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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23820

FusionGeneSummary for NDST3_ZNF483

check button Fusion gene summary
Fusion gene informationFusion gene name: NDST3_ZNF483
Fusion gene ID: 23820
HgeneTgene
Gene symbol

NDST3

ZNF483

Gene ID

9348

158399

Gene nameN-deacetylase and N-sulfotransferase 3zinc finger protein 483
SynonymsHSST3ZKSCAN16|ZSCAN48
Cytomap

4q26

9q31.3

Type of geneprotein-codingprotein-coding
Descriptionbifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3GlcNAc N-deacetylase/ N-sulfotransferase 3N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3N-deacetylase/N-sulfotransferase 3N-heparan sulfate sulfotransferase 3glucosaminyl N-deazinc finger protein 483zinc finger protein HIT-10zinc finger protein with KRAB and SCAN domains 16
Modification date2018032920180523
UniProtAcc

O95803

Q8TF39

Ensembl transtripts involved in fusion geneENST00000296499, ENST00000433996, 
ENST00000358151, ENST00000355824, 
ENST00000309235, ENST00000374374, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 1 X 3=9
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NDST3 [Title/Abstract] AND ZNF483 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNDST3

GO:0015012

heparan sulfate proteoglycan biosynthetic process

9915799

HgeneNDST3

GO:0015014

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

9915799


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-14-0871-01ANDST3chr4

119064839

+ZNF483chr9

114338645

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000296499ENST00000358151NDST3chr4

119064839

+ZNF483chr9

114338645

+
5CDS-intronENST00000296499ENST00000355824NDST3chr4

119064839

+ZNF483chr9

114338645

+
5CDS-intronENST00000296499ENST00000309235NDST3chr4

119064839

+ZNF483chr9

114338645

+
5CDS-intronENST00000296499ENST00000374374NDST3chr4

119064839

+ZNF483chr9

114338645

+
Frame-shiftENST00000433996ENST00000358151NDST3chr4

119064839

+ZNF483chr9

114338645

+
5CDS-intronENST00000433996ENST00000355824NDST3chr4

119064839

+ZNF483chr9

114338645

+
5CDS-intronENST00000433996ENST00000309235NDST3chr4

119064839

+ZNF483chr9

114338645

+
5CDS-intronENST00000433996ENST00000374374NDST3chr4

119064839

+ZNF483chr9

114338645

+

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FusionProtFeatures for NDST3_ZNF483


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDST3

O95803

ZNF483

Q8TF39

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of theglycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcAdisaccharide repeating sugar backbone to make N-sulfatedheparosan, a prerequisite substrate for later modifications inheparin biosynthesis. Has high deacetylase activity but lowsulfotransferase activity. {ECO:0000269|PubMed:9915799}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NDST3_ZNF483


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NDST3_ZNF483


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NDST3ZNF483KIAA0368, APP, CBX5, MEOX2, ZNF24, USHBP1, ZNF496, TRIM69, ZSCAN22, ZYG11A, TRIM24, ZKSCAN3, ZKSCAN4, ZNF174, ZNF197, VTN, SCAND1, ZKSCAN1, ZNF446, ZNF445, ZNF397, DGCR8, ZNF18, ZKSCAN8, WDR46, MECP2, CCDC59, ZSCAN25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NDST3_ZNF483


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NDST3_ZNF483


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDST3C0036341Schizophrenia2PSYGENET
HgeneNDST3C0005586Bipolar Disorder1PSYGENET