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Fusion gene ID: 23778 |
FusionGeneSummary for NDFIP1_NDUFAF2 |
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Fusion gene information | Fusion gene name: NDFIP1_NDUFAF2 | Fusion gene ID: 23778 | Hgene | Tgene | Gene symbol | NDFIP1 | NDUFAF2 | Gene ID | 80762 | 91942 |
Gene name | Nedd4 family interacting protein 1 | NADH:ubiquinone oxidoreductase complex assembly factor 2 | |
Synonyms | N4WBP5 | B17.2L|MMTN|NDUFA12L|mimitin | |
Cytomap | 5q31.3 | 5q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | NEDD4 family-interacting protein 1Nedd4 WW domain-binding protein 5breast cancer-associated protein SGA-1Mputative MAPK-activating protein PM13putative NF-kappa-B-activating protein 164putative NFKB and MAPK-activating protein | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9BT67 | Q8N183 | |
Ensembl transtripts involved in fusion gene | ENST00000253814, ENST00000509436, | ENST00000296597, ENST00000511107, ENST00000512623, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 6 X 4 X 3=72 |
# samples | 3 | 6 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NDFIP1 [Title/Abstract] AND NDUFAF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NDFIP1 | GO:0031398 | positive regulation of protein ubiquitination | 25631046 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A7-A56D-01A | NDFIP1 | chr5 | 141524241 | + | NDUFAF2 | chr5 | 60448531 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000253814 | ENST00000296597 | NDFIP1 | chr5 | 141524241 | + | NDUFAF2 | chr5 | 60448531 | + |
3UTR-3UTR | ENST00000253814 | ENST00000511107 | NDFIP1 | chr5 | 141524241 | + | NDUFAF2 | chr5 | 60448531 | + |
3UTR-3UTR | ENST00000253814 | ENST00000512623 | NDFIP1 | chr5 | 141524241 | + | NDUFAF2 | chr5 | 60448531 | + |
intron-3CDS | ENST00000509436 | ENST00000296597 | NDFIP1 | chr5 | 141524241 | + | NDUFAF2 | chr5 | 60448531 | + |
intron-3UTR | ENST00000509436 | ENST00000511107 | NDFIP1 | chr5 | 141524241 | + | NDUFAF2 | chr5 | 60448531 | + |
intron-3UTR | ENST00000509436 | ENST00000512623 | NDFIP1 | chr5 | 141524241 | + | NDUFAF2 | chr5 | 60448531 | + |
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FusionProtFeatures for NDFIP1_NDUFAF2 |
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Hgene | Tgene |
NDFIP1 | NDUFAF2 |
Activates HECT domain-containing E3 ubiquitin-proteinligases, including NEDD4 and ITCH, and consequently modulates thestability of their targets. As a result, controls many cellularprocesses. Prevents chronic T-helper cell-mediated inflammation byactivating ITCH and thus controlling JUNB degradation (Bysimilarity). Promotes pancreatic beta cell death throughdegradation of JUNB and inhibition of the unfolded proteinresponse, leading to reduction of insulin secretion(PubMed:26319551). Restricts the production of proinflammatorycytokines in effector Th17 T-cells by promoting ITCH-mediatedubiquitination and degradation of RORC (By similarity). Togetherwith NDFIP2, limits the cytokine signaling and expansion ofeffector Th2 T-cells by promoting degradation of JAK1, probably byITCH- and NEDD4L-mediated ubiquitination (By similarity).Regulates peripheral T-cell tolerance to self and foreignantigens, forcing the exit of naive CD4+ T-cells from the cellcycle before they become effector T-cells (By similarity).Negatively regulates RLR-mediated antiviral response by promotingSMURF1-mediated ubiquitination and subsequent degradation of MAVS(PubMed:23087404). Negatively regulates KCNH2 potassium channelactivity by decreasing its cell-surface expression and interferingwith channel maturation through recruitment of NEDD4L to the Golgiapparatus where it mediates KCNH2 degradation (PubMed:26363003).In cortical neurons, mediates the ubiquitination of the divalentmetal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and irontoxicity (PubMed:19706893). Important for normal development ofdendrites and dendritic spines in cortex (By similarity). Enhancesthe ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCHand is required for the nuclear localization of ubiquitinatedBRAT1 (PubMed:25631046). Enhances the ITCH-mediated ubiquitinationof MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 toITCH (By similarity). Modulates EGFR signaling through multiplepathways. In particular, may regulate the ratio of AKT1-to-MAPK8signaling in response to EGF, acting on AKT1 probably through PTENdestabilization and on MAPK8 through ITCH-dependent MAP2K4inactivation. As a result, may control cell growth rate(PubMed:20534535). Inhibits cell proliferation by promoting PTENnuclear localization and changing its signaling specificity(PubMed:25801959). {ECO:0000250|UniProtKB:Q8R0W6,ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:19706893,ECO:0000269|PubMed:20534535, ECO:0000269|PubMed:23087404,ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:25801959,ECO:0000269|PubMed:26319551, ECO:0000269|PubMed:26363003}. | Acts as a molecular chaperone for mitochondrial complexI assembly (PubMed:16200211). Complex I functions in the transferof electrons from NADH to the respiratory chain. The immediateelectron acceptor for the enzyme is believed to be ubiquinone(PubMed:16200211, PubMed:27626371). {ECO:0000269|PubMed:16200211,ECO:0000269|PubMed:27626371}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NDFIP1_NDUFAF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NDFIP1_NDUFAF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NDFIP1 | SLC11A2, PTEN, EGFR, NEDD4L, MAVS, SMURF1, PRRG3, TSPAN3, TMEM231, TGFBR2, TEX29, GINM1, WWP2, PTGFR, ZDHHC7, TNFRSF10B, HEPACAM2, OPN4, IQCF3, TMEM92, UNK, MAP3K7, ITCH, UBE2L3, NEDD4, SNCA, SLC1A1, MANSC1, LRRIQ1, MRAP2, C16orf58, IFNGR1, SLC20A1, ENTPD7, C14orf37, TPCN2, DRD2, CD83, IZUMO1, FAM8A1 | NDUFAF2 | ACOT13, CDV3, RPS24, RPS26, PPIF, SUGP2, SON, ATXN3, CHST15, COQ9, C15orf48, NDUFA4, PTPMT1, COQ2, CBLN4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDFIP1_NDUFAF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDFIP1_NDUFAF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NDUFAF2 | C0752109 | Brain Diseases, Metabolic, Inborn | 1 | CTD_human |