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Fusion gene ID: 23908 |
FusionGeneSummary for NEAT1_C4orf19 |
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Fusion gene information | Fusion gene name: NEAT1_C4orf19 | Fusion gene ID: 23908 | Hgene | Tgene | Gene symbol | NEAT1 | C4orf19 | Gene ID | 283131 | 55286 |
Gene name | nuclear paraspeckle assembly transcript 1 | chromosome 4 open reading frame 19 | |
Synonyms | LINC00084|NCRNA00084|TncRNA|VINC | - | |
Cytomap | 11q13.1 | 4p14 | |
Type of gene | ncRNA | protein-coding | |
Description | MENepsilon/betalong intergenic non-protein coding RNA 84nuclear enriched abundant transcript 1nuclear paraspeckle assembly transcript 1 (non-protein coding)trophoblast MHC class II suppressortrophoblast-derived noncoding RNAvirus inducible non-codin | uncharacterized protein C4orf19 | |
Modification date | 20180520 | 20180519 | |
UniProtAcc | Q8IY42 | ||
Ensembl transtripts involved in fusion gene | ENST00000384994, | ENST00000381980, ENST00000508175, ENST00000284437, | |
Fusion gene scores | * DoF score | 24 X 30 X 3=2160 | 2 X 3 X 1=6 |
# samples | 31 | 3 | |
** MAII score | log2(31/2160*10)=-2.80069119177659 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
Context | PubMed: NEAT1 [Title/Abstract] AND C4orf19 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CV372969 | NEAT1 | chr11 | 65191803 | + | C4orf19 | chr4 | 37570178 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000384994 | ENST00000381980 | NEAT1 | chr11 | 65191803 | + | C4orf19 | chr4 | 37570178 | + |
intron-intron | ENST00000384994 | ENST00000508175 | NEAT1 | chr11 | 65191803 | + | C4orf19 | chr4 | 37570178 | + |
intron-intron | ENST00000384994 | ENST00000284437 | NEAT1 | chr11 | 65191803 | + | C4orf19 | chr4 | 37570178 | + |
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FusionProtFeatures for NEAT1_C4orf19 |
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Hgene | Tgene |
NEAT1 | C4orf19 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NEAT1_C4orf19 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NEAT1_C4orf19 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NEAT1_C4orf19 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NEAT1_C4orf19 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NEAT1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | NEAT1 | C3495559 | Juvenile arthritis | 1 | CTD_human |