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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23851

FusionGeneSummary for NDUFAF2_UBC

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFAF2_UBC
Fusion gene ID: 23851
HgeneTgene
Gene symbol

NDUFAF2

UBC

Gene ID

91942

7316

Gene nameNADH:ubiquinone oxidoreductase complex assembly factor 2ubiquitin C
SynonymsB17.2L|MMTN|NDUFA12L|mimitinHMG20
Cytomap

5q12.1

12q24.31

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1 polyubiquitin-C
Modification date2018052320180523
UniProtAcc

Q8N183

P0CG48

Ensembl transtripts involved in fusion geneENST00000296597, ENST00000511107, 
ENST00000512623, 
ENST00000536769, 
ENST00000538617, ENST00000546120, 
ENST00000339647, ENST00000536661, 
Fusion gene scores* DoF score3 X 2 X 3=1814 X 14 X 3=588
# samples 315
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(15/588*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDUFAF2 [Title/Abstract] AND UBC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-J4-A67S-01ANDUFAF2chr5

60241209

+UBCchr12

125398320

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000296597ENST00000536769NDUFAF2chr5

60241209

+UBCchr12

125398320

-
5CDS-5UTRENST00000296597ENST00000538617NDUFAF2chr5

60241209

+UBCchr12

125398320

-
5CDS-5UTRENST00000296597ENST00000546120NDUFAF2chr5

60241209

+UBCchr12

125398320

-
5CDS-5UTRENST00000296597ENST00000339647NDUFAF2chr5

60241209

+UBCchr12

125398320

-
5CDS-intronENST00000296597ENST00000536661NDUFAF2chr5

60241209

+UBCchr12

125398320

-
5CDS-5UTRENST00000511107ENST00000536769NDUFAF2chr5

60241209

+UBCchr12

125398320

-
5CDS-5UTRENST00000511107ENST00000538617NDUFAF2chr5

60241209

+UBCchr12

125398320

-
5CDS-5UTRENST00000511107ENST00000546120NDUFAF2chr5

60241209

+UBCchr12

125398320

-
5CDS-5UTRENST00000511107ENST00000339647NDUFAF2chr5

60241209

+UBCchr12

125398320

-
5CDS-intronENST00000511107ENST00000536661NDUFAF2chr5

60241209

+UBCchr12

125398320

-
intron-5UTRENST00000512623ENST00000536769NDUFAF2chr5

60241209

+UBCchr12

125398320

-
intron-5UTRENST00000512623ENST00000538617NDUFAF2chr5

60241209

+UBCchr12

125398320

-
intron-5UTRENST00000512623ENST00000546120NDUFAF2chr5

60241209

+UBCchr12

125398320

-
intron-5UTRENST00000512623ENST00000339647NDUFAF2chr5

60241209

+UBCchr12

125398320

-
intron-intronENST00000512623ENST00000536661NDUFAF2chr5

60241209

+UBCchr12

125398320

-

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FusionProtFeatures for NDUFAF2_UBC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDUFAF2

Q8N183

UBC

P0CG48

Acts as a molecular chaperone for mitochondrial complexI assembly (PubMed:16200211). Complex I functions in the transferof electrons from NADH to the respiratory chain. The immediateelectron acceptor for the enzyme is believed to be ubiquinone(PubMed:16200211, PubMed:27626371). {ECO:0000269|PubMed:16200211,ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NDUFAF2_UBC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NDUFAF2_UBC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NDUFAF2ACOT13, CDV3, RPS24, RPS26, PPIF, SUGP2, SON, ATXN3, CHST15, COQ9, C15orf48, NDUFA4, PTPMT1, COQ2, CBLN4UBCDAZAP2, RNF11, DLGAP4, UCHL1, HSPA8, SFPQ, SH3KBP1, ATXN3, ADRM1, RBCK1, USP5, OTUD5, RNF125, UBA1, USP3, CBL, E2F1, UIMC1, BRCA1, USP16, HDAC6, MLH1, PMS2, PMS1, LAPTM5, STAM, DDB1, CUL4A, USP2, PSMD4, HGS, RAD23A, POLH, CDC42, GRB2, RAC1, DAXX, JUN, MDM2, USP15, ITGA5, AMFR, MYSM1, UBASH3B, UBASH3A, GGA1, GGA3, HERC3, STUB1, SNCA, CDK5RAP3, TNF, OTUB1, TAB2, EPS15, ANKS1B, ANKS1A, ING1, RNF185, UBTD2, MKI67, RBBP4, ACPP, RANBP9, BAG2, DNAJA2, DNAJA4, DNAJB1, HSPB1, SGTA, CCT5, CCT3, DNAJA3, CHD4, H2AFZ, RIOK3, CYB5R3, ACTL6A, ACTR2, ACTR1A, DCTN2, DYNC1I2, TUBGCP5, LAMA1, STOML2, MYH1, MYO6, NASP, RFC3, RFC2, RUVBL1, RUVBL2, PURA, CYB5R1, NDUFS3, NDUFS1, NDUFA13, SDHA, UQCRC1, MTR, PFKFB2, DHCR7, ALDH1B1, ARV1, MTHFD1, CBS, PHGDH, HSD17B4, ALDOC, PYGL, PSAT1, PDHA1, HSD17B12, HADHA, LMNB1, NPLOC4, NUP133, FRY, GPN1, HIVEP3, KIF21B, MAEA, STOM, HLA-C, HLA-A, TMEM39B, RIMKLB, PCMT1, ACP2, ADSL, ARF1, COX5B, MRE11A, MTCH2, BPIFA1, FLOT1, PPIH, PEF1, ERLIN1, XPO5, APPBP2, SEC61A1, TOM1, IPO7, EXOSC2, EXOSC8, FBL, HNRNPA0, HNRNPA3, HNRNPK, HNRNPM, HNRNPR, HNRNPA2B1, HNRNPC, RBM3, SRSF1, PRPF4, POLR2C, DHX9, DDX18, SYNCRIP, SSB, MATR3, RAE1, AIMP1, NOP56, PABPN1, PCBP2, PTBP1, RBM39, ALYREF, BRE, PRKAR1A, CSNK2A1, CSNK2A2, COPS4, ATF6, GNB2, G3BP1, G3BP2, PPP2R1A, PPP1CB, SDCBP, TXNL1, TSC22D3, REXO4, HIVEP1, MRPS18B, MRPS31, MRPS7, RPS12, RPS20, RPS8, RPLP0, RPLP2, RPL22, RPL9, EEF1B2, EIF3H, EIF3F, MRPS22, MRPS35, DAP3, MRPL27, ATP5C1, SLC25A13, VDAC3, NUP37, NUP43, ATP6V0D1, FARSA, NARS, IARS, ANKRD13A, BIRC6, PSMD8, APC, ANAPC7, SKP1, FBXO7, BTRC, ASPSCR1, ANKIB1, PSME3, RHBDD3, USP4, UCHL5, UBR2, UBE2C, UBE2N, UBE2D3, NEDD8, NACA, RNF213, TRIM26, AAR2, CCDC64B, EMC3, AMOT, DLG5, FGD2, GRWD1, HAX1, PCID2, MYCBP2, SPRYD7, PNMAL1, LAS1L, FAM175A, CHCHD3, CCDC134, PDE12, LSM12, C10orf90, ATG13, FAM115A, TNRC6B, TRABD, MIB1, MARC1, DCAF5, C1orf35, BABAM1, DCAKD, KLHL12, NCDN, OCIAD1, PPP6R1, GPN3, TBC1D15, C19orf44, TIMM50, CHCHD6, FHL1, FHL2, WDR5, RNF114, TRIM27, COPB1, ARCN1, COPE, HSPD1, DNAJB6, TRAP1, CCT6A, PHB, RFC5, NAP1L1, DHFR, DLST, HADHB, UCK2, TRO, DCD, KPNB1, HNRNPL, HNRNPU, POLR1C, IGF2BP3, NCL, NPM1, PABPC4, DDX17, RBM12, TRIM28, TUFM, ATP5O, VDAC1, RARS, DARS, PSMD14, CUL1, PRPF19, PJA1, RAD18, RLIM, RNF19B, WDR26, SPG20, RNF126, WDR77, MLF2, FHL3, DNAJA1, GLUL, EMD, TRAFD1, C1QBP, HNRNPF, HNRNPH1, TNRC6A, RPS11, RPL28, AGO2, AGO1, ATP5A1, KCTD10, PSMD10, PSMD12, UBR4, RNF25, UBE2T, RAD23B, ERLIN2, AGO3, PSMC1, PSMC6, PSMD7, PSMA2, PSMA7, PSMB2, PSMB5, PSMB6, VCP, UBL4A, GET4, UBQLN1, PSMC3, PSMC4, PSMC5, PSMD11, PSMA1, PSMA3, PSMA5, PSMA6, PSMB1, PSMB7, BIRC2, IKBKG, RYK, BECN1, PRPF8, FAM175B, BRCC3, CDC34, INPPL1, CBLB, TRAF3IP2, YOD1, PELI1, TNFAIP3, YWHAB, YWHAG, YWHAZ, ATXN3L, TRAF6, NEDD4, EGFR, UBXN1, HMGCR, SQSTM1, RGS2, OTUD7B, TRAF2, USP13, CYLD, ZRANB1, PCK1, BFAR, REV1, UBE2S, USP7, USP21, STAMBP, UCHL3, RAD21, STAMBPL1, SOD1, HERC2, ARRB1, ARRB2, LAMB1, POLI, FKBP8, GTF2H1, PLAA, TNIP2, TNIP1, TNIP3, VPS36, TSG101, UBE3C, RABGEF1, UBE2K, RNF168, RNF169, AUP1, DCLRE1A, STAM2, UBE2D2, UBL7, USP10, TAB3, PTCRA, ZFAND5, UBE2G2, TUBA1A, UBE2V2, UBE2V1, FAF1, MAP3K14, VPRBP, OPTN, NEURL3, FANCD2, NBR1, ASB2, XIAP, LTN1, MUL1, DNAJB2, UBR5, BIRC3, DPH1, USP1, USP8, USP11, USP25, RNF182, RCHY1, NEDD4L, CUEDC2, EPN1, EPN2, NSFL1C, TAX1BP1, TOLLIP, UBAP1, CCDC50, ZFAND6, CALCOCO2, N4BP1, ZFAND3, TTC3, UBFD1, ARID3A, KLHL7, CUL3, CUL4B, CUL5, CUL2, UBA6, COPS5, COPS6, DCUN1D1, CAND1, BIRC7, PSMD5, SPRTN, TRIM36, UBE3A, ARIH2, PTPN14, CTBP2, RNF115, RNF2, TRIM17, ITCH, WWP2, UBE2E3, UBE2J2, HERC4, HERPUD1, IRS1, CRK, AP2M1, TRIM5, RB1CC1, CASP8, PARK2, JOSD1, USP28, TRIM39, NSMCE1, RNF151, TOM1L2, WRNIP1, VPS37C, R3HDM4, ZNF716, ZNF705G, ZHX1, UNC93B3, UEVLD, TUBGCP2, TTC28, TMEM160, TMEM132A, THG1L, TCP10, TCHH, TAC3, SNTB2, SNRNP25, SLIT2, SGK1, SEPT1, SEMA3F, RTTN, RPL7L1, PTOV1, PPL, PDS5A, OTOG, OR7G3, OPRM1, NT5C1B, NEK8, MUC16, MTERF4, MDN1, MAD1L1, LTF, CHD3, KLHL13, KIAA1211, KEL, ISX, NCKAP5L, ERVK13-1, HMGN2, GFPT2, GARNL3, LOC100130417, FETUB, EFS, ECE2, DNASE2B, DMBX1, DECR2, COL1A1, CEP164, CDY1B, CDH2, CEP83, ANAPC1, ACLY, HUWE1, HRNR, RABEP2, UFD1L, SUN5, HSPA5, CBR3, CBR1, TUBA3C, TUBA3D, ZCWPW2, CD2, CEP192, BTD, UNC79, ZNF792, LOC100272216, RASAL2, BCAS2, FBXO44, NCOA6, ZNF148, KLHL11, TNFAIP6, TIAM1, DOCK6, SPAG1, MRPL37, HYDIN, HYDIN2, C8orf34, PTH1R, SYNE2, RGPD3, SEPT7P2, MUC5B, BARX1, ADH7, SNTG1, TTC36, CENPE, XPNPEP1, RPL12, ANKRD30A, GTF2IRD1, PRR23B, CHGA, PUS7L, PPM1D, SOCS5, DHX15, FAT1, NDC1, TBXAS1, TSTA3, FLOT2, ANGPTL3, SBF2, NBPF12, NBPF14, NBPF10, NBPF8, NBPF9, NBPF1, NBPF11, POP5, ELL, BRF1, ZNF213, P4HTM, FGA, MAP4, LIMA1, CDH22, SDK1, PHF20L1, WFDC8, KIAA0586, SPECC1L, DNAH7, LARP1B, RABEP1, PPARG, ZFYVE9, NOD1, SMURF1, CLN8, EPAS1, UBC, USP9X, USP9Y, USP14, USP48, USP37, TRIM32, FN1, VCAM1, AXIN1, RNF5, VPS28, TRIM21, RIPK2, FAM86B2, METTL21B, METTL21C, VCPKMT, METTL23, ITGA4, SMURF2, OTULIN, RNF31, ADRB2, FKBPL, BCR, ABL1, CD2AP, KLF1, UBXN7, MAP1LC3A, ATG16L1, UBA2, SMAD1, UBE2R2, HIST2H2AC, HIST2H2BE, RPA3, RPA2, RPA1, JOSD2, PTPN5, LIN28B, PGAM2, IKZF3, MAPT, ASB10, ASB11, RNF4, PARP10, ZC3H12A, USP19, LGR4, PINK1, MARCH7, MDM4, SLX4, SHFM1, PTEN, TBX21, AMPH, BIN1, USP12, OTUB2, CBLC, MARCH6, RNF130, TRIP12, UBE2B, UBE2L3, FAF2, BRAP, KCMF1, XPC, UBR1, HECTD1, RNF20, FOXN2, UBE2O, CALM1, CCT2, HSP90AB1, EEF1A2, CCT4, CCT7, CCT8, ATAD3B, KHSRP, ATP1A1, VAPB, ASNA1, VCPIP1, IKBKE, OTUD3, OTUD6A, OTUD1, OTUD4, OTUD7A, USP33, SART3, PSEN1, TP53, FUS, TOPORS, REST, CTRC, ANAPC11, RAPGEF2, H2AFX, HIST1H2AB, IDE, RHOA, CDKN1B, AURKB, CCNE1, MOV10, NXF1, EP300, HLTF, PRAME, PSMC2, PSMD1, CUL7, OBSL1, CCDC8, RNF8, FAN1, SNRPA, ZNF451, BAP1, CLU, VHL, MID1, UBAC2, DDI1, DDX58, ERCC6, TOM1L1, UBQLN4, UBE2D1, ANKRD13B, ANKRD13D, ZNRF1, ZNRF2, SUMO1, SUMO3, SUMO2, TMEM189, NOD2, ZBTB1, C1orf86, NUB1, LCK, NCK2, KEAP1, RIPK1, RELA, CISH, NFE2L2, USP30, UBE2A, AMBRA1, NTRK1, UBQLN2, IBTK, AREL1, RNF38, WDR48, RC3H2, WWP1, HECW1, TP53BP1, RNF181, FKBP15, ASXL2, ASXL1, MCM2, MCM5, RNF165, RNF111, NCAPG, TRAF1, CDC20, ZFAND2B, PTPN23, USP27X, NAT10, RAG1, RPN1, FBXO18, SEPT4, CDC73, CPS1, TRIM25, TNFRSF1A, CDH1, RHOT2, NDUFS8, OPA3, ILF3, PPA1, EIF3A, RFC1, CEP55, VPS37A, CFAP36, MORC3, DDI2, CCDC92, HIST2H2AA3, CHUK, IKBKB, TCEAL1, TRIP4, ASCC2, CUEDC1, AP2B1, AP2A1, AP2A2, EPS15L1, ITSN2, ASCC3, PDCD6IP, FCHO2, AP2S1, ANP32E, PSMD2, PSMD6, PSMD13, PSMD3, MYCBP, OGT, CHP1, HERC1, UBAC1, RPS3, CAPN15, KCTD7, PRDX4, GLG1, SDC4, HSD17B11, LACTB, SHARPIN, TCEB1, PCMTD1, USP24, KHDRBS1, PRKCI, LAMC1, CDK17, HSPG2, OSBPL8, AGRN, GTF2I, LAMA5, PRKCDBP, MVP, PTRF, PIK3C2B, NDUFB9, TAPBP, TAB1, MAP3K7, ACTL8, PTPN2, HPDL, FAM127A, FAM127C, TMEM223, RECQL, ARMC1, USP32, AGTPBP1, TCOF1, SDF2, ATP5H, FBXL15, DPY30, RNF123, USP40, ELOVL5, ITGAV, YARS2, WARS, MYL1, MYL3, PLEC, BSG, SLC38A5, ABCB7, CCDC132, TMEM201, YIPF5, GBF1, MAP2K4, PHPT1, PTPLB, ERGIC2, ALG1, ACTC1, ACTA1, NFIA, TMEM120A, CDC45, TOR1AIP2, PTPLA, SGPP1, NAA10, TBC1D5, TTF2, SMYD4, SRPRB, CDKN2A, SCD, ANTXR1, CPT1A, DDX19B, KDM3B, MBOAT7, NFX1, NPTN, WDR33, NXPH4, TRAM1, MAPRE2, SLC27A2, MACF1, SLC5A6, CDK7, RBBP8, WBP2, TRIM23, TRAF5, CAV1, WDR81, MAP1LC3B, MAP1LC3C, PIP5K1C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NDUFAF2_UBC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NDUFAF2_UBC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDUFAF2C0752109Brain Diseases, Metabolic, Inborn1CTD_human