![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 23811 |
FusionGeneSummary for NDRG3_CPLX1 |
![]() |
Fusion gene information | Fusion gene name: NDRG3_CPLX1 | Fusion gene ID: 23811 | Hgene | Tgene | Gene symbol | NDRG3 | CPLX1 | Gene ID | 57446 | 10815 |
Gene name | NDRG family member 3 | complexin 1 | |
Synonyms | - | CPX-I|CPX1|EIEE63 | |
Cytomap | 20q11.23 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein NDRG3N-myc downstream-regulated gene 3 protein | complexin-1CPX Icomplexin Isynaphin 2 | |
Modification date | 20180523 | 20180525 | |
UniProtAcc | Q9UGV2 | O14810 | |
Ensembl transtripts involved in fusion gene | ENST00000373803, ENST00000359675, ENST00000349004, ENST00000373773, ENST00000540765, | ENST00000304062, ENST00000505203, | |
Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 4 X 3 X 4=48 |
# samples | 7 | 5 | |
** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NDRG3 [Title/Abstract] AND CPLX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-C9-A47Z-01A | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000373803 | ENST00000304062 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
5UTR-3CDS | ENST00000373803 | ENST00000505203 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
5UTR-3CDS | ENST00000359675 | ENST00000304062 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
5UTR-3CDS | ENST00000359675 | ENST00000505203 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
5UTR-3CDS | ENST00000349004 | ENST00000304062 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
5UTR-3CDS | ENST00000349004 | ENST00000505203 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
intron-3CDS | ENST00000373773 | ENST00000304062 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
intron-3CDS | ENST00000373773 | ENST00000505203 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
5UTR-3CDS | ENST00000540765 | ENST00000304062 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
5UTR-3CDS | ENST00000540765 | ENST00000505203 | NDRG3 | chr20 | 35374448 | - | CPLX1 | chr4 | 786396 | - |
Top |
FusionProtFeatures for NDRG3_CPLX1 |
![]() |
Hgene | Tgene |
NDRG3 | CPLX1 |
Positively regulates a late step in exocytosis ofvarious cytoplasmic vesicles, such as synaptic vesicles and othersecretory vesicles (PubMed:21785414). Organizes the SNAREs into across-linked zigzag topology that, when interposed between thevesicle and plasma membranes, is incompatible with fusion, therebypreventing SNAREs from releasing neurotransmitters until an actionpotential arrives at the synapse (PubMed:21785414). Also involvedin glucose-induced secretion of insulin by pancreatic beta-cells.Essential for motor behavior. {ECO:0000250|UniProtKB:P63040,ECO:0000269|PubMed:21785414}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for NDRG3_CPLX1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for NDRG3_CPLX1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NDRG3 | ELAVL1, LACTB2, LAGE3, CPLX1, PICK1, CSTF1, GARS, NPEPL1, TARDBP, FXYD1, TUSC3, TRIM25 | CPLX1 | STX1A, SNAP25, VAMP2, FLNA, KHSRP, PPIA, SEC24C, STAM, GGA2, TACC3, DPY30, GLO1, NDRG3, PFDN5, S100A9, SGTA, UBE2V2, UBE2B, PSMD9, SNRPA, PSMD2, POMP, TAGLN2, RNF114, TRIP6, HBS1L, HN1, NEDD8, NENF, NUBP2, GINS3, IQCB1, AGTRAP, CMTM5, CPLX2, VAMP3, GYPB |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NDRG3_CPLX1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NDRG3_CPLX1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CPLX1 | C0005586 | Bipolar Disorder | 1 | CTD_human |
Tgene | CPLX1 | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | CPLX1 | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | CPLX1 | C0033975 | Psychotic Disorders | 1 | CTD_human |
Tgene | CPLX1 | C0036341 | Schizophrenia | 1 | CTD_human |