA


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FusionGenePPI for NEBL_CAMK1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NEBLMYPN, ZYX, MED28, XIRP2, XIRP1, PRKAB2, TRIM63, TRIM55, ACTN3, GOLGA2, TRIM27, TRAF1, TRAF2, MAD1L1, HOMER3, GMCL1, CCDC136, LZTS2, MIPOL1, FAM9B, NUTM1, ZDHHC17, CEP170, CEP128, SCLT1, DCTN1, CDH1, ZNF764, GCHFR, DHX38, CARKDCAMK1DNEDD4, NEDD4L, POT1, APP, BAG3, TNFSF13, ASAH1, CDC25A, CUL3, GMFG, BNIP3L, DCPS, HSPA1L, NAE1, NUCB2, PCYT2, TUBB6, TUFM, UBA3, XPO1, CAMK1, CAMK1G, ZG16B, QPCTL, MUC7, AMY1C, CKS2, CST4, XYLT2, CDH1, LAMP3, CST1, C9orf173, GNRHR, CALM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEBL_CAMK1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEBL_CAMK1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource