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Fusion gene ID: 23929 |
FusionGeneSummary for NEBL_CAMK1D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEBL_CAMK1D | Fusion gene ID: 23929 | Hgene | Tgene | Gene symbol | NEBL | CAMK1D | Gene ID | 10529 | 57118 |
| Gene name | nebulette | calcium/calmodulin dependent protein kinase ID | |
| Synonyms | LASP2|LNEBL | CKLiK|CaM-K1|CaMKID | |
| Cytomap | 10p12.31 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk protein | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O76041 | Q8IU85 | |
| Ensembl transtripts involved in fusion gene | ENST00000377122, ENST00000417816, ENST00000377159, ENST00000377119, ENST00000464278, | ENST00000378847, ENST00000487696, ENST00000378845, | |
| Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 8 X 9 X 6=432 |
| # samples | 10 | 10 | |
| ** MAII score | log2(10/224*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEBL [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-A8HD-01A | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000377122 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377122 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377122 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| In-frame | ENST00000417816 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| 5CDS-intron | ENST00000417816 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| 5CDS-intron | ENST00000417816 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-3CDS | ENST00000377159 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377159 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377159 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-3CDS | ENST00000377119 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377119 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377119 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-3CDS | ENST00000464278 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000464278 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000464278 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
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FusionProtFeatures for NEBL_CAMK1D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEBL | CAMK1D |
| Binds to actin and plays an important role in theassembly of the Z-disk. May functionally link sarcomeric actin tothe desmin intermediate filaments in the heart muscle sarcomeres(PubMed:27733623). Isoform 2 might play a role in the assembly offocal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028,ECO:0000269|PubMed:27733623}. | Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascadeand, upon calcium influx, activates CREB-dependent genetranscription, regulates calcium-mediated granulocyte function andrespiratory burst and promotes basal dendritic growth ofhippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratoryburst. Activates the transcription factor CREB1 in hippocampalneuron nuclei. May play a role in apoptosis of erythroleukemiacells. In vitro, phosphorylates transcription factor CREM isoformBeta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691,ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NEBL_CAMK1D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NEBL_ENST00000417816_chr10_21461312_-_CAMK1D_ENST00000378847_chr10_12595224_+_410aa MNPQCARCGKVVTPTEKVNCLDKTWHKGCFHCEVCKMALNMNNYKGTEKKPTCNAGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSI ENEIAVLRKIKHENIVALEDITESPNHLYLVMQLVSGGELFDRIVEKGFTTEKDASTLIRQVLDAVYTLHRMGIVHRDLKPENLLYYSQD EESKIMISDFGLSKMEGKGDVMSTACGTPGTVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFTDENDSKLFEQILKAETEFDSPYWD DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NEBL_ENST00000417816_chr10_21461312_-_CAMK1D_ENST00000378847_chr10_12595224_+_1230nt ATGAACCCCCAGTGCGCCCGTTGCGGAAAAGTCGTGTATCCCACCGAGAAAGTCAACTGCCTGGATAAGTATTGGCATAAAGGATGTTTC CATTGTGAGGTCTGCAAGATGGCACTCAACATGAACAACTACAAAGGCTATGAAAAGAAGCCCTATTGTAATGCCGGGGCCTTTTCCGAA GTGGTTTTAGCTGAAGAGAAGGCAACTGGCAAGCTCTTTGCTGTGAAGTGTATCCCTAAGAAGGCGCTGAAGGGCAAGGAAAGCAGCATA GAGAATGAGATAGCCGTCCTGAGAAAGATTAAGCATGAAAATATTGTTGCCCTGGAAGACATTTATGAAAGCCCAAATCACCTGTACTTG GTCATGCAGCTGGTGTCCGGTGGAGAGCTGTTTGACCGGATAGTGGAGAAGGGGTTTTATACAGAGAAGGATGCCAGCACTCTGATCCGC CAAGTCTTGGACGCCGTGTACTATCTCCACAGAATGGGCATCGTCCACAGAGACCTCAAGCCCGAAAATCTCTTGTACTACAGTCAAGAT GAGGAGTCCAAAATAATGATCAGTGACTTTGGATTGTCAAAAATGGAGGGCAAAGGAGATGTGATGTCCACTGCCTGTGGAACTCCAGGC TATGTCGCTCCTGAAGTCCTCGCCCAGAAACCTTACAGCAAAGCCGTTGACTGCTGGTCCATCGGAGTGATTGCCTACATCTTGCTCTGC GGCTACCCTCCTTTTTATGATGAAAATGACTCCAAGCTCTTTGAGCAGATCCTCAAGGCGGAATATGAGTTTGACTCTCCCTACTGGGAT GACATCTCCGACTCTGCAAAAGACTTCATTCGGAACCTGATGGAGAAGGACCCGAATAAAAGATACACGTGTGAGCAGGCAGCTCGGCAC CCATGGATCGCTGGTGACACAGCCCTCAACAAAAACATCCACGAGTCCGTCAGCGCCCAGATCCGGAAAAACTTTGCCAAGAGCAAATGG AGACAAGCATTTAATGCCACGGCCGTCGTCAGACATATGAGAAAACTACACCTCGGCAGCAGCCTGGACAGTTCAAATGCAAGTGTTTCG AGCAGCCTCAGTTTGGCCAGCCAAAAAGACTGTCTGGCACCTTCCACGCTCTGTAGTTTCATTTCTTCTTCGTCGGGGGTCTCAGGAGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NEBL_ENST00000417816_chr10_21461312_-_CAMK1D_ENST00000378847_chr10_12595224_+_8243nt CCTGCGCGGCGGCGGCGGCGAGGCGGGGGAGCGAGTGAGCGCGAGGGGCGGGCGCGAGTGACTGTGTGAGTCACCCGTACCTGGAGTGCG AGCGACGCAGAGCCAGCGGCGCGGAGCCGGAGCCGGAGCCGAGACCCAGCGCCTGCGAGCCCGAGAGCGCGGCCGGCCCCAGGCGCCAGG CCCCGTCGCCCTCCCCGTGCACTCACCCGTGGCCCGGCGCCGACTCCCTACCCGGCGCCCGCCGCCCGCAGCCCTCCCGCCTGCCAGGAG GCGGTGCGGGGCTCGCCGGGGGATGTCACAGCGGCTCCTGGGAGCCAGCAGCCGCCGCCGCCGCCGCCCCCGGGAACCGCGATCATGAAC CCCCAGTGCGCCCGTTGCGGAAAAGTCGTGTATCCCACCGAGAAAGTCAACTGCCTGGATAAGTATTGGCATAAAGGATGTTTCCATTGT GAGGTCTGCAAGATGGCACTCAACATGAACAACTACAAAGGCTATGAAAAGAAGCCCTATTGTAATGCCGGGGCCTTTTCCGAAGTGGTT TTAGCTGAAGAGAAGGCAACTGGCAAGCTCTTTGCTGTGAAGTGTATCCCTAAGAAGGCGCTGAAGGGCAAGGAAAGCAGCATAGAGAAT GAGATAGCCGTCCTGAGAAAGATTAAGCATGAAAATATTGTTGCCCTGGAAGACATTTATGAAAGCCCAAATCACCTGTACTTGGTCATG CAGCTGGTGTCCGGTGGAGAGCTGTTTGACCGGATAGTGGAGAAGGGGTTTTATACAGAGAAGGATGCCAGCACTCTGATCCGCCAAGTC TTGGACGCCGTGTACTATCTCCACAGAATGGGCATCGTCCACAGAGACCTCAAGCCCGAAAATCTCTTGTACTACAGTCAAGATGAGGAG TCCAAAATAATGATCAGTGACTTTGGATTGTCAAAAATGGAGGGCAAAGGAGATGTGATGTCCACTGCCTGTGGAACTCCAGGCTATGTC GCTCCTGAAGTCCTCGCCCAGAAACCTTACAGCAAAGCCGTTGACTGCTGGTCCATCGGAGTGATTGCCTACATCTTGCTCTGCGGCTAC CCTCCTTTTTATGATGAAAATGACTCCAAGCTCTTTGAGCAGATCCTCAAGGCGGAATATGAGTTTGACTCTCCCTACTGGGATGACATC TCCGACTCTGCAAAAGACTTCATTCGGAACCTGATGGAGAAGGACCCGAATAAAAGATACACGTGTGAGCAGGCAGCTCGGCACCCATGG ATCGCTGGTGACACAGCCCTCAACAAAAACATCCACGAGTCCGTCAGCGCCCAGATCCGGAAAAACTTTGCCAAGAGCAAATGGAGACAA GCATTTAATGCCACGGCCGTCGTCAGACATATGAGAAAACTACACCTCGGCAGCAGCCTGGACAGTTCAAATGCAAGTGTTTCGAGCAGC CTCAGTTTGGCCAGCCAAAAAGACTGTCTGGCACCTTCCACGCTCTGTAGTTTCATTTCTTCTTCGTCGGGGGTCTCAGGAGTTGGAGCC GAGCGGAGACCCAGGCCCACCACTGTGACGGCAGTGCACTCTGGAAGCAAGTGACTGGCCCTGGAGGTGGGGCCCGGGGTCGGGGCTGGG GAAGGGGAGCCCCAGGGTCGCCAGAGCCGCGAGCCACTCCAGCGAGACCCCACCTTGCATGGTGCCCCTTCCTGCATAGGACTGGAAGAC CGAAGTTTTTTTATGGCCATATTTTCTACTGCAATTCTGAAGTGTTCATTTCTCACAAACTGTACTGACTCGAGGGGCGCTGATTTCATA GGATCTGGTGCTGTATATACGAATCTTGCAAAGCTCTAACTGAACGGACCTTCTTATTCCTCTCCCCTAACACCATCGTTTCCACTCTTC TCAGTGTAGGTAACCGTCTATGGTGTGTTTTTTCATTAATGACAAAAAAAAAAAGGTTTCAACTGGATTATTTAAATATTGGTAAATATT GTGCATTAGGGTTTGTTTTTCCTTTTAAGAAGTATGTCCTTTGTATCTCTAAGTTACATGACCTATATCTTTTCCTCTTTAATAGTAGTT TTATGTTAACCTTTAAGAGATTTGTTTTTCCTCAAAGGAGAATTTAAAGGTATTTTTTAAAATTCTAATAAGAGGATCAGCCGGGTGCAA TGACTCATGCCTGTAATCCCAGCACGTTGGGAGGCCAAGTCGGGCGGATCACAAGGTCAGGAGATCAAGGCCATCCTGGCCAACATGGTG AAACCCCACGTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCACACACCTGTAGTCCCGGCTACTCGGGAGGCTGAGGCAGGAG AATTGCTTGAACCCGGGAGACGGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCA AAAAAAAAAAAAAAAATTCTAACAAGAGGATCATGAATCTGTCTCCAAGGCTAAGAGTGCCCTTCACCTCTACTCCTTCTGTTTCTCTCC CCTTCCCCAGGAGGAGGGGCCCCTCAGTTCTGCGAGGCTCTCTTCTCTGCGGGGGACTTTGGTAGAGAATCTGCACAGAGCCTTTGCTGG CAACCCATCCAGCAGAACCCACACCCACCAGAGACCCTAGAGGCCTCTTGCCATCAGCAACCAGAAATAAGCCTGCTCCCCCGAGACGCA GGGCTCAGCTTCACAGGCCAGACTTGCTGTGAGTGAGATGCCCACACTGCAGAGATGCAGGACCCTCCCTTGCAAAAGGAACCAGCTGCC ATGTTGCTGAAAGTGGGCCCACACACAACCCTCATTTCTCACGAGAGCTAACAGATGAAAGCTCAGCTATGCAGTGTTAAAATTCATCTC TTTCTCTGTGGTTTTTAAAAAAATGCATTTCTAATCTTACACTTCACGTGGCCTCCAACACAAAGTTCTTTCTCCACATTTTTACCCTCT TCTCACATGAATGTTTTCCAAGGGAAGGAAGGGAGGGAAGCAGCCTTGGGAAAGGATCCATTTCTGGTGGTAAGGAGAGGGGGCCCTGCC AGGCTAATGGGACTTCAGCCACCACAGAGATGACCAAAGACCACCTCCGCCAGGCCCAGCCAGTGCTTGCAGCCCTCCCATTGGTCAGGG GAGTCTAAAATCAAAGATACATGGTGGTAGGGTCACCAAACGTCCCATTTGCCCGAGACTGAAGGATTTCTCAGGCTGTGGACATTTAAT GCCAAAACCAGGAATATCCGGGGCAAAGCAGGCTGTGTTGTTCGCCTTTGTGGAGCCAGGCAGTGTGTGGCCCAGGGAAAGCTGCGTTTC ATGGAGGCTTCCAGGAGGCTGCCCTGTAAAGCCAGGCAGGTGGCTTCAAGTGCCATTCCTGCAAGTGCCCCTGCTTCAGCTCTCAGGCCC ATCCAATGCCTCGAGCCCACGGGGGTGTCCCGGCAGGTCTGCGTCATCACGACCCAGTAACGCTGCTGGCTGTGTCCTCATGCCCTCTTC CTCTGGCTGGCCAGTCATGGGAAGTCCTGTTGGTTGAGTCATCTTTGTCACTTCTACACCTTTGAGTATGTACAGGCTGAATGTTGAGTG ATGCCCCCCCACCCTCTCAATAAACACACACACACACACACACACACACACACACACACACAATGTTATTAGGCACAGCAGCTCCATCCT GCTCCCTGAGAATGGCAGTGCAGGCACAGAGAAGAGCAGTTGGGAAGACAGGCAGCTGGTCTACCCTGTCCCCGCACACTTCACAGGCAC TCCACTGCTTGGCAGGAATTCTGCATGGCATCTGCCACGCATGCTCACAGGGTGAAAAATCAAGCTGTCACTCTGCAAAATCTAAAAACC CTGGAAAGGTCTATAAGATGACATTAGACCCAGTTAAGAAGCAAGTGTCACCTGAGTTGGCCATGCAATGAATGAATATTATAAGCAGTA TTGGAGAACTAGGCGGTTGCTTACTAAGAAGTGTCTTGGAAACATTCGAGTTCATACAGTGCATGACAAAGTAATAGAAGGCTGCAAGCG CTGAAAATGCACCCGAATCTGGTACCTAGGATGAGTACATGAATAGTGATGAATAGCCCTTTGTGCTGTGTGCTATATACAACCATTTGC ATTCAGAAAGCAGCATTTGAAGCTGAGTTCCATTACTGGTGATTGAAGTATTTTCAGGAGCAGATACATGTGGTGCATGTTATATGCACT TAGTTTGAAAGTATCCCTCACCCAAAAAGTGCAGAACCTCTGAAAGGTGAGCCGTGGTGCAGGTGCCCCCCTCGCTGTTCGGGTCAGTTC TTGGCCATGCTTGGCCTGTCACACGCCGGGTCTCAACAACATCGTGCGAGGAGACAGTGACTGGTTTCAGCCCAAGAGTCAACTGTTGAG CATGACATCAGGAAGCCTGTACTGTCCTGATCCCACCAGGCTTGGGTTAATTTCCTATTGCTTCAGAGAAAGAGAGGCGCTCTTGTGCTT TTGAGAGAGCTCTCATGTTAAAAAGAGGTTGTCTTTGCACTGCGCTTGGTATGATTTGTTTTCTTATAAAACAGGAAGAGAACCTAGAAT GTGCCTTTCGTGAAGGTCTGACAAATGGGGTCTCAGAGTCCTAGGACCCGCACCAAGGTCAGAGTCCACCTGTAGAGGCTGAGCATTTCT ACATGCACCCAGGGTGCTGGGCTGAGGCTAAGGGTGGACGCGTAGACCCCATCACAGGCTTCCTTCCTGAGCCCAAGTCCCCCATTTGGT CACTATCCCTTCTCAGAGCAAGTGGATTCTCTTTTCCTCACTTGGAGTATTCAATGTTGAAGTAGTGGCCTGGAGTGGCCTTTCCCTCAG CTGCCTGTCTGGGCCTCCCTGGCTTCCCGGATCTTCATCTCATACGTGAGGCAATAGGAGGAGTTTCTATTCATTGAGACAAACAGTGAG CGGGCACCAACAGGCCAGCAGCTTGGCCCTTTTCACAGAGGTGGCCTTGGAGTCTGGAGTCTGGGCAGCTGTCTGCCTCTCTACGGCTCT GCTTCCCAGCGGGCACACGGGTCCGGAGCCTCAGAATGAAGTGGTGCAGAGGCGCAGGGCACACCTAGGAGAAGCTCAATGACCACCAAA GCCCTTGAGGAGAGACGGGGTTTGCTGTGTTAGAGAAATGGCAACCCCCAGGACCATGCACGGCTCTGGCAGTGCACAGTGGCTGATTTT CACCAGTTCCTCCTACCCCTGCCTCTGTCGGAGACTAGAAAACATTCTACCCCTTCAGGTCTTCTTTTAAAAGAAAAGAGCTATGGCAAA GCGTGCCATACAAAGTTAAAAAAAGGAAGAGTGGCTTTGCGTTCTTGACCATGGCCACAATTCTGGTCACTTCTAGCATCTGACCTTGAG AACGGTGTAGAGTCTCTGAGCCACCGCTGGCCTTTGAGAGAGTCTCACTCTCCAGCTAGCTCTTTGTGTAGTGTCCAGGGCCCCGGCAGT CAGGATAGAGCGAGCAAAAGAAGATGGACAGTGGACAGGGCGCAGTGGCTCACGCCTGTAATCCCAGCGCTTTGGGAGAGCGAGGCGGGC AGATCACAAGGTCAAGAGATCAAGACCATTCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAATTAGCTGGGCATGGTG GTGCGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGT GCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAGATGGCCATGCTGGCCAAGGCTGGGCTCATAGGAAATATCT GTAGTAGGATGAAAGGAATCTGGCCTAGGGAGCCCCGGACTCGGTTTACCTACCCCGTACTCATCCCACTCATCTGTCTACCCTAGTGTC CATCATGCCCTGGATGAATCGTAGGTGGGAGGGACAGAAGCCGAGAACACCAGGCACACGGGGTGGGGGGAATGGGGGGAGCCCAGGTGA TCCCCTTTGGAAAGTGGATTGATCCTCTCCCCTGTGGAATGACAGCTTAACCTGATTAACCCACTGGGGCTTGCTATTTTATGAGCATTT TTAAACAGAAAGGAAAGATGATATCCCAGTGCAGGTAGACTTTATTTTTGAAAGCATCGTGGCCCCTCACCTCTCCCTCTCCCCCAGAAC CTTGGCCAGAATTGAGTCTTCGCGTTGGGGAGGCCACGCTGGAACCATTGCTCTAGGGCTGAAGGTGGAAGTAGGGCCACTGCCGCAGCT TCAGCCAGAGCCCTCGCTGCTTCGCAGAATTTAACAAGCACACGACTGGGATTCCTTTGGATATGAGAAAGGAAGGCAAGTGCGGGCAAA GGGAAGCTCCTCCCGTTTTTCATAAACAGAAGTAAGATGTCCTCTTTCCCAGGTTTGCACAATCACTTCTGGCAAATTAATTGAAGGTCC TTGAATTCAGCCAGTGCACGAAACCTTTGCATGTTCTTCTGAAACTGTACTTCTTCCCTATTCTGTCTACCCACACTCTGCGAACTTTGC CTTTTCCTTAAACACATTCCAGACCAAACACTGTTCAGTTTGTTAAAAAAAAAAAAAAAAAAAAAAGATGTATATACCTGTATGTGATCC ACCACCCTTTTGAGGGGCACCTGGTCCTCGGTTGGGGCTGCAGGTGTGCCTGACATTTGCAAAAGATATTCCAGTCTTTCGATGTTCAGA ATTGAAAATGTGGAGATAGAAAAGCTCAAACAGACTCCTAAAAGGAGGGTTTCTTTCCTGAAGACTCCAAGAAAATGAGTGTGCAGATGA GTTAGCTTGACAACCTCAACTCTGGGGAGCAGGCAGGCGGTCTGAGGAAGATAAGGGCCCACGCCCCACTCACCTGGCACCTGTTCGGTG GTCCCGGGGCATCATGGTCTGCAGCTCTGGGCCCCCAGCCCCACTGTGAAGTCAGTCCTGCATGCTGGCCGAGGCCCGGCCACCTCCCGA TGCCTCCAGAGTCAGTGGGAAGGAGTCAGCCCTTCCCAGACTTCCCCGCCACCTCCAGCAGGAGCAGCTCAGTTTGTGGCTCTGGGAGCT CCGCTTTTGCAAACCCAAAAAGGCTGTGCATTTGGAAGCCAAACGCTCAGCATGCGGCTGCCGAGTCTGGTTTTGTGGACAAAGCAAACT GTGGAATGGCTTCTCGGTGTCTGTATAAAGGGACAAACGGTTGCATTCACCCTTTGTACTATAACACCGCTTCTGCATTCGCCATATCCG TTTTTTAACCTTTTTGTCTCCGGGGAACTTCTCATTCGATTATTATGTCTTCTGATGATTTGCCATGTTATTTTAAAGGTGATTTTATTT TCTTATGGACAGGAAAAAAGAAAATGAGGAGGAGTTGGTTTTACTCTTAGAGATAAGACTTCAGCAGGGGCTCAGAAACCCCAAACTCTA GTTAAATTGCTTCTCGGAGGAAAATCTTAATCTAGACAGATTCAGATTCCCAGGCTCTCCTGGAAGCCCTGCACTTCAGGGCACAGGGGC CCTGGGACGTGGTTGGCAGCCAGGCTGCGAGAGAGCTAAAAAGGAACAAGAACATCAGCTCGGATGTTTGTCTCTCAGCCCTGACACCTG CCACTCTCCTTCCCGGGGCACTTGGCCCTATCAGAGGGACATGAAATGCTGTCCGAATGGTGGCAGAAATGCAGCGACATTGCATGCAGC AGAGTCTTTGCTTCGAAAGATGGGGCGCCATGTTTCAGAGAACATTTATCTTAGTCCCACGTTCAGGTGAGAAGACCTCAAAGGTACCCT CTGTCCAGAATAAACATTGGAACAATCTCTCAATTGGCTTTTGTCACTACACATAATGTAATCTCCCTTCTTTCAGCTCCCCCAACAGTG AGCATGCTTCCCAAAAAATTACAACATCAAAACCAGGAATGTCCCCGCATCTACTATTACCAGGCTTGCAATTGGTTCAATTTTCCCATA AAAACATGTTTGTCCAAAAGAAGGGAAACTGTGAATTTATTCCATGCATGTAATAAACTCTGCAAGAAGTTTAACCCACATAGGTTTGCG GCACTGCAAAATTGTTCATGGGTCTATGTAGCAAATGATTCTCTGCCTTGACAATCATGTATACATATCAAGATTTCTATCATAATGATA |
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FusionGenePPI for NEBL_CAMK1D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NEBL | MYPN, ZYX, MED28, XIRP2, XIRP1, PRKAB2, TRIM63, TRIM55, ACTN3, GOLGA2, TRIM27, TRAF1, TRAF2, MAD1L1, HOMER3, GMCL1, CCDC136, LZTS2, MIPOL1, FAM9B, NUTM1, ZDHHC17, CEP170, CEP128, SCLT1, DCTN1, CDH1, ZNF764, GCHFR, DHX38, CARKD | CAMK1D | NEDD4, NEDD4L, POT1, APP, BAG3, TNFSF13, ASAH1, CDC25A, CUL3, GMFG, BNIP3L, DCPS, HSPA1L, NAE1, NUCB2, PCYT2, TUBB6, TUFM, UBA3, XPO1, CAMK1, CAMK1G, ZG16B, QPCTL, MUC7, AMY1C, CKS2, CST4, XYLT2, CDH1, LAMP3, CST1, C9orf173, GNRHR, CALM3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEBL_CAMK1D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEBL_CAMK1D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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