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Fusion gene ID: 23851 |
FusionGeneSummary for NDUFAF2_UBC |
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Fusion gene information | Fusion gene name: NDUFAF2_UBC | Fusion gene ID: 23851 | Hgene | Tgene | Gene symbol | NDUFAF2 | UBC | Gene ID | 91942 | 7316 |
Gene name | NADH:ubiquinone oxidoreductase complex assembly factor 2 | ubiquitin C | |
Synonyms | B17.2L|MMTN|NDUFA12L|mimitin | HMG20 | |
Cytomap | 5q12.1 | 12q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1 | polyubiquitin-C | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8N183 | P0CG48 | |
Ensembl transtripts involved in fusion gene | ENST00000296597, ENST00000511107, ENST00000512623, | ENST00000536769, ENST00000538617, ENST00000546120, ENST00000339647, ENST00000536661, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 14 X 14 X 3=588 |
# samples | 3 | 15 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/588*10)=-1.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NDUFAF2 [Title/Abstract] AND UBC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-J4-A67S-01A | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000296597 | ENST00000536769 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
5CDS-5UTR | ENST00000296597 | ENST00000538617 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
5CDS-5UTR | ENST00000296597 | ENST00000546120 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
5CDS-5UTR | ENST00000296597 | ENST00000339647 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
5CDS-intron | ENST00000296597 | ENST00000536661 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
5CDS-5UTR | ENST00000511107 | ENST00000536769 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
5CDS-5UTR | ENST00000511107 | ENST00000538617 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
5CDS-5UTR | ENST00000511107 | ENST00000546120 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
5CDS-5UTR | ENST00000511107 | ENST00000339647 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
5CDS-intron | ENST00000511107 | ENST00000536661 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
intron-5UTR | ENST00000512623 | ENST00000536769 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
intron-5UTR | ENST00000512623 | ENST00000538617 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
intron-5UTR | ENST00000512623 | ENST00000546120 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
intron-5UTR | ENST00000512623 | ENST00000339647 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
intron-intron | ENST00000512623 | ENST00000536661 | NDUFAF2 | chr5 | 60241209 | + | UBC | chr12 | 125398320 | - |
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FusionProtFeatures for NDUFAF2_UBC |
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Hgene | Tgene |
NDUFAF2 | UBC |
Acts as a molecular chaperone for mitochondrial complexI assembly (PubMed:16200211). Complex I functions in the transferof electrons from NADH to the respiratory chain. The immediateelectron acceptor for the enzyme is believed to be ubiquinone(PubMed:16200211, PubMed:27626371). {ECO:0000269|PubMed:16200211,ECO:0000269|PubMed:27626371}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDUFAF2_UBC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NDUFAF2_UBC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NDUFAF2 | ACOT13, CDV3, RPS24, RPS26, PPIF, SUGP2, SON, ATXN3, CHST15, COQ9, C15orf48, NDUFA4, PTPMT1, COQ2, CBLN4 | UBC | DAZAP2, RNF11, DLGAP4, UCHL1, HSPA8, SFPQ, SH3KBP1, ATXN3, ADRM1, RBCK1, USP5, OTUD5, RNF125, UBA1, USP3, CBL, E2F1, UIMC1, BRCA1, USP16, HDAC6, MLH1, PMS2, PMS1, LAPTM5, STAM, DDB1, CUL4A, USP2, PSMD4, HGS, RAD23A, POLH, CDC42, GRB2, RAC1, DAXX, JUN, MDM2, USP15, ITGA5, AMFR, MYSM1, UBASH3B, UBASH3A, GGA1, GGA3, HERC3, STUB1, SNCA, CDK5RAP3, TNF, OTUB1, TAB2, EPS15, ANKS1B, ANKS1A, ING1, RNF185, UBTD2, MKI67, RBBP4, ACPP, RANBP9, BAG2, DNAJA2, DNAJA4, DNAJB1, HSPB1, SGTA, CCT5, CCT3, DNAJA3, CHD4, H2AFZ, RIOK3, CYB5R3, ACTL6A, ACTR2, ACTR1A, DCTN2, DYNC1I2, TUBGCP5, LAMA1, STOML2, MYH1, MYO6, NASP, RFC3, RFC2, RUVBL1, RUVBL2, PURA, CYB5R1, NDUFS3, NDUFS1, NDUFA13, SDHA, UQCRC1, MTR, PFKFB2, DHCR7, ALDH1B1, ARV1, MTHFD1, CBS, PHGDH, HSD17B4, ALDOC, PYGL, PSAT1, PDHA1, HSD17B12, HADHA, LMNB1, NPLOC4, NUP133, FRY, GPN1, HIVEP3, KIF21B, MAEA, STOM, HLA-C, HLA-A, TMEM39B, RIMKLB, PCMT1, ACP2, ADSL, ARF1, COX5B, MRE11A, MTCH2, BPIFA1, FLOT1, PPIH, PEF1, ERLIN1, XPO5, APPBP2, SEC61A1, TOM1, IPO7, EXOSC2, EXOSC8, FBL, HNRNPA0, HNRNPA3, HNRNPK, HNRNPM, HNRNPR, HNRNPA2B1, HNRNPC, RBM3, SRSF1, PRPF4, POLR2C, DHX9, DDX18, SYNCRIP, SSB, MATR3, RAE1, AIMP1, NOP56, PABPN1, PCBP2, PTBP1, RBM39, ALYREF, BRE, PRKAR1A, CSNK2A1, CSNK2A2, COPS4, ATF6, GNB2, G3BP1, G3BP2, PPP2R1A, PPP1CB, SDCBP, TXNL1, TSC22D3, REXO4, HIVEP1, MRPS18B, MRPS31, MRPS7, RPS12, RPS20, RPS8, RPLP0, RPLP2, RPL22, RPL9, EEF1B2, EIF3H, EIF3F, MRPS22, MRPS35, DAP3, MRPL27, ATP5C1, SLC25A13, VDAC3, NUP37, NUP43, ATP6V0D1, FARSA, NARS, IARS, ANKRD13A, BIRC6, PSMD8, APC, ANAPC7, SKP1, FBXO7, BTRC, ASPSCR1, ANKIB1, PSME3, RHBDD3, USP4, UCHL5, UBR2, UBE2C, UBE2N, UBE2D3, NEDD8, NACA, RNF213, TRIM26, AAR2, CCDC64B, EMC3, AMOT, DLG5, FGD2, GRWD1, HAX1, PCID2, MYCBP2, SPRYD7, PNMAL1, LAS1L, FAM175A, CHCHD3, CCDC134, PDE12, LSM12, C10orf90, ATG13, FAM115A, TNRC6B, TRABD, MIB1, MARC1, DCAF5, C1orf35, BABAM1, DCAKD, KLHL12, NCDN, OCIAD1, PPP6R1, GPN3, TBC1D15, C19orf44, TIMM50, CHCHD6, FHL1, FHL2, WDR5, RNF114, TRIM27, COPB1, ARCN1, COPE, HSPD1, DNAJB6, TRAP1, CCT6A, PHB, RFC5, NAP1L1, DHFR, DLST, HADHB, UCK2, TRO, DCD, KPNB1, HNRNPL, HNRNPU, POLR1C, IGF2BP3, NCL, NPM1, PABPC4, DDX17, RBM12, TRIM28, TUFM, ATP5O, VDAC1, RARS, DARS, PSMD14, CUL1, PRPF19, PJA1, RAD18, RLIM, RNF19B, WDR26, SPG20, RNF126, WDR77, MLF2, FHL3, DNAJA1, GLUL, EMD, TRAFD1, C1QBP, HNRNPF, HNRNPH1, TNRC6A, RPS11, RPL28, AGO2, AGO1, ATP5A1, KCTD10, PSMD10, PSMD12, UBR4, RNF25, UBE2T, RAD23B, ERLIN2, AGO3, PSMC1, PSMC6, PSMD7, PSMA2, PSMA7, PSMB2, PSMB5, PSMB6, VCP, UBL4A, GET4, UBQLN1, PSMC3, PSMC4, PSMC5, PSMD11, PSMA1, PSMA3, PSMA5, PSMA6, PSMB1, PSMB7, BIRC2, IKBKG, RYK, BECN1, PRPF8, FAM175B, BRCC3, CDC34, INPPL1, CBLB, TRAF3IP2, YOD1, PELI1, TNFAIP3, YWHAB, YWHAG, YWHAZ, ATXN3L, TRAF6, NEDD4, EGFR, UBXN1, HMGCR, SQSTM1, RGS2, OTUD7B, TRAF2, USP13, CYLD, ZRANB1, PCK1, BFAR, REV1, UBE2S, USP7, USP21, STAMBP, UCHL3, RAD21, STAMBPL1, SOD1, HERC2, ARRB1, ARRB2, LAMB1, POLI, FKBP8, GTF2H1, PLAA, TNIP2, TNIP1, TNIP3, VPS36, TSG101, UBE3C, RABGEF1, UBE2K, RNF168, RNF169, AUP1, DCLRE1A, STAM2, UBE2D2, UBL7, USP10, TAB3, PTCRA, ZFAND5, UBE2G2, TUBA1A, UBE2V2, UBE2V1, FAF1, MAP3K14, VPRBP, OPTN, NEURL3, FANCD2, NBR1, ASB2, XIAP, LTN1, MUL1, DNAJB2, UBR5, BIRC3, DPH1, USP1, USP8, USP11, USP25, RNF182, RCHY1, NEDD4L, CUEDC2, EPN1, EPN2, NSFL1C, TAX1BP1, TOLLIP, UBAP1, CCDC50, ZFAND6, CALCOCO2, N4BP1, ZFAND3, TTC3, UBFD1, ARID3A, KLHL7, CUL3, CUL4B, CUL5, CUL2, UBA6, COPS5, COPS6, DCUN1D1, CAND1, BIRC7, PSMD5, SPRTN, TRIM36, UBE3A, ARIH2, PTPN14, CTBP2, RNF115, RNF2, TRIM17, ITCH, WWP2, UBE2E3, UBE2J2, HERC4, HERPUD1, IRS1, CRK, AP2M1, TRIM5, RB1CC1, CASP8, PARK2, JOSD1, USP28, TRIM39, NSMCE1, RNF151, TOM1L2, WRNIP1, VPS37C, R3HDM4, ZNF716, ZNF705G, ZHX1, UNC93B3, UEVLD, TUBGCP2, TTC28, TMEM160, TMEM132A, THG1L, TCP10, TCHH, TAC3, SNTB2, SNRNP25, SLIT2, SGK1, SEPT1, SEMA3F, RTTN, RPL7L1, PTOV1, PPL, PDS5A, OTOG, OR7G3, OPRM1, NT5C1B, NEK8, MUC16, MTERF4, MDN1, MAD1L1, LTF, CHD3, KLHL13, KIAA1211, KEL, ISX, NCKAP5L, ERVK13-1, HMGN2, GFPT2, GARNL3, LOC100130417, FETUB, EFS, ECE2, DNASE2B, DMBX1, DECR2, COL1A1, CEP164, CDY1B, CDH2, CEP83, ANAPC1, ACLY, HUWE1, HRNR, RABEP2, UFD1L, SUN5, HSPA5, CBR3, CBR1, TUBA3C, TUBA3D, ZCWPW2, CD2, CEP192, BTD, UNC79, ZNF792, LOC100272216, RASAL2, BCAS2, FBXO44, NCOA6, ZNF148, KLHL11, TNFAIP6, TIAM1, DOCK6, SPAG1, MRPL37, HYDIN, HYDIN2, C8orf34, PTH1R, SYNE2, RGPD3, SEPT7P2, MUC5B, BARX1, ADH7, SNTG1, TTC36, CENPE, XPNPEP1, RPL12, ANKRD30A, GTF2IRD1, PRR23B, CHGA, PUS7L, PPM1D, SOCS5, DHX15, FAT1, NDC1, TBXAS1, TSTA3, FLOT2, ANGPTL3, SBF2, NBPF12, NBPF14, NBPF10, NBPF8, NBPF9, NBPF1, NBPF11, POP5, ELL, BRF1, ZNF213, P4HTM, FGA, MAP4, LIMA1, CDH22, SDK1, PHF20L1, WFDC8, KIAA0586, SPECC1L, DNAH7, LARP1B, RABEP1, PPARG, ZFYVE9, NOD1, SMURF1, CLN8, EPAS1, UBC, USP9X, USP9Y, USP14, USP48, USP37, TRIM32, FN1, VCAM1, AXIN1, RNF5, VPS28, TRIM21, RIPK2, FAM86B2, METTL21B, METTL21C, VCPKMT, METTL23, ITGA4, SMURF2, OTULIN, RNF31, ADRB2, FKBPL, BCR, ABL1, CD2AP, KLF1, UBXN7, MAP1LC3A, ATG16L1, UBA2, SMAD1, UBE2R2, HIST2H2AC, HIST2H2BE, RPA3, RPA2, RPA1, JOSD2, PTPN5, LIN28B, PGAM2, IKZF3, MAPT, ASB10, ASB11, RNF4, PARP10, ZC3H12A, USP19, LGR4, PINK1, MARCH7, MDM4, SLX4, SHFM1, PTEN, TBX21, AMPH, BIN1, USP12, OTUB2, CBLC, MARCH6, RNF130, TRIP12, UBE2B, UBE2L3, FAF2, BRAP, KCMF1, XPC, UBR1, HECTD1, RNF20, FOXN2, UBE2O, CALM1, CCT2, HSP90AB1, EEF1A2, CCT4, CCT7, CCT8, ATAD3B, KHSRP, ATP1A1, VAPB, ASNA1, VCPIP1, IKBKE, OTUD3, OTUD6A, OTUD1, OTUD4, OTUD7A, USP33, SART3, PSEN1, TP53, FUS, TOPORS, REST, CTRC, ANAPC11, RAPGEF2, H2AFX, HIST1H2AB, IDE, RHOA, CDKN1B, AURKB, CCNE1, MOV10, NXF1, EP300, HLTF, PRAME, PSMC2, PSMD1, CUL7, OBSL1, CCDC8, RNF8, FAN1, SNRPA, ZNF451, BAP1, CLU, VHL, MID1, UBAC2, DDI1, DDX58, ERCC6, TOM1L1, UBQLN4, UBE2D1, ANKRD13B, ANKRD13D, ZNRF1, ZNRF2, SUMO1, SUMO3, SUMO2, TMEM189, NOD2, ZBTB1, C1orf86, NUB1, LCK, NCK2, KEAP1, RIPK1, RELA, CISH, NFE2L2, USP30, UBE2A, AMBRA1, NTRK1, UBQLN2, IBTK, AREL1, RNF38, WDR48, RC3H2, WWP1, HECW1, TP53BP1, RNF181, FKBP15, ASXL2, ASXL1, MCM2, MCM5, RNF165, RNF111, NCAPG, TRAF1, CDC20, ZFAND2B, PTPN23, USP27X, NAT10, RAG1, RPN1, FBXO18, SEPT4, CDC73, CPS1, TRIM25, TNFRSF1A, CDH1, RHOT2, NDUFS8, OPA3, ILF3, PPA1, EIF3A, RFC1, CEP55, VPS37A, CFAP36, MORC3, DDI2, CCDC92, HIST2H2AA3, CHUK, IKBKB, TCEAL1, TRIP4, ASCC2, CUEDC1, AP2B1, AP2A1, AP2A2, EPS15L1, ITSN2, ASCC3, PDCD6IP, FCHO2, AP2S1, ANP32E, PSMD2, PSMD6, PSMD13, PSMD3, MYCBP, OGT, CHP1, HERC1, UBAC1, RPS3, CAPN15, KCTD7, PRDX4, GLG1, SDC4, HSD17B11, LACTB, SHARPIN, TCEB1, PCMTD1, USP24, KHDRBS1, PRKCI, LAMC1, CDK17, HSPG2, OSBPL8, AGRN, GTF2I, LAMA5, PRKCDBP, MVP, PTRF, PIK3C2B, NDUFB9, TAPBP, TAB1, MAP3K7, ACTL8, PTPN2, HPDL, FAM127A, FAM127C, TMEM223, RECQL, ARMC1, USP32, AGTPBP1, TCOF1, SDF2, ATP5H, FBXL15, DPY30, RNF123, USP40, ELOVL5, ITGAV, YARS2, WARS, MYL1, MYL3, PLEC, BSG, SLC38A5, ABCB7, CCDC132, TMEM201, YIPF5, GBF1, MAP2K4, PHPT1, PTPLB, ERGIC2, ALG1, ACTC1, ACTA1, NFIA, TMEM120A, CDC45, TOR1AIP2, PTPLA, SGPP1, NAA10, TBC1D5, TTF2, SMYD4, SRPRB, CDKN2A, SCD, ANTXR1, CPT1A, DDX19B, KDM3B, MBOAT7, NFX1, NPTN, WDR33, NXPH4, TRAM1, MAPRE2, SLC27A2, MACF1, SLC5A6, CDK7, RBBP8, WBP2, TRIM23, TRAF5, CAV1, WDR81, MAP1LC3B, MAP1LC3C, PIP5K1C |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDUFAF2_UBC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDUFAF2_UBC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NDUFAF2 | C0752109 | Brain Diseases, Metabolic, Inborn | 1 | CTD_human |