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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23736

FusionGeneSummary for NCOR2_MORN3

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR2_MORN3
Fusion gene ID: 23736
HgeneTgene
Gene symbol

NCOR2

MORN3

Gene ID

9612

283385

Gene namenuclear receptor corepressor 2MORN repeat containing 3
SynonymsCTG26|N-CoR2|SMAP270|SMRT|SMRTE|SMRTE-tau|TNRC14|TRAC|TRAC-1|TRAC1-
Cytomap

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressorMORN repeat-containing protein 3membrane occupation and recognition nexus repeat containing protein
Modification date2018052720180519
UniProtAcc

Q9Y618

Q6PF18

Ensembl transtripts involved in fusion geneENST00000405201, ENST00000404621, 
ENST00000404121, ENST00000356219, 
ENST00000397355, ENST00000429285, 
ENST00000355329, 
Fusion gene scores* DoF score18 X 20 X 15=54003 X 3 X 3=27
# samples 303
** MAII scorelog2(30/5400*10)=-4.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOR2 [Title/Abstract] AND MORN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVDLBCTCGA-FA-A7DS-01ANCOR2chr12

124979693

-MORN3chr12

122097254

-
TCGALDDLBCTCGA-FA-A7DS-01ANCOR2chr12

124979693

-MORN3chr12

122090714

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000405201ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122097254

-
Frame-shiftENST00000404621ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122097254

-
5UTR-3CDSENST00000404121ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122097254

-
Frame-shiftENST00000356219ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122097254

-
Frame-shiftENST00000397355ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122097254

-
Frame-shiftENST00000429285ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122097254

-
In-frameENST00000405201ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122090714

-
Frame-shiftENST00000404621ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122090714

-
5UTR-3CDSENST00000404121ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122090714

-
Frame-shiftENST00000356219ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122090714

-
Frame-shiftENST00000397355ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122090714

-
Frame-shiftENST00000429285ENST00000355329NCOR2chr12

124979693

-MORN3chr12

122090714

-

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FusionProtFeatures for NCOR2_MORN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR2

Q9Y618

MORN3

Q6PF18

Transcriptional corepressor. Mediates thetranscriptional repression activity of some nuclear receptors bypromoting chromatin condensation, thus preventing access of thebasal transcription. Isoform 1 and isoform 5 have differentaffinities for different nuclear receptors. Involved in theregulation BCL6-dependent of the germinal center (GC) reactions,mainly through the control of the GC B-cells proliferation andsurvival. {ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:23911289}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMORN3chr12:124979693chr12:122097254ENST00000355329-06114_13648285RepeatNote=MORN 4
TgeneMORN3chr12:124979693chr12:122097254ENST00000355329-06137_15948285RepeatNote=MORN 5
TgeneMORN3chr12:124979693chr12:122097254ENST00000355329-06160_18248285RepeatNote=MORN 6
TgeneMORN3chr12:124979693chr12:122097254ENST00000355329-06184_20548285RepeatNote=MORN 7
TgeneMORN3chr12:124979693chr12:122097254ENST00000355329-0662_8448285RepeatNote=MORN 2
TgeneMORN3chr12:124979693chr12:122097254ENST00000355329-0691_11348285RepeatNote=MORN 3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-248174_215352522Coiled coilOntology_term=ECO:0000255
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-248522_561352522Coiled coilOntology_term=ECO:0000255
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-248174_215352522Coiled coilOntology_term=ECO:0000255
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-248522_561352522Coiled coilOntology_term=ECO:0000255
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-2481392_1397352522Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-2481850_1854352522Compositional biasNote=Poly-Gly
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-2482487_2490352522Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-248494_510352522Compositional biasNote=Poly-Gln
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-248682_685352522Compositional biasNote=Poly-Lys
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-248778_820352522Compositional biasNote=Pro-rich
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-248995_1003352522Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-2481392_1397352522Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-2481850_1854352522Compositional biasNote=Poly-Gly
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-2482487_2490352522Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-248494_510352522Compositional biasNote=Poly-Gln
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-248682_685352522Compositional biasNote=Poly-Lys
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-248778_820352522Compositional biasNote=Pro-rich
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-248995_1003352522Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-248427_478352522DomainSANT 1
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-248610_661352522DomainSANT 2
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-248427_478352522DomainSANT 1
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-248610_661352522DomainSANT 2
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-2482147_2151352522MotifNote=CORNR box of ID1
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-2482350_2354352522MotifNote=CORNR box of ID2
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-2482147_2151352522MotifNote=CORNR box of ID1
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-2482350_2354352522MotifNote=CORNR box of ID2
TgeneMORN3chr12:124979693chr12:122090714ENST00000355329-36114_136216285RepeatNote=MORN 4
TgeneMORN3chr12:124979693chr12:122090714ENST00000355329-36137_159216285RepeatNote=MORN 5
TgeneMORN3chr12:124979693chr12:122090714ENST00000355329-36160_182216285RepeatNote=MORN 6
TgeneMORN3chr12:124979693chr12:122090714ENST00000355329-36184_205216285RepeatNote=MORN 7
TgeneMORN3chr12:124979693chr12:122090714ENST00000355329-3638_60216285RepeatNote=MORN 1
TgeneMORN3chr12:124979693chr12:122090714ENST00000355329-3662_84216285RepeatNote=MORN 2
TgeneMORN3chr12:124979693chr12:122090714ENST00000355329-3691_113216285RepeatNote=MORN 3
TgeneMORN3chr12:124979693chr12:122097254ENST00000355329-0638_6048285RepeatNote=MORN 1


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FusionGeneSequence for NCOR2_MORN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NCOR2_ENST00000405201_chr12_124979693_-_MORN3_ENST00000355329_chr12_122097254_-_35aa

>In-frame_NCOR2_ENST00000405201_chr12_124979693_-_MORN3_ENST00000355329_chr12_122090714_-_60aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NCOR2_ENST00000405201_chr12_124979693_-_MORN3_ENST00000355329_chr12_122097254_-_105nt
ATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGATC

>In-frame_NCOR2_ENST00000405201_chr12_124979693_-_MORN3_ENST00000355329_chr12_122090714_-_180nt
ATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGATC
GCCCGGACGCACACGGTCAAAATCCTAGACCCTGATGGTGTGCTGGCGGAGGCCTTGGCCATGTTCAGGAAGACAGAGGAAGGAGATTGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_NCOR2_ENST00000405201_chr12_124979693_-_MORN3_ENST00000355329_chr12_122097254_-_1217nt
CATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGAT
CGCCCGGACGCACACGGGAAAGGAACACAGGTCTGGAAGAAGAAAGGAGCCATCTATGAGGGGGACTGGAAGTTTGGGAAGCGAGACGGC
TACGGCACCCTCAGCCTTCCTGACCAACAGACAGGAAAGTGCAGGAGAGTCTACTCAGGCTGGTGGAAAGGTGATAAGAAATCGGGTTAT
GGGATCCAGTTTTTCGGACCCAAGGAGTATTATGAGGGTGACTGGTGTGGCAGCCAGCGCAGCGGGTGGGGCCGCATGTATTACAGCAAC
GGCGACATCTACGAGGGACAGTGGGAGAACGACAAGCCCAACGGGGAGGGCATGCTGCGCCTGAAGAACGGGAACCGCTACGAGGGCTGC
TGGGAGAGAGGCATGAAGAACGGGGCGGGGCGTTTCTTCCATCTGGACCACGGCCAGCTGTTTGAAGGCTTCTGGGTGGACAATATGGCC
AAATGCGGGACGATGATCGACTTTGGCCGTGACGAGGCCCCTGAGCCCACTCAGTTCCCCATTCCTGAGGTCAAAATCCTAGACCCTGAT
GGTGTGCTGGCGGAGGCCTTGGCCATGTTCAGGAAGACAGAGGAAGGAGATTGATGCCAGAGAACACAAACGCTTCAGGAGAAATTCAAG
CCTGTGTCACCCGATCGCTCAGACCAGTGCGGCTCTGGCTGGAGGAGTCAGCAGCAGCTCCAGGCATGACCCCGGCACCCTCATAGGGCC
CCTCACTACCCCCAGCACTGGGTCATTTCTTGCCAATAGGAAGGCTGGTGCTTCTCTCCCAGGCTGTCCTCGGGACCCTCTTCATTCTCT
GATCTCATCCTGGAATGCATGAGAATAAAGAATAACCAAGTGGTATAAGCCTGGGCCTATGGGATAAGGATGGGGCACTCGAGGGGGCTC
AGCAGGGCTTTCAGGTTTAGAAGAGGGAAGACCTGCCTTGGCTGGGCTGCCTGGGTTTAGCTTGGGGGAGTAAGGGCAGGTCTTAGGCCG
GGTGCAGTGGCTCATTCCTGTAATCCCAGAACTTGGGAGGCCAAGGTAAGAGGACTGCCTGAGGCCAGGAGTTCGAGACCAGCTTAGGCA

>In-frame_NCOR2_ENST00000405201_chr12_124979693_-_MORN3_ENST00000355329_chr12_122090714_-_714nt
CATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGAT
CGCCCGGACGCACACGGTCAAAATCCTAGACCCTGATGGTGTGCTGGCGGAGGCCTTGGCCATGTTCAGGAAGACAGAGGAAGGAGATTG
ATGCCAGAGAACACAAACGCTTCAGGAGAAATTCAAGCCTGTGTCACCCGATCGCTCAGACCAGTGCGGCTCTGGCTGGAGGAGTCAGCA
GCAGCTCCAGGCATGACCCCGGCACCCTCATAGGGCCCCTCACTACCCCCAGCACTGGGTCATTTCTTGCCAATAGGAAGGCTGGTGCTT
CTCTCCCAGGCTGTCCTCGGGACCCTCTTCATTCTCTGATCTCATCCTGGAATGCATGAGAATAAAGAATAACCAAGTGGTATAAGCCTG
GGCCTATGGGATAAGGATGGGGCACTCGAGGGGGCTCAGCAGGGCTTTCAGGTTTAGAAGAGGGAAGACCTGCCTTGGCTGGGCTGCCTG
GGTTTAGCTTGGGGGAGTAAGGGCAGGTCTTAGGCCGGGTGCAGTGGCTCATTCCTGTAATCCCAGAACTTGGGAGGCCAAGGTAAGAGG


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FusionGenePPI for NCOR2_MORN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOR2SPEN, ZBTB16, AR, IKZF1, RUNX1T1, HDAC3, TBL1X, RELA, NFKBIA, HDAC4, HDAC7, SNW1, HDAC1, HDAC10, PML, PPARD, BCL6, NCOR1, SMARCA4, SIN3A, HDAC2, SAP30, HDAC5, RBPJ, POU2F1, RARA, INPP5K, CIR1, JUN, FOS, SRF, NR3C1, PPARA, THRB, VDR, NR4A1, PGR, RXRA, NCOA6, ZBTB7A, NR4A2, EP300, CREBBP, CNOT2, AKT1, CHUK, HIST1H4A, NR1I2, HNF4A, ATXN1, ATXN1L, SF1, SP1, CEBPB, NFE2L2, PPARG, FOXP1, NFKBIB, NFKBIE, NFKB1, SKIL, THRA, ESR1, ESR2, BACH2, NCOA3, GPS2, SUMO1, UBE2I, IRF5, CDKN1A, RARB, RARG, AP2M1, RANBP9, RXRG, NR1H2, TNIP2, CEP63, TNIK, SOX2, E2F4, NRD1, CTBP1, ARNT, AHR, NR1D1, NR1H4, C1D, RUNX1, CBX6, BTRC, E2F1, BCOR, AURKA, HMGA1, KLF5, HSPA5, SEC16A, FBXO22, RGMA, FOXK2, NANOG, POU5F1, ITGAV, EYA2, TBL1Y, ZSCAN5A, LASP1, USP44, TRIM25MORN3GOLGA2, KRT15, MAGEA6, MEOX2, SOX5, TRAF1, TRAF2, TRIP13, IKZF3, ADAMTSL4, FAM208B, CDCA7L, LZTS2, RSPH1, DYNLL2, ALOXE3, RNASE7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR2chr12:124979693chr12:122090714ENST00000356219-248254_312352522SIN3A/B
HgeneNCOR2chr12:124979693chr12:122097254ENST00000356219-248254_312352522SIN3A/B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOR2_MORN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCOR2_MORN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR2C0005586Bipolar Disorder1PSYGENET
HgeneNCOR2C0023893Liver Cirrhosis, Experimental1CTD_human