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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23776

FusionGeneSummary for NDEL1_WSCD1

check button Fusion gene summary
Fusion gene informationFusion gene name: NDEL1_WSCD1
Fusion gene ID: 23776
HgeneTgene
Gene symbol

NDEL1

WSCD1

Gene ID

81565

23302

Gene namenudE neurodevelopment protein 1 like 1WSC domain containing 1
SynonymsEOPA|MITAP1|NDE1L1|NDE2|NUDEL-
Cytomap

17p13.1

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear distribution protein nudE-like 1endooligopeptidase Amitosin-associated protein 1mitosin-associated protein MITAP1nudE nuclear distribution E homolog-like 1nudE nuclear distribution gene E homolog-like 1protein NudelWSC domain-containing protein 1
Modification date2018052320180403
UniProtAcc

Q9GZM8

Q658N2

Ensembl transtripts involved in fusion geneENST00000334527, ENST00000299734, 
ENST00000585098, ENST00000380025, 
ENST00000402554, ENST00000583066, 
ENST00000563763, ENST00000574946, 
ENST00000573634, ENST00000317744, 
ENST00000574232, ENST00000539421, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 3 X 3=27
# samples 53
** MAII scorelog2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NDEL1 [Title/Abstract] AND WSCD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-B0-4694-01ANDEL1chr17

8363478

+WSCD1chr17

5998422

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334527ENST00000563763NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000334527ENST00000574946NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000334527ENST00000573634NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000334527ENST00000317744NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000334527ENST00000574232NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000334527ENST00000539421NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000299734ENST00000563763NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000299734ENST00000574946NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000299734ENST00000573634NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000299734ENST00000317744NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000299734ENST00000574232NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000299734ENST00000539421NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000585098ENST00000563763NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000585098ENST00000574946NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000585098ENST00000573634NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000585098ENST00000317744NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000585098ENST00000574232NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000585098ENST00000539421NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000380025ENST00000563763NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000380025ENST00000574946NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000380025ENST00000573634NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000380025ENST00000317744NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000380025ENST00000574232NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000380025ENST00000539421NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000402554ENST00000563763NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000402554ENST00000574946NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000402554ENST00000573634NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000402554ENST00000317744NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000402554ENST00000574232NDEL1chr17

8363478

+WSCD1chr17

5998422

+
5CDS-intronENST00000402554ENST00000539421NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000583066ENST00000563763NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000583066ENST00000574946NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000583066ENST00000573634NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000583066ENST00000317744NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000583066ENST00000574232NDEL1chr17

8363478

+WSCD1chr17

5998422

+
intron-intronENST00000583066ENST00000539421NDEL1chr17

8363478

+WSCD1chr17

5998422

+

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FusionProtFeatures for NDEL1_WSCD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDEL1

Q9GZM8

WSCD1

Q658N2

Required for organization of the cellular microtubulearray and microtubule anchoring at the centrosome. May regulatemicrotubule organization at least in part by targeting themicrotubule severing protein KATNA1 to the centrosome. Alsopositively regulates the activity of the minus-end directedmicrotubule motor protein dynein. May enhance dynein-mediatedmicrotubule sliding by targeting dynein to the microtubule plusends. Required for several dynein- and microtubule-dependentprocesses such as the maintenance of Golgi integrity, thecentripetal motion of secretory vesicles and the coupling of thenucleus and centrosome. Also required during brain development forthe migration of newly formed neurons from theventricular/subventricular zone toward the cortical plate. Plays arole, together with DISC1, in the regulation of neurite outgrowth.Required for mitosis in some cell types but appears to bedispensible for mitosis in cortical neuronal progenitors, whichinstead requires NDE1. Facilitates the polymerization ofneurofilaments from the individual subunits NEFH and NEFL.Positively regulates lysosome peripheral distribution and ruffledborder formation in osteoclasts (By similarity).{ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484,ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865,ECO:0000269|PubMed:17600710}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NDEL1_WSCD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NDEL1_WSCD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NDEL1MBIP, MAGEA11, DISC1, YWHAE, PAFAH1B1, DYNC1H1, CDK5, LMNB1, TACC3, YWHAG, IMMT, CCDC88A, CENPF, CEP170, CEP63, KALRN, ZNF197, ANK2, CCSER1, SYNE1, LUC7L2, CCSER2, MLLT10, DIXDC1, ZNF10, SNX6, MRC2, ZNF17, ZNF211, ZNF230, ZNF91, MIS18A, DCTN2, TUBG1, TUBA1A, KATNA1, KATNB1, APP, NDE1, BMI1, DTNB, GOLGA2, KIFC3, PKP2, TRIM27, XPA, ZNF180, AIMP2, USP2, ZNF264, SNAPC5, NDC80, MTUS2, ZNF544, CCHCR1, ZNF490, TRAF3IP3, NDEL1, KRT40, ZNF572, CWF19L2, ZNF417, ZNF599, ZNF844, ZNF260, CCDC183, SNAP29, C17orf59, SCARA3, NAP1L5, DYNC1I1, SSX2IP, CEP152, CEP128, CEP135, NINL, DYNLT1, CTR9, KIF20B, GRIPAP1, ANKRD26, NUP54, UTRN, SNTB1, FBXW5, SNTB2, SNTA1, ZNF445, MTCL1, CLPX, CCDC18, SLC25A43, KIAA1598, BCAS2, KTN1, OFD1, TRIM7, TRIOBP, RPS6KA3, EVI5, PRPF19, PTPN14, PAFAH1B2WSCD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NDEL1_WSCD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NDEL1_WSCD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDEL1C0036341Schizophrenia4PSYGENET
HgeneNDEL1C0033975Psychotic Disorders2PSYGENET
HgeneNDEL1C0349204Nonorganic psychosis1PSYGENET
HgeneNDEL1C3495559Juvenile arthritis1CTD_human
TgeneWSCD1C0023903Liver neoplasms1CTD_human
TgeneWSCD1C0032927Precancerous Conditions1CTD_human