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Fusion gene ID: 23822 |
FusionGeneSummary for NDUFA10_ANXA4 |
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Fusion gene information | Fusion gene name: NDUFA10_ANXA4 | Fusion gene ID: 23822 | Hgene | Tgene | Gene symbol | NDUFA10 | ANXA4 | Gene ID | 4705 | 307 |
Gene name | NADH:ubiquinone oxidoreductase subunit A10 | annexin A4 | |
Synonyms | CI-42KD|CI-42k | ANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36 | |
Cytomap | 2q37.3 | 2p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialNADH-ubiquinone oxidoreductase 42 kDa subunitcomplex I 42kDa subunit | annexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-indu | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O95299 | P09525 | |
Ensembl transtripts involved in fusion gene | ENST00000252711, ENST00000471378, ENST00000404554, ENST00000307300, ENST00000407129, | ENST00000418066, ENST00000409920, ENST00000394295, ENST00000536030, | |
Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 8 X 3 X 7=168 |
# samples | 8 | 10 | |
** MAII score | log2(8/90*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/168*10)=-0.748461233004036 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NDUFA10 [Title/Abstract] AND ANXA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ANXA4 | GO:0006357 | regulation of transcription by RNA polymerase II | 20237821 |
Tgene | ANXA4 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20237821 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-HR-A2OH-01A | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
TCGA | RV | SKCM | TCGA-HR-A2OH-06A | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000252711 | ENST00000418066 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000252711 | ENST00000409920 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000252711 | ENST00000394295 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000252711 | ENST00000536030 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
intron-3UTR | ENST00000471378 | ENST00000418066 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
intron-5UTR | ENST00000471378 | ENST00000409920 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
intron-5UTR | ENST00000471378 | ENST00000394295 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
intron-5UTR | ENST00000471378 | ENST00000536030 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-3UTR | ENST00000404554 | ENST00000418066 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000404554 | ENST00000409920 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000404554 | ENST00000394295 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000404554 | ENST00000536030 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-3UTR | ENST00000307300 | ENST00000418066 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000307300 | ENST00000409920 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000307300 | ENST00000394295 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
5CDS-5UTR | ENST00000307300 | ENST00000536030 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
intron-3UTR | ENST00000407129 | ENST00000418066 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
intron-5UTR | ENST00000407129 | ENST00000409920 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
intron-5UTR | ENST00000407129 | ENST00000394295 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
intron-5UTR | ENST00000407129 | ENST00000536030 | NDUFA10 | chr2 | 240929491 | - | ANXA4 | chr2 | 70008652 | + |
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FusionProtFeatures for NDUFA10_ANXA4 |
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Hgene | Tgene |
NDUFA10 | ANXA4 |
Accessory subunit of the mitochondrial membranerespiratory chain NADH dehydrogenase (Complex I), that is believednot to be involved in catalysis. Complex I functions in thetransfer of electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to beubiquinone. {ECO:0000269|PubMed:27626371}. | Calcium/phospholipid-binding protein which promotesmembrane fusion and is involved in exocytosis. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDUFA10_ANXA4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NDUFA10_ANXA4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NDUFA10 | BRCC3, MME, NDUFV2, MPV17, SDHB, ABCC2, MDC1, HDAC11, PARK2, LGR4, RNF2, MTIF2, ACAD10, CLUH, KDM1B, DECR1, RNF123, PLXDC2, SIRT3, CLPP, NDUFAF5, SPATA20, RSPRY1, NDUFAF7, DHRS4, BCKDK, PPOX, B3GNT2, NTRK1, COX4I1, COX5B, IMMT, NDUFB7, NDUFA12, NDUFS2, NDUFV1, UQCRB, UQCRQ, NDUFA9, NDUFA11, PLK1, VAPA, GOLT1B, ELMSAN1, NDUFS3, NDUFA4, C15orf48, COX6B1, DCX, NDUFB11, RAB8A, SOAT1 | ANXA4 | NFKB1, H2AFX, UCHL5, SMPD1, NMT2, TINF2, POT1, DNAJB11, ANXA7, MPST, ANXA3, ANXA1, PADI4, EZH2, RAB8A, RHOU, CDH1, SF3A3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDUFA10_ANXA4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDUFA10_ANXA4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ANXA4 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | ANXA4 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | ANXA4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ANXA4 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | ANXA4 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | ANXA4 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | ANXA4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ANXA4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | ANXA4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ANXA4 | C2239176 | Liver carcinoma | 1 | CTD_human |