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Fusion gene ID: 23762 |
FusionGeneSummary for NDC80_PPP4R1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDC80_PPP4R1 | Fusion gene ID: 23762 | Hgene | Tgene | Gene symbol | NDC80 | PPP4R1 | Gene ID | 10403 | 9989 |
| Gene name | NDC80, kinetochore complex component | protein phosphatase 4 regulatory subunit 1 | |
| Synonyms | HEC|HEC1|HsHec1|KNTC2|TID3|hsNDC80 | MEG1|PP4(Rmeg)|PP4R1 | |
| Cytomap | 18p11.32 | 18p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinetochore protein NDC80 homologNDC80 homolog, kinetochore complex componentNDC80 kinetochore complex component homologhighly expressed in cancer proteinhighly expressed in cancer, rich in leucine heptad repeatskinetochore associated 2kinetochore p | serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O14777 | Q8TF05 | |
| Ensembl transtripts involved in fusion gene | ENST00000261597, | ENST00000400556, ENST00000400555, ENST00000580583, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 8 X 7 X 5=280 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NDC80 [Title/Abstract] AND PPP4R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-G2-AA3D-01A | NDC80 | chr18 | 2579028 | + | PPP4R1 | chr18 | 9562073 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261597 | ENST00000400556 | NDC80 | chr18 | 2579028 | + | PPP4R1 | chr18 | 9562073 | - |
| In-frame | ENST00000261597 | ENST00000400555 | NDC80 | chr18 | 2579028 | + | PPP4R1 | chr18 | 9562073 | - |
| 5CDS-intron | ENST00000261597 | ENST00000580583 | NDC80 | chr18 | 2579028 | + | PPP4R1 | chr18 | 9562073 | - |
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FusionProtFeatures for NDC80_PPP4R1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDC80 | PPP4R1 |
| Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosomesegregation and spindle checkpoint activity (PubMed:9315664,PubMed:12351790, PubMed:14654001, PubMed:14699129,PubMed:15062103, PubMed:15235793, PubMed:15239953,PubMed:15548592, PubMed:16732327). Required for kinetochoreintegrity and the organization of stable microtubule binding sitesin the outer plate of the kinetochore (PubMed:15548592). The NDC80complex synergistically enhances the affinity of the SKA1 complexfor microtubules and may allow the NDC80 complex to trackdepolymerizing microtubules (PubMed:23085020). Plays a role inchromosome congression and is essential for the end-on attachmentof the kinetochores to spindle microtubules (PubMed:25743205,PubMed:23891108). {ECO:0000269|PubMed:12351790,ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129,ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793,ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592,ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020,ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205,ECO:0000269|PubMed:9315664}. | Regulatory subunit of serine/threonine-proteinphosphatase 4. May play a role in regulation of cell division inrenal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role indephosphorylation and regulation of HDAC3.{ECO:0000269|PubMed:15805470}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 568_606 | 565 | 934 | Repeat | Note=HEAT 11 |
| Tgene | >PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 698_734 | 565 | 934 | Repeat | Note=HEAT 12 |
| Tgene | >PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 799_837 | 565 | 934 | Repeat | Note=HEAT 13 |
| Tgene | >PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 861_898 | 565 | 934 | Repeat | Note=HEAT 14 |
| Tgene | >PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 698_734 | 582 | 951 | Repeat | Note=HEAT 12 |
| Tgene | >PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 799_837 | 582 | 951 | Repeat | Note=HEAT 13 |
| Tgene | >PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 861_898 | 582 | 951 | Repeat | Note=HEAT 14 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NDC80 | chr18:2579028 | chr18:9562073 | ENST00000261597 | + | 6 | 17 | 261_403 | 193 | 643 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NDC80 | chr18:2579028 | chr18:9562073 | ENST00000261597 | + | 6 | 17 | 458_642 | 193 | 643 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NDC80 | chr18:2579028 | chr18:9562073 | ENST00000261597 | + | 6 | 17 | 1_250 | 193 | 643 | Region | Note=Nuclear localization |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 127_164 | 565 | 934 | Repeat | Note=HEAT 5 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 168_206 | 565 | 934 | Repeat | Note=HEAT 6 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 1_25 | 565 | 934 | Repeat | Note=HEAT 1 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 208_246 | 565 | 934 | Repeat | Note=HEAT 7 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 248_285 | 565 | 934 | Repeat | Note=HEAT 8 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 26_63 | 565 | 934 | Repeat | Note=HEAT 2 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 287_324 | 565 | 934 | Repeat | Note=HEAT 9 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 505_542 | 565 | 934 | Repeat | Note=HEAT 10 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 65_81 | 565 | 934 | Repeat | Note=HEAT 3 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400555 | - | 11 | 20 | 82_119 | 565 | 934 | Repeat | Note=HEAT 4 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 127_164 | 582 | 951 | Repeat | Note=HEAT 5 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 168_206 | 582 | 951 | Repeat | Note=HEAT 6 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 1_25 | 582 | 951 | Repeat | Note=HEAT 1 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 208_246 | 582 | 951 | Repeat | Note=HEAT 7 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 248_285 | 582 | 951 | Repeat | Note=HEAT 8 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 26_63 | 582 | 951 | Repeat | Note=HEAT 2 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 287_324 | 582 | 951 | Repeat | Note=HEAT 9 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 505_542 | 582 | 951 | Repeat | Note=HEAT 10 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 568_606 | 582 | 951 | Repeat | Note=HEAT 11 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 65_81 | 582 | 951 | Repeat | Note=HEAT 3 |
| Tgene | PPP4R1 | chr18:2579028 | chr18:9562073 | ENST00000400556 | - | 11 | 20 | 82_119 | 582 | 951 | Repeat | Note=HEAT 4 |
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FusionGeneSequence for NDC80_PPP4R1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NDC80_ENST00000261597_chr18_2579028_+_PPP4R1_ENST00000400556_chr18_9562073_-_562aa MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKRTSGHGSRNSQLGIFSSSEKIKDPRPLNDKA FIQQCIRQLCEFLTENGYAHNVSMKSLQAPSVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPH IVAALVWLIDCIKNMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQ NWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLV TDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWS GRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFA >In-frame_NDC80_ENST00000261597_chr18_2579028_+_PPP4R1_ENST00000400555_chr18_9562073_-_562aa MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKRTSGHGSRNSQLGIFSSSEKIKDPRPLNDKA FIQQCIRQLCEFLTENGYAHNVSMKSLQAPSVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPH IVAALVWLIDCIKNMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQ NWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLV TDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWS GRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NDC80_ENST00000261597_chr18_2579028_+_PPP4R1_ENST00000400556_chr18_9562073_-_1686nt ATGAAGCGCAGTTCAGTTTCCAGCGGTGGTGCTGGCCGCCTCTCCATGCAGGAGTTAAGATCCCAGGATGTAAATAAACAAGGCCTCTAT ACCCCTCAAACCAAAGAGAAACCAACCTTTGGAAAGTTGAGTATAAACAAACCGACATCTGAAAGAAAAGTCTCGCTATTTGGCAAAAGA ACTAGTGGACATGGATCCCGGAATAGTCAACTTGGTATATTTTCCAGTTCTGAGAAAATCAAGGACCCGAGACCACTTAATGACAAAGCA TTCATTCAGCAGTGTATTCGACAACTCTGTGAGTTTCTTACAGAAAATGGTTATGCACATAATGTGTCCATGAAATCTCTACAAGCTCCC TCTGTTAAAGACTTCCTGAAGATCTTCACATTTCTTTATGGCTTCCTGTGCCCCTCATACGAACTTCCTGACACAAAGTTTGAAGAAGAG GTTCCAAGAATCTTTAAAGACCTTGGGTATCCTTTTGCACTATCCAAAAGCTCCATGTACACAGTGGGGGCTCCTCATACATGGCCTCAC ATTGTGGCAGCCTTAGTTTGGCTAATAGACTGCATCAAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCAAC AATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAGATGTTGTACCTCAGGCGTTGTTAGATCAGTATTTATCTATGACT GACCCTTCTCGTGCACAGACGGTTGACACTGAAATTGCTAAGCACTGTGCATATAGCCTCCCTGGTGTGGCCTTGACACTCGGAAGACAG AATTGGCACTGCCTGAGAGAGACGTATGAGACTCTGGCCTCAGACATGCAGTGGAAAGTTCGACGAACTCTAGCATTCTCCATCCACGAG CTTGCAGTTATTCTTGGAGATCAATTGACAGCTGCAGATCTGGTTCCAATTTTTAATGGATTTTTAAAAGACCTCGATGAAGTCAGGATA GGTGTTCTTAAACACTTGCATGATTTTCTGAAGCTTCTTCATATTGACAAAAGAAGAGAATATCTTTATCAACTTCAGGAGTTTTTGGTG ACAGATAATAGTAGAAATTGGCGGTTTCGAGCTGAACTGGCTGAACAGCTGATTTTACTTCTAGAGTTATATAGTCCCAGAGATGTTTAT GACTATTTACGTCCCATTGCTCTGAATCTGTGTGCAGACAAAGTTTCTTCTGTTCGTTGGATTTCCTACAAGTTGGTCAGCGAGATGGTG AAGAAGCTGCACGCGGCAACACCACCAACGTTCGGAGTGGACCTCATCAATGAGCTTGTGGAGAACTTTGGCAGATGTCCCAAGTGGTCT GGTCGGCAAGCCTTTGTCTTTGTCTGCCAGACTGTCATTGAGGATGACTGCCTTCCCATGGACCAGTTTGCTGTGCATCTCATGCCGCAT CTGCTAACCTTAGCAAATGACAGGGTTCCTAACGTGCGAGTGCTGCTTGCAAAGACATTAAGACAAACTCTACTAGAAAAAGACTATTTC TTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCA >In-frame_NDC80_ENST00000261597_chr18_2579028_+_PPP4R1_ENST00000400555_chr18_9562073_-_1686nt ATGAAGCGCAGTTCAGTTTCCAGCGGTGGTGCTGGCCGCCTCTCCATGCAGGAGTTAAGATCCCAGGATGTAAATAAACAAGGCCTCTAT ACCCCTCAAACCAAAGAGAAACCAACCTTTGGAAAGTTGAGTATAAACAAACCGACATCTGAAAGAAAAGTCTCGCTATTTGGCAAAAGA ACTAGTGGACATGGATCCCGGAATAGTCAACTTGGTATATTTTCCAGTTCTGAGAAAATCAAGGACCCGAGACCACTTAATGACAAAGCA TTCATTCAGCAGTGTATTCGACAACTCTGTGAGTTTCTTACAGAAAATGGTTATGCACATAATGTGTCCATGAAATCTCTACAAGCTCCC TCTGTTAAAGACTTCCTGAAGATCTTCACATTTCTTTATGGCTTCCTGTGCCCCTCATACGAACTTCCTGACACAAAGTTTGAAGAAGAG GTTCCAAGAATCTTTAAAGACCTTGGGTATCCTTTTGCACTATCCAAAAGCTCCATGTACACAGTGGGGGCTCCTCATACATGGCCTCAC ATTGTGGCAGCCTTAGTTTGGCTAATAGACTGCATCAAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCAAC AATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAGATGTTGTACCTCAGGCGTTGTTAGATCAGTATTTATCTATGACT GACCCTTCTCGTGCACAGACGGTTGACACTGAAATTGCTAAGCACTGTGCATATAGCCTCCCTGGTGTGGCCTTGACACTCGGAAGACAG AATTGGCACTGCCTGAGAGAGACGTATGAGACTCTGGCCTCAGACATGCAGTGGAAAGTTCGACGAACTCTAGCATTCTCCATCCACGAG CTTGCAGTTATTCTTGGAGATCAATTGACAGCTGCAGATCTGGTTCCAATTTTTAATGGATTTTTAAAAGACCTCGATGAAGTCAGGATA GGTGTTCTTAAACACTTGCATGATTTTCTGAAGCTTCTTCATATTGACAAAAGAAGAGAATATCTTTATCAACTTCAGGAGTTTTTGGTG ACAGATAATAGTAGAAATTGGCGGTTTCGAGCTGAACTGGCTGAACAGCTGATTTTACTTCTAGAGTTATATAGTCCCAGAGATGTTTAT GACTATTTACGTCCCATTGCTCTGAATCTGTGTGCAGACAAAGTTTCTTCTGTTCGTTGGATTTCCTACAAGTTGGTCAGCGAGATGGTG AAGAAGCTGCACGCGGCAACACCACCAACGTTCGGAGTGGACCTCATCAATGAGCTTGTGGAGAACTTTGGCAGATGTCCCAAGTGGTCT GGTCGGCAAGCCTTTGTCTTTGTCTGCCAGACTGTCATTGAGGATGACTGCCTTCCCATGGACCAGTTTGCTGTGCATCTCATGCCGCAT CTGCTAACCTTAGCAAATGACAGGGTTCCTAACGTGCGAGTGCTGCTTGCAAAGACATTAAGACAAACTCTACTAGAAAAAGACTATTTC TTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NDC80_ENST00000261597_chr18_2579028_+_PPP4R1_ENST00000400556_chr18_9562073_-_2866nt ACTGCGCGCGTCGTGCGTAATGACGTCAGCGCCGGCGGAGAATTTCAAATTCGAACGGCTTTGGCGGGCCGAGGAAGGACCTGGTGTTTT GATGACCGCTGTCCTGTCTAGCAGATACTTGCACGGTTTACAGAAATTCGGTCCCTGGGTCGTGTCAGGAAACTGGAAAAAAGGTCATAA GCATGAAGCGCAGTTCAGTTTCCAGCGGTGGTGCTGGCCGCCTCTCCATGCAGGAGTTAAGATCCCAGGATGTAAATAAACAAGGCCTCT ATACCCCTCAAACCAAAGAGAAACCAACCTTTGGAAAGTTGAGTATAAACAAACCGACATCTGAAAGAAAAGTCTCGCTATTTGGCAAAA GAACTAGTGGACATGGATCCCGGAATAGTCAACTTGGTATATTTTCCAGTTCTGAGAAAATCAAGGACCCGAGACCACTTAATGACAAAG CATTCATTCAGCAGTGTATTCGACAACTCTGTGAGTTTCTTACAGAAAATGGTTATGCACATAATGTGTCCATGAAATCTCTACAAGCTC CCTCTGTTAAAGACTTCCTGAAGATCTTCACATTTCTTTATGGCTTCCTGTGCCCCTCATACGAACTTCCTGACACAAAGTTTGAAGAAG AGGTTCCAAGAATCTTTAAAGACCTTGGGTATCCTTTTGCACTATCCAAAAGCTCCATGTACACAGTGGGGGCTCCTCATACATGGCCTC ACATTGTGGCAGCCTTAGTTTGGCTAATAGACTGCATCAAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCA ACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAGATGTTGTACCTCAGGCGTTGTTAGATCAGTATTTATCTATGA CTGACCCTTCTCGTGCACAGACGGTTGACACTGAAATTGCTAAGCACTGTGCATATAGCCTCCCTGGTGTGGCCTTGACACTCGGAAGAC AGAATTGGCACTGCCTGAGAGAGACGTATGAGACTCTGGCCTCAGACATGCAGTGGAAAGTTCGACGAACTCTAGCATTCTCCATCCACG AGCTTGCAGTTATTCTTGGAGATCAATTGACAGCTGCAGATCTGGTTCCAATTTTTAATGGATTTTTAAAAGACCTCGATGAAGTCAGGA TAGGTGTTCTTAAACACTTGCATGATTTTCTGAAGCTTCTTCATATTGACAAAAGAAGAGAATATCTTTATCAACTTCAGGAGTTTTTGG TGACAGATAATAGTAGAAATTGGCGGTTTCGAGCTGAACTGGCTGAACAGCTGATTTTACTTCTAGAGTTATATAGTCCCAGAGATGTTT ATGACTATTTACGTCCCATTGCTCTGAATCTGTGTGCAGACAAAGTTTCTTCTGTTCGTTGGATTTCCTACAAGTTGGTCAGCGAGATGG TGAAGAAGCTGCACGCGGCAACACCACCAACGTTCGGAGTGGACCTCATCAATGAGCTTGTGGAGAACTTTGGCAGATGTCCCAAGTGGT CTGGTCGGCAAGCCTTTGTCTTTGTCTGCCAGACTGTCATTGAGGATGACTGCCTTCCCATGGACCAGTTTGCTGTGCATCTCATGCCGC ATCTGCTAACCTTAGCAAATGACAGGGTTCCTAACGTGCGAGTGCTGCTTGCAAAGACATTAAGACAAACTCTACTAGAAAAAGACTATT TCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTG CAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGAGCACAGCGTCCTCAACCTACTAGAAGGCTTGAATCTCGGTGTCTT TCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCATGTGACCTGGGATAGCTTTCGGGGGAGGAGAGACCTTCCTCTCCT GCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGGATTTCAAGAGTCAAGAGAAAGTACAGTAAACACTATTATCTTATC TTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCACCGAAGCCTTAAATCCTTCTGTCTTCCTGACTGAATGAAACTTGAA TTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGACCTGCATTGCTTTCTCCTGGTTTTATTTAACAATCGACAAATGAAA TTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGACCTTCAGTATCAGCCCTAACTCTTCTCTCCCAGGAAGGACTTGCTG GGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTTTGTGACGTGTGCAAATGGGAAAGGAGGGGTTTTTACATCTCCTAA AGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGCGCAGCATATTGCTGTACACATTTACAGAATGGTTGCTGAGTGTCT GTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATTAGACGTATAATGTATGTCTGGTGTTTTTAACTTGATCATGATCAG CTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCACTCTTGGGAGTGCTGCAGTCTTTAATCATGCTGTTTAAACTGTTGT GGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTATAGAGAGAGATATATACACTTTTGATTGTTTTCTAGATGTCTACCA >In-frame_NDC80_ENST00000261597_chr18_2579028_+_PPP4R1_ENST00000400555_chr18_9562073_-_2866nt ACTGCGCGCGTCGTGCGTAATGACGTCAGCGCCGGCGGAGAATTTCAAATTCGAACGGCTTTGGCGGGCCGAGGAAGGACCTGGTGTTTT GATGACCGCTGTCCTGTCTAGCAGATACTTGCACGGTTTACAGAAATTCGGTCCCTGGGTCGTGTCAGGAAACTGGAAAAAAGGTCATAA GCATGAAGCGCAGTTCAGTTTCCAGCGGTGGTGCTGGCCGCCTCTCCATGCAGGAGTTAAGATCCCAGGATGTAAATAAACAAGGCCTCT ATACCCCTCAAACCAAAGAGAAACCAACCTTTGGAAAGTTGAGTATAAACAAACCGACATCTGAAAGAAAAGTCTCGCTATTTGGCAAAA GAACTAGTGGACATGGATCCCGGAATAGTCAACTTGGTATATTTTCCAGTTCTGAGAAAATCAAGGACCCGAGACCACTTAATGACAAAG CATTCATTCAGCAGTGTATTCGACAACTCTGTGAGTTTCTTACAGAAAATGGTTATGCACATAATGTGTCCATGAAATCTCTACAAGCTC CCTCTGTTAAAGACTTCCTGAAGATCTTCACATTTCTTTATGGCTTCCTGTGCCCCTCATACGAACTTCCTGACACAAAGTTTGAAGAAG AGGTTCCAAGAATCTTTAAAGACCTTGGGTATCCTTTTGCACTATCCAAAAGCTCCATGTACACAGTGGGGGCTCCTCATACATGGCCTC ACATTGTGGCAGCCTTAGTTTGGCTAATAGACTGCATCAAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACTTGAGCA ACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAGATGTTGTACCTCAGGCGTTGTTAGATCAGTATTTATCTATGA CTGACCCTTCTCGTGCACAGACGGTTGACACTGAAATTGCTAAGCACTGTGCATATAGCCTCCCTGGTGTGGCCTTGACACTCGGAAGAC AGAATTGGCACTGCCTGAGAGAGACGTATGAGACTCTGGCCTCAGACATGCAGTGGAAAGTTCGACGAACTCTAGCATTCTCCATCCACG AGCTTGCAGTTATTCTTGGAGATCAATTGACAGCTGCAGATCTGGTTCCAATTTTTAATGGATTTTTAAAAGACCTCGATGAAGTCAGGA TAGGTGTTCTTAAACACTTGCATGATTTTCTGAAGCTTCTTCATATTGACAAAAGAAGAGAATATCTTTATCAACTTCAGGAGTTTTTGG TGACAGATAATAGTAGAAATTGGCGGTTTCGAGCTGAACTGGCTGAACAGCTGATTTTACTTCTAGAGTTATATAGTCCCAGAGATGTTT ATGACTATTTACGTCCCATTGCTCTGAATCTGTGTGCAGACAAAGTTTCTTCTGTTCGTTGGATTTCCTACAAGTTGGTCAGCGAGATGG TGAAGAAGCTGCACGCGGCAACACCACCAACGTTCGGAGTGGACCTCATCAATGAGCTTGTGGAGAACTTTGGCAGATGTCCCAAGTGGT CTGGTCGGCAAGCCTTTGTCTTTGTCTGCCAGACTGTCATTGAGGATGACTGCCTTCCCATGGACCAGTTTGCTGTGCATCTCATGCCGC ATCTGCTAACCTTAGCAAATGACAGGGTTCCTAACGTGCGAGTGCTGCTTGCAAAGACATTAAGACAAACTCTACTAGAAAAAGACTATT TCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGTATTTTG CAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGAGCACAGCGTCCTCAACCTACTAGAAGGCTTGAATCTCGGTGTCTT TCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCATGTGACCTGGGATAGCTTTCGGGGGAGGAGAGACCTTCCTCTCCT GCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGGATTTCAAGAGTCAAGAGAAAGTACAGTAAACACTATTATCTTATC TTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCACCGAAGCCTTAAATCCTTCTGTCTTCCTGACTGAATGAAACTTGAA TTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGACCTGCATTGCTTTCTCCTGGTTTTATTTAACAATCGACAAATGAAA TTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGACCTTCAGTATCAGCCCTAACTCTTCTCTCCCAGGAAGGACTTGCTG GGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTTTGTGACGTGTGCAAATGGGAAAGGAGGGGTTTTTACATCTCCTAA AGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGCGCAGCATATTGCTGTACACATTTACAGAATGGTTGCTGAGTGTCT GTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATTAGACGTATAATGTATGTCTGGTGTTTTTAACTTGATCATGATCAG CTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCACTCTTGGGAGTGCTGCAGTCTTTAATCATGCTGTTTAAACTGTTGT GGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTATAGAGAGAGATATATACACTTTTGATTGTTTTCTAGATGTCTACCA 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FusionGenePPI for NDC80_PPP4R1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NDC80 | BLOC1S6, KLHL12, CCDC53, USHBP1, AMOTL2, CALCOCO1, MIS12, SPC24, SPC25, NUF2, TOM1L1, NEK2, PSMC2, BUB1, NDC80, ZWINT, PFDN1, NSL1, SKA1, CASC5, PLK1, CCNB1, AURKA, AURKB, CENPH, INPP1, NDE1, ATF4, ATP5O, CCNH, KRT6B, MFAP1, TP53BP2, STX11, CCNK, HGS, TNIP1, TFIP11, MED4, CCHCR1, NDEL1, IFT20, CCDC101, HAUS1, SFR1, KLC3, TXLNA, RUFY4, SHMT2, NXF1, BUB1B, PPP1CC, CCDC68, DSN1, IFT81, SMC1A, PLS1, NTRK1, PCM1, OFD1, SPICE1, DCTN1, ESR1, SNW1, CDC5L, CKAP5, PMF1, EXOC1, WDYHV1, CENPC, SYNC, MLF1, FAM170A | PPP4R1 | PPP4C, DISC1, CEP63, MAP4, EHBP1L1, GPHN, HNRNPR, MTA2, POLR2A, POLR2C, SPTAN1, TRAF2, TRAF6, PPP2CB, PMPCB, AQR, NTRK1, XPO1, CTNND1, LDHB, NDUFB4, PPP2CA, PPP2R1A, PPP2R1B, CCDC6, MAP7, MED24, SEC61A1, FASTKD5, RALBP1, C1S, KIF1B, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NDC80 | chr18:2579028 | chr18:9562073 | ENST00000261597 | + | 6 | 17 | 251_618 | 193 | 643 | NEK2 and ZWINT |
| Hgene | NDC80 | chr18:2579028 | chr18:9562073 | ENST00000261597 | + | 6 | 17 | 361_547 | 193 | 643 | PSMC2 and SMC1A |
| Hgene | NDC80 | chr18:2579028 | chr18:9562073 | ENST00000261597 | + | 6 | 17 | 128_251 | 193 | 643 | RB1 |
| Hgene | NDC80 | chr18:2579028 | chr18:9562073 | ENST00000261597 | + | 6 | 17 | 251_431 | 193 | 643 | SMC1A |
| Hgene | NDC80 | chr18:2579028 | chr18:9562073 | ENST00000261597 | + | 6 | 17 | 446_642 | 193 | 643 | the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex |
| Hgene | NDC80 | chr18:2579028 | chr18:9562073 | ENST00000261597 | + | 6 | 17 | 1_445 | 193 | 643 | the N-terminus of CDCA1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NDC80_PPP4R1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NDC80_PPP4R1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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