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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23741

FusionGeneSummary for NCOR2_RABGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR2_RABGAP1
Fusion gene ID: 23741
HgeneTgene
Gene symbol

NCOR2

RABGAP1

Gene ID

9612

23637

Gene namenuclear receptor corepressor 2RAB GTPase activating protein 1
SynonymsCTG26|N-CoR2|SMAP270|SMRT|SMRTE|SMRTE-tau|TNRC14|TRAC|TRAC-1|TRAC1GAPCENA|TBC1D11
Cytomap

12q24.31

9q33.2-q33.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressorrab GTPase-activating protein 1GAP and centrosome-associated proteinRab6 GTPase activating protein, GAPCenATBC1 domain family, member 11rab6 GTPase activating protein (GAP and centrosome-associated)rab6 GTPase-activating protein GAPCenA
Modification date2018052720180523
UniProtAcc

Q9Y618

Q9Y3P9

Ensembl transtripts involved in fusion geneENST00000405201, ENST00000404621, 
ENST00000404121, ENST00000356219, 
ENST00000397355, ENST00000429285, 
ENST00000373647, ENST00000493854, 
ENST00000373643, 
Fusion gene scores* DoF score18 X 20 X 15=54005 X 5 X 2=50
# samples 305
** MAII scorelog2(30/5400*10)=-4.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: NCOR2 [Title/Abstract] AND RABGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRABGAP1

GO:0043087

regulation of GTPase activity

17562788


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A24L-01ANCOR2chr12

124922476

-RABGAP1chr9

125827627

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000405201ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000405201ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000405201ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
Frame-shiftENST00000404621ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000404621ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000404621ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5UTR-3CDSENST00000404121ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5UTR-3UTRENST00000404121ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5UTR-5UTRENST00000404121ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
Frame-shiftENST00000356219ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000356219ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000356219ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
Frame-shiftENST00000397355ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000397355ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000397355ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
Frame-shiftENST00000429285ENST00000373647NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-3UTRENST00000429285ENST00000493854NCOR2chr12

124922476

-RABGAP1chr9

125827627

+
5CDS-5UTRENST00000429285ENST00000373643NCOR2chr12

124922476

-RABGAP1chr9

125827627

+

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FusionProtFeatures for NCOR2_RABGAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR2

Q9Y618

RABGAP1

Q9Y3P9

Transcriptional corepressor. Mediates thetranscriptional repression activity of some nuclear receptors bypromoting chromatin condensation, thus preventing access of thebasal transcription. Isoform 1 and isoform 5 have differentaffinities for different nuclear receptors. Involved in theregulation BCL6-dependent of the germinal center (GC) reactions,mainly through the control of the GC B-cells proliferation andsurvival. {ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:23911289}. May act as a GTPase-activating protein of RAB6A. Mayplay a role in microtubule nucleation by centrosome. Mayparticipate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141,ECO:0000269|PubMed:16395330}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948174_2152942522Coiled coilOntology_term=ECO:0000255
TgeneRABGAP1chr12:124922476chr9:125827627ENST00000373647+1226798_10475981070Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948522_5612942522Coiled coilOntology_term=ECO:0000255
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9481392_13972942522Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9481850_18542942522Compositional biasNote=Poly-Gly
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9482487_24902942522Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948494_5102942522Compositional biasNote=Poly-Gln
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948682_6852942522Compositional biasNote=Poly-Lys
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948778_8202942522Compositional biasNote=Pro-rich
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948995_10032942522Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948427_4782942522DomainSANT 1
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948610_6612942522DomainSANT 2
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9482147_21512942522MotifNote=CORNR box of ID1
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-9482350_23542942522MotifNote=CORNR box of ID2
TgeneRABGAP1chr12:124922476chr9:125827627ENST00000373647+1226142_2985981070DomainPID
TgeneRABGAP1chr12:124922476chr9:125827627ENST00000373647+1226566_7525981070DomainRab-GAP TBC


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FusionGeneSequence for NCOR2_RABGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NCOR2_ENST00000405201_chr12_124922476_-_RABGAP1_ENST00000373647_chr9_125827627_+_766aa
MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQELHLRPESHS
YLPELGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENI
KINQAMRKKLILYFKRRNHARKQWESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPE
EQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGIS
VIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRR
LQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSII
GDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NCOR2_ENST00000405201_chr12_124922476_-_RABGAP1_ENST00000373647_chr9_125827627_+_2298nt
ATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGATC
GCCCGGACGCACACGGACGTCGGGCTCCTGGAGTACCAGCACCACTCCCGCGACTATGCCTCCCACCTGTCGCCCGGCTCCATCATCCAG
CCCCAGCGGCGGAGGCCCTCCCTGCTGTCTGAGTTCCAGCCCGGGAATGAACGGTCCCAGGAGCTCCACCTGCGGCCAGAGTCCCACTCA
TACCTGCCCGAGCTGGGGAAGTCAGAGATGGAGTTCATTGAAAGCAAGCGCCCTCGGCTAGAGCTGCTGCCTGACCCCCTGCTGCGACCG
TCACCCCTGCTGGCCACGGGCCAGCCTGCGGGATCTGAAGACCTCACCAAGGACCGTAGCCTGACGGGCAAGCTGGAACCGGTGTCTCCC
CCCAGCCCCCCGCACACTGACCCTGAGCTGGAGCTGGTGCCGCCACGGCTGTCCAAGGAGGAGCTGATCCAGAACATGGACCGCGTGGAC
CGAGAGATCACCATGGTAGAGCAGCAGATCTCTAAGCTGAAGAAGAAGCAGCAACAGCTGGAGGAGGAGGCTGCCAAGCCGCCCGAGCCT
GAGAAGCCCGTGTCACCGCCGCCCATCGAGTCGAAGCACCGCAGCCTGGTGCAGATCATCTACGACGAGAACCGGAAGAAGGCTGAAGCT
GCACATCGGATTCTGGAAGGCCTGGGGCCCCAGGTGGAGCTGCCGCTGTACAACCAGCCCTCCGACACCCGGCAGTATCATGAGAACATC
AAAATAAACCAGGCGATGCGGAAGAAGCTAATCTTGTACTTCAAGAGGAGGAATCACGCTCGGAAACAATGGGAGTCTCCCCAGGACAGT
GCTATCACCCGGGATATTAACCGAACATTCCCAGCCCATGACTACTTTAAGGACACAGGAGGAGATGGACAAGATTCCTTATATAAAATA
TGCAAGGCTTATTCTGTGTATGATGAAGAGATTGGTTATTGCCAGGGCCAGTCATTTCTTGCTGCTGTGCTCCTTCTCCATATGCCTGAA
GAACAGGCATTCAGTGTTCTGGTCAAGATCATGTTTGACTATGGGCTCAGGGAACTTTTCAAGCAAAACTTCGAAGATTTGCATTGCAAA
TTTTACCAGTTGGAGCGCCTCATGCAGGAATACATTCCTGACCTGTACAACCACTTCCTGGATATAAGCCTTGAAGCACACATGTATGCC
TCCCAGTGGTTTCTTACTCTTTTCACTGCAAAATTCCCTCTCTACATGGTCTTCCATATCATCGACCTGCTTTTATGTGAGGGAATAAGT
GTTATTTTTAATGTCGCCCTTGGATTATTAAAGACTTCGAAAGATGACCTGCTGTTGACAGACTTTGAAGGTGCCTTGAAGTTCTTTAGG
GTTCAGCTTCCTAAGAGATACCGCTCAGAAGAAAATGCAAAAAAACTAATGGAATTAGCCTGCAACATGAAGATTAGTCAGAAGAAGTTG
AAAAAATACGAGAAAGAATATCACACCATGAGGGAACAGCAGGCCCAGCAAGAAGACCCCATCGAGCGATTTGAGCGGGAGAATAGGCGT
CTACAAGAAGCTAACATGAGGTTGGAACAGGAAAACGATGACTTAGCCCATGAGCTGGTGACCAGCAAGATTGCACTACGGAAGGACCTG
GATAACGCTGAGGAAAAGGCAGATGCTCTGAATAAGGAGCTGCTGATGACCAAACAGAAGTTGATTGATGCAGAAGAAGAGAAAAGACGG
CTGGAAGAAGAGTCTGCTCAGTTAAAAGAAATGTGCCGTCGGGAACTCGACAAGGCAGAATCTGAGATTAAAAAAAACAGTTCTATCATT
GGTGACTATAAGCAGATTTGTTCTCAGTTGAGTGAAAGATTGGAGAAGCAGCAGACAGCCAATAAGGTGGAAATTGAGAAAATTCGGCAA
AAAGTGGATGACTGTGAGCGGTGCCGGGAATTTTTCAACAAAGAAGGGCGTGTAAAAGGCATAAGCTCAACCAAGGAGGTTTTAGATGAG
GACACGGATGAAGAGAAAGAGACGCTCAAGAACCAGCTGAGAGAAATGGAGCTAGAACTGGCACAGACCAAACTCCAGCTGGTGGAGGCC
GAGTGTAAGATACAGGACTTGGAACACCATTTAGGGCTTGCCCTCAATGAGGTGCAGGCAGCCAAGAAGACGTGGTTTAACCGAACACTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NCOR2_ENST00000405201_chr12_124922476_-_RABGAP1_ENST00000373647_chr9_125827627_+_3952nt
CATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGAT
CGCCCGGACGCACACGGACGTCGGGCTCCTGGAGTACCAGCACCACTCCCGCGACTATGCCTCCCACCTGTCGCCCGGCTCCATCATCCA
GCCCCAGCGGCGGAGGCCCTCCCTGCTGTCTGAGTTCCAGCCCGGGAATGAACGGTCCCAGGAGCTCCACCTGCGGCCAGAGTCCCACTC
ATACCTGCCCGAGCTGGGGAAGTCAGAGATGGAGTTCATTGAAAGCAAGCGCCCTCGGCTAGAGCTGCTGCCTGACCCCCTGCTGCGACC
GTCACCCCTGCTGGCCACGGGCCAGCCTGCGGGATCTGAAGACCTCACCAAGGACCGTAGCCTGACGGGCAAGCTGGAACCGGTGTCTCC
CCCCAGCCCCCCGCACACTGACCCTGAGCTGGAGCTGGTGCCGCCACGGCTGTCCAAGGAGGAGCTGATCCAGAACATGGACCGCGTGGA
CCGAGAGATCACCATGGTAGAGCAGCAGATCTCTAAGCTGAAGAAGAAGCAGCAACAGCTGGAGGAGGAGGCTGCCAAGCCGCCCGAGCC
TGAGAAGCCCGTGTCACCGCCGCCCATCGAGTCGAAGCACCGCAGCCTGGTGCAGATCATCTACGACGAGAACCGGAAGAAGGCTGAAGC
TGCACATCGGATTCTGGAAGGCCTGGGGCCCCAGGTGGAGCTGCCGCTGTACAACCAGCCCTCCGACACCCGGCAGTATCATGAGAACAT
CAAAATAAACCAGGCGATGCGGAAGAAGCTAATCTTGTACTTCAAGAGGAGGAATCACGCTCGGAAACAATGGGAGTCTCCCCAGGACAG
TGCTATCACCCGGGATATTAACCGAACATTCCCAGCCCATGACTACTTTAAGGACACAGGAGGAGATGGACAAGATTCCTTATATAAAAT
ATGCAAGGCTTATTCTGTGTATGATGAAGAGATTGGTTATTGCCAGGGCCAGTCATTTCTTGCTGCTGTGCTCCTTCTCCATATGCCTGA
AGAACAGGCATTCAGTGTTCTGGTCAAGATCATGTTTGACTATGGGCTCAGGGAACTTTTCAAGCAAAACTTCGAAGATTTGCATTGCAA
ATTTTACCAGTTGGAGCGCCTCATGCAGGAATACATTCCTGACCTGTACAACCACTTCCTGGATATAAGCCTTGAAGCACACATGTATGC
CTCCCAGTGGTTTCTTACTCTTTTCACTGCAAAATTCCCTCTCTACATGGTCTTCCATATCATCGACCTGCTTTTATGTGAGGGAATAAG
TGTTATTTTTAATGTCGCCCTTGGATTATTAAAGACTTCGAAAGATGACCTGCTGTTGACAGACTTTGAAGGTGCCTTGAAGTTCTTTAG
GGTTCAGCTTCCTAAGAGATACCGCTCAGAAGAAAATGCAAAAAAACTAATGGAATTAGCCTGCAACATGAAGATTAGTCAGAAGAAGTT
GAAAAAATACGAGAAAGAATATCACACCATGAGGGAACAGCAGGCCCAGCAAGAAGACCCCATCGAGCGATTTGAGCGGGAGAATAGGCG
TCTACAAGAAGCTAACATGAGGTTGGAACAGGAAAACGATGACTTAGCCCATGAGCTGGTGACCAGCAAGATTGCACTACGGAAGGACCT
GGATAACGCTGAGGAAAAGGCAGATGCTCTGAATAAGGAGCTGCTGATGACCAAACAGAAGTTGATTGATGCAGAAGAAGAGAAAAGACG
GCTGGAAGAAGAGTCTGCTCAGTTAAAAGAAATGTGCCGTCGGGAACTCGACAAGGCAGAATCTGAGATTAAAAAAAACAGTTCTATCAT
TGGTGACTATAAGCAGATTTGTTCTCAGTTGAGTGAAAGATTGGAGAAGCAGCAGACAGCCAATAAGGTGGAAATTGAGAAAATTCGGCA
AAAAGTGGATGACTGTGAGCGGTGCCGGGAATTTTTCAACAAAGAAGGGCGTGTAAAAGGCATAAGCTCAACCAAGGAGGTTTTAGATGA
GGACACGGATGAAGAGAAAGAGACGCTCAAGAACCAGCTGAGAGAAATGGAGCTAGAACTGGCACAGACCAAACTCCAGCTGGTGGAGGC
CGAGTGTAAGATACAGGACTTGGAACACCATTTAGGGCTTGCCCTCAATGAGGTGCAGGCAGCCAAGAAGACGTGGTTTAACCGAACACT
GAGCTCCATAAAGACAGCAACCGGGGTTCAAGGGAAAGAGACTTGCTGAGAGCAGCTGCCGCCTCCCGACACCTTCAGAAAACACGACAC
CTTTTGTTGCCTTCTTTGGCCAGATGTGTGATTCTGTGACTTGTCCCAGGACCAGAATGTACCTAAGTCAGATCCATAGACGCATGTTGG
TAGGTCACTGGACCAGAGCTTGTGAAGCAGGCAACCTCTGGGGTAAGACTACTGATACTAACAGGCCTGCTAGCTCAGCCGACGCTCTGG
ACACTCTAGAAATCACTCCTCAGTGTGACCTCCCAGGCCTCTTCCCCGTGTACGTCAACACCTCACCCAGCCTAAAGGCTGAGTTTACAT
GATCAGAGTTAGGGGATCCTTCAGTCTGTTGATTTTTTTTCTAAACCTTTTTTTTTTAATATACATATATATATATATATATATATATAT
ATATATATATATATATATATATAGTGGGGGTGGGGCAAGGGATCAGAAATTCAAATAATTCTTTTCTGCTTCAATGCCAGCAGAAGGTCC
CCCAGGTAGACATGGAGAAGCACTTTGTTTTAAATAGGAGGGTTTCATAGTTGCATCTGAAGCCACCTGGTTCTGTTAAACTGTATGGTG
CAGGTTTTGGGTTTGGCATTATTCATGTTTCTGATCAATTCTATGCAACTCTCATAGTTCCTGTTACTTTTTAGCATTAGCTGCCAAATG
ACTTCAAAAGGCTGGGGTGGGTGACTTGACTGTGAGACTGGATTATAACATGGACAAATCTTATTTTGCTTAATGTGTTTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTATGTATATATATATATAAATATCTTTCCCAATATGCCCCGTTGACAGTGTTTAAATTCCAGACTAGGA
CTGCTGATCTGCACAATTTAATTATGTGGTTATTCGAGCACTTAATTTCACTCAAGGTTCATTGGGCTCTGCTCTCCTCCCTGCCATTAC
GGGAGCTGTGGACAGAGCTCCCTCACTTCAAGATTCCTAGTGTTTTTGCACAACAGGTTGTCCAAGTGAGAAAGACTGAGTTGCGTGTCT
GTAAATGTCTGCGCAGGGTGCACATGCTGCGAGGTCTCCATCCTCCGGGCCTGTCCCTCCCAGATGGGCTGGGCCTTTGGGCCCTCCTCA
GAGTATGCCTGGGTACAAACCTCACTGTTCAGATGGGCTGTAAGTTCTCACTTCAAAGCTATGGAATGGATTTTAGCACCTTTAAAAAAA
AAAAAAACTTTGACTTTTAATTTATATAGTGATATGCTGACAGGCTGACACGCAGATGGTTTTGTCCTCTTTTCTGCGTTCAGTGTTGAG
GCGGCTGCTTACAAGAGGCACTGGTTTTGTATATAAAGACACTCGGGTTGTTTTGTAGCTCTTTTTCTTATTGGCTGTACTAACGCTTGC
TGAGGTTATCTGTAATAAGGGAGGTAACAAGTGGCAACCCCCTCCCCACCAACCATCCCCTTTGCTGCTTTCTGTGTCTTTCTTGTTCAG
TTACCAAAATAGCTGTAAGCCTATCTAATGCTAGGTGTGTGGACATTGTGCTAAGGTAGTTTCAGTGTGTCAACTTTATGAATTGAAATA


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FusionGenePPI for NCOR2_RABGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOR2SPEN, ZBTB16, AR, IKZF1, RUNX1T1, HDAC3, TBL1X, RELA, NFKBIA, HDAC4, HDAC7, SNW1, HDAC1, HDAC10, PML, PPARD, BCL6, NCOR1, SMARCA4, SIN3A, HDAC2, SAP30, HDAC5, RBPJ, POU2F1, RARA, INPP5K, CIR1, JUN, FOS, SRF, NR3C1, PPARA, THRB, VDR, NR4A1, PGR, RXRA, NCOA6, ZBTB7A, NR4A2, EP300, CREBBP, CNOT2, AKT1, CHUK, HIST1H4A, NR1I2, HNF4A, ATXN1, ATXN1L, SF1, SP1, CEBPB, NFE2L2, PPARG, FOXP1, NFKBIB, NFKBIE, NFKB1, SKIL, THRA, ESR1, ESR2, BACH2, NCOA3, GPS2, SUMO1, UBE2I, IRF5, CDKN1A, RARB, RARG, AP2M1, RANBP9, RXRG, NR1H2, TNIP2, CEP63, TNIK, SOX2, E2F4, NRD1, CTBP1, ARNT, AHR, NR1D1, NR1H4, C1D, RUNX1, CBX6, BTRC, E2F1, BCOR, AURKA, HMGA1, KLF5, HSPA5, SEC16A, FBXO22, RGMA, FOXK2, NANOG, POU5F1, ITGAV, EYA2, TBL1Y, ZSCAN5A, LASP1, USP44, TRIM25RABGAP1RAB6A, GABARAPL1, RABGAP1L, DISC1, ELAVL1, MAP1LC3A, CARM1, VCP, RAB4A, COPE, COPG1, KIF5B, SENP1, SENP5, TEX35, HOXC4, LIMS1, KIR2DS2, CCDC68, TUFT1, CORO1A, WIPI2, ORC2, NTRK1, STAT3, CCDC53, VIPR2, TRIM11, GGA1, CD79B, DLK2, TMEM206, MANSC1, TSKS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR2chr12:124922476chr9:125827627ENST00000356219-948254_3122942522SIN3A/B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOR2_RABGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCOR2_RABGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR2C0005586Bipolar Disorder1PSYGENET
HgeneNCOR2C0023893Liver Cirrhosis, Experimental1CTD_human