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Fusion gene ID: 23849 |
FusionGeneSummary for NDUFAF2_ANKRD31 |
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Fusion gene information | Fusion gene name: NDUFAF2_ANKRD31 | Fusion gene ID: 23849 | Hgene | Tgene | Gene symbol | NDUFAF2 | ANKRD31 | Gene ID | 91942 | 256006 |
Gene name | NADH:ubiquinone oxidoreductase complex assembly factor 2 | ankyrin repeat domain 31 | |
Synonyms | B17.2L|MMTN|NDUFA12L|mimitin | - | |
Cytomap | 5q12.1 | 5q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1 | putative ankyrin repeat domain-containing protein 31ankyrin repeat domain-containing protein 31 | |
Modification date | 20180523 | 20180403 | |
UniProtAcc | Q8N183 | Q8N7Z5 | |
Ensembl transtripts involved in fusion gene | ENST00000296597, ENST00000511107, ENST00000512623, | ENST00000504022, ENST00000274361, ENST00000506364, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 4 X 3=36 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NDUFAF2 [Title/Abstract] AND ANKRD31 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AO-A0JD-01A | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
TCGA | LD | BRCA | TCGA-AO-A0JD-01A | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000296597 | ENST00000504022 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
5CDS-5UTR | ENST00000296597 | ENST00000274361 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
5CDS-5UTR | ENST00000296597 | ENST00000506364 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
5CDS-5UTR | ENST00000511107 | ENST00000504022 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
5CDS-5UTR | ENST00000511107 | ENST00000274361 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
5CDS-5UTR | ENST00000511107 | ENST00000506364 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
intron-5UTR | ENST00000512623 | ENST00000504022 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
intron-5UTR | ENST00000512623 | ENST00000274361 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
intron-5UTR | ENST00000512623 | ENST00000506364 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74380199 | - |
5CDS-5UTR | ENST00000296597 | ENST00000504022 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
5CDS-5UTR | ENST00000296597 | ENST00000274361 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
5CDS-5UTR | ENST00000296597 | ENST00000506364 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
5CDS-5UTR | ENST00000511107 | ENST00000504022 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
5CDS-5UTR | ENST00000511107 | ENST00000274361 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
5CDS-5UTR | ENST00000511107 | ENST00000506364 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
intron-5UTR | ENST00000512623 | ENST00000504022 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
intron-5UTR | ENST00000512623 | ENST00000274361 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
intron-5UTR | ENST00000512623 | ENST00000506364 | NDUFAF2 | chr5 | 60241209 | + | ANKRD31 | chr5 | 74464946 | - |
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FusionProtFeatures for NDUFAF2_ANKRD31 |
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Hgene | Tgene |
NDUFAF2 | ANKRD31 |
Acts as a molecular chaperone for mitochondrial complexI assembly (PubMed:16200211). Complex I functions in the transferof electrons from NADH to the respiratory chain. The immediateelectron acceptor for the enzyme is believed to be ubiquinone(PubMed:16200211, PubMed:27626371). {ECO:0000269|PubMed:16200211,ECO:0000269|PubMed:27626371}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDUFAF2_ANKRD31 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NDUFAF2_ANKRD31 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NDUFAF2 | ACOT13, CDV3, RPS24, RPS26, PPIF, SUGP2, SON, ATXN3, CHST15, COQ9, C15orf48, NDUFA4, PTPMT1, COQ2, CBLN4 | ANKRD31 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDUFAF2_ANKRD31 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDUFAF2_ANKRD31 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NDUFAF2 | C0752109 | Brain Diseases, Metabolic, Inborn | 1 | CTD_human |