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Fusion gene ID: 23724 |
FusionGeneSummary for NCOR1_SF3B1 |
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Fusion gene information | Fusion gene name: NCOR1_SF3B1 | Fusion gene ID: 23724 | Hgene | Tgene | Gene symbol | NCOR1 | SF3B1 | Gene ID | 9611 | 23451 |
Gene name | nuclear receptor corepressor 1 | splicing factor 3b subunit 1 | |
Synonyms | N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR | Hsh155|MDS|PRP10|PRPF10|SAP155|SF3b155 | |
Cytomap | 17p12-p11.2 | 2q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1 | splicing factor 3B subunit 1pre-mRNA processing 10pre-mRNA splicing factor SF3b, 155 kDa subunitspliceosome-associated protein 155splicing factor 3b, subunit 1, 155kDa | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | O75376 | O75533 | |
Ensembl transtripts involved in fusion gene | ENST00000268712, ENST00000395851, ENST00000395857, ENST00000395848, ENST00000583226, | ENST00000335508, ENST00000462613, ENST00000409915, ENST00000414963, ENST00000487698, | |
Fusion gene scores | * DoF score | 18 X 14 X 10=2520 | 3 X 6 X 1=18 |
# samples | 16 | 6 | |
** MAII score | log2(16/2520*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/18*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NCOR1 [Title/Abstract] AND SF3B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NCOR1 | GO:0046329 | negative regulation of JNK cascade | 11931768 |
Tgene | SF3B1 | GO:0000398 | mRNA splicing, via spliceosome | 11252167|28781166 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM836125 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000268712 | ENST00000335508 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000268712 | ENST00000462613 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000268712 | ENST00000409915 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000268712 | ENST00000414963 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000268712 | ENST00000487698 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-3CDS | ENST00000395851 | ENST00000335508 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395851 | ENST00000462613 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395851 | ENST00000409915 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395851 | ENST00000414963 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395851 | ENST00000487698 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-3CDS | ENST00000395857 | ENST00000335508 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395857 | ENST00000462613 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395857 | ENST00000409915 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395857 | ENST00000414963 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395857 | ENST00000487698 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-3CDS | ENST00000395848 | ENST00000335508 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395848 | ENST00000462613 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395848 | ENST00000409915 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395848 | ENST00000414963 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000395848 | ENST00000487698 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-3CDS | ENST00000583226 | ENST00000335508 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000583226 | ENST00000462613 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000583226 | ENST00000409915 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000583226 | ENST00000414963 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
intron-intron | ENST00000583226 | ENST00000487698 | NCOR1 | chr17 | 16029416 | - | SF3B1 | chr2 | 198264892 | - |
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FusionProtFeatures for NCOR1_SF3B1 |
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Hgene | Tgene |
NCOR1 | SF3B1 |
Mediates transcriptional repression by certain nuclearreceptors. Part of a complex which promotes histone deacetylationand the formation of repressive chromatin structures which mayimpede the access of basal transcription factors. Participates inthe transcriptional repressor activity produced by BCL6.{ECO:0000269|PubMed:14527417}. | Involved in pre-mRNA splicing as a component of thesplicing factor SF3B complex (PubMed:27720643). SF3B complex isrequired for 'A' complex assembly formed by the stable binding ofU2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequenceindependent binding of SF3A/SF3B complex upstream of the branchsite is essential, it may anchor U2 snRNP to the pre-mRNA(PubMed:12234937). May also be involved in the assembly of the 'E'complex (PubMed:10882114). Belongs also to the minor U12-dependentspliceosome, which is involved in the splicing of rare class ofnuclear pre-mRNA intron (PubMed:15146077).{ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937,ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NCOR1_SF3B1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NCOR1_SF3B1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NCOR1_SF3B1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NCOR1_SF3B1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NCOR1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | NCOR1 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Hgene | NCOR1 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | NCOR1 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | NCOR1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | NCOR1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | SF3B1 | C0220633 | Uveal melanoma | 2 | CTD_human;ORPHANET |
Tgene | SF3B1 | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
Tgene | SF3B1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |