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Fusion gene ID: 23872 |
FusionGeneSummary for NDUFB9_NSMCE2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDUFB9_NSMCE2 | Fusion gene ID: 23872 | Hgene | Tgene | Gene symbol | NDUFB9 | NSMCE2 | Gene ID | 4715 | 286053 |
| Gene name | NADH:ubiquinone oxidoreductase subunit B9 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase | |
| Synonyms | B22|CI-B22|LYRM3|UQOR22 | C8orf36|MMS21|NSE2|ZMIZ7 | |
| Cytomap | 8q24.13 | 8q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9LYR motif-containing protein 3NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDaNADH-ubiquinone oxidoreductase B22 subunitcomplex I B22 subunit | E3 SUMO-protein ligase NSE2E3 SUMO-protein transferase NSE2NSMCE2/PVT1 fusionPVT1/NSMCE2 fusionmethyl methanesulfonate sensitivity gene 21non-SMC element 2, MMS21 homolognon-structural maintenance of chromosomes element 2 homologzinc finger, MIZ-ty | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y6M9 | Q96MF7 | |
| Ensembl transtripts involved in fusion gene | ENST00000522532, ENST00000276689, ENST00000518008, ENST00000517367, ENST00000517830, | ENST00000287437, ENST00000522563, ENST00000517315, ENST00000521460, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 11 X 6 X 6=396 |
| # samples | 4 | 12 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/396*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NDUFB9 [Title/Abstract] AND NSMCE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-FD-A5BV-01A | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000522532 | ENST00000287437 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| Frame-shift | ENST00000522532 | ENST00000522563 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| Frame-shift | ENST00000522532 | ENST00000517315 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| 5CDS-intron | ENST00000522532 | ENST00000521460 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| Frame-shift | ENST00000276689 | ENST00000287437 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| Frame-shift | ENST00000276689 | ENST00000522563 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| Frame-shift | ENST00000276689 | ENST00000517315 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| 5CDS-intron | ENST00000276689 | ENST00000521460 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| In-frame | ENST00000518008 | ENST00000287437 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| In-frame | ENST00000518008 | ENST00000522563 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| In-frame | ENST00000518008 | ENST00000517315 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| 5CDS-intron | ENST00000518008 | ENST00000521460 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| Frame-shift | ENST00000517367 | ENST00000287437 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| Frame-shift | ENST00000517367 | ENST00000522563 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| Frame-shift | ENST00000517367 | ENST00000517315 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| 5CDS-intron | ENST00000517367 | ENST00000521460 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| intron-3CDS | ENST00000517830 | ENST00000287437 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| intron-3CDS | ENST00000517830 | ENST00000522563 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| intron-3CDS | ENST00000517830 | ENST00000517315 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
| intron-intron | ENST00000517830 | ENST00000521460 | NDUFB9 | chr8 | 125559354 | + | NSMCE2 | chr8 | 126369461 | + |
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FusionProtFeatures for NDUFB9_NSMCE2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDUFB9 | NSMCE2 |
| Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believedto be not involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}. | E3 SUMO-protein ligase component of the SMC5-SMC6complex, a complex involved in DNA double-strand break repair byhomologous recombination. Is not be required for the stability ofthe complex. The complex may promote sister chromatid homologousrecombination by recruiting the SMC1-SMC3 cohesin complex todouble-strand breaks. The complex is required for telomeremaintenance via recombination in ALT (alternative lengthening oftelomeres) cell lines and mediates sumoylation of shelterincomplex (telosome) components which is proposed to lead toshelterin complex disassembly in ALT-associated PML bodies (APBs).Acts as an E3 ligase mediating SUMO attachment to various proteinssuch as SMC6L1 and TRAX, the shelterin complex subunits TERF1,TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21and STAG2. Required for recruitment of telomeres to PML nuclearbodies. SUMO protein-ligase activity is required for theprevention of DNA damage-induced apoptosis by facilitating DNArepair, and for formation of APBs in ALT cell lines. Required forsister chromatid cohesion during prometaphase and mitoticprogression. {ECO:0000269|PubMed:16055714,ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526,ECO:0000269|PubMed:19502785}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDUFB9_NSMCE2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NDUFB9_ENST00000518008_chr8_125559354_+_NSMCE2_ENST00000287437_chr8_126369461_+_353aa MAFLASGPYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTS YERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVRSTCTSLFLSYVDGVKFCSPQAEVQIPAMTVTLGPCFSDILXY LSVSIXHLXSPYKXVKVHSLVVLALSLILLQISFSLVLCLTFLPSCYTFPQPASPLFSXAFFSHGGLQADREADGTEGVDEDIIVTQSQT >In-frame_NDUFB9_ENST00000518008_chr8_125559354_+_NSMCE2_ENST00000522563_chr8_126369461_+_353aa MAFLASGPYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTS YERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVRSTCTSLFLSYVDGVKFCSPQAEVQIPAMTVTLGPCFSDILXY LSVSIXHLXSPYKXVKVHSLVVLALSLILLQISFSLVLCLTFLPSCYTFPQPASPLFSXAFFSHGGLQADREADGTEGVDEDIIVTQSQT >In-frame_NDUFB9_ENST00000518008_chr8_125559354_+_NSMCE2_ENST00000517315_chr8_126369461_+_353aa MAFLASGPYLTHQQKVLRLYKRALRHLESWCVQRDKYRYFACLMRARFEEHKNEKDMAKATQLLKEAEEEFWYRQHPQPYIFPDSPGGTS YERYDCYKVPEWCLDDWHPSEKAMYPDYFAKREQWKKLRRESWEREVRSTCTSLFLSYVDGVKFCSPQAEVQIPAMTVTLGPCFSDILXY LSVSIXHLXSPYKXVKVHSLVVLALSLILLQISFSLVLCLTFLPSCYTFPQPASPLFSXAFFSHGGLQADREADGTEGVDEDIIVTQSQT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NDUFB9_ENST00000518008_chr8_125559354_+_NSMCE2_ENST00000287437_chr8_126369461_+_1059nt ATGGCGTTCTTGGCGTCGGGACCCTACCTGACCCATCAGCAAAAGGTGTTGCGGCTTTATAAGCGGGCGCTACGCCACCTCGAGTCGTGG TGCGTCCAGAGAGACAAATACCGATACTTTGCTTGTTTGATGAGAGCCCGGTTTGAAGAACATAAGAATGAAAAGGATATGGCGAAGGCC ACCCAGCTGCTGAAGGAGGCCGAGGAAGAATTCTGGTACCGTCAGCATCCACAGCCATACATCTTCCCTGACTCTCCTGGGGGCACCTCC TATGAGAGATACGATTGCTACAAGGTCCCAGAATGGTGCTTAGATGACTGGCATCCTTCTGAGAAGGCAATGTATCCTGATTACTTTGCC AAGAGAGAACAGTGGAAGAAACTGCGGAGGGAAAGCTGGGAACGAGAGGTGCGTTCTACTTGTACTTCGTTATTCCTTAGCTATGTAGAT GGAGTGAAGTTTTGCTCCCCACAAGCAGAGGTCCAGATTCCAGCCATGACAGTTACTCTGGGCCCTTGCTTCTCAGATATACTTTAGTAT CTAAGTGTATCAATTTAACATTTATAATCACCTTACAAGTAAGTTAAAGTGCATTCCCTGGTCGTTTTGGCTTTGTCTTTGATTTTGCTT CAGATCTCCTTCTCTTTAGTCCTTTGTCTGACTTTTTTGCCTTCTTGCTATACTTTCCCTCAACCTGCCTCTCCACTATTTTCTTAGGCA TTTTTCAGTCATGGTGGTCTTCAAGCTGACAGAGAAGCTGACGGAACAGAAGGAGTGGATGAAGATATAATTGTGACCCAAAGTCAGACC AACTTCACCTGCCCCATTACAAAGGAGGAAATGAAGAAGCCAGTGAAAAATAAAGTGTGTGGCCACACCTATGAAGAGGACGCCATTGTT CGCATGATTGAGTCCAGGCAAAAGCGGAAGAAAAAGGCCTATTGCCCTCAAATTGGCTGTAGCCACACGGATATAAGAAAGTCAGATCTT >In-frame_NDUFB9_ENST00000518008_chr8_125559354_+_NSMCE2_ENST00000522563_chr8_126369461_+_1059nt ATGGCGTTCTTGGCGTCGGGACCCTACCTGACCCATCAGCAAAAGGTGTTGCGGCTTTATAAGCGGGCGCTACGCCACCTCGAGTCGTGG TGCGTCCAGAGAGACAAATACCGATACTTTGCTTGTTTGATGAGAGCCCGGTTTGAAGAACATAAGAATGAAAAGGATATGGCGAAGGCC ACCCAGCTGCTGAAGGAGGCCGAGGAAGAATTCTGGTACCGTCAGCATCCACAGCCATACATCTTCCCTGACTCTCCTGGGGGCACCTCC TATGAGAGATACGATTGCTACAAGGTCCCAGAATGGTGCTTAGATGACTGGCATCCTTCTGAGAAGGCAATGTATCCTGATTACTTTGCC AAGAGAGAACAGTGGAAGAAACTGCGGAGGGAAAGCTGGGAACGAGAGGTGCGTTCTACTTGTACTTCGTTATTCCTTAGCTATGTAGAT GGAGTGAAGTTTTGCTCCCCACAAGCAGAGGTCCAGATTCCAGCCATGACAGTTACTCTGGGCCCTTGCTTCTCAGATATACTTTAGTAT CTAAGTGTATCAATTTAACATTTATAATCACCTTACAAGTAAGTTAAAGTGCATTCCCTGGTCGTTTTGGCTTTGTCTTTGATTTTGCTT CAGATCTCCTTCTCTTTAGTCCTTTGTCTGACTTTTTTGCCTTCTTGCTATACTTTCCCTCAACCTGCCTCTCCACTATTTTCTTAGGCA TTTTTCAGTCATGGTGGTCTTCAAGCTGACAGAGAAGCTGACGGAACAGAAGGAGTGGATGAAGATATAATTGTGACCCAAAGTCAGACC AACTTCACCTGCCCCATTACAAAGGAGGAAATGAAGAAGCCAGTGAAAAATAAAGTGTGTGGCCACACCTATGAAGAGGACGCCATTGTT CGCATGATTGAGTCCAGGCAAAAGCGGAAGAAAAAGGCCTATTGCCCTCAAATTGGCTGTAGCCACACGGATATAAGAAAGTCAGATCTT >In-frame_NDUFB9_ENST00000518008_chr8_125559354_+_NSMCE2_ENST00000517315_chr8_126369461_+_1059nt ATGGCGTTCTTGGCGTCGGGACCCTACCTGACCCATCAGCAAAAGGTGTTGCGGCTTTATAAGCGGGCGCTACGCCACCTCGAGTCGTGG TGCGTCCAGAGAGACAAATACCGATACTTTGCTTGTTTGATGAGAGCCCGGTTTGAAGAACATAAGAATGAAAAGGATATGGCGAAGGCC ACCCAGCTGCTGAAGGAGGCCGAGGAAGAATTCTGGTACCGTCAGCATCCACAGCCATACATCTTCCCTGACTCTCCTGGGGGCACCTCC TATGAGAGATACGATTGCTACAAGGTCCCAGAATGGTGCTTAGATGACTGGCATCCTTCTGAGAAGGCAATGTATCCTGATTACTTTGCC AAGAGAGAACAGTGGAAGAAACTGCGGAGGGAAAGCTGGGAACGAGAGGTGCGTTCTACTTGTACTTCGTTATTCCTTAGCTATGTAGAT GGAGTGAAGTTTTGCTCCCCACAAGCAGAGGTCCAGATTCCAGCCATGACAGTTACTCTGGGCCCTTGCTTCTCAGATATACTTTAGTAT CTAAGTGTATCAATTTAACATTTATAATCACCTTACAAGTAAGTTAAAGTGCATTCCCTGGTCGTTTTGGCTTTGTCTTTGATTTTGCTT CAGATCTCCTTCTCTTTAGTCCTTTGTCTGACTTTTTTGCCTTCTTGCTATACTTTCCCTCAACCTGCCTCTCCACTATTTTCTTAGGCA TTTTTCAGTCATGGTGGTCTTCAAGCTGACAGAGAAGCTGACGGAACAGAAGGAGTGGATGAAGATATAATTGTGACCCAAAGTCAGACC AACTTCACCTGCCCCATTACAAAGGAGGAAATGAAGAAGCCAGTGAAAAATAAAGTGTGTGGCCACACCTATGAAGAGGACGCCATTGTT CGCATGATTGAGTCCAGGCAAAAGCGGAAGAAAAAGGCCTATTGCCCTCAAATTGGCTGTAGCCACACGGATATAAGAAAGTCAGATCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NDUFB9_ENST00000518008_chr8_125559354_+_NSMCE2_ENST00000287437_chr8_126369461_+_1213nt AAGGAATTTTCTTTTTGCAGAGACAAATACCGATACTTTGCTTGTTTGATGAGAGCCCGGTTTGAAGAACATAAGAATGAAAAGGATATG GCGAAGGCCACCCAGCTGCTGAAGGAGGCCGAGGAAGAATTCTGGTACCGTCAGCATCCACAGCCATACATCTTCCCTGACTCTCCTGGG GGCACCTCCTATGAGAGATACGATTGCTACAAGGTCCCAGAATGGTGCTTAGATGACTGGCATCCTTCTGAGAAGGCAATGTATCCTGAT TACTTTGCCAAGAGAGAACAGTGGAAGAAACTGCGGAGGGAAAGCTGGGAACGAGAGGTGCGTTCTACTTGTACTTCGTTATTCCTTAGC TATGTAGATGGAGTGAAGTTTTGCTCCCCACAAGCAGAGGTCCAGATTCCAGCCATGACAGTTACTCTGGGCCCTTGCTTCTCAGATATA CTTTAGTATCTAAGTGTATCAATTTAACATTTATAATCACCTTACAAGTAAGTTAAAGTGCATTCCCTGGTCGTTTTGGCTTTGTCTTTG ATTTTGCTTCAGATCTCCTTCTCTTTAGTCCTTTGTCTGACTTTTTTGCCTTCTTGCTATACTTTCCCTCAACCTGCCTCTCCACTATTT TCTTAGGCATTTTTCAGTCATGGTGGTCTTCAAGCTGACAGAGAAGCTGACGGAACAGAAGGAGTGGATGAAGATATAATTGTGACCCAA AGTCAGACCAACTTCACCTGCCCCATTACAAAGGAGGAAATGAAGAAGCCAGTGAAAAATAAAGTGTGTGGCCACACCTATGAAGAGGAC GCCATTGTTCGCATGATTGAGTCCAGGCAAAAGCGGAAGAAAAAGGCCTATTGCCCTCAAATTGGCTGTAGCCACACGGATATAAGAAAG TCAGATCTTATCCAGGATGAAGCACTTAGAAGGGCAATTGAGAACCATAACAAGAAAAGACATCGTCATTCCGAGTAGGAAAAGCCACCT GCCTGCAGGGACACCAGCAGCCTACCTCCTACCCCAGCTGTCTGTTGAGAGCAGTGCTGACCCCAGCAGTTAGGGACTGGCTGCATAGCA TACTTGTTGGGGGTAAAACTTGTTGCTTTTATGTGTGCTTGAAAACATTTTTCAAAGTTACACAACAGAAATGCAATCATATTGTTTATT >In-frame_NDUFB9_ENST00000518008_chr8_125559354_+_NSMCE2_ENST00000522563_chr8_126369461_+_1168nt AAGGAATTTTCTTTTTGCAGAGACAAATACCGATACTTTGCTTGTTTGATGAGAGCCCGGTTTGAAGAACATAAGAATGAAAAGGATATG GCGAAGGCCACCCAGCTGCTGAAGGAGGCCGAGGAAGAATTCTGGTACCGTCAGCATCCACAGCCATACATCTTCCCTGACTCTCCTGGG GGCACCTCCTATGAGAGATACGATTGCTACAAGGTCCCAGAATGGTGCTTAGATGACTGGCATCCTTCTGAGAAGGCAATGTATCCTGAT TACTTTGCCAAGAGAGAACAGTGGAAGAAACTGCGGAGGGAAAGCTGGGAACGAGAGGTGCGTTCTACTTGTACTTCGTTATTCCTTAGC TATGTAGATGGAGTGAAGTTTTGCTCCCCACAAGCAGAGGTCCAGATTCCAGCCATGACAGTTACTCTGGGCCCTTGCTTCTCAGATATA CTTTAGTATCTAAGTGTATCAATTTAACATTTATAATCACCTTACAAGTAAGTTAAAGTGCATTCCCTGGTCGTTTTGGCTTTGTCTTTG ATTTTGCTTCAGATCTCCTTCTCTTTAGTCCTTTGTCTGACTTTTTTGCCTTCTTGCTATACTTTCCCTCAACCTGCCTCTCCACTATTT TCTTAGGCATTTTTCAGTCATGGTGGTCTTCAAGCTGACAGAGAAGCTGACGGAACAGAAGGAGTGGATGAAGATATAATTGTGACCCAA AGTCAGACCAACTTCACCTGCCCCATTACAAAGGAGGAAATGAAGAAGCCAGTGAAAAATAAAGTGTGTGGCCACACCTATGAAGAGGAC GCCATTGTTCGCATGATTGAGTCCAGGCAAAAGCGGAAGAAAAAGGCCTATTGCCCTCAAATTGGCTGTAGCCACACGGATATAAGAAAG TCAGATCTTATCCAGGATGAAGCACTTAGAAGGGCAATTGAGAACCATAACAAGAAAAGACATCGTCATTCCGAGTAGGAAAAGCCACCT GCCTGCAGGGACACCAGCAGCCTACCTCCTACCCCAGCTGTCTGTTGAGAGCAGTGCTGACCCCAGCAGTTAGGGACTGGCTGCATAGCA >In-frame_NDUFB9_ENST00000518008_chr8_125559354_+_NSMCE2_ENST00000517315_chr8_126369461_+_1211nt AAGGAATTTTCTTTTTGCAGAGACAAATACCGATACTTTGCTTGTTTGATGAGAGCCCGGTTTGAAGAACATAAGAATGAAAAGGATATG GCGAAGGCCACCCAGCTGCTGAAGGAGGCCGAGGAAGAATTCTGGTACCGTCAGCATCCACAGCCATACATCTTCCCTGACTCTCCTGGG GGCACCTCCTATGAGAGATACGATTGCTACAAGGTCCCAGAATGGTGCTTAGATGACTGGCATCCTTCTGAGAAGGCAATGTATCCTGAT TACTTTGCCAAGAGAGAACAGTGGAAGAAACTGCGGAGGGAAAGCTGGGAACGAGAGGTGCGTTCTACTTGTACTTCGTTATTCCTTAGC TATGTAGATGGAGTGAAGTTTTGCTCCCCACAAGCAGAGGTCCAGATTCCAGCCATGACAGTTACTCTGGGCCCTTGCTTCTCAGATATA CTTTAGTATCTAAGTGTATCAATTTAACATTTATAATCACCTTACAAGTAAGTTAAAGTGCATTCCCTGGTCGTTTTGGCTTTGTCTTTG ATTTTGCTTCAGATCTCCTTCTCTTTAGTCCTTTGTCTGACTTTTTTGCCTTCTTGCTATACTTTCCCTCAACCTGCCTCTCCACTATTT TCTTAGGCATTTTTCAGTCATGGTGGTCTTCAAGCTGACAGAGAAGCTGACGGAACAGAAGGAGTGGATGAAGATATAATTGTGACCCAA AGTCAGACCAACTTCACCTGCCCCATTACAAAGGAGGAAATGAAGAAGCCAGTGAAAAATAAAGTGTGTGGCCACACCTATGAAGAGGAC GCCATTGTTCGCATGATTGAGTCCAGGCAAAAGCGGAAGAAAAAGGCCTATTGCCCTCAAATTGGCTGTAGCCACACGGATATAAGAAAG TCAGATCTTATCCAGGATGAAGCACTTAGAAGGGCAATTGAGAACCATAACAAGAAAAGACATCGTCATTCCGAGTAGGAAAAGCCACCT GCCTGCAGGGACACCAGCAGCCTACCTCCTACCCCAGCTGTCTGTTGAGAGCAGTGCTGACCCCAGCAGTTAGGGACTGGCTGCATAGCA TACTTGTTGGGGGTAAAACTTGTTGCTTTTATGTGTGCTTGAAAACATTTTTCAAAGTTACACAACAGAAATGCAATCATATTGTTTATT |
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FusionGenePPI for NDUFB9_NSMCE2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NDUFB9 | MAGEA11, GDF9, FEZ1, IKBKAP, SH3GL3, HAP1, IMMT, RBBP6, NDUFA2, NDUFB5, NDUFS1, NDUFA12, NDUFB10, NDUFA5, ATP5B, ATP5O, ATP5F1, ATP5J2, ATP5C1, MPV17, ABCC1, ABCC2, LAMTOR3, MSLN, SYNE2, HSPA1L, STX4, ILF3, SDHB, MRPS28, MEF2A, XRN1, NXF1, NDUFS3, PRPS1, PRRT2, SPG7, ENPP6, NDUFA8, CLTC, LYRM5, NDUFA6, NDUFA9, NDUFB8, MTCH2, NDUFB7, POR, RAB1A, RPN1, VDAC2, NDUFS5, TIMMDC1, FBXW7, C15orf48, NDUFA4, NDUFB11, NDUFS6, RHPN1, KLHL22, NDUFS7, CSGALNACT2, FUT1, UBC, TRIM25 | NSMCE2 | NSMCE1, SMC6, RAD21, STAG2, SMC5, SMC1A, SMC3, PDS5A, PDS5B, WAPAL, ETV1, TSNAX, PAN2, TXLNA, USP28, EID3, ZNF597, NDNL2, EWSR1, ILK, SORT1, NIPSNAP1, TM9SF4, SYNCRIP, SAMD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDUFB9_NSMCE2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDUFB9_NSMCE2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NDUFB9 | C0043094 | Weight Gain | 1 | CTD_human |
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