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Fusion gene ID: 23820 |
FusionGeneSummary for NDST3_ZNF483 |
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Fusion gene information | Fusion gene name: NDST3_ZNF483 | Fusion gene ID: 23820 | Hgene | Tgene | Gene symbol | NDST3 | ZNF483 | Gene ID | 9348 | 158399 |
Gene name | N-deacetylase and N-sulfotransferase 3 | zinc finger protein 483 | |
Synonyms | HSST3 | ZKSCAN16|ZSCAN48 | |
Cytomap | 4q26 | 9q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3GlcNAc N-deacetylase/ N-sulfotransferase 3N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3N-deacetylase/N-sulfotransferase 3N-heparan sulfate sulfotransferase 3glucosaminyl N-dea | zinc finger protein 483zinc finger protein HIT-10zinc finger protein with KRAB and SCAN domains 16 | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | O95803 | Q8TF39 | |
Ensembl transtripts involved in fusion gene | ENST00000296499, ENST00000433996, | ENST00000358151, ENST00000355824, ENST00000309235, ENST00000374374, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 1 X 3=9 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NDST3 [Title/Abstract] AND ZNF483 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NDST3 | GO:0015012 | heparan sulfate proteoglycan biosynthetic process | 9915799 |
Hgene | NDST3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process | 9915799 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | GBM | TCGA-14-0871-01A | NDST3 | chr4 | 119064839 | + | ZNF483 | chr9 | 114338645 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000296499 | ENST00000358151 | NDST3 | chr4 | 119064839 | + | ZNF483 | chr9 | 114338645 | + |
5CDS-intron | ENST00000296499 | ENST00000355824 | NDST3 | chr4 | 119064839 | + | ZNF483 | chr9 | 114338645 | + |
5CDS-intron | ENST00000296499 | ENST00000309235 | NDST3 | chr4 | 119064839 | + | ZNF483 | chr9 | 114338645 | + |
5CDS-intron | ENST00000296499 | ENST00000374374 | NDST3 | chr4 | 119064839 | + | ZNF483 | chr9 | 114338645 | + |
Frame-shift | ENST00000433996 | ENST00000358151 | NDST3 | chr4 | 119064839 | + | ZNF483 | chr9 | 114338645 | + |
5CDS-intron | ENST00000433996 | ENST00000355824 | NDST3 | chr4 | 119064839 | + | ZNF483 | chr9 | 114338645 | + |
5CDS-intron | ENST00000433996 | ENST00000309235 | NDST3 | chr4 | 119064839 | + | ZNF483 | chr9 | 114338645 | + |
5CDS-intron | ENST00000433996 | ENST00000374374 | NDST3 | chr4 | 119064839 | + | ZNF483 | chr9 | 114338645 | + |
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FusionProtFeatures for NDST3_ZNF483 |
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Hgene | Tgene |
NDST3 | ZNF483 |
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of theglycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcAdisaccharide repeating sugar backbone to make N-sulfatedheparosan, a prerequisite substrate for later modifications inheparin biosynthesis. Has high deacetylase activity but lowsulfotransferase activity. {ECO:0000269|PubMed:9915799}. | May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDST3_ZNF483 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NDST3_ZNF483 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NDST3 | ZNF483 | KIAA0368, APP, CBX5, MEOX2, ZNF24, USHBP1, ZNF496, TRIM69, ZSCAN22, ZYG11A, TRIM24, ZKSCAN3, ZKSCAN4, ZNF174, ZNF197, VTN, SCAND1, ZKSCAN1, ZNF446, ZNF445, ZNF397, DGCR8, ZNF18, ZKSCAN8, WDR46, MECP2, CCDC59, ZSCAN25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDST3_ZNF483 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDST3_ZNF483 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NDST3 | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | NDST3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |