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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23806

FusionGeneSummary for NDRG2_RPL38

check button Fusion gene summary
Fusion gene informationFusion gene name: NDRG2_RPL38
Fusion gene ID: 23806
HgeneTgene
Gene symbol

NDRG2

RPL38

Gene ID

57447

6169

Gene nameNDRG family member 2ribosomal protein L38
SynonymsSYLDL38
Cytomap

14q11.2

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionprotein NDRG2N-myc downstream regulator 2N-myc downstream-regulated gene 2 proteinNDR1-related protein NDR2cytoplasmic protein Ndr1syld709613 protein60S ribosomal protein L38large ribosomal subunit protein eL38
Modification date2018052320180523
UniProtAcc

Q9UN36

P63173

Ensembl transtripts involved in fusion geneENST00000403829, ENST00000298687, 
ENST00000350792, ENST00000397858, 
ENST00000554104, ENST00000555158, 
ENST00000553503, ENST00000397853, 
ENST00000360463, ENST00000556147, 
ENST00000397856, ENST00000397855, 
ENST00000554143, ENST00000397851, 
ENST00000397847, ENST00000298684, 
ENST00000397844, ENST00000554277, 
ENST00000439590, ENST00000311111, 
ENST00000584577, ENST00000534490, 
ENST00000533498, 
Fusion gene scores* DoF score11 X 10 X 2=22010 X 10 X 1=100
# samples 1210
** MAII scorelog2(12/220*10)=-0.874469117916141
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/100*10)=0
Context

PubMed: NDRG2 [Title/Abstract] AND RPL38 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPL38

GO:0002181

cytoplasmic translation

25957688


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CK004088NDRG2chr14

21486161

-RPL38chr17

72200288

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000403829ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000403829ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000403829ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000403829ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000403829ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298687ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000350792ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397858ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554104ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000555158ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000553503ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397853ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000360463ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000556147ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397856ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397855ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554143ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397851ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397847ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000298684ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000397844ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000439590NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000311111NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000584577NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000534490NDRG2chr14

21486161

-RPL38chr17

72200288

+
intron-3CDSENST00000554277ENST00000533498NDRG2chr14

21486161

-RPL38chr17

72200288

+

Top

FusionProtFeatures for NDRG2_RPL38


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDRG2

Q9UN36

RPL38

P63173


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NDRG2_RPL38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NDRG2_RPL38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NDRG2_RPL38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NDRG2_RPL38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDRG2C0007787Transient Ischemic Attack1CTD_human
HgeneNDRG2C0009375Colonic Neoplasms1CTD_human
HgeneNDRG2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNDRG2C0086543Cataract1CTD_human