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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23917

FusionGeneSummary for NEAT1_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: NEAT1_MBP
Fusion gene ID: 23917
HgeneTgene
Gene symbol

NEAT1

MBP

Gene ID

283131

5553

Gene namenuclear paraspeckle assembly transcript 1proteoglycan 2, pro eosinophil major basic protein
SynonymsLINC00084|NCRNA00084|TncRNA|VINCBMPG|MBP|MBP1|proMBP
Cytomap

11q13.1

11q12.1

Type of genencRNAprotein-coding
DescriptionMENepsilon/betalong intergenic non-protein coding RNA 84nuclear enriched abundant transcript 1nuclear paraspeckle assembly transcript 1 (non-protein coding)trophoblast MHC class II suppressortrophoblast-derived noncoding RNAvirus inducible non-codinbone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018052020180519
UniProtAcc

P02686

Ensembl transtripts involved in fusion geneENST00000384994, ENST00000382582, 
ENST00000355994, ENST00000397875, 
ENST00000397866, ENST00000397865, 
ENST00000527041, ENST00000359645, 
ENST00000528160, ENST00000397869, 
ENST00000354542, ENST00000526111, 
ENST00000580402, ENST00000579129, 
ENST00000578193, ENST00000397863, 
ENST00000397860, ENST00000487778, 
Fusion gene scores* DoF score24 X 30 X 3=216026 X 20 X 3=1560
# samples 3127
** MAII scorelog2(31/2160*10)=-2.80069119177659
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEAT1 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB167927NEAT1chr11

65206894

+MBPchr18

74729016

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000384994ENST00000382582NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000355994NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000397875NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000397866NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000397865NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000527041NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-intronENST00000384994ENST00000359645NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-intronENST00000384994ENST00000528160NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-intronENST00000384994ENST00000397869NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000354542NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000526111NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000580402NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000579129NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000578193NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000397863NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000397860NEAT1chr11

65206894

+MBPchr18

74729016

-
intron-5UTRENST00000384994ENST00000487778NEAT1chr11

65206894

+MBPchr18

74729016

-

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FusionProtFeatures for NEAT1_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEAT1

MBP

P02686

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NEAT1_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NEAT1_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NEAT1_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEAT1_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEAT1C0023903Liver neoplasms1CTD_human
HgeneNEAT1C3495559Juvenile arthritis1CTD_human
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human