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Fusion gene ID: 2375 |
FusionGeneSummary for ARHGAP15_KYNU |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGAP15_KYNU | Fusion gene ID: 2375 | Hgene | Tgene | Gene symbol | ARHGAP15 | KYNU | Gene ID | 55843 | 8942 |
| Gene name | Rho GTPase activating protein 15 | kynureninase | |
| Synonyms | BM046 | KYNUU|VCRL2 | |
| Cytomap | 2q22.2-q22.3 | 2q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GTPase-activating protein 15rho-type GTPase-activating protein 15 | kynureninaseL-kynurenine hydrolase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q53QZ3 | Q16719 | |
| Ensembl transtripts involved in fusion gene | ENST00000409869, ENST00000295095, ENST00000473426, | ENST00000264170, ENST00000375773, ENST00000409512, ENST00000410015, | |
| Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 8 X 7 X 6=336 |
| # samples | 6 | 10 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/336*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGAP15 [Title/Abstract] AND KYNU [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGAP15 | GO:0008360 | regulation of cell shape | 12650940 |
| Tgene | KYNU | GO:0019805 | quinolinate biosynthetic process | 9291104 |
| Tgene | KYNU | GO:0034341 | response to interferon-gamma | 9291104 |
| Tgene | KYNU | GO:0043420 | anthranilate metabolic process | 11985583 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-38-4630-01A | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| TCGA | RV | LUSC | TCGA-NC-A5HJ-01A | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000409869 | ENST00000264170 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| intron-3CDS | ENST00000409869 | ENST00000375773 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| intron-3CDS | ENST00000409869 | ENST00000409512 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| intron-intron | ENST00000409869 | ENST00000410015 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| In-frame | ENST00000295095 | ENST00000264170 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| In-frame | ENST00000295095 | ENST00000375773 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| In-frame | ENST00000295095 | ENST00000409512 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| 5CDS-intron | ENST00000295095 | ENST00000410015 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| intron-3CDS | ENST00000473426 | ENST00000264170 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| intron-3CDS | ENST00000473426 | ENST00000375773 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| intron-3CDS | ENST00000473426 | ENST00000409512 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| intron-intron | ENST00000473426 | ENST00000410015 | ARHGAP15 | chr2 | 144008169 | + | KYNU | chr2 | 143742653 | + |
| intron-5UTR | ENST00000409869 | ENST00000264170 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| intron-5UTR | ENST00000409869 | ENST00000375773 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| intron-5UTR | ENST00000409869 | ENST00000409512 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| intron-5UTR | ENST00000409869 | ENST00000410015 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| 5UTR-5UTR | ENST00000295095 | ENST00000264170 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| 5UTR-5UTR | ENST00000295095 | ENST00000375773 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| 5UTR-5UTR | ENST00000295095 | ENST00000409512 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| 5UTR-5UTR | ENST00000295095 | ENST00000410015 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| intron-5UTR | ENST00000473426 | ENST00000264170 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| intron-5UTR | ENST00000473426 | ENST00000375773 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| intron-5UTR | ENST00000473426 | ENST00000409512 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
| intron-5UTR | ENST00000473426 | ENST00000410015 | ARHGAP15 | chr2 | 143887035 | + | KYNU | chr2 | 143642918 | + |
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FusionProtFeatures for ARHGAP15_KYNU |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGAP15 | KYNU |
| Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preferencefor the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyaseactivity. {ECO:0000269|PubMed:11985583,ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876,ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARHGAP15_KYNU |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ARHGAP15_ENST00000295095_chr2_144008169_+_KYNU_ENST00000264170_chr2_143742653_+_381aa MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQGCYVGFDLAHAVGNVELYLHDW GVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMK ALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFH >In-frame_ARHGAP15_ENST00000295095_chr2_144008169_+_KYNU_ENST00000375773_chr2_143742653_+_223aa MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQGCYVGFDLAHAVGNVELYLHDW >In-frame_ARHGAP15_ENST00000295095_chr2_144008169_+_KYNU_ENST00000409512_chr2_143742653_+_381aa MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAK IADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQGCYVGFDLAHAVGNVELYLHDW GVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMK ALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ARHGAP15_ENST00000295095_chr2_144008169_+_KYNU_ENST00000264170_chr2_143742653_+_1143nt ATGCAGAAATCTACAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAAT GCCAACAGCCACCATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGA AGGAATCATTCACAGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAA ATTGCAGATGGAGGAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCC AAGCAACAGGCTCTGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAA TCGAGCAGAAAGAATGTCTTTCAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGG GGAGTTGATTTTGCCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCC CATACGATTAAACCTGCATTAGTGGGATGGTTTGGCCATGAACTCAGCACCAGATTTAAGATGGATAACAAACTGCAGTTAATCCCTGGG GTCTGTGGATTCCGAATTTCAAATCCTCCCATTTTGTTGGTCTGTTCCTTGCATGCTAGTTTAGAGATCTTTAAGCAAGCGACAATGAAG GCATTGCGGAAAAAATCTGTTTTGCTAACTGGCTATCTGGAATACCTGATCAAGCATAACTATGGCAAAGATAAAGCAGCAACCAAGAAA CCAGTTGTGAACATAATTACTCCGTCTCATGTAGAGGAGCGGGGGTGCCAGCTAACAATAACATTTTCTGTTCCAAACAAAGATGTTTTC CAAGAACTAGAAAAAAGAGGAGTGGTTTGTGACAAGCGGAATCCAAATGGCATTCGAGTGGCTCCAGTTCCTCTCTATAATTCTTTCCAT >In-frame_ARHGAP15_ENST00000295095_chr2_144008169_+_KYNU_ENST00000375773_chr2_143742653_+_669nt ATGCAGAAATCTACAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAAT GCCAACAGCCACCATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGA AGGAATCATTCACAGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAA ATTGCAGATGGAGGAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCC AAGCAACAGGCTCTGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAA TCGAGCAGAAAGAATGTCTTTCAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGG GGAGTTGATTTTGCCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCC >In-frame_ARHGAP15_ENST00000295095_chr2_144008169_+_KYNU_ENST00000409512_chr2_143742653_+_1143nt ATGCAGAAATCTACAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAAT GCCAACAGCCACCATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGA AGGAATCATTCACAGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAA ATTGCAGATGGAGGAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCC AAGCAACAGGCTCTGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAA TCGAGCAGAAAGAATGTCTTTCAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGG GGAGTTGATTTTGCCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCC CATACGATTAAACCTGCATTAGTGGGATGGTTTGGCCATGAACTCAGCACCAGATTTAAGATGGATAACAAACTGCAGTTAATCCCTGGG GTCTGTGGATTCCGAATTTCAAATCCTCCCATTTTGTTGGTCTGTTCCTTGCATGCTAGTTTAGAGATCTTTAAGCAAGCGACAATGAAG GCATTGCGGAAAAAATCTGTTTTGCTAACTGGCTATCTGGAATACCTGATCAAGCATAACTATGGCAAAGATAAAGCAGCAACCAAGAAA CCAGTTGTGAACATAATTACTCCGTCTCATGTAGAGGAGCGGGGGTGCCAGCTAACAATAACATTTTCTGTTCCAAACAAAGATGTTTTC CAAGAACTAGAAAAAAGAGGAGTGGTTTGTGACAAGCGGAATCCAAATGGCATTCGAGTGGCTCCAGTTCCTCTCTATAATTCTTTCCAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ARHGAP15_ENST00000295095_chr2_144008169_+_KYNU_ENST00000264170_chr2_143742653_+_1459nt GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA ATGTCTTTCAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGGGGAGTTGATTTTG CCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAAC CTGCATTAGTGGGATGGTTTGGCCATGAACTCAGCACCAGATTTAAGATGGATAACAAACTGCAGTTAATCCCTGGGGTCTGTGGATTCC GAATTTCAAATCCTCCCATTTTGTTGGTCTGTTCCTTGCATGCTAGTTTAGAGATCTTTAAGCAAGCGACAATGAAGGCATTGCGGAAAA AATCTGTTTTGCTAACTGGCTATCTGGAATACCTGATCAAGCATAACTATGGCAAAGATAAAGCAGCAACCAAGAAACCAGTTGTGAACA TAATTACTCCGTCTCATGTAGAGGAGCGGGGGTGCCAGCTAACAATAACATTTTCTGTTCCAAACAAAGATGTTTTCCAAGAACTAGAAA AAAGAGGAGTGGTTTGTGACAAGCGGAATCCAAATGGCATTCGAGTGGCTCCAGTTCCTCTCTATAATTCTTTCCATGATGTTTATAAAT TTACCAATCTGCTCACTTCTATACTTGACTCTGCAGAAACAAAAAATTAGCAGTGTTTTCTAGAACAACTTAAGCAAATTATACTGAAAG CTGCTGTGGTTATTTCAGTATTATTCGATTTTTAATTATTGAAAGTATGTCACCATTGACCACATGTAACTAACAATAAATAATATACCT >In-frame_ARHGAP15_ENST00000295095_chr2_144008169_+_KYNU_ENST00000375773_chr2_143742653_+_1070nt GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA ATGTCTTTCAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGGGGAGTTGATTTTG CCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAAC CTGCGAGATCGGAGTTCTTTAATTAGGAATGGAATGCAACAGATTTGGACAAGTCAAGGACAAGAGCTTTAGAGAGACCAAAGAGTTTTT CACTGTTAAAGTGTCCAGTATGTAGCCGAGAACCATATGGAGAACATCAAATACAGTGGAACAAATGTAACTGCTATTGATGTCACACTT >In-frame_ARHGAP15_ENST00000295095_chr2_144008169_+_KYNU_ENST00000409512_chr2_143742653_+_1310nt GCCTTTTTCTTCCCCCAGTACTGAAATTAAGCAGCATCCAACACAGGCCTACTCTTACGACATGTGACTTTACTGTTTTCCGTTTTTGTT GAAAGAGTCATTAACAGTTAGGAGTTGATGGCAGTTTCAATAACAGGTCATTGCCGAGAAAAGGATAGCACTATAATATGCAGAAATCTA CAAATTCTGATACTTCCGTGGAAACACTGAATTCTACCCGCCAAGGCACAGGAGCTGTGCAAATGAGAATCAAAAATGCCAACAGCCACC ATGACAGGCTCAGCCAAAGTAAATCCATGATCCTCACCGATGTCGGGAAGGTCACTGAACCTATATCCAGACACAGAAGGAATCATTCAC AGCATATCTTGAAAGATGTCATTCCTCCATTGGAACAACTGATGGTTGAAAAAGAAGGTTATCTGCAAAAAGCTAAAATTGCAGATGGAG GAAAGAAACTAAGGAAAAACTGGTCTACTTCCTGGATTGTTCTTTCTAGTCGAAGAATTGAATTTTACAAAGAATCCAAGCAACAGGCTC TGTCCAATATGAAAACTGGGCACAAACCAGAAAGTGTGGATTTGTGTGGAGCACACATTGAATGGGCCAAGGAAAAATCGAGCAGAAAGA ATGTCTTTCAGGGTTGTTATGTTGGCTTTGATCTAGCACATGCAGTTGGAAATGTTGAACTCTACTTACATGACTGGGGAGTTGATTTTG CCTGCTGGTGTTCCTACAAGTATTTAAATGCAGGAGCAGGAGGAATTGCTGGTGCCTTCATTCATGAAAAGCATGCCCATACGATTAAAC CTGCATTAGTGGGATGGTTTGGCCATGAACTCAGCACCAGATTTAAGATGGATAACAAACTGCAGTTAATCCCTGGGGTCTGTGGATTCC GAATTTCAAATCCTCCCATTTTGTTGGTCTGTTCCTTGCATGCTAGTTTAGAGATCTTTAAGCAAGCGACAATGAAGGCATTGCGGAAAA AATCTGTTTTGCTAACTGGCTATCTGGAATACCTGATCAAGCATAACTATGGCAAAGATAAAGCAGCAACCAAGAAACCAGTTGTGAACA TAATTACTCCGTCTCATGTAGAGGAGCGGGGGTGCCAGCTAACAATAACATTTTCTGTTCCAAACAAAGATGTTTTCCAAGAACTAGAAA AAAGAGGAGTGGTTTGTGACAAGCGGAATCCAAATGGCATTCGAGTGGCTCCAGTTCCTCTCTATAATTCTTTCCATGATGTTTATAAAT |
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FusionGenePPI for ARHGAP15_KYNU |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ARHGAP15 | RAC1, SNCA, PRNP, CD93, KDM1A, APP, DHPS | KYNU | TPM3, SMARCD2, COIL, SEC23IP, NUP210, PALM2, SMS, PPM1G, SMEK2, SSU72, ASNS, SIRT1, SGTA, LYN, CNDP2, ADSS, BCCIP, CHORDC1, CSE1L, GDA, GNS, GSR, LDHAL6B, MVD, NAGK, C11orf58, LDHA, NDRG1, PEPD, RPS6KA1, NXF1, ADK, ASS1, CFL1, DSTN, ETFA, FUBP1, GLRX, FH, KHSRP, MEMO1, PPIA, PSAT1, SPR, RET |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGAP15_KYNU |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | KYNU | Q16719 | DB00114 | Pyridoxal Phosphate | Kynureninase {ECO:0000255|HAMAP-Rule:MF_03017} | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for ARHGAP15_KYNU |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KYNU | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | KYNU | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | KYNU | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | KYNU | C0268474 | Hydroxykynureninuria | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | KYNU | C0344315 | Depressed mood | 1 | PSYGENET |
| Tgene | KYNU | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
| Tgene | KYNU | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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