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Fusion gene ID: 23837 |
FusionGeneSummary for NDUFA4L2_AVIL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDUFA4L2_AVIL | Fusion gene ID: 23837 | Hgene | Tgene | Gene symbol | NDUFA4L2 | AVIL | Gene ID | 56901 | 10677 |
| Gene name | NDUFA4, mitochondrial complex associated like 2 | advillin | |
| Synonyms | NUOMS | ADVIL|DOC6|p92 | |
| Cytomap | 12q13.3 | 12q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2NADH:ubiquinone oxidoreductase MLRQ subunit homolog | advillin | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9NRX3 | O75366 | |
| Ensembl transtripts involved in fusion gene | ENST00000554503, ENST00000393825, ENST00000556732, ENST00000557276, | ENST00000537081, ENST00000257861, ENST00000550083, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 15 X 10 X 6=900 |
| # samples | 1 | 16 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(16/900*10)=-2.49185309632967 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NDUFA4L2 [Title/Abstract] AND AVIL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-06-0129-01A | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000554503 | ENST00000537081 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| In-frame | ENST00000554503 | ENST00000257861 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| 5CDS-5UTR | ENST00000554503 | ENST00000550083 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| Frame-shift | ENST00000393825 | ENST00000537081 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| Frame-shift | ENST00000393825 | ENST00000257861 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| 5CDS-5UTR | ENST00000393825 | ENST00000550083 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| In-frame | ENST00000556732 | ENST00000537081 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| In-frame | ENST00000556732 | ENST00000257861 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| 5CDS-5UTR | ENST00000556732 | ENST00000550083 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| intron-3CDS | ENST00000557276 | ENST00000537081 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| intron-3CDS | ENST00000557276 | ENST00000257861 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
| intron-5UTR | ENST00000557276 | ENST00000550083 | NDUFA4L2 | chr12 | 57630376 | - | AVIL | chr12 | 58197174 | - |
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FusionProtFeatures for NDUFA4L2_AVIL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDUFA4L2 | AVIL |
| Ca(2+)-regulated actin-binding protein. May have aunique function in the morphogenesis of neuronal cells which formganglia. Required for SREC1-mediated regulation of neurite-likeoutgrowth. Plays a role in regenerative sensory axon outgrowth andremodeling processes after peripheral injury in neonates. Involvedin the formation of long fine actin-containing filopodia-likestructures in fibroblast. Plays a role in ciliogenesis.{ECO:0000269|PubMed:20393563}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 753_819 | 605 | 820 | Domain | HP |
| Tgene | >AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 753_819 | 598 | 813 | Domain | HP |
| Tgene | >AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 731_819 | 605 | 820 | Region | Headpiece |
| Tgene | >AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 731_819 | 598 | 813 | Region | Headpiece |
| Tgene | >AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 628_669 | 605 | 820 | Repeat | Note=Gelsolin-like 6 |
| Tgene | >AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 628_669 | 598 | 813 | Repeat | Note=Gelsolin-like 6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 109_116 | 605 | 820 | Region | Polyphosphoinositide binding |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 135_143 | 605 | 820 | Region | Polyphosphoinositide binding |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 1_731 | 605 | 820 | Region | Core |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 109_116 | 598 | 813 | Region | Polyphosphoinositide binding |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 135_143 | 598 | 813 | Region | Polyphosphoinositide binding |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 1_731 | 598 | 813 | Region | Core |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 145_185 | 605 | 820 | Repeat | Note=Gelsolin-like 2 |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 24_73 | 605 | 820 | Repeat | Note=Gelsolin-like 1 |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 262_306 | 605 | 820 | Repeat | Note=Gelsolin-like 3 |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 403_454 | 605 | 820 | Repeat | Note=Gelsolin-like 4 |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000257861 | - | 13 | 19 | 525_565 | 605 | 820 | Repeat | Note=Gelsolin-like 5 |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 145_185 | 598 | 813 | Repeat | Note=Gelsolin-like 2 |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 24_73 | 598 | 813 | Repeat | Note=Gelsolin-like 1 |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 262_306 | 598 | 813 | Repeat | Note=Gelsolin-like 3 |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 403_454 | 598 | 813 | Repeat | Note=Gelsolin-like 4 |
| Tgene | AVIL | chr12:57630376 | chr12:58197174 | ENST00000537081 | - | 13 | 19 | 525_565 | 598 | 813 | Repeat | Note=Gelsolin-like 5 |
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FusionGeneSequence for NDUFA4L2_AVIL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NDUFA4L2_ENST00000554503_chr12_57630376_-_AVIL_ENST00000537081_chr12_58197174_-_263aa MAGASLGARFYRQIKRHPGIIPMIGLICLGMGSAALYLLRLALRSPDVXLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVM LLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMR >In-frame_NDUFA4L2_ENST00000554503_chr12_57630376_-_AVIL_ENST00000257861_chr12_58197174_-_263aa MAGASLGARFYRQIKRHPGIIPMIGLICLGMGSAALYLLRLALRSPDVXLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVM LLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMR >In-frame_NDUFA4L2_ENST00000556732_chr12_57630376_-_AVIL_ENST00000537081_chr12_58197174_-_263aa MAGASLGARFYRQIKRHPGIIPMIGLICLGMGSAALYLLRLALRSPDVXLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVM LLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMR >In-frame_NDUFA4L2_ENST00000556732_chr12_57630376_-_AVIL_ENST00000257861_chr12_58197174_-_263aa MAGASLGARFYRQIKRHPGIIPMIGLICLGMGSAALYLLRLALRSPDVXLQQEILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVM LLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NDUFA4L2_ENST00000554503_chr12_57630376_-_AVIL_ENST00000537081_chr12_58197174_-_789nt ATGGCAGGAGCCAGTCTTGGGGCCCGCTTCTACCGGCAGATCAAAAGACATCCGGGGATCATCCCGATGATCGGCTTAATCTGCCTGGGC ATGGGCAGCGCTGCGCTTTACTTGCTGCGACTCGCCCTTCGCAGCCCCGACGTCTGACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGT CTCTTTGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGACGTGATG CTCCTAGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAG TACCTGCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGG TTCCTAGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGA ATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAAC CAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACA >In-frame_NDUFA4L2_ENST00000554503_chr12_57630376_-_AVIL_ENST00000257861_chr12_58197174_-_789nt ATGGCAGGAGCCAGTCTTGGGGCCCGCTTCTACCGGCAGATCAAAAGACATCCGGGGATCATCCCGATGATCGGCTTAATCTGCCTGGGC ATGGGCAGCGCTGCGCTTTACTTGCTGCGACTCGCCCTTCGCAGCCCCGACGTCTGACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGT CTCTTTGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGACGTGATG CTCCTAGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAG TACCTGCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGG TTCCTAGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGA ATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAAC CAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACA >In-frame_NDUFA4L2_ENST00000556732_chr12_57630376_-_AVIL_ENST00000537081_chr12_58197174_-_789nt ATGGCAGGAGCCAGTCTTGGGGCCCGCTTCTACCGGCAGATCAAAAGACATCCGGGGATCATCCCGATGATCGGCTTAATCTGCCTGGGC ATGGGCAGCGCTGCGCTTTACTTGCTGCGACTCGCCCTTCGCAGCCCCGACGTCTGACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGT CTCTTTGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGACGTGATG CTCCTAGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAG TACCTGCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGG TTCCTAGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGA ATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAAC CAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACA >In-frame_NDUFA4L2_ENST00000556732_chr12_57630376_-_AVIL_ENST00000257861_chr12_58197174_-_789nt ATGGCAGGAGCCAGTCTTGGGGCCCGCTTCTACCGGCAGATCAAAAGACATCCGGGGATCATCCCGATGATCGGCTTAATCTGCCTGGGC ATGGGCAGCGCTGCGCTTTACTTGCTGCGACTCGCCCTTCGCAGCCCCGACGTCTGACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGT CTCTTTGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGACGTGATG CTCCTAGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAG TACCTGCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGG TTCCTAGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGA ATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAAC CAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NDUFA4L2_ENST00000554503_chr12_57630376_-_AVIL_ENST00000537081_chr12_58197174_-_1542nt CAGGTGCAGACATCTGGAGGAGAGAGTCGGAGAGCAGAAACCACTTGGCTCCCAGACAATTCCCCTACAGGCTTTGGGCCTGGAATTGAG GAGAAAGTGAGCTAAGTTGGGGTGGGGTGAGTCCAAAGAAGCACGGGCTGGGCCAAGCTAAGCTGCTCTGGGCTGGGCTGATCCCTCCCC ACTCAGGGGCGGGACCCCAGGAGGAGGGAGAGGACAGAGCCACTGCAGAGGACCAGACTGGGAAAACAACGATATGGCAGGAGCCAGTCT TGGGGCCCGCTTCTACCGGCAGATCAAAAGACATCCGGGGATCATCCCGATGATCGGCTTAATCTGCCTGGGCATGGGCAGCGCTGCGCT TTACTTGCTGCGACTCGCCCTTCGCAGCCCCGACGTCTGACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGTCTCTTTGAATGTTCCAA TAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGACGTGATGCTCCTAGATACCTGGGA CCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAGTACCTGCACACTCACCC CAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGGTTCCTAGCCTGGGACCC TAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACATGAA GAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCC TGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGC TCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAAGGCCACAGAAAA GAGCAGATAGTGCCAATATCAGGAAATAATTTATCCACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAATAGAGTCTGCAA ATCACGGCATGTTCTCCATTTTTTCTCATCCTTGCATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTTTTGGGTTTTGTG GCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAAACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAACAATGCTTAAAA TGTTTAATAACTTTATGTTTAATATTATACCAGGACCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCTATTTAGCCTGTA AATCATTGAAATCATATATGCACTCCATAGGCAAAATCCAAATACCCAGATCTGTAATGTGTCAAAGCATTTTTCACTTTTCAAATAAAG >In-frame_NDUFA4L2_ENST00000554503_chr12_57630376_-_AVIL_ENST00000257861_chr12_58197174_-_1042nt CAGGTGCAGACATCTGGAGGAGAGAGTCGGAGAGCAGAAACCACTTGGCTCCCAGACAATTCCCCTACAGGCTTTGGGCCTGGAATTGAG GAGAAAGTGAGCTAAGTTGGGGTGGGGTGAGTCCAAAGAAGCACGGGCTGGGCCAAGCTAAGCTGCTCTGGGCTGGGCTGATCCCTCCCC ACTCAGGGGCGGGACCCCAGGAGGAGGGAGAGGACAGAGCCACTGCAGAGGACCAGACTGGGAAAACAACGATATGGCAGGAGCCAGTCT TGGGGCCCGCTTCTACCGGCAGATCAAAAGACATCCGGGGATCATCCCGATGATCGGCTTAATCTGCCTGGGCATGGGCAGCGCTGCGCT TTACTTGCTGCGACTCGCCCTTCGCAGCCCCGACGTCTGACTTCAGCAGGAAATCCTAGATGTCCAGTCTCGTCTCTTTGAATGTTCCAA TAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGACGTGATGCTCCTAGATACCTGGGA CCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGCACAGCAGTACCTGCACACTCACCC CAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCACAGGCTGGTTCCTAGCCTGGGACCC TAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACATGAA GAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCC TGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGC >In-frame_NDUFA4L2_ENST00000556732_chr12_57630376_-_AVIL_ENST00000537081_chr12_58197174_-_1296nt CAACGATATGGCAGGAGCCAGTCTTGGGGCCCGCTTCTACCGGCAGATCAAAAGACATCCGGGGATCATCCCGATGATCGGCTTAATCTG CCTGGGCATGGGCAGCGCTGCGCTTTACTTGCTGCGACTCGCCCTTCGCAGCCCCGACGTCTGACTTCAGCAGGAAATCCTAGATGTCCA GTCTCGTCTCTTTGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGA CGTGATGCTCCTAGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGC ACAGCAGTACCTGCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCAC AGGCTGGTTCCTAGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTAT CATGCGAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTT GAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGG CATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAAAGCAAGAAGGCCTA TACCTATTGCAAGGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATCCACCAATTTCTGCCTGACATTCAGCTACTTA ATTTAGATATAATAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGCATTCCTTGCTTGTTATATACCTAAAATGTTA ACCATATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAAACTGCATAAATCTGGAGAAATCAAAAGAAAG AGAACCAAAAAACAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGACCTACCTTTGTTTTCAATTTTAAGATGATTA TTTCTAAAATCTATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAAATCCAAATACCCAGATCTGTAATGTGTCAAA >In-frame_NDUFA4L2_ENST00000556732_chr12_57630376_-_AVIL_ENST00000257861_chr12_58197174_-_796nt CAACGATATGGCAGGAGCCAGTCTTGGGGCCCGCTTCTACCGGCAGATCAAAAGACATCCGGGGATCATCCCGATGATCGGCTTAATCTG CCTGGGCATGGGCAGCGCTGCGCTTTACTTGCTGCGACTCGCCCTTCGCAGCCCCGACGTCTGACTTCAGCAGGAAATCCTAGATGTCCA GTCTCGTCTCTTTGAATGTTCCAATAAGACCGGCCAATTCGTTGTCACTGAGATCACAGACTTCACCCAGGATGACCTGAACCCTACTGA CGTGATGCTCCTAGATACCTGGGACCAGGTGTTCTTGTGGATTGGGGCTGAGGCCAATGCCACGGAGAAGGAGAGTGCCCTTGCCACAGC ACAGCAGTACCTGCACACTCACCCCAGCGGCCGAGATCCCGACACACCAATCCTGATCATTAAGCAGGGGTTTGAGCCTCCCATCTTCAC AGGCTGGTTCCTAGCCTGGGACCCTAACATTTGGAGTGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTAT CATGCGAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTT GAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGG |
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FusionGenePPI for NDUFA4L2_AVIL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NDUFA4L2 | ANXA9, PARK2, QTRT1, C14orf1, DYNLL1, KAT5, KCNA4, LUC7L2, UBR1, SLC35F6, POTEI, HSP90AA4P, ACTBL2, ACTC1 | AVIL | CRK, RBSN, DDX11, DUS3L, FIGNL1, SCYL1, DOCK7, VIL1, TMOD2, RICTOR, RIPK4, DCTN6, MCM8, THUMPD3, BRIP1, MYO5C, ALMS1, MYO1F, TUBA4A, TUBB8, MYO1B, MYO5A, USP47, C14orf80, TUBB3, DDX11L8, WDR59, BBS1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDUFA4L2_AVIL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDUFA4L2_AVIL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NDUFA4L2 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
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