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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 23726

FusionGeneSummary for NCOR1_UNC45B

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR1_UNC45B
Fusion gene ID: 23726
HgeneTgene
Gene symbol

NCOR1

UNC45B

Gene ID

9611

146862

Gene namenuclear receptor corepressor 1unc-45 myosin chaperone B
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoRCMYA4|CTRCT43|SMUNC45|UNC-45B|UNC45
Cytomap

17p12-p11.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1protein unc-45 homolog Bcardiomyopathy associated 4striated muscle UNC45unc-45 homolog B
Modification date2018052320180523
UniProtAcc

O75376

Q8IWX7

Ensembl transtripts involved in fusion geneENST00000268712, ENST00000395851, 
ENST00000395857, ENST00000395848, 
ENST00000583226, 		ENST00000378449, 
ENST00000433649, ENST00000268876, 
ENST00000394570, ENST00000591048, 
Fusion gene scores* DoF score18 X 14 X 10=25205 X 4 X 4=80
# samples 165
** MAII scorelog2(16/2520*10)=-3.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOR1 [Title/Abstract] AND UNC45B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A3TO-01ANCOR1chr17

16021202

-UNC45Bchr17

33475283

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000268712ENST00000378449NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000268712ENST00000433649NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000268712ENST00000268876NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000268712ENST00000394570NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000268712ENST00000591048NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395851ENST00000378449NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395851ENST00000433649NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395851ENST00000268876NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395851ENST00000394570NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395851ENST00000591048NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
intron-5UTRENST00000395857ENST00000378449NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
intron-5UTRENST00000395857ENST00000433649NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
intron-5UTRENST00000395857ENST00000268876NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
intron-5UTRENST00000395857ENST00000394570NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
intron-5UTRENST00000395857ENST00000591048NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395848ENST00000378449NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395848ENST00000433649NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395848ENST00000268876NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395848ENST00000394570NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5CDS-5UTRENST00000395848ENST00000591048NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5UTR-5UTRENST00000583226ENST00000378449NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5UTR-5UTRENST00000583226ENST00000433649NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5UTR-5UTRENST00000583226ENST00000268876NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5UTR-5UTRENST00000583226ENST00000394570NCOR1chr17

16021202

-UNC45Bchr17

33475283

+
5UTR-5UTRENST00000583226ENST00000591048NCOR1chr17

16021202

-UNC45Bchr17

33475283

+

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FusionProtFeatures for NCOR1_UNC45B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

UNC45B

Q8IWX7

Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}. Acts as a co-chaperone for HSP90 and is required forproper folding of the myosin motor domain. Plays a role insarcomere formation during muscle cell development. Is necessaryfor normal early lens development. {ECO:0000250|UniProtKB:Q6DGE9,ECO:0000250|UniProtKB:Q8CGY6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NCOR1_UNC45B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NCOR1_UNC45B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NCOR1NELFE, AR, KDM4A, HSPA4, CORO2A, HDAC3, GPS2, TBL1XR1, KIF11, ZBTB33, TRIM33, CHD1, CLK1, PTMA, TBL1X, HDAC9, TAB2, NFKB1, HDAC4, HDAC7, HDAC5, PML, SIN3A, SKI, PHB, PPARD, BCL6, NCOR2, SMARCB1, SMARCA4, SAP30, SRCAP, SMARCC2, SMARCC1, SF3B3, SF3A1, TRIM28, CBFA2T3, RUNX1T1, NCOA1, NR3C1, PDCD2, ZMYND11, MYOD1, TXNRD2, PPARA, RARG, RARA, ZBTB16, HEY2, HTT, NR1D1, NR1D2, MECP2, VDR, ESR1, DZIP3, THRA, KDM5C, REST, ZBTB7A, THRB, PGR, DACH1, BACH1, TP53, ATXN3, CREBBP, EP300, NR1I2, NR1H4, SIRT1, PRAM1, CNOT2, PIAS1, UBE2I, CBFA2T2, SPEN, HIST1H3A, SAFB, SAFB2, NR1H3, NR1H2, PPP1CA, PPP1CB, PPP1CC, PPARG, ATXN1L, NCOA3, POU1F1, SP1, CEBPB, NFE2L2, HIST1H4A, ETS1, ETS2, THAP7, NFKBIA, ETV6, RUNX1, COPS2, RXRA, SKIL, HESX1, SNW1, TAF9, GTF2B, TAF6, MYB, BAZ1A, EMD, IRF5, CDKN1A, SOX2, KDM5B, NRD1, ERBB4, ATXN1, RBBP4, SMARCA2, SMARCE1, HMGXB4, BPTF, SMARCD1, CHUK, YWHAZ, C1D, CXADR, CSNK2A1, SMAD4, SQSTM1, JUN, CREB1, PHB2, RFPL4B, QPRT, KLF5, MYC, EWSR1, FGFR1OP, NINL, KIF5B, KPNA1, RAB5A, KIF18A, SGOL1, EXOSC1, FOXK1, FOXK2, TEAD4, FBXW7, ITGAV, EYA2, TBL1Y, HNRNPLL, C6orf141, CDC16, IL17RA, ZSCAN5A, NCAPH2, OLFM2, USP44, TRIM25UNC45BILF3, HSP90AB1, HSP90AA1, AHSA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NCOR1_UNC45B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NCOR1_UNC45B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNCOR1C0005695Bladder Neoplasm1CTD_human
HgeneNCOR1C0007138Carcinoma, Transitional Cell1CTD_human
HgeneNCOR1C0014175Endometriosis1CTD_human
HgeneNCOR1C0017636Glioblastoma1CTD_human
HgeneNCOR1C0023903Liver neoplasms1CTD_human
HgeneNCOR1C1458155Mammary Neoplasms1CTD_human
TgeneUNC45BC0018799Heart Diseases1CTD_human
TgeneUNC45BC0376634Craniofacial Abnormalities1CTD_human
TgeneUNC45BC0522224Paralysed1CTD_human
TgeneUNC45BC4225389CATARACT 431UNIPROT