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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23769

FusionGeneSummary for NDE1_REG3A

check button Fusion gene summary
Fusion gene informationFusion gene name: NDE1_REG3A
Fusion gene ID: 23769
HgeneTgene
Gene symbol

NDE1

REG3A

Gene ID

54820

5068

Gene namenudE neurodevelopment protein 1regenerating family member 3 alpha
SynonymsHOM-TES-87|LIS4|MHAC|NDE|NUDE|NUDE1HIP|HIP/PAP|INGAP|PAP|PAP-H|PAP1|PBCGF|REG-III|REG3
Cytomap

16p13.11

2p12

Type of geneprotein-codingprotein-coding
Descriptionnuclear distribution protein nudE homolog 1LIS1-interacting protein NUDE1, rat homolognudE nuclear distribution E homolog 1nudE nuclear distribution gene E homolog 1regenerating islet-derived protein 3-alphaPAP homologous proteinREG-3-alphahepatocarcinoma-intestine-pancreashepatointestinal pancreatic proteinhuman proislet peptidepancreatic beta cell growth factorpancreatitis-associated protein 1proliferation-
Modification date2018052320180523
UniProtAcc

Q9NXR1

Q06141

Ensembl transtripts involved in fusion geneENST00000396353, ENST00000396355, 
ENST00000396354, ENST00000342673, 
ENST00000571896, 
ENST00000409839, 
ENST00000393878, ENST00000305165, 
Fusion gene scores* DoF score7 X 8 X 1=564 X 4 X 2=32
# samples 103
** MAII scorelog2(10/56*10)=0.836501267717121
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/32*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDE1 [Title/Abstract] AND REG3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA494454NDE1chr16

15797411

+REG3Achr2

79386879

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000396353ENST00000409839NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000396353ENST00000393878NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000396353ENST00000305165NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-3CDSENST00000396355ENST00000409839NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000396355ENST00000393878NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000396355ENST00000305165NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-3CDSENST00000396354ENST00000409839NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000396354ENST00000393878NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000396354ENST00000305165NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-3CDSENST00000342673ENST00000409839NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000342673ENST00000393878NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000342673ENST00000305165NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-3CDSENST00000571896ENST00000409839NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000571896ENST00000393878NDE1chr16

15797411

+REG3Achr2

79386879

-
intron-intronENST00000571896ENST00000305165NDE1chr16

15797411

+REG3Achr2

79386879

-

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FusionProtFeatures for NDE1_REG3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDE1

Q9NXR1

REG3A

Q06141

Required for centrosome duplication and formation andfunction of the mitotic spindle. Essential for the development ofthe cerebral cortex. May regulate the production of neurons bycontrolling the orientation of the mitotic spindle during divisionof cortical neuronal progenitors of the proliferative ventricularzone of the brain. Orientation of the division plane perpendicularto the layers of the cortex gives rise to two proliferativeneuronal progenitors whereas parallel orientation of the divisionplane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate withinthe progenitor population may result in an overall reduction inthe final number of neurons and an increase in the number ofneurons in the deeper layers of the cortex.{ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:21529752}. Bactericidal C-type lectin which acts exclusivelyagainst Gram-positive bacteria and mediates bacterial killing bybinding to surface-exposed carbohydrate moieties of peptidoglycan.Regulates keratinocyte proliferation and differentiation afterskin injury via activation of EXTL3-PI3K-AKT signaling pathway.{ECO:0000269|PubMed:16931762}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NDE1_REG3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NDE1_REG3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NDE1_REG3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NDE1_REG3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNDE1C0036341Schizophrenia4PSYGENET
HgeneNDE1C0033975Psychotic Disorders1PSYGENET
HgeneNDE1C0349204Nonorganic psychosis1PSYGENET