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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23890

FusionGeneSummary for NDUFS4_TMPRSS2

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFS4_TMPRSS2
Fusion gene ID: 23890
HgeneTgene
Gene symbol

NDUFS4

TMPRSS2

Gene ID

4724

7113

Gene nameNADH:ubiquinone oxidoreductase subunit S4transmembrane serine protease 2
SynonymsAQDQ|CI-18|CI-18 kDa|CI-AQDQPP9284|PRSS10
Cytomap

5q11.2

21q22.3

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)NADH-ubiquinone oxidoreductase 18 kDa subunitcomplex I 18kDa subunitcomplex I-AQDQmitochondrial respitransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2
Modification date2018052320180523
UniProtAcc

O43181

O15393

Ensembl transtripts involved in fusion geneENST00000296684, ENST00000332149, 
ENST00000398585, ENST00000458356, 
ENST00000497881, 
Fusion gene scores* DoF score7 X 4 X 7=19616 X 12 X 3=576
# samples 720
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/576*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDUFS4 [Title/Abstract] AND TMPRSS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

TgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-B9-A5W9-01ANDUFS4chr5

52954454

+TMPRSS2chr21

42838080

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000296684ENST00000332149NDUFS4chr5

52954454

+TMPRSS2chr21

42838080

-
In-frameENST00000296684ENST00000398585NDUFS4chr5

52954454

+TMPRSS2chr21

42838080

-
Frame-shitENST00000296684ENST00000458356NDUFS4chr5

52954454

+TMPRSS2chr21

42838080

-
5CDS-intronENST00000296684ENST00000497881NDUFS4chr5

52954454

+TMPRSS2chr21

42838080

-

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FusionProtFeatures for NDUFS4_TMPRSS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDUFS4

O43181

TMPRSS2

O15393

Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:12611891,ECO:0000269|PubMed:9463323}. Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NDUFS4_TMPRSS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NDUFS4_ENST00000296684_chr5_52954454_+_TMPRSS2_ENST00000398585_chr21_42838080_-_145aa
MAAVSMSVVLRQTLWRRRAVAVAALSVSRVPTRSLRTSTWRLAQDQTQDTQLITVDEKLDITTLTGVPEEHIKTRKVRIFVPARNNMQSG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NDUFS4_ENST00000296684_chr5_52954454_+_TMPRSS2_ENST00000398585_chr21_42838080_-_436nt
ATGGCGGCGGTGTCAATGTCAGTGGTACTGAGGCAGACGTTGTGGCGGAGAAGGGCAGTGGCTGTAGCTGCCCTTTCCGTTTCCAGGGTT
CCGACCAGGTCGTTGAGGACTTCCACATGGAGATTGGCACAGGACCAGACTCAAGACACACAACTCATAACAGTTGATGAAAAATTGGAT
ATCACTACTTTAACTGGAGTTCCAGAAGAGCATATAAAAACTAGAAAAGTCAGGATCTTTGTTCCTGCTCGCAATAACATGCAGTCTGGA
GTAAACAACACAAAGAAATGGAAGATGGAGTTTGATACCAGAGAGCGATGGGAAAATCCTTTGATGGGTTGGGCATCAACGGCTGATCCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NDUFS4_ENST00000296684_chr5_52954454_+_TMPRSS2_ENST00000398585_chr21_42838080_-_2053nt
TTTCATCCTGGCGTTTGCCTGCAGCAAGATGGCGGCGGTGTCAATGTCAGTGGTACTGAGGCAGACGTTGTGGCGGAGAAGGGCAGTGGC
TGTAGCTGCCCTTTCCGTTTCCAGGGTTCCGACCAGGTCGTTGAGGACTTCCACATGGAGATTGGCACAGGACCAGACTCAAGACACACA
ACTCATAACAGTTGATGAAAAATTGGATATCACTACTTTAACTGGAGTTCCAGAAGAGCATATAAAAACTAGAAAAGTCAGGATCTTTGT
TCCTGCTCGCAATAACATGCAGTCTGGAGTAAACAACACAAAGAAATGGAAGATGGAGTTTGATACCAGAGAGCGATGGGAAAATCCTTT
GATGGGTTGGGCATCAACGGCTGATCCCTTATCCAACATGGTTCTAACCTTCAGTACTAAAGAAGATGCAGTTTCCTTTGCAGAAAAAAA
TGGCAGACGGCTAATCCACATGGTCTTCGTCCTTGACGTCGTTTTACAAGAAAACAATGGGGCTGGTTTTGCTTCCCCGTGCATGATTTA
CTCTTAGAGATGATTCAGAGGTCACTTCATTTTTATTAAACAGTGAACTTGTCTGGCTTTGGCACTCTCTGCCATTCTGTGCAGGCTGCA
GTGGCTCCCCTGCCCAGCCTGCTCTCCCTAACCCCTTGTCCGCAAGGGGTGATGGCCGGCTGGTTGTGGGCACTGGCGGTCAAGTGTGGA
GGAGAGGGGTGGAGGCTGCCCCATTGAGATCTTCCTGCTGAGTCCTTTCCAGGGGCCAATTTTGGATGAGCATGGAGCTGTCACCTCTCA
GCTGCTGGATGACTTGAGATGAAAAAGGAGAGACATGGAAAGGGAGACAGCCAGGTGGCACCTGCAGCGGCTGCCCTCTGGGGCCACTTG
GTAGTGTCCCCAGCCTACCTCTCCACAAGGGGATTTTGCTGATGGGTTCTTAGAGCCTTAGCAGCCCTGGATGGTGGCCAGAAATAAAGG
GACCAGCCCTTCATGGGTGGTGACGTGGTAGTCACTTGTAAGGGGAACAGAAACATTTTTGTTCTTATGGGGTGAGAATATAGACAGTGC
CCTTGGTGCGAGGGAAGCAATTGAAAAGGAACTTGCCCTGAGCACTCCTGGTGCAGGTCTCCACCTGCACATTGGGTGGGGCTCCTGGGA
GGGAGACTCAGCCTTCCTCCTCATCCTCCCTGACCCTGCTCCTAGCACCCTGGAGAGTGCACATGCCCCTTGGTCCTGGCAGGGCGCCAA
GTCTGGCACCATGTTGGCCTCTTCAGGCCTGCTAGTCACTGGAAATTGAGGTCCATGGGGGAAATCAAGGATGCTCAGTTTAAGGTACAC
TGTTTCCATGTTATGTTTCTACACATTGCTACCTCAGTGCTCCTGGAAACTTAGCTTTTGATGTCTCCAAGTAGTCCACCTTCATTTAAC
TCTTTGAAACTGTATCATCTTTGCCAAGTAAGAGTGGTGGCCTATTTCAGCTGCTTTGACAAAATGACTGGCTCCTGACTTAACGTTCTA
TAAATGAATGTGCTGAAGCAAAGTGCCCATGGTGGCGGCGAAGAAGAGAAAGATGTGTTTTGTTTTGGACTCTCTGTGGTCCCTTCCAAT
GCTGTGGGTTTCCAACCAGGGGAAGGGTCCCTTTTGCATTGCCAAGTGCCATAACCATGAGCACTACTCTACCATGGTTCTGCCTCCTGG
CCAAGCAGGCTGGTTTGCAAGAATGAAATGAATGATTCTACAGCTAGGACTTAACCTTGAAATGGAAAGTCATGCAATCCCATTTGCAGG
ATCTGTCTGTGCACATGCCTCTGTAGAGAGCAGCATTCCCAGGGACCTTGGAAACAGTTGGCACTGTAAGGTGCTTGCTCCCCAAGACAC
ATCCTAAAAGGTGTTGTAATGGTGAAAACGTCTTCCTTCTTTATTGCCCCTTCTTATTTATGTGAACAACTGTTTGTCTTTTTTTGTATC


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FusionGenePPI for NDUFS4_TMPRSS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NDUFS4APP, NDUFA12, NDUFS6, NDUFB5, NDUFS7, CYC1, UQCRB, ATP5O, MRPL15, M6PR, COX15, DLAT, NDUFAF3, RPS2, NUP188, PRPH, ABCD3, MGST3, CACNA2D1, MARC1, TOMM20, UBE2G2, PARK2, NDUFS3, DNAJC30, PRRT2, NDUFA8, ATP5C1, ALDOA, ALDOC, ATAD3A, ATP1A1, ATP2A2, ATP5A1, ATP5F1, ATP6V0D1, COX4I1, FUBP1, FUBP3, NDUFA2, NDUFS1, OGDH, RPL23, RPS14, SDHB, SLC25A5, UQCRC2, UQCRH, VDAC3, NDUFV1, RPL14, VDAC1, VDAC2, NDUFA9, NDUFA13, NDUFV3, NDUFV2, COX7A2L, NDUFB8, NDUFS2, ND5, NDUFA11, NDUFB10, ND4, NDUFB4, NDUFA7, NDUFS8, ND1, NDUFS5, VAPA, GOLT1B, NDUFA4, COX6B1, NDUFB11, YIPF3, VAPB, GDPD5, FUT1, IL1R2, GALNT6TMPRSS2CLK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NDUFS4_TMPRSS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NDUFS4_TMPRSS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDUFS4C0023264Leigh Disease1CTD_human;ORPHANET
TgeneTMPRSS2C0033578Prostatic Neoplasms2CTD_human